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Items: 17


Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab.

Chin SM, Kimberlin CR, Roe-Zurz Z, Zhang P, Xu A, Liao-Chan S, Sen D, Nager AR, Oakdale NS, Brown C, Wang F, Yang Y, Lindquist K, Yeung YA, Salek-Ardakani S, Chaparro-Riggers J.

Nat Commun. 2018 Nov 8;9(1):4679. doi: 10.1038/s41467-018-07136-7.


BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone.

Ye F, Nager AR, Nachury MV.

J Cell Biol. 2018 May 7;217(5):1847-1868. doi: 10.1083/jcb.201709041. Epub 2018 Feb 26.


Covalently linked HslU hexamers support a probabilistic mechanism that links ATP hydrolysis to protein unfolding and translocation.

Baytshtok V, Chen J, Glynn SE, Nager AR, Grant RA, Baker TA, Sauer RT.

J Biol Chem. 2017 Apr 7;292(14):5695-5704. doi: 10.1074/jbc.M116.768978. Epub 2017 Feb 21.


An Actin Network Dispatches Ciliary GPCRs into Extracellular Vesicles to Modulate Signaling.

Nager AR, Goldstein JS, Herranz-Pérez V, Portran D, Ye F, Garcia-Verdugo JM, Nachury MV.

Cell. 2017 Jan 12;168(1-2):252-263.e14. doi: 10.1016/j.cell.2016.11.036. Epub 2016 Dec 22.


Loss of the BBSome perturbs endocytic trafficking and disrupts virulence of Trypanosoma brucei.

Langousis G, Shimogawa MM, Saada EA, Vashisht AA, Spreafico R, Nager AR, Barshop WD, Nachury MV, Wohlschlegel JA, Hill KL.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):632-7. doi: 10.1073/pnas.1518079113. Epub 2015 Dec 31.


Erratum: Coordinated gripping of substrate by subunits of an AAA+ proteolytic machine.

Iosefson O, Nager AR, Baker TA, Sauer RT.

Nat Chem Biol. 2015 Apr;11(4):299. doi: 10.1038/nchembio0415-299a. No abstract available.


Coordinated gripping of substrate by subunits of a AAA+ proteolytic machine.

Iosefson O, Nager AR, Baker TA, Sauer RT.

Nat Chem Biol. 2015 Mar;11(3):201-6. doi: 10.1038/nchembio.1732. Epub 2015 Jan 19. Erratum in: Nat Chem Biol. 2015 Apr;11(4):299.


The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3.

Liew GM, Ye F, Nager AR, Murphy JP, Lee JS, Aguiar M, Breslow DK, Gygi SP, Nachury MV.

Dev Cell. 2014 Nov 10;31(3):265-278. doi: 10.1016/j.devcel.2014.09.004. Epub 2014 Oct 30.


Structural basis for membrane targeting of the BBSome by ARL6.

Mourão A, Nager AR, Nachury MV, Lorentzen E.

Nat Struct Mol Biol. 2014 Dec;21(12):1035-41. doi: 10.1038/nsmb.2920. Epub 2014 Nov 17.


Mechanochemical basis of protein degradation by a double-ring AAA+ machine.

Olivares AO, Nager AR, Iosefson O, Sauer RT, Baker TA.

Nat Struct Mol Biol. 2014 Oct;21(10):871-5. doi: 10.1038/nsmb.2885. Epub 2014 Sep 7.


Nucleotide binding and conformational switching in the hexameric ring of a AAA+ machine.

Stinson BM, Nager AR, Glynn SE, Schmitz KR, Baker TA, Sauer RT.

Cell. 2013 Apr 25;153(3):628-39. doi: 10.1016/j.cell.2013.03.029.


Engineering fluorescent protein substrates for the AAA+ Lon protease.

Wohlever ML, Nager AR, Baker TA, Sauer RT.

Protein Eng Des Sel. 2013 Apr;26(4):299-305. doi: 10.1093/protein/gzs105. Epub 2013 Jan 28.


Dynamic and static components power unfolding in topologically closed rings of a AAA+ proteolytic machine.

Glynn SE, Nager AR, Baker TA, Sauer RT.

Nat Struct Mol Biol. 2012 May 6;19(6):616-22. doi: 10.1038/nsmb.2288.


Stepwise unfolding of a β barrel protein by the AAA+ ClpXP protease.

Nager AR, Baker TA, Sauer RT.

J Mol Biol. 2011 Oct 14;413(1):4-16. doi: 10.1016/j.jmb.2011.07.041. Epub 2011 Jul 29. Erratum in: J Mol Biol. 2013 Apr 12;425(7):1241-3.


Glycine dimerization motif in the N-terminal transmembrane domain of the high density lipoprotein receptor SR-BI required for normal receptor oligomerization and lipid transport.

Gaidukov L, Nager AR, Xu S, Penman M, Krieger M.

J Biol Chem. 2011 May 27;286(21):18452-64. doi: 10.1074/jbc.M111.229872. Epub 2011 Mar 25.


Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine.

Glynn SE, Martin A, Nager AR, Baker TA, Sauer RT.

Cell. 2009 Nov 13;139(4):744-56. doi: 10.1016/j.cell.2009.09.034.


A dynamic model for replication protein A (RPA) function in DNA processing pathways.

Fanning E, Klimovich V, Nager AR.

Nucleic Acids Res. 2006;34(15):4126-37. Epub 2006 Aug 25. Review.

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