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Blood-Brain Barrier Dysfunction in Idiopathic Intracranial Hypertension.

Hasan-Olive MM, Hansson HA, Enger R, Nagelhus EA, Eide PK.

J Neuropathol Exp Neurol. 2019 Sep 1;78(9):808-818. doi: 10.1093/jnen/nlz063.


Astroglial endfeet exhibit distinct Ca2+ signals during hypoosmotic conditions.

Eilert-Olsen M, Hjukse JB, Thoren AE, Tang W, Enger R, Jensen V, Pettersen KH, Nagelhus EA.

Glia. 2019 Dec;67(12):2399-2409. doi: 10.1002/glia.23692. Epub 2019 Jul 27.


Aquaporin-4-independent volume dynamics of astroglial endfeet during cortical spreading depression.

Rosic B, Dukefoss DB, Åbjørsbråten KS, Tang W, Jensen V, Ottersen OP, Enger R, Nagelhus EA.

Glia. 2019 Jun;67(6):1113-1121. doi: 10.1002/glia.23604. Epub 2019 Feb 21.


Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study.

Ohene Y, Harrison IF, Nahavandi P, Ismail O, Bird EV, Ottersen OP, Nagelhus EA, Thomas DL, Lythgoe MF, Wells JA.

Neuroimage. 2019 Mar;188:515-523. doi: 10.1016/j.neuroimage.2018.12.026. Epub 2018 Dec 15.


Loss of perivascular aquaporin-4 in idiopathic normal pressure hydrocephalus.

Hasan-Olive MM, Enger R, Hansson HA, Nagelhus EA, Eide PK.

Glia. 2019 Jan;67(1):91-100. doi: 10.1002/glia.23528. Epub 2018 Oct 10.


Ca2+ Signals in Astrocytes Facilitate Spread of Epileptiform Activity.

Heuser K, Nome CG, Pettersen KH, Åbjørsbråten KS, Jensen V, Tang W, Sprengel R, Taubøll E, Nagelhus EA, Enger R.

Cereb Cortex. 2018 Nov 1;28(11):4036-4048. doi: 10.1093/cercor/bhy196.


Cerebral microvascular abnormalities in patients with idiopathic intracranial hypertension.

Eidsvaag VA, Hansson HA, Heuser K, Nagelhus EA, Eide PK.

Brain Res. 2018 May 1;1686:72-82. doi: 10.1016/j.brainres.2018.02.017. Epub 2018 Feb 22.


Brain Capillary Ultrastructure in Idiopathic Normal Pressure Hydrocephalus: Relationship With Static and Pulsatile Intracranial Pressure.

Eidsvaag VA, Hansson HA, Heuser K, Nagelhus EA, Eide PK.

J Neuropathol Exp Neurol. 2017 Dec 1;76(12):1034-1045. doi: 10.1093/jnen/nlx091.


Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow.

Holter KE, Kehlet B, Devor A, Sejnowski TJ, Dale AM, Omholt SW, Ottersen OP, Nagelhus EA, Mardal KA, Pettersen KH.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):9894-9899. doi: 10.1073/pnas.1706942114. Epub 2017 Aug 28.


Deletion of Aquaporin-4 Curtails Extracellular Glutamate Elevation in Cortical Spreading Depression in Awake Mice.

Enger R, Dukefoss DB, Tang W, Pettersen KH, Bjørnstad DM, Helm PJ, Jensen V, Sprengel R, Vervaeke K, Ottersen OP, Nagelhus EA.

Cereb Cortex. 2017 Jan 1;27(1):24-33. doi: 10.1093/cercor/bhw359.


Human and mouse cortical astrocytes differ in aquaporin-4 polarization toward microvessels.

Eidsvaag VA, Enger R, Hansson HA, Eide PK, Nagelhus EA.

Glia. 2017 Jun;65(6):964-973. doi: 10.1002/glia.23138. Epub 2017 Mar 20.


Loss or Mislocalization of Aquaporin-4 Affects Diffusion Properties and Intermediary Metabolism in Gray Matter of Mice.

Pavlin T, Nagelhus EA, Brekken C, Eyjolfsson EM, Thoren A, Haraldseth O, Sonnewald U, Ottersen OP, Håberg AK.

Neurochem Res. 2017 Jan;42(1):77-91. doi: 10.1007/s11064-016-2139-y. Epub 2016 Dec 30.


Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation.

Vindedal GF, Thoren AE, Jensen V, Klungland A, Zhang Y, Holtzman MJ, Ottersen OP, Nagelhus EA.

Mol Cell Neurosci. 2016 Dec;77:47-52. doi: 10.1016/j.mcn.2016.10.004. Epub 2016 Oct 14.


Cortical astrogliosis and increased perivascular aquaporin-4 in idiopathic intracranial hypertension.

Eide PK, Eidsvaag VA, Nagelhus EA, Hansson HA.

Brain Res. 2016 Aug 1;1644:161-75. doi: 10.1016/j.brainres.2016.05.024. Epub 2016 May 14.


Dynamics of Ionic Shifts in Cortical Spreading Depression.

Enger R, Tang W, Vindedal GF, Jensen V, Johannes Helm P, Sprengel R, Looger LL, Nagelhus EA.

Cereb Cortex. 2015 Nov;25(11):4469-76. doi: 10.1093/cercor/bhv054. Epub 2015 Apr 2.


Augmentation of Ca(2+) signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy.

Szokol K, Heuser K, Tang W, Jensen V, Enger R, Bedner P, Steinhäuser C, Taubøll E, Ottersen OP, Nagelhus EA.

Front Cell Neurosci. 2015 Feb 25;9:49. doi: 10.3389/fncel.2015.00049. eCollection 2015.


Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.

Tang W, Szokol K, Jensen V, Enger R, Trivedi CA, Hvalby Ø, Helm PJ, Looger LL, Sprengel R, Nagelhus EA.

J Neurosci. 2015 Feb 18;35(7):3016-21. doi: 10.1523/JNEUROSCI.3319-14.2015.


Deletion of aquaporin-4 increases extracellular K(+) concentration during synaptic stimulation in mouse hippocampus.

Haj-Yasein NN, Bugge CE, Jensen V, Østby I, Ottersen OP, Hvalby Ø, Nagelhus EA.

Brain Struct Funct. 2015 Jul;220(4):2469-74. doi: 10.1007/s00429-014-0767-z. Epub 2014 Apr 18.


Research into glia and epilepsy.

Nagelhus EA.

Tidsskr Nor Laegeforen. 2014 Jan 14;134(1):6. doi: 10.4045/tidsskr.13.1519. English, Norwegian. No abstract available.


Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering.

Rangroo Thrane V, Thrane AS, Wang F, Cotrina ML, Smith NA, Chen M, Xu Q, Kang N, Fujita T, Nagelhus EA, Nedergaard M.

Nat Med. 2013 Dec;19(12):1643-8. doi: 10.1038/nm.3400. Epub 2013 Nov 17.


The glia doctrine: addressing the role of glial cells in healthy brain ageing.

Nagelhus EA, Amiry-Moghaddam M, Bergersen LH, Bjaalie JG, Eriksson J, Gundersen V, Leergaard TB, Morth JP, Storm-Mathisen J, Torp R, Walhovd KB, Tønjum T.

Mech Ageing Dev. 2013 Oct;134(10):449-59. doi: 10.1016/j.mad.2013.10.001. Epub 2013 Oct 17. Review.


Physiological roles of aquaporin-4 in brain.

Nagelhus EA, Ottersen OP.

Physiol Rev. 2013 Oct;93(4):1543-62. doi: 10.1152/physrev.00011.2013. Review.


Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain.

Rangroo Thrane V, Thrane AS, Plog BA, Thiyagarajan M, Iliff JJ, Deane R, Nagelhus EA, Nedergaard M.

Sci Rep. 2013;3:2582. doi: 10.1038/srep02582.


Evidence that pericytes regulate aquaporin-4 polarization in mouse cortical astrocytes.

Gundersen GA, Vindedal GF, Skare O, Nagelhus EA.

Brain Struct Funct. 2014 Nov;219(6):2181-6. doi: 10.1007/s00429-013-0629-0. Epub 2013 Aug 28.


In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression.

Thrane AS, Takano T, Rangroo Thrane V, Wang F, Peng W, Ottersen OP, Nedergaard M, Nagelhus EA.

J Cereb Blood Flow Metab. 2013 Jul;33(7):996-9. doi: 10.1038/jcbfm.2013.63. Epub 2013 Apr 24.


General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex.

Thrane AS, Rangroo Thrane V, Zeppenfeld D, Lou N, Xu Q, Nagelhus EA, Nedergaard M.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18974-9. doi: 10.1073/pnas.1209448109. Epub 2012 Oct 29.


Molecular scaffolds underpinning macroglial polarization: an analysis of retinal Müller cells and brain astrocytes in mouse.

Enger R, Gundersen GA, Haj-Yasein NN, Eilert-Olsen M, Thoren AE, Vindedal GF, Petersen PH, Skare Ø, Nedergaard M, Ottersen OP, Nagelhus EA.

Glia. 2012 Dec;60(12):2018-26. doi: 10.1002/glia.22416. Epub 2012 Sep 17.


A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M.

Sci Transl Med. 2012 Aug 15;4(147):147ra111. doi: 10.1126/scitranslmed.3003748.


Loss of perivascular Kir4.1 potassium channels in the sclerotic hippocampus of patients with mesial temporal lobe epilepsy.

Heuser K, Eid T, Lauritzen F, Thoren AE, Vindedal GF, Taubøll E, Gjerstad L, Spencer DD, Ottersen OP, Nagelhus EA, de Lanerolle NC.

J Neuropathol Exp Neurol. 2012 Sep;71(9):814-25. doi: 10.1097/NEN.0b013e318267b5af.


Real-time analysis of microglial activation and motility in hepatic and hyperammonemic encephalopathy.

Rangroo Thrane V, Thrane AS, Chang J, Alleluia V, Nagelhus EA, Nedergaard M.

Neuroscience. 2012 Sep 18;220:247-55. doi: 10.1016/j.neuroscience.2012.06.022. Epub 2012 Jun 21. Erratum in: Neuroscience. 2013 Mar 13;233:184. Chanag, J [corrected to Chang, J].


Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: a gene deletion study in mouse hippocampus.

Haj-Yasein NN, Jensen V, Østby I, Omholt SW, Voipio J, Kaila K, Ottersen OP, Hvalby Ø, Nagelhus EA.

Glia. 2012 May;60(6):867-74. doi: 10.1002/glia.22319. Epub 2012 Mar 14.


Aquaporin-4 and epilepsy.

Binder DK, Nagelhus EA, Ottersen OP.

Glia. 2012 Aug;60(8):1203-14. doi: 10.1002/glia.22317. Epub 2012 Feb 29. Review.


Deletion of aquaporin-4 changes the perivascular glial protein scaffold without disrupting the brain endothelial barrier.

Eilert-Olsen M, Haj-Yasein NN, Vindedal GF, Enger R, Gundersen GA, Hoddevik EH, Petersen PH, Haug FM, Skare Ø, Adams ME, Froehner SC, Burkhardt JM, Thoren AE, Nagelhus EA.

Glia. 2012 Mar;60(3):432-40. doi: 10.1002/glia.22277. Epub 2011 Nov 30.


Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet.

Haj-Yasein NN, Vindedal GF, Eilert-Olsen M, Gundersen GA, Skare Ø, Laake P, Klungland A, Thorén AE, Burkhardt JM, Ottersen OP, Nagelhus EA.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17815-20. doi: 10.1073/pnas.1110655108. Epub 2011 Oct 11.


Is the brain water channel aquaporin-4 a pathogenetic factor in idiopathic intracranial hypertension? Results from a combined clinical and genetic study in a Norwegian cohort.

Kerty E, Heuser K, Indahl UG, Berg PR, Nakken S, Lien S, Omholt SW, Ottersen OP, Nagelhus EA.

Acta Ophthalmol. 2013 Feb;91(1):88-91. doi: 10.1111/j.1755-3768.2011.02231.x. Epub 2011 Sep 13.


Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human Kir4.1 gene (KCNJ10).

Haj-Yasein NN, Jensen V, Vindedal GF, Gundersen GA, Klungland A, Ottersen OP, Hvalby O, Nagelhus EA.

Glia. 2011 Nov;59(11):1635-42. doi: 10.1002/glia.21205. Epub 2011 Jul 11.


Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.

Thrane AS, Rappold PM, Fujita T, Torres A, Bekar LK, Takano T, Peng W, Wang F, Rangroo Thrane V, Enger R, Haj-Yasein NN, Skare Ø, Holen T, Klungland A, Ottersen OP, Nedergaard M, Nagelhus EA.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):846-51. doi: 10.1073/pnas.1015217108. Epub 2010 Dec 27.


Temporal lobe epilepsy and matrix metalloproteinase 9: a tempting relation but negative genetic association.

Heuser K, Hoddevik EH, Taubøll E, Gjerstad L, Indahl U, Kaczmarek L, Berg PR, Lien S, Nagelhus EA, Ottersen OP.

Seizure. 2010 Jul;19(6):335-8. doi: 10.1016/j.seizure.2010.05.003. Epub 2010 Jun 3.


Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy.

Heuser K, Nagelhus EA, Taubøll E, Indahl U, Berg PR, Lien S, Nakken S, Gjerstad L, Ottersen OP.

Epilepsy Res. 2010 Jan;88(1):55-64. doi: 10.1016/j.eplepsyres.2009.09.023. Epub 2009 Oct 28.


Phenotypic characteristics of temporal lobe epilepsy: the impact of hippocampal sclerosis.

Heuser K, Taubøll E, Nagelhus EA, Cvancarova M, Petter Ottersen O, Gjerstad L.

Acta Neurol Scand Suppl. 2009;(189):8-13. doi: 10.1111/j.1600-0404.2009.01205.x.


Astrocytic mechanisms explaining neural-activity-induced shrinkage of extraneuronal space.

Østby I, Øyehaug L, Einevoll GT, Nagelhus EA, Plahte E, Zeuthen T, Lloyd CM, Ottersen OP, Omholt SW.

PLoS Comput Biol. 2009 Jan;5(1):e1000272. doi: 10.1371/journal.pcbi.1000272. Epub 2009 Jan 23.


Differential effect of alpha-syntrophin knockout on aquaporin-4 and Kir4.1 expression in retinal macroglial cells in mice.

Puwarawuttipanit W, Bragg AD, Frydenlund DS, Mylonakou MN, Nagelhus EA, Peters MF, Kotchabhakdi N, Adams ME, Froehner SC, Haug FM, Ottersen OP, Amiry-Moghaddam M.

Neuroscience. 2006;137(1):165-75. Epub 2005 Oct 28.


Carbonic anhydrase XIV is enriched in specific membrane domains of retinal pigment epithelium, Muller cells, and astrocytes.

Nagelhus EA, Mathiisen TM, Bateman AC, Haug FM, Ottersen OP, Grubb JH, Waheed A, Sly WS.

Proc Natl Acad Sci U S A. 2005 May 31;102(22):8030-5. Epub 2005 May 18.


Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1.

Nagelhus EA, Mathiisen TM, Ottersen OP.

Neuroscience. 2004;129(4):905-13. Review.


Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice.

Amiry-Moghaddam M, Williamson A, Palomba M, Eid T, de Lanerolle NC, Nagelhus EA, Adams ME, Froehner SC, Agre P, Ottersen OP.

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13615-20. Epub 2003 Nov 3.


High-resolution immunogold cytochemistry indicates that AQP4 is concentrated along the basal membrane of parietal cell in rat stomach.

Fujita A, Horio Y, Nielsen S, Nagelhus EA, Hata F, Ottersen OP, Kurachi Y.

FEBS Lett. 1999 Oct 15;459(3):305-9.


Cellular and subcellular expression of monocarboxylate transporters in the pigment epithelium and retina of the rat.

Bergersen L, Jóhannsson E, Veruki ML, Nagelhus EA, Halestrap A, Sejersted OM, Ottersen OP.

Neuroscience. 1999 Apr;90(1):319-31.


Ontogeny of water transport in rat brain: postnatal expression of the aquaporin-4 water channel.

Wen H, Nagelhus EA, Amiry-Moghaddam M, Agre P, Ottersen OP, Nielsen S.

Eur J Neurosci. 1999 Mar;11(3):935-45.


Select types of supporting cell in the inner ear express aquaporin-4 water channel protein.

Takumi Y, Nagelhus EA, Eidet J, Matsubara A, Usami S, Shinkawa H, Nielsen S, Ottersen OP.

Eur J Neurosci. 1998 Dec;10(12):3584-95.


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