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Interviral recombination between plant, insect and fungal RNA viruses: The role of intracellular Ca++/Mn++ pump.

Kovalev N, Pogany J, Nagy PD.

J Virol. 2019 Oct 9. pii: JVI.01015-19. doi: 10.1128/JVI.01015-19. [Epub ahead of print]


Screening Legionella effectors for antiviral effects reveals Rab1 GTPase as a proviral factor coopted for tombusvirus replication.

Inaba JI, Xu K, Kovalev N, Ramanathan H, Roy CR, Lindenbach BD, Nagy PD.

Proc Natl Acad Sci U S A. 2019 Oct 7. pii: 201911108. doi: 10.1073/pnas.1911108116. [Epub ahead of print]


Blocking tombusvirus replication through the antiviral functions of DDX17-like RH30 DEAD-box helicase.

Wu CY, Nagy PD.

PLoS Pathog. 2019 May 28;15(5):e1007771. doi: 10.1371/journal.ppat.1007771. eCollection 2019 May.


Recruitment of Vps34 PI3K and enrichment of PI3P phosphoinositide in the viral replication compartment is crucial for replication of a positive-strand RNA virus.

Feng Z, Xu K, Kovalev N, Nagy PD.

PLoS Pathog. 2019 Jan 9;15(1):e1007530. doi: 10.1371/journal.ppat.1007530. eCollection 2019 Jan.


Assembly-hub function of ER-localized SNARE proteins in biogenesis of tombusvirus replication compartment.

Sasvari Z, Kovalev N, Gonzalez PA, Xu K, Nagy PD.

PLoS Pathog. 2018 May 10;14(5):e1007028. doi: 10.1371/journal.ppat.1007028. eCollection 2018 May.


Tombusvirus RNA replication depends on the TOR pathway in yeast and plants.

Inaba JI, Nagy PD.

Virology. 2018 Jun;519:207-222. doi: 10.1016/j.virol.2018.04.010. Epub 2018 May 7.


The Glycolytic Pyruvate Kinase Is Recruited Directly into the Viral Replicase Complex to Generate ATP for RNA Synthesis.

Chuang C, Prasanth KR, Nagy PD.

Cell Host Microbe. 2017 Nov 8;22(5):639-652.e7. doi: 10.1016/j.chom.2017.10.004. Epub 2017 Nov 5.


Co-opting ATP-generating glycolytic enzyme PGK1 phosphoglycerate kinase facilitates the assembly of viral replicase complexes.

Prasanth KR, Chuang C, Nagy PD.

PLoS Pathog. 2017 Oct 23;13(10):e1006689. doi: 10.1371/journal.ppat.1006689. eCollection 2017 Oct.


Exploitation of a surrogate host, Saccharomyces cerevisiae, to identify cellular targets and develop novel antiviral approaches.

Nagy PD.

Curr Opin Virol. 2017 Oct;26:132-140. doi: 10.1016/j.coviro.2017.07.031. Epub 2017 Aug 23. Review.


The role of co-opted ESCRT proteins and lipid factors in protection of tombusviral double-stranded RNA replication intermediate against reconstituted RNAi in yeast.

Kovalev N, Inaba JI, Li Z, Nagy PD.

PLoS Pathog. 2017 Jul 31;13(7):e1006520. doi: 10.1371/journal.ppat.1006520. eCollection 2017 Jul.


Sterol Binding by the Tombusviral Replication Proteins Is Essential for Replication in Yeast and Plants.

Xu K, Nagy PD.

J Virol. 2017 Mar 13;91(7). pii: e01984-16. doi: 10.1128/JVI.01984-16. Print 2017 Apr 1.


Building Viral Replication Organelles: Close Encounters of the Membrane Types.

Nagy PD, Strating JR, van Kuppeveld FJ.

PLoS Pathog. 2016 Oct 27;12(10):e1005912. doi: 10.1371/journal.ppat.1005912. eCollection 2016 Oct. Review. No abstract available.


Enrichment of Phosphatidylethanolamine in Viral Replication Compartments via Co-opting the Endosomal Rab5 Small GTPase by a Positive-Strand RNA Virus.

Xu K, Nagy PD.

PLoS Biol. 2016 Oct 19;14(10):e2000128. doi: 10.1371/journal.pbio.2000128. eCollection 2016 Oct.


Tombusvirus-Host Interactions: Co-Opted Evolutionarily Conserved Host Factors Take Center Court.

Nagy PD.

Annu Rev Virol. 2016 Sep 29;3(1):491-515. Epub 2016 Aug 8. Review.


Three-dimensional imaging of the intracellular assembly of a functional viral RNA replicase complex.

Fernández de Castro I, Fernández JJ, Barajas D, Nagy PD, Risco C.

J Cell Sci. 2017 Jan 1;130(1):260-268. doi: 10.1242/jcs.181586. Epub 2016 Mar 29.


Viral Replication Protein Inhibits Cellular Cofilin Actin Depolymerization Factor to Regulate the Actin Network and Promote Viral Replicase Assembly.

Nawaz-ul-Rehman MS, Prasanth KR, Xu K, Sasvari Z, Kovalev N, de Castro Martín IF, Barajas D, Risco C, Nagy PD.

PLoS Pathog. 2016 Feb 10;12(2):e1005440. doi: 10.1371/journal.ppat.1005440. eCollection 2016 Feb.


Role of Viral RNA and Co-opted Cellular ESCRT-I and ESCRT-III Factors in Formation of Tombusvirus Spherules Harboring the Tombusvirus Replicase.

Kovalev N, de Castro Martín IF, Pogany J, Barajas D, Pathak K, Risco C, Nagy PD.

J Virol. 2016 Jan 20;90(7):3611-26. doi: 10.1128/JVI.02775-15.


Screening a yeast library of temperature-sensitive mutants reveals a role for actin in tombusvirus RNA recombination.

Prasanth KR, Kovalev N, de Castro Martín IF, Baker J, Nagy PD.

Virology. 2016 Feb;489:233-42. doi: 10.1016/j.virol.2015.12.007. Epub 2016 Jan 14.


Cellular Ubc2/Rad6 E2 ubiquitin-conjugating enzyme facilitates tombusvirus replication in yeast and plants.

Imura Y, Molho M, Chuang C, Nagy PD.

Virology. 2015 Oct;484:265-75. doi: 10.1016/j.virol.2015.05.022. Epub 2015 Jun 30.


RNA virus replication depends on enrichment of phosphatidylethanolamine at replication sites in subcellular membranes.

Xu K, Nagy PD.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1782-91. doi: 10.1073/pnas.1418971112. Epub 2015 Mar 25.


Coordinated function of cellular DEAD-box helicases in suppression of viral RNA recombination and maintenance of viral genome integrity.

Chuang C, Prasanth KR, Nagy PD.

PLoS Pathog. 2015 Feb 18;11(2):e1004680. doi: 10.1371/journal.ppat.1004680. eCollection 2015 Feb.


Salicylic Acid Inhibits the Replication of Tomato bushy stunt virus by Directly Targeting a Host Component in the Replication Complex.

Tian M, Sasvari Z, Gonzalez PA, Friso G, Rowland E, Liu XM, van Wijk KJ, Nagy PD, Klessig DF.

Mol Plant Microbe Interact. 2015 Apr;28(4):379-86. doi: 10.1094/MPMI-09-14-0259-R.


Novel mechanism of regulation of tomato bushy stunt virus replication by cellular WW-domain proteins.

Barajas D, Kovalev N, Qin J, Nagy PD.

J Virol. 2015 Feb;89(4):2064-79. doi: 10.1128/JVI.02719-14. Epub 2014 Dec 3.


Expanding use of multi-origin subcellular membranes by positive-strand RNA viruses during replication.

Xu K, Nagy PD.

Curr Opin Virol. 2014 Dec;9:119-26. doi: 10.1016/j.coviro.2014.09.015. Epub 2014 Oct 22. Review.


Tombusviruses upregulate phospholipid biosynthesis via interaction between p33 replication protein and yeast lipid sensor proteins during virus replication in yeast.

Barajas D, Xu K, Sharma M, Wu CY, Nagy PD.

Virology. 2014 Dec;471-473:72-80. doi: 10.1016/j.virol.2014.10.005. Epub 2014 Oct 28.


Co-opted oxysterol-binding ORP and VAP proteins channel sterols to RNA virus replication sites via membrane contact sites.

Barajas D, Xu K, de Castro Martín IF, Sasvari Z, Brandizzi F, Risco C, Nagy PD.

PLoS Pathog. 2014 Oct 16;10(10):e1004388. doi: 10.1371/journal.ppat.1004388. eCollection 2014 Oct.


Tombusvirus-yeast interactions identify conserved cell-intrinsic viral restriction factors.

Sasvari Z, Alatriste Gonzalez P, Nagy PD.

Front Plant Sci. 2014 Aug 11;5:383. doi: 10.3389/fpls.2014.00383. eCollection 2014. Review.


The hop-like stress-induced protein 1 cochaperone is a novel cell-intrinsic restriction factor for mitochondrial tombusvirus replication.

Xu K, Lin JY, Nagy PD.

J Virol. 2014 Aug;88(16):9361-78. doi: 10.1128/JVI.00561-14. Epub 2014 Jun 11.


Noncanonical role for the host Vps4 AAA+ ATPase ESCRT protein in the formation of Tomato bushy stunt virus replicase.

Barajas D, Martín IF, Pogany J, Risco C, Nagy PD.

PLoS Pathog. 2014 Apr 24;10(4):e1004087. doi: 10.1371/journal.ppat.1004087. eCollection 2014 Apr.


How yeast can be used as a genetic platform to explore virus-host interactions: from 'omics' to functional studies.

Nagy PD, Pogany J, Lin JY.

Trends Microbiol. 2014 Jun;22(6):309-16. doi: 10.1016/j.tim.2014.02.003. Epub 2014 Mar 16. Review.


Template role of double-stranded RNA in tombusvirus replication.

Kovalev N, Pogany J, Nagy PD.

J Virol. 2014 May;88(10):5638-51. doi: 10.1128/JVI.03842-13. Epub 2014 Mar 5.


Inactivation of the host lipin gene accelerates RNA virus replication through viral exploitation of the expanded endoplasmic reticulum membrane.

Chuang C, Barajas D, Qin J, Nagy PD.

PLoS Pathog. 2014 Feb 20;10(2):e1003944. doi: 10.1371/journal.ppat.1003944. eCollection 2014 Feb.


Methylation of translation elongation factor 1A by the METTL10-like See1 methyltransferase facilitates tombusvirus replication in yeast and plants.

Li Z, Gonzalez PA, Sasvari Z, Kinzy TG, Nagy PD.

Virology. 2014 Jan 5;448:43-54. doi: 10.1016/j.virol.2013.09.012. Epub 2013 Oct 18.


Tombusvirus replication depends on Sec39p endoplasmic reticulum-associated transport protein.

Sasvari Z, Gonzalez PA, Rachubinski RA, Nagy PD.

Virology. 2013 Dec;447(1-2):21-31. doi: 10.1016/j.virol.2013.07.039. Epub 2013 Sep 14.


Cyclophilin A binds to the viral RNA and replication proteins, resulting in inhibition of tombusviral replicase assembly.

Kovalev N, Nagy PD.

J Virol. 2013 Dec;87(24):13330-42. doi: 10.1128/JVI.02101-13. Epub 2013 Oct 2.


Characterization of dominant-negative and temperature-sensitive mutants of tombusvirus replication proteins affecting replicase assembly.

Pathak KB, Jiang Z, Ochanine V, Sharma M, Pogany J, Nagy PD.

Virology. 2013 Mar 1;437(1):48-61. doi: 10.1016/j.virol.2012.12.009. Epub 2013 Jan 16.


Viral replication--in search of the perfect host.

Nagy PD, Richardson CD.

Curr Opin Virol. 2012 Dec;2(6):663-8. No abstract available.


The GEF1 proton-chloride exchanger affects tombusvirus replication via regulation of copper metabolism in yeast.

Sasvari Z, Kovalev N, Nagy PD.

J Virol. 2013 Feb;87(3):1800-10. doi: 10.1128/JVI.02003-12. Epub 2012 Nov 28.


Yeast screens for host factors in positive-strand RNA virus replication based on a library of temperature-sensitive mutants.

Nawaz-ul-Rehman MS, Reddisiva Prasanth K, Baker J, Nagy PD.

Methods. 2013 Feb;59(2):207-16. doi: 10.1016/j.ymeth.2012.11.001. Epub 2012 Nov 10.


Host factors with regulatory roles in tombusvirus replication.

Nagy PD, Barajas D, Pogany J.

Curr Opin Virol. 2012 Dec;2(6):691-8. doi: 10.1016/j.coviro.2012.10.004. Epub 2012 Nov 2. Review.


Authentic in vitro replication of two tombusviruses in isolated mitochondrial and endoplasmic reticulum membranes.

Xu K, Huang TS, Nagy PD.

J Virol. 2012 Dec;86(23):12779-94. doi: 10.1128/JVI.00973-12. Epub 2012 Sep 12.


p33-Independent activation of a truncated p92 RNA-dependent RNA polymerase of Tomato bushy stunt virus in yeast cell-free extract.

Pogany J, Nagy PD.

J Virol. 2012 Nov;86(22):12025-38. doi: 10.1128/JVI.01303-12. Epub 2012 Aug 29.


Similar roles for yeast Dbp2 and Arabidopsis RH20 DEAD-box RNA helicases to Ded1 helicase in tombusvirus plus-strand synthesis.

Kovalev N, Barajas D, Nagy PD.

Virology. 2012 Oct 25;432(2):470-84. doi: 10.1016/j.virol.2012.06.030. Epub 2012 Jul 24.


Proteome-wide overexpression of host proteins for identification of factors affecting tombusvirus RNA replication: an inhibitory role of protein kinase C.

Shah Nawaz-ul-Rehman M, Martinez-Ochoa N, Pascal H, Sasvari Z, Herbst C, Xu K, Baker J, Sharma M, Herbst A, Nagy PD.

J Virol. 2012 Sep;86(17):9384-95. doi: 10.1128/JVI.00019-12. Epub 2012 Jun 20.

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