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Items: 1 to 50 of 173

1.

Inhibition of bioenergetics provides novel insights into recruitment of PINK1-dependent neuronal mitophagy.

Shin YS, Ryall JG, Britto JM, Lau CL, Devenish RJ, Nagley P, Beart PM.

J Neurochem. 2019 Apr;149(2):269-283. doi: 10.1111/jnc.14667. Epub 2019 Feb 12.

PMID:
30664245
2.

Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1.

Atkin JD, Farg MA, Turner BJ, Tomas D, Lysaght JA, Nunan J, Rembach A, Nagley P, Beart PM, Cheema SS, Horne MK.

J Biol Chem. 2017 Jul 14;292(28):12007. doi: 10.1074/jbc.A117.603393. No abstract available.

3.

Mitochondrial research in Australia: a major player in worldwide trends.

Nagley P, St John J, Gabriel K, McKenzie M.

Biochim Biophys Acta. 2014 Apr;1840(4):1225-6. doi: 10.1016/j.bbagen.2014.01.028. Epub 2014 Jan 24. No abstract available.

PMID:
24468066
4.

Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis.

Atkin JD, Farg MA, Soo KY, Walker AK, Halloran M, Turner BJ, Nagley P, Horne MK.

J Neurochem. 2014 Apr;129(1):190-204. doi: 10.1111/jnc.12493. Epub 2013 Nov 13.

5.

Mitochondrially localised MUL1 is a novel modulator of antiviral signaling.

Jenkins K, Khoo JJ, Sadler A, Piganis R, Wang D, Borg NA, Hjerrild K, Gould J, Thomas BJ, Nagley P, Hertzog PJ, Mansell A.

Immunol Cell Biol. 2013 Apr;91(4):321-30. doi: 10.1038/icb.2013.7. Epub 2013 Feb 12.

PMID:
23399697
6.

Transitory phases of autophagic death and programmed necrosis during superoxide-induced neuronal cell death.

Higgins GC, Devenish RJ, Beart PM, Nagley P.

Free Radic Biol Med. 2012 Nov 15;53(10):1960-7. doi: 10.1016/j.freeradbiomed.2012.08.586. Epub 2012 Sep 5.

PMID:
22982049
7.

Application of flow cytometry to determine differential redistribution of cytochrome c and Smac/DIABLO from mitochondria during cell death signaling.

Ng H, Smith DJ, Nagley P.

PLoS One. 2012;7(7):e42298. doi: 10.1371/journal.pone.0042298. Epub 2012 Jul 27.

8.

Bim links ER stress and apoptosis in cells expressing mutant SOD1 associated with amyotrophic lateral sclerosis.

Soo KY, Atkin JD, Farg M, Walker AK, Horne MK, Nagley P.

PLoS One. 2012;7(4):e35413. doi: 10.1371/journal.pone.0035413. Epub 2012 Apr 16.

9.

Identification of a novel gene product that promotes survival of Mycobacterium smegmatis in macrophages.

Pelosi A, Smith D, Brammananth R, Topolska A, Billman-Jacobe H, Nagley P, Crellin PK, Coppel RL.

PLoS One. 2012;7(2):e31788. doi: 10.1371/journal.pone.0031788. Epub 2012 Feb 21.

10.

Modulation of cellular Hsp72 levels in undifferentiated and neuron-like SH-SY5Y cells determines resistance to staurosporine-induced apoptosis.

Cheng L, Smith DJ, Anderson RL, Nagley P.

PLoS One. 2011;6(9):e24473. doi: 10.1371/journal.pone.0024473. Epub 2011 Sep 6.

11.

Human neuroblastoma SH-SY5Y cells show increased resistance to hyperthermic stress after differentiation, associated with elevated levels of Hsp72.

Cheng L, Smith DJ, Anderson RL, Nagley P.

Int J Hyperthermia. 2011;27(5):415-26. doi: 10.3109/02656736.2010.531075. Epub 2011 Apr 5.

PMID:
21756039
12.

Autophagic activity in cortical neurons under acute oxidative stress directly contributes to cell death.

Higgins GC, Devenish RJ, Beart PM, Nagley P.

Cell Mol Life Sci. 2011 Nov;68(22):3725-40. doi: 10.1007/s00018-011-0667-9. Epub 2011 Mar 25.

PMID:
21437645
13.

Sensitive and specific detection of α-synuclein in human plasma.

Tinsley RB, Kotschet K, Modesto D, Ng H, Wang Y, Nagley P, Shaw G, Horne MK.

J Neurosci Res. 2010 Sep;88(12):2693-700. doi: 10.1002/jnr.22417.

PMID:
20648655
14.

Oxidative stress: emerging mitochondrial and cellular themes and variations in neuronal injury.

Higgins GC, Beart PM, Shin YS, Chen MJ, Cheung NS, Nagley P.

J Alzheimers Dis. 2010;20 Suppl 2:S453-73. doi: 10.3233/JAD-2010-100321. Review.

PMID:
20463398
15.

Age-related decline in stress responses of human myocardium may not be explained by changes in mtDNA.

Miller F, Nagley P, Mariani JA, Ou R, Liu VW, Zhang C, Linnane AW, Pepe S, Rosenfeldt F.

Mech Ageing Dev. 2009 Nov-Dec;130(11-12):742-7. doi: 10.1016/j.mad.2009.09.003.

PMID:
19819254
16.

Multifaceted deaths orchestrated by mitochondria in neurones.

Nagley P, Higgins GC, Atkin JD, Beart PM.

Biochim Biophys Acta. 2010 Jan;1802(1):167-85. doi: 10.1016/j.bbadis.2009.09.004. Epub 2009 Sep 12. Review.

17.

Oxidative stress triggers neuronal caspase-independent death: endonuclease G involvement in programmed cell death-type III.

Higgins GC, Beart PM, Nagley P.

Cell Mol Life Sci. 2009 Aug;66(16):2773-87. doi: 10.1007/s00018-009-0079-2. Epub 2009 Jul 7.

PMID:
19582370
18.

GABAergic striatal neurons exhibit caspase-independent, mitochondrially mediated programmed cell death.

Diwakarla S, Mercer LD, Kardashsyan L, Chu PW, Shin YS, Lau CL, Hughes ML, Nagley P, Beart PM.

J Neurochem. 2009 May;109 Suppl 1:198-206. doi: 10.1111/j.1471-4159.2009.05937.x.

19.

Recruitment of mitochondria into apoptotic signaling correlates with the presence of inclusions formed by amyotrophic lateral sclerosis-associated SOD1 mutations.

Soo KY, Atkin JD, Horne MK, Nagley P.

J Neurochem. 2009 Feb;108(3):578-90. doi: 10.1111/j.1471-4159.2008.05799.x. Epub 2008 Nov 27.

20.

Differential insult-dependent recruitment of the intrinsic mitochondrial pathway during neuronal programmed cell death.

Diwakarla S, Nagley P, Hughes ML, Chen B, Beart PM.

Cell Mol Life Sci. 2009 Jan;66(1):156-72. doi: 10.1007/s00018-008-8490-7.

PMID:
18989621
21.

Lack of correlation between MYCN expression and the Warburg effect in neuroblastoma cell lines.

Smith DJ, Cossins LR, Hatzinisiriou I, Haber M, Nagley P.

BMC Cancer. 2008 Sep 14;8:259. doi: 10.1186/1471-2407-8-259.

22.
23.

The mitochondrial gateway to cell death.

Smith DJ, Ng H, Kluck RM, Nagley P.

IUBMB Life. 2008 Jun;60(6):383-9. doi: 10.1002/iub.44. Review.

24.

Hierarchical recruitment by AMPA but not staurosporine of pro-apoptotic mitochondrial signaling in cultured cortical neurons: evidence for caspase-dependent/independent cross-talk.

Beart PM, Lim ML, Chen B, Diwakarla S, Mercer LD, Cheung NS, Nagley P.

J Neurochem. 2007 Dec;103(6):2408-27. Epub 2007 Sep 20.

25.

Rotenone and MPP+ preferentially redistribute apoptosis-inducing factor in apoptotic dopamine neurons.

Lim ML, Mercer LD, Nagley P, Beart PM.

Neuroreport. 2007 Mar 5;18(4):307-12.

PMID:
17435593
26.

Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1.

Atkin JD, Farg MA, Turner BJ, Tomas D, Lysaght JA, Nunan J, Rembach A, Nagley P, Beart PM, Cheema SS, Horne MK.

J Biol Chem. 2006 Oct 6;281(40):30152-65. Epub 2006 Jul 17. Retraction in: J Biol Chem. 2017 Jul 14;292(28):12007.

28.

Microsatellite instability in mitochondrial genome of common female cancers.

Wang Y, Liu VW, Tsang PC, Chiu PM, Cheung AN, Khoo US, Nagley P, Ngan HY.

Int J Gynecol Cancer. 2006 Jan-Feb;16 Suppl 1:259-66.

PMID:
16515601
29.

Smac/DIABLO is not released from mitochondria during apoptotic signalling in cells deficient in cytochrome c.

Hansen TM, Smith DJ, Nagley P.

Cell Death Differ. 2006 Jul;13(7):1181-90. Epub 2005 Oct 21.

30.

Frequent occurrence of mitochondrial microsatellite instability in the D-loop region of human cancers.

Wang Y, Liu VW, Ngan HY, Nagley P.

Ann N Y Acad Sci. 2005 May;1042:123-9.

PMID:
15965053
31.

Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue.

Rosenfeldt F, Marasco S, Lyon W, Wowk M, Sheeran F, Bailey M, Esmore D, Davis B, Pick A, Rabinov M, Smith J, Nagley P, Pepe S.

J Thorac Cardiovasc Surg. 2005 Jan;129(1):25-32.

32.

The oligomycin axis of mitochondrial ATP synthase: OSCP and the proton channel.

Devenish RJ, Prescott M, Boyle GM, Nagley P.

J Bioenerg Biomembr. 2000 Oct;32(5):507-15. Review.

PMID:
15254386
34.

Response of the senescent heart to stress: clinical therapeutic strategies and quest for mitochondrial predictors of biological age.

Rosenfeldt F, Miller F, Nagley P, Hadj A, Marasco S, Quick D, Sheeran F, Wowk M, Pepe S.

Ann N Y Acad Sci. 2004 Jun;1019:78-84.

PMID:
15246998
35.

Each yeast mitochondrial F1F0-ATP synthase complex contains a single copy of subunit 8.

Stephens AN, Nagley P, Devenish RJ.

Biochim Biophys Acta. 2003 Dec 8;1607(2-3):181-9.

PMID:
14670608
36.

High frequency of mitochondrial genome instability in human endometrial carcinomas.

Liu VW, Yang HJ, Wang Y, Tsang PC, Cheung AN, Chiu PM, Ng TY, Wong LC, Nagley P, Ngan HY.

Br J Cancer. 2003 Aug 18;89(4):697-701.

37.

AIF: a multifunctional cog in the life and death machine.

Hansen TM, Nagley P.

Sci STKE. 2003 Jul 29;2003(193):PE31. Review.

PMID:
12888619
38.

Mitochondrial DNA variant 16189T>C is associated with susceptibility to endometrial cancer.

Liu VW, Wang Y, Yang HJ, Tsang PC, Ng TY, Wong LC, Nagley P, Ngan HY.

Hum Mutat. 2003 Aug;22(2):173-4. No abstract available.

PMID:
12872259
39.

Microscopic photosensitization: a new tool to investigate the role of mitochondria in cell death.

Lum MG, Minamikawa T, Nagley P.

ScientificWorldJournal. 2002 May 3;2:1198-208.

40.
42.

The molecular neighborhood of subunit 8 of yeast mitochondrial F1F0-ATP synthase probed by cysteine scanning mutagenesis and chemical modification.

Stephens AN, Khan MA, Roucou X, Nagley P, Devenish RJ.

J Biol Chem. 2003 May 16;278(20):17867-75. Epub 2003 Mar 7.

43.

Subunit gamma-green fluorescent protein fusions are functionally incorporated into mitochondrial F1F0-ATP synthase, arguing against a rigid cap structure at the top of F1.

Prescott M, Nowakowski S, Gavin P, Nagley P, Whisstock JC, Devenish RJ.

J Biol Chem. 2003 Jan 3;278(1):251-6. Epub 2002 Oct 31.

44.

On the release of cytochrome c from mitochondria during cell death signaling.

Lim ML, Lum MG, Hansen TM, Roucou X, Nagley P.

J Biomed Sci. 2002;9(6 Pt 1):488-506. Review.

PMID:
12372987
45.

The effects of ageing on the response to cardiac surgery: protective strategies for the ageing myocardium.

Rosenfeldt FL, Pepe S, Linnane A, Nagley P, Rowland M, Ou R, Marasco S, Lyon W.

Biogerontology. 2002;3(1-2):37-40.

PMID:
12014839
46.

Coenzyme Q10 protects the aging heart against stress: studies in rats, human tissues, and patients.

Rosenfeldt FL, Pepe S, Linnane A, Nagley P, Rowland M, Ou R, Marasco S, Lyon W, Esmore D.

Ann N Y Acad Sci. 2002 Apr;959:355-9; discussion 463-5.

PMID:
11976209
47.

Microscopic Photosensitization with Chloromethyl-X-Rosamine on a Subpopulation of Mitochondria Induces Apoptosis in Human Osteosarcoma Cells.

Lum M, Minamikawa T, Nagley P.

ScientificWorldJournal. 2001 Dec 12;1:55. doi: 10.1100/tsw.2001.169. eCollection 2001. No abstract available.

48.
49.

High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas.

Liu VW, Shi HH, Cheung AN, Chiu PM, Leung TW, Nagley P, Wong LC, Ngan HY.

Cancer Res. 2001 Aug 15;61(16):5998-6001.

50.

Mitochondrial DNA deletions parallel age-linked decline in rat sensory nerve function.

Nagley P, Zhang C, Lim ML, Merhi M, Needham BE, Khalil Z.

Neurobiol Aging. 2001 Jul-Aug;22(4):635-43.

PMID:
11445264

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