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Items: 1 to 50 of 51

1.

Solution-Based Determination of Dissociation Constants for the Binding of Aβ42 to Antibodies.

Zhang T, Nagel-Steger L, Willbold D.

ChemistryOpen. 2019 Jul 22;8(7):989-994. doi: 10.1002/open.201900167. eCollection 2019 Jul.

2.

Posttranslational modification of the NADP-malic enzyme involved in C4 photosynthesis fine-tunes the enzymatic activity during the day.

Bovdilova A, Alexandre BM, Höppner A, Matias Luís I, Alvarez CE, Bickel D, Gohlke H, Decker C, Nagel-Steger L, Alseekh S, Fernie AR, Drincovich MF, Abreu IA, Maurino VG.

Plant Cell. 2019 Jul 30. pii: tpc.00406.2019. doi: 10.1105/tpc.19.00406. [Epub ahead of print]

PMID:
31363039
3.

Farnesylation of human guanylate-binding protein 1 as safety mechanism preventing structural rearrangements and uninduced dimerization.

Lorenz C, Ince S, Zhang T, Cousin A, Batra-Safferling R, Nagel-Steger L, Herrmann C, Stadler AM.

FEBS J. 2019 Jul 22. doi: 10.1111/febs.15015. [Epub ahead of print]

PMID:
31330084
4.

Molecular adaptations of NADP-malic enzyme for its function in C4 photosynthesis in grasses.

Alvarez CE, Bovdilova A, Höppner A, Wolff CC, Saigo M, Trajtenberg F, Zhang T, Buschiazzo A, Nagel-Steger L, Drincovich MF, Lercher MJ, Maurino VG.

Nat Plants. 2019 Jul;5(7):755-765. doi: 10.1038/s41477-019-0451-7. Epub 2019 Jun 24.

PMID:
31235877
5.

Interference with Amyloid-β Nucleation by Transient Ligand Interaction.

Zhang T, Loschwitz J, Strodel B, Nagel-Steger L, Willbold D.

Molecules. 2019 Jun 5;24(11). pii: E2129. doi: 10.3390/molecules24112129.

6.

Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association.

Kukuk L, Dingley AJ, Granzin J, Nagel-Steger L, Thiagarajan-Rosenkranz P, Ciupka D, Hänel K, Batra-Safferling R, Pacheco V, Stoldt M, Pfeffer K, Beer-Hammer S, Willbold D, Koenig BW.

Sci Rep. 2019 Jan 10;9(1):54. doi: 10.1038/s41598-018-37185-3.

7.

Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response.

Bhatia S, Diedrich D, Frieg B, Ahlert H, Stein S, Bopp B, Lang F, Zang T, Kröger T, Ernst T, Kögler G, Krieg A, Lüdeke S, Kunkel H, Rodrigues Moita AJ, Kassack MU, Marquardt V, Opitz FV, Oldenburg M, Remke M, Babor F, Grez M, Hochhaus A, Borkhardt A, Groth G, Nagel-Steger L, Jose J, Kurz T, Gohlke H, Hansen FK, Hauer J.

Blood. 2018 Jul 19;132(3):307-320. doi: 10.1182/blood-2017-10-810986. Epub 2018 May 3.

8.

Inhibition of amyloid Aβ aggregation by high pressures or specific d-enantiomeric peptides.

Cavini IA, Munte CE, Erlach MB, van Groen T, Kadish I, Zhang T, Ziehm T, Nagel-Steger L, Kutzsche J, Kremer W, Willbold D, Kalbitzer HR.

Chem Commun (Camb). 2018 Mar 27;54(26):3294-3297. doi: 10.1039/c8cc01458b.

PMID:
29537428
9.

Stoichiometric Zn2+ interferes with the self-association of Aβ42: Insights from size distribution analysis.

Zhang T, Pauly T, Nagel-Steger L.

Int J Biol Macromol. 2018 Jul 1;113:631-639. doi: 10.1016/j.ijbiomac.2018.02.123. Epub 2018 Feb 22.

PMID:
29476859
10.

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology.

van Groen T, Schemmert S, Brener O, Gremer L, Ziehm T, Tusche M, Nagel-Steger L, Kadish I, Schartmann E, Elfgen A, Jürgens D, Willuweit A, Kutzsche J, Willbold D.

Sci Rep. 2017 Nov 24;7(1):16275. doi: 10.1038/s41598-017-16565-1.

11.

Aβ42 pentamers/hexamers are the smallest detectable oligomers in solution.

Wolff M, Zhang-Haagen B, Decker C, Barz B, Schneider M, Biehl R, Radulescu A, Strodel B, Willbold D, Nagel-Steger L.

Sci Rep. 2017 May 30;7(1):2493. doi: 10.1038/s41598-017-02370-3.

12.

EDTA aggregates induce SYPRO orange-based fluorescence in thermal shift assay.

Kroeger T, Frieg B, Zhang T, Hansen FK, Marmann A, Proksch P, Nagel-Steger L, Groth G, Smits SHJ, Gohlke H.

PLoS One. 2017 May 4;12(5):e0177024. doi: 10.1371/journal.pone.0177024. eCollection 2017.

13.

An unpredicted aggregation-critical region of the actin-polymerizing protein TRIOBP-1/Tara, determined by elucidation of its domain structure.

Bradshaw NJ, Yerabham ASK, Marreiros R, Zhang T, Nagel-Steger L, Korth C.

J Biol Chem. 2017 Jun 9;292(23):9583-9598. doi: 10.1074/jbc.M116.767939. Epub 2017 Apr 24.

14.

A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations.

Yerabham ASK, Mas PJ, Decker C, Soares DC, Weiergräber OH, Nagel-Steger L, Willbold D, Hart DJ, Bradshaw NJ, Korth C.

J Biol Chem. 2017 Apr 21;292(16):6468-6477. doi: 10.1074/jbc.M116.773903. Epub 2017 Mar 1.

15.

The Chlamydia pneumoniae Adhesin Pmp21 Forms Oligomers with Adhesive Properties.

Luczak SE, Smits SH, Decker C, Nagel-Steger L, Schmitt L, Hegemann JH.

J Biol Chem. 2016 Oct 21;291(43):22806-22818. Epub 2016 Aug 22.

16.

Characterizing the Effect of Multivalent Conjugates Composed of Aβ-Specific Ligands and Metal Nanoparticles on Neurotoxic Fibrillar Aggregation.

Streich C, Akkari L, Decker C, Bormann J, Rehbock C, Müller-Schiffmann A, Niemeyer FC, Nagel-Steger L, Willbold D, Sacca B, Korth C, Schrader T, Barcikowski S.

ACS Nano. 2016 Aug 23;10(8):7582-97. doi: 10.1021/acsnano.6b02627. Epub 2016 Jul 20.

PMID:
27404114
17.

Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d-Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species.

Ziehm T, Brener O, van Groen T, Kadish I, Frenzel D, Tusche M, Kutzsche J, Reiß K, Gremer L, Nagel-Steger L, Willbold D.

ACS Chem Neurosci. 2016 Aug 17;7(8):1088-96. doi: 10.1021/acschemneuro.6b00047. Epub 2016 Jun 9.

PMID:
27240424
18.

Monomeric Amyloid Beta Peptide in Hexafluoroisopropanol Detected by Small Angle Neutron Scattering.

Zhang-Haagen B, Biehl R, Nagel-Steger L, Radulescu A, Richter D, Willbold D.

PLoS One. 2016 Feb 26;11(2):e0150267. doi: 10.1371/journal.pone.0150267. eCollection 2016.

19.

An Account of Amyloid Oligomers: Facts and Figures Obtained from Experiments and Simulations.

Nagel-Steger L, Owen MC, Strodel B.

Chembiochem. 2016 Apr 15;17(8):657-76. doi: 10.1002/cbic.201500623. Epub 2016 Mar 21. Review.

PMID:
26910367
20.

Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11.

Nouri K, Moll JM, Milroy LG, Hain A, Dvorsky R, Amin E, Lenders M, Nagel-Steger L, Howe S, Smits SH, Hengel H, Schmitt L, Münk C, Brunsveld L, Ahmadian MR.

PLoS One. 2015 Dec 1;10(12):e0143634. doi: 10.1371/journal.pone.0143634. eCollection 2015.

21.

QIAD assay for quantitating a compound's efficacy in elimination of toxic Aβ oligomers.

Brener O, Dunkelmann T, Gremer L, van Groen T, Mirecka EA, Kadish I, Willuweit A, Kutzsche J, Jürgens D, Rudolph S, Tusche M, Bongen P, Pietruszka J, Oesterhelt F, Langen KJ, Demuth HU, Janssen A, Hoyer W, Funke SA, Nagel-Steger L, Willbold D.

Sci Rep. 2015 Sep 23;5:13222. doi: 10.1038/srep13222.

22.

The mammalian autophagy initiator complex contains 2 HORMA domain proteins.

Michel M, Schwarten M, Decker C, Nagel-Steger L, Willbold D, Weiergräber OH.

Autophagy. 2015;11(12):2300-8. doi: 10.1080/15548627.2015.1076605.

23.

Amyloid β Oligomeric Species Present in the Lag Phase of Amyloid Formation.

Wolff M, Unuchek D, Zhang B, Gordeliy V, Willbold D, Nagel-Steger L.

PLoS One. 2015 May 29;10(5):e0127865. doi: 10.1371/journal.pone.0127865. eCollection 2015.

24.

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation.

Zhao H, Ghirlando R, Alfonso C, Arisaka F, Attali I, Bain DL, Bakhtina MM, Becker DF, Bedwell GJ, Bekdemir A, Besong TM, Birck C, Brautigam CA, Brennerman W, Byron O, Bzowska A, Chaires JB, Chaton CT, Cölfen H, Connaghan KD, Crowley KA, Curth U, Daviter T, Dean WL, Díez AI, Ebel C, Eckert DM, Eisele LE, Eisenstein E, England P, Escalante C, Fagan JA, Fairman R, Finn RM, Fischle W, de la Torre JG, Gor J, Gustafsson H, Hall D, Harding SE, Cifre JG, Herr AB, Howell EE, Isaac RS, Jao SC, Jose D, Kim SJ, Kokona B, Kornblatt JA, Kosek D, Krayukhina E, Krzizike D, Kusznir EA, Kwon H, Larson A, Laue TM, Le Roy A, Leech AP, Lilie H, Luger K, Luque-Ortega JR, Ma J, May CA, Maynard EL, Modrak-Wojcik A, Mok YF, Mücke N, Nagel-Steger L, Narlikar GJ, Noda M, Nourse A, Obsil T, Park CK, Park JK, Pawelek PD, Perdue EE, Perkins SJ, Perugini MA, Peterson CL, Peverelli MG, Piszczek G, Prag G, Prevelige PE, Raynal BD, Rezabkova L, Richter K, Ringel AE, Rosenberg R, Rowe AJ, Rufer AC, Scott DJ, Seravalli JG, Solovyova AS, Song R, Staunton D, Stoddard C, Stott K, Strauss HM, Streicher WW, Sumida JP, Swygert SG, Szczepanowski RH, Tessmer I, Toth RT 4th, Tripathy A, Uchiyama S, Uebel SF, Unzai S, Gruber AV, von Hippel PH, Wandrey C, Wang SH, Weitzel SE, Wielgus-Kutrowska B, Wolberger C, Wolff M, Wright E, Wu YS, Wubben JM, Schuck P.

PLoS One. 2015 May 21;10(5):e0126420. doi: 10.1371/journal.pone.0126420. eCollection 2015.

25.

Immobilization of homogeneous monomeric, oligomeric and fibrillar Aβ species for reliable SPR measurements.

Frenzel D, Glück JM, Brener O, Oesterhelt F, Nagel-Steger L, Willbold D.

PLoS One. 2014 Mar 3;9(3):e89490. doi: 10.1371/journal.pone.0089490. eCollection 2014.

26.

Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins.

Kötter S, Unger A, Hamdani N, Lang P, Vorgerd M, Nagel-Steger L, Linke WA.

J Cell Biol. 2014 Jan 20;204(2):187-202. doi: 10.1083/jcb.201306077. Epub 2014 Jan 13.

27.

Amyloid aggregation inhibitory mechanism of arginine-rich D-peptides.

Olubiyi OO, Frenzel D, Bartnik D, Glück JM, Brener O, Nagel-Steger L, Funke SA, Willbold D, Strodel B.

Curr Med Chem. 2014;21(12):1448-57.

PMID:
24304283
28.

The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.

Thakur HC, Singh M, Nagel-Steger L, Kremer J, Prumbaum D, Fansa EK, Ezzahoini H, Nouri K, Gremer L, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP.

J Biol Chem. 2014 Jan 3;289(1):74-88. doi: 10.1074/jbc.M113.532333. Epub 2013 Nov 22.

29.

The off-rate of monomers dissociating from amyloid-β protofibrils.

Grüning CS, Klinker S, Wolff M, Schneider M, Toksöz K, Klein AN, Nagel-Steger L, Willbold D, Hoyer W.

J Biol Chem. 2013 Dec 27;288(52):37104-11. doi: 10.1074/jbc.M113.513432. Epub 2013 Nov 18.

30.

Seeded fibrillation as molecular basis of the species barrier in human prion diseases.

Luers L, Bannach O, Stöhr J, Wördehoff MM, Wolff M, Nagel-Steger L, Riesner D, Willbold D, Birkmann E.

PLoS One. 2013 Aug 20;8(8):e72623. doi: 10.1371/journal.pone.0072623. eCollection 2013.

31.

Rho-kinase: regulation, (dys)function, and inhibition.

Amin E, Dubey BN, Zhang SC, Gremer L, Dvorsky R, Moll JM, Taha MS, Nagel-Steger L, Piekorz RP, Somlyo AV, Ahmadian MR.

Biol Chem. 2013 Nov;394(11):1399-410. doi: 10.1515/hsz-2013-0181. Review.

32.

Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division.

Thakur HC, Singh M, Nagel-Steger L, Prumbaum D, Fansa EK, Gremer L, Ezzahoini H, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP.

Biol Chem. 2013 Nov;394(11):1411-23. doi: 10.1515/hsz-2013-0184. Review.

PMID:
23787465
33.

Double-strand DNA end-binding and sliding of the toroidal CRISPR-associated protein Csn2.

Arslan Z, Wurm R, Brener O, Ellinger P, Nagel-Steger L, Oesterhelt F, Schmitt L, Willbold D, Wagner R, Gohlke H, Smits SH, Pul U.

Nucleic Acids Res. 2013 Jul;41(12):6347-59. doi: 10.1093/nar/gkt315. Epub 2013 Apr 26.

34.

Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation.

Kroth H, Ansaloni A, Varisco Y, Jan A, Sreenivasachary N, Rezaei-Ghaleh N, Giriens V, Lohmann S, López-Deber MP, Adolfsson O, Pihlgren M, Paganetti P, Froestl W, Nagel-Steger L, Willbold D, Schrader T, Zweckstetter M, Pfeifer A, Lashuel HA, Muhs A.

J Biol Chem. 2012 Oct 5;287(41):34786-800. doi: 10.1074/jbc.M112.357665. Epub 2012 Aug 13.

35.

Identification and characterization of an aβ oligomer precipitating peptide that may be useful to explore gene therapeutic approaches to Alzheimer disease.

Funke SA, Liu H, Sehl T, Bartnik D, Brener O, Nagel-Steger L, Wiesehan K, Willbold D.

Rejuvenation Res. 2012 Apr;15(2):144-7. doi: 10.1089/rej.2011.1262.

PMID:
22533419
36.

Rational design of β-sheet ligands against Aβ42-induced toxicity.

Hochdörffer K, März-Berberich J, Nagel-Steger L, Epple M, Meyer-Zaika W, Horn AH, Sticht H, Sinha S, Bitan G, Schrader T.

J Am Chem Soc. 2011 Mar 30;133(12):4348-58. doi: 10.1021/ja107675n. Epub 2011 Mar 7.

PMID:
21381732
37.

Sequence-independent control of peptide conformation in liposomal vaccines for targeting protein misfolding diseases.

Hickman DT, López-Deber MP, Ndao DM, Silva AB, Nand D, Pihlgren M, Giriens V, Madani R, St-Pierre A, Karastaneva H, Nagel-Steger L, Willbold D, Riesner D, Nicolau C, Baldus M, Pfeifer A, Muhs A.

J Biol Chem. 2011 Apr 22;286(16):13966-76. doi: 10.1074/jbc.M110.186338. Epub 2011 Feb 22.

38.

Molecular interactions between prions as seeds and recombinant prion proteins as substrates resemble the biological interspecies barrier in vitro.

Panza G, Luers L, Stöhr J, Nagel-Steger L, Weiss J, Riesner D, Willbold D, Birkmann E.

PLoS One. 2010 Dec 9;5(12):e14283. doi: 10.1371/journal.pone.0014283.

39.

Combining independent drug classes into superior, synergistically acting hybrid molecules.

Müller-Schiffmann A, März-Berberich J, Andreyeva A, Rönicke R, Bartnik D, Brener O, Kutzsche J, Horn AH, Hellmert M, Polkowska J, Gottmann K, Reymann KG, Funke SA, Nagel-Steger L, Moriscot C, Schoehn G, Sticht H, Willbold D, Schrader T, Korth C.

Angew Chem Int Ed Engl. 2010 Nov 8;49(46):8743-6. doi: 10.1002/anie.201004437. No abstract available.

PMID:
20922735
40.

Oral treatment with the d-enantiomeric peptide D3 improves the pathology and behavior of Alzheimer's Disease transgenic mice.

Aileen Funke S, van Groen T, Kadish I, Bartnik D, Nagel-Steger L, Brener O, Sehl T, Batra-Safferling R, Moriscot C, Schoehn G, Horn AH, Müller-Schiffmann A, Korth C, Sticht H, Willbold D.

ACS Chem Neurosci. 2010 Sep 15;1(9):639-48. doi: 10.1021/cn100057j. Epub 2010 Aug 2.

41.

Determinants of structural and functional plasticity of a widely conserved protease chaperone complex.

Merdanovic M, Mamant N, Meltzer M, Poepsel S, Auckenthaler A, Melgaard R, Hauske P, Nagel-Steger L, Clarke AR, Kaiser M, Huber R, Ehrmann M.

Nat Struct Mol Biol. 2010 Jul;17(7):837-43. doi: 10.1038/nsmb.1839. Epub 2010 Jun 27.

PMID:
20581826
42.

Modulation of aggregate size- and shape-distributions of the amyloid-beta peptide by a designed beta-sheet breaker.

Nagel-Steger L, Demeler B, Meyer-Zaika W, Hochdörffer K, Schrader T, Willbold D.

Eur Biophys J. 2010 Feb;39(3):415-22. doi: 10.1007/s00249-009-0416-2. Epub 2009 Feb 24.

PMID:
19238376
43.

Analysis of heterogeneity in molecular weight and shape by analytical ultracentrifugation using parallel distributed computing.

Demeler B, Brookes E, Nagel-Steger L.

Methods Enzymol. 2009;454:87-113. doi: 10.1016/S0076-6879(08)03804-4.

PMID:
19216924
44.

Reduction of Alzheimer's disease amyloid plaque load in transgenic mice by D3, A D-enantiomeric peptide identified by mirror image phage display.

van Groen T, Wiesehan K, Funke SA, Kadish I, Nagel-Steger L, Willbold D.

ChemMedChem. 2008 Dec;3(12):1848-52. doi: 10.1002/cmdc.200800273. No abstract available.

PMID:
19016284
45.

Mechanisms of prion protein assembly into amyloid.

Stöhr J, Weinmann N, Wille H, Kaimann T, Nagel-Steger L, Birkmann E, Panza G, Prusiner SB, Eigen M, Riesner D.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2409-14. doi: 10.1073/pnas.0712036105. Epub 2008 Feb 11.

46.

Inhibition of cytotoxicity and amyloid fibril formation by a D-amino acid peptide that specifically binds to Alzheimer's disease amyloid peptide.

Wiesehan K, Stöhr J, Nagel-Steger L, van Groen T, Riesner D, Willbold D.

Protein Eng Des Sel. 2008 Apr;21(4):241-6. doi: 10.1093/protein/gzm054. Epub 2008 Feb 5.

PMID:
18252750
47.

Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice.

Muhs A, Hickman DT, Pihlgren M, Chuard N, Giriens V, Meerschman C, van der Auwera I, van Leuven F, Sugawara M, Weingertner MC, Bechinger B, Greferath R, Kolonko N, Nagel-Steger L, Riesner D, Brady RO, Pfeifer A, Nicolau C.

Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9810-5. Epub 2007 May 21.

48.

Interaction of the cellular prion protein with raft-like lipid membranes.

Elfrink K, Nagel-Steger L, Riesner D.

Biol Chem. 2007 Jan;388(1):79-89.

PMID:
17214553
49.

The structural transition of the prion protein into its pathogenic conformation is induced by unmasking hydrophobic sites.

Leffers KW, Schell J, Jansen K, Lucassen R, Kaimann T, Nagel-Steger L, Tatzelt J, Riesner D.

J Mol Biol. 2004 Nov 26;344(3):839-53.

PMID:
15533449
50.

Prevention of Alzheimer's disease-associated Abeta aggregation by rationally designed nonpeptidic beta-sheet ligands.

Rzepecki P, Nagel-Steger L, Feuerstein S, Linne U, Molt O, Zadmard R, Aschermann K, Wehner M, Schrader T, Riesner D.

J Biol Chem. 2004 Nov 12;279(46):47497-505. Epub 2004 Aug 20.

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