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Peripheral CD4 T follicular cells induced by a conjugated pneumococcal vaccine correlate with enhanced opsonophagocytic antibody responses in younger individuals.

Sterrett S, Peng BJ, Burton RL, LaFon DC, Westfall AO, Singh S, Pride M, Anderson AS, Ippolito GC, Schroeder HW Jr, Nahm MH, Krishna Prasad A, Goepfert P, Bansal A.

Vaccine. 2020 Jan 3. pii: S0264-410X(19)31665-2. doi: 10.1016/j.vaccine.2019.12.023. [Epub ahead of print]


Pneumococci Can Become Virulent by Acquiring a New Capsule From Oral Streptococci.

Nahm MH, Brissac T, Kilian M, Vlach J, Orihuela CJ, Saad JS, Ganaie F.

J Infect Dis. 2019 Sep 7. pii: jiz456. doi: 10.1093/infdis/jiz456. [Epub ahead of print]


Development for Clinical Use of a Multiplexed Immunoassay Using Sputum Samples for Streptococcus pneumoniae: a Non-Culture-Based Approach for Serotype-Specific Detection.

Kim SJ, Jeong YJ, Kim JH, Yoon YK, Sohn JW, Nahm MH, Kim MJ.

J Clin Microbiol. 2019 Sep 24;57(10). pii: e01782-18. doi: 10.1128/JCM.01782-18. Print 2019 Oct.


Molecular typing, antibiotic susceptibility, and biofilm production in nonencapsulated Streptococcus pneumoniae isolated from children in Japan.

Takeuchi N, Ohkusu M, Wada N, Kurosawa S, Miyabe A, Yamaguchi M, Nahm MH, Ishiwada N.

J Infect Chemother. 2019 Oct;25(10):750-757. doi: 10.1016/j.jiac.2019.02.007. Epub 2019 Jun 22.


Putative novel cps loci in a large global collection of pneumococci.

van Tonder AJ, Gladstone RA, Lo SW, Nahm MH, du Plessis M, Cornick J, Kwambana-Adams B, Madhi SA, Hawkins PA, Benisty R, Dagan R, Everett D, Antonio M, Klugman KP, von Gottberg A, Breiman RF, McGee L, Bentley SD, The Global Pneumococcal Sequencing Consortium.

Microb Genom. 2019 Jul;5(7). doi: 10.1099/mgen.0.000274. Epub 2019 Jun 11.


A High-throughput Shigella-specific Bactericidal Assay.

Weerts HP, Yu J, Kaminski RW, Nahm MH.

J Vis Exp. 2019 Feb 27;(144). doi: 10.3791/59164.


Serocorrelates of protection against infant group B streptococcus disease.

Le Doare K, Kampmann B, Vekemans J, Heath PT, Goldblatt D, Nahm MH, Baker C, Edwards MS, Kwatra G, Andrews N, Madhi SA, Ter Meulen AS, Anderson AS, Corsaro B, Fischer P, Gorringe A.

Lancet Infect Dis. 2019 May;19(5):e162-e171. doi: 10.1016/S1473-3099(18)30659-5. Epub 2019 Jan 22. Review.


Ficolin-2 binds to serotype 35B pneumococcus as it does to serotypes 11A and 31, and these serotypes cause more infections in older adults than in children.

Geno KA, Spencer BL, Bae S, Nahm MH.

PLoS One. 2018 Dec 26;13(12):e0209657. doi: 10.1371/journal.pone.0209657. eCollection 2018.


Measuring quantity and function of pneumococcal antibodies in immunoglobulin products.

LaFon DC, Nahm MH.

Transfusion. 2018 Dec;58 Suppl 3:3114-3120. doi: 10.1111/trf.15015. Review.


Interlaboratory variability in multiplexed pneumococcal antibody testing.

LaFon DC, Nahm MH.

J Allergy Clin Immunol. 2019 Mar;143(3):1255-1257. doi: 10.1016/j.jaci.2018.10.057. Epub 2018 Nov 20. No abstract available. Erratum in: J Allergy Clin Immunol. 2019 Aug;144(2):626.


Measuring immune responses to pneumococcal vaccines.

LaFon DC, Nahm MH.

J Immunol Methods. 2018 Oct;461:37-43. doi: 10.1016/j.jim.2018.08.002. Epub 2018 Aug 8. Review.


Development, Interlaboratory Evaluations, and Application of a Simple, High-Throughput Shigella Serum Bactericidal Assay.

Nahm MH, Yu J, Weerts HP, Wenzel H, Tamilselvi CS, Chandrasekaran L, Pasetti MF, Mani S, Kaminski RW.

mSphere. 2018 Jun 13;3(3). pii: e00146-18. doi: 10.1128/mSphere.00146-18. Print 2018 Jun 27.


Effect of prior vaccination on carriage rates of Streptococcus pneumoniae in older adults: A longitudinal surveillance study.

Branche AR, Yang H, Java J, Holden-Wiltse J, Topham DJ, Peasley M, Frost MR, Nahm MH, Falsey AR.

Vaccine. 2018 Jul 5;36(29):4304-4310. doi: 10.1016/j.vaccine.2018.05.107. Epub 2018 Jun 2.


Creation, characterization, and assignment of opsonic values for a new pneumococcal OPA calibration serum panel (Ewha QC sera panel A) for 13 serotypes.

Burton RL, Kim HW, Lee S, Kim H, Seok JH, Lee SH, Balloch A, Licciardi P, Marimla R, Bae S, Nahm MH, Kim KH.

Medicine (Baltimore). 2018 Apr;97(17):e0567. doi: 10.1097/MD.0000000000010567. Erratum in: Medicine (Baltimore). 2018 Jun;97(23):e11171.


Randomized clinical trial of a single versus a double dose of 13-valent pneumococcal conjugate vaccine in adults 55 through 74 years of age previously vaccinated with 23-valent pneumococcal polysaccharide vaccine.

Jackson LA, El Sahly HM, George S, Winokur P, Edwards K, Brady RC, Rouphael N, Keitel WA, Mulligan MJ, Burton RL, Nakamura A, Ferreria J, Nahm MH.

Vaccine. 2018 Jan 29;36(5):606-614. doi: 10.1016/j.vaccine.2017.12.061. Epub 2017 Dec 24.


WciG O-Acetyltransferase Functionality Differentiates Pneumococcal Serotypes 35C and 42.

Geno KA, Bush CA, Wang M, Jin C, Nahm MH, Yang J.

J Clin Microbiol. 2017 Sep;55(9):2775-2784. doi: 10.1128/JCM.00822-17. Epub 2017 Jun 28.


The Pneumococcal Serotype 15C Capsule Is Partially O-Acetylated and Allows for Limited Evasion of 23-Valent Pneumococcal Polysaccharide Vaccine-Elicited Anti-Serotype 15B Antibodies.

Spencer BL, Shenoy AT, Orihuela CJ, Nahm MH.

Clin Vaccine Immunol. 2017 Aug 4;24(8). pii: e00099-17. doi: 10.1128/CVI.00099-17. Print 2017 Aug.


Position of O-Acetylation within the Capsular Repeat Unit Impacts the Biological Properties of Pneumococcal Serotypes 33A and 33F.

Spencer BL, Saad JS, Shenoy AT, Orihuela CJ, Nahm MH.

Infect Immun. 2017 Jun 20;85(7). pii: e00132-17. doi: 10.1128/IAI.00132-17. Print 2017 Jul.


Discovery of Novel Pneumococcal Serotype 35D, a Natural WciG-Deficient Variant of Serotype 35B.

Geno KA, Saad JS, Nahm MH.

J Clin Microbiol. 2017 May;55(5):1416-1425. doi: 10.1128/JCM.00054-17. Epub 2017 Feb 15.


Indirect Effects of Pneumococcal Conjugate Vaccines in National Immunization Programs for Children on Adult Pneumococcal Disease.

Kim YK, LaFon D, Nahm MH.

Infect Chemother. 2016 Dec;48(4):257-266. doi: 10.3947/ic.2016.48.4.257. Review.


Assignment of Opsonic Values to Pneumococcal Reference Serum 007sp for Use in Opsonophagocytic Assays for 13 Serotypes.

Burton RL, Antonello J, Cooper D, Goldblatt D, Kim KH, Plikaytis BD, Roalfe L, Wauters D, Williams F, Xie GL, Nahm MH, Akkoyunlu M.

Clin Vaccine Immunol. 2017 Feb 6;24(2). pii: e00457-16. doi: 10.1128/CVI.00457-16. Print 2017 Feb.


Ficolin-2 inhibitors are present in sera after prolonged storage at -80 °C.

Geno KA, Kennedy RE, Sawyer P, Brown CJ, Nahm MH.

PeerJ. 2016 Nov 17;4:e2705. eCollection 2016.


A high throughput serum bactericidal assay for antibodies to Haemophilus influenzae type b.

Kim HW, Kim KH, Kim J, Nahm MH.

BMC Infect Dis. 2016 Sep 5;16:473. doi: 10.1186/s12879-016-1808-4.


Monoclonal Antibodies to Shigella Lipopolysaccharide Are Useful for Vaccine Production.

Lin J, Smith MA, Benjamin WH Jr, Kaminski RW, Wenzel H, Nahm MH.

Clin Vaccine Immunol. 2016 Aug 5;23(8):681-8. doi: 10.1128/CVI.00148-16. Print 2016 Aug.


Pneumococcus with the "6E" cps Locus Produces Serotype 6B Capsular Polysaccharide.

Burton RL, Geno KA, Saad JS, Nahm MH.

J Clin Microbiol. 2016 Apr;54(4):967-71. doi: 10.1128/JCM.03194-15. Epub 2016 Jan 27.


Molecular epidemiology of nonencapsulated Streptococcus pneumoniae among Japanese children with acute otitis media.

Hotomi M, Nakajima K, Hiraoka M, Nahm MH, Yamanaka N.

J Infect Chemother. 2016 Feb;22(2):72-7. doi: 10.1016/j.jiac.2015.10.006. Epub 2015 Dec 17.


NOD-Like Receptors in Infection, Immunity, and Diseases.

Kim YK, Shin JS, Nahm MH.

Yonsei Med J. 2016 Jan;57(1):5-14. doi: 10.3349/ymj.2016.57.1.5. Review.


Discovery of Streptococcus pneumoniae serotype 6 variants with glycosyltransferases synthesizing two differing repeating units.

Oliver MB, van der Linden MP, Küntzel SA, Saad JS, Nahm MH.

J Biol Chem. 2015 Oct 30;290(44):26474-5. doi: 10.1074/jbc.A113.480152. No abstract available.


Pneumococcal Capsules and Their Types: Past, Present, and Future.

Geno KA, Gilbert GL, Song JY, Skovsted IC, Klugman KP, Jones C, Konradsen HB, Nahm MH.

Clin Microbiol Rev. 2015 Jul;28(3):871-99. doi: 10.1128/CMR.00024-15. Review.


Rapid and efficient purification of ficolin-2 using a disposable CELLine bioreactor.

Geno KA, Spencer BL, Nahm MH.

J Immunol Methods. 2015 Sep;424:106-10. doi: 10.1016/j.jim.2015.05.008. Epub 2015 May 30.


Nonencapsulated Streptococcus pneumoniae Cause Acute Otitis Media in the Chinchilla That Is Enhanced by Pneumococcal Surface Protein K.

Keller LE, Friley J, Dixit C, Nahm MH, McDaniel LS.

Open Forum Infect Dis. 2014 Jul 1;1(2):ofu037. doi: 10.1093/ofid/ofu037. eCollection 2014 Sep.


Genetic, biochemical, and serological characterization of a new pneumococcal serotype, 6H, and generation of a pneumococcal strain producing three different capsular repeat units.

Park IH, Geno KA, Yu J, Oliver MB, Kim KH, Nahm MH.

Clin Vaccine Immunol. 2015 Mar;22(3):313-8. doi: 10.1128/CVI.00647-14. Epub 2015 Jan 14.


Commercially available complement component-depleted sera are unexpectedly codepleted of ficolin-2.

Brady AM, Geno KA, Dalecki AG, Cheng X, Nahm MH.

Clin Vaccine Immunol. 2014 Sep;21(9):1323-9. doi: 10.1128/CVI.00370-14. Epub 2014 Jul 16.


Identification of Streptococcus pneumoniae serotype 11E, serovariant 11Av and mixed populations by high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and flow cytometric serotyping assay (FCSA).

Camilli R, Spencer BL, Moschioni M, Pinto V, Berti F, Nahm MH, Pantosti A.

PLoS One. 2014 Jun 26;9(6):e100722. doi: 10.1371/journal.pone.0100722. eCollection 2014.


Population-based analysis of invasive nontypeable pneumococci reveals that most have defective capsule synthesis genes.

Park IH, Geno KA, Sherwood LK, Nahm MH, Beall B.

PLoS One. 2014 May 15;9(5):e97825. doi: 10.1371/journal.pone.0097825. eCollection 2014.


Impact of preceding flu-like illness on the serotype distribution of pneumococcal pneumonia.

Song JY, Nahm MH, Cheong HJ, Kim WJ.

PLoS One. 2014 Apr 1;9(4):e93477. doi: 10.1371/journal.pone.0093477. eCollection 2014.


Low invasiveness of pneumococcal serotype 11A is linked to ficolin-2 recognition of O-acetylated capsule epitopes and lectin complement pathway activation.

Brady AM, Calix JJ, Yu J, Geno KA, Cutter GR, Nahm MH.

J Infect Dis. 2014 Oct 1;210(7):1155-65. doi: 10.1093/infdis/jiu195. Epub 2014 Mar 27.


Impaired serotype-specific immune function following pneumococcal vaccination in infants with prior carriage.

Licciardi PV, Russell FM, Balloch A, Burton RL, Nahm MH, Gilbert G, Tang ML, Mulholland EK.

Vaccine. 2014 Apr 25;32(20):2321-7. doi: 10.1016/j.vaccine.2014.02.064. Epub 2014 Mar 6.


Diagnosis of pneumococcal pneumonia: current pitfalls and the way forward.

Song JY, Eun BW, Nahm MH.

Infect Chemother. 2013 Dec;45(4):351-66. doi: 10.3947/ic.2013.45.4.351. Epub 2013 Dec 27. Review.


L-rhamnose is often an important part of immunodominant epitope for pneumococcal serotype 23F polysaccharide antibodies in human sera immunized with PPV23.

Park S, Nahm MH.

PLoS One. 2013 Dec 31;8(12):e83810. doi: 10.1371/journal.pone.0083810. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/84458b5b-2bae-4d71-b003-7d584c1bfd8c.


Towards New Broader Spectrum Pneumococcal Vaccines: The Future of Pneumococcal Disease Prevention.

Lee LH, Gu XX, Nahm MH.

Vaccines (Basel). 2014 Feb 14;2(1):112-28. doi: 10.3390/vaccines2010112. Review.


Spectrum of pneumococcal serotype 11A variants results from incomplete loss of capsule O-acetylation.

Calix JJ, Brady AM, Du VY, Saad JS, Nahm MH.

J Clin Microbiol. 2014 Mar;52(3):758-65. doi: 10.1128/JCM.02695-13. Epub 2013 Dec 18.


Blood collection tubes influence serum ficolin-1 and ficolin-2 levels.

Brady AM, Spencer BL, Falsey AR, Nahm MH.

Clin Vaccine Immunol. 2014 Jan;21(1):51-5. doi: 10.1128/CVI.00607-13. Epub 2013 Oct 30.


Streptococcus pneumoniae serotype 6C presenting as recurrent prosthetic knee joint infection in a patient with a history of congenital asplenia and underlying autoimmune disease: a case report and literature review.

Roberts AL, Hewlett AL, Yu J, Nahm MH, Fey PD, Iwen PC.

Diagn Microbiol Infect Dis. 2013 Dec;77(4):376-9. doi: 10.1016/j.diagmicrobio.2013.09.011. Epub 2013 Sep 28. Review.


Invasive and noninvasive Streptococcus pneumoniae capsule and surface protein diversity following the use of a conjugate vaccine.

Croney CM, Nahm MH, Juhn SK, Briles DE, Crain MJ.

Clin Vaccine Immunol. 2013 Nov;20(11):1711-8. doi: 10.1128/CVI.00381-13. Epub 2013 Sep 4.


Modified opsonization, phagocytosis, and killing assays to measure potentially protective antibodies against pneumococcal surface protein A.

Daniels CC, Kim KH, Burton RL, Mirza S, Walker M, King J, Hale Y, Coan P, Rhee DK, Nahm MH, Briles DE.

Clin Vaccine Immunol. 2013 Oct;20(10):1549-58. doi: 10.1128/CVI.00371-13. Epub 2013 Aug 7.


Discovery of Streptococcus pneumoniae serotype 6 variants with glycosyltransferases synthesizing two differing repeating units.

Oliver MB, van der Linden MP, Küntzel SA, Saad JS, Nahm MH.

J Biol Chem. 2013 Sep 6;288(36):25976-85. doi: 10.1074/jbc.M113.480152. Epub 2013 Jul 29. Erratum in: J Biol Chem. 2015 Oct 30;290(44):26474-5.


Draft Genome Sequences of Five Multilocus Sequence Types of Nonencapsulated Streptococcus pneumoniae.

Keller LE, Thomas JC, Luo X, Nahm MH, McDaniel LS, Robinson DA.

Genome Announc. 2013 Jul 25;1(4). pii: e00520-13. doi: 10.1128/genomeA.00520-13.


Streptococcus pneumoniae serotype 11D has a bispecific glycosyltransferase and expresses two different capsular polysaccharide repeating units.

Oliver MB, Jones C, Larson TR, Calix JJ, Zartler ER, Yother J, Nahm MH.

J Biol Chem. 2013 Jul 26;288(30):21945-54. doi: 10.1074/jbc.M113.488528. Epub 2013 Jun 4.

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