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Items: 21

1.

Adaptive mutability of colorectal cancers in response to targeted therapies.

Russo M, Crisafulli G, Sogari A, Reilly NM, Arena S, Lamba S, Bartolini A, Amodio V, Magrì A, Novara L, Sarotto I, Nagel ZD, Piett CG, Amatu A, Sartore-Bianchi A, Siena S, Bertotti A, Trusolino L, Corigliano M, Gherardi M, Lagomarsino MC, Di Nicolantonio F, Bardelli A.

Science. 2019 Nov 7. pii: eaav4474. doi: 10.1126/science.aav4474. [Epub ahead of print]

PMID:
31699882
2.

Defective base excision repair in the response to DNA damaging agents in triple negative breast cancer.

Lee KJ, Piett CG, Andrews JF, Mann E, Nagel ZD, Gassman NR.

PLoS One. 2019 Oct 9;14(10):e0223725. doi: 10.1371/journal.pone.0223725. eCollection 2019.

3.

Sodium sulfide selectively induces oxidative stress, DNA damage, and mitochondrial dysfunction and radiosensitizes glioblastoma (GBM) cells.

Xiao AY, Maynard MR, Piett CG, Nagel ZD, Alexander JS, Kevil CG, Berridge MV, Pattillo CB, Rosen LR, Miriyala S, Harrison L.

Redox Biol. 2019 Sep;26:101220. doi: 10.1016/j.redox.2019.101220. Epub 2019 May 16.

4.

WRN helicase is a synthetic lethal target in microsatellite unstable cancers.

Chan EM, Shibue T, McFarland JM, Gaeta B, Ghandi M, Dumont N, Gonzalez A, McPartlan JS, Li T, Zhang Y, Bin Liu J, Lazaro JB, Gu P, Piett CG, Apffel A, Ali SO, Deasy R, Keskula P, Ng RWS, Roberts EA, Reznichenko E, Leung L, Alimova M, Schenone M, Islam M, Maruvka YE, Liu Y, Roper J, Raghavan S, Giannakis M, Tseng YY, Nagel ZD, D'Andrea A, Root DE, Boehm JS, Getz G, Chang S, Golub TR, Tsherniak A, Vazquez F, Bass AJ.

Nature. 2019 Apr;568(7753):551-556. doi: 10.1038/s41586-019-1102-x. Epub 2019 Apr 10.

5.

Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells.

Nagel ZD, Beharry AA, Mazzucato P, Kitange GJ, Sarkaria JN, Kool ET, Samson LD.

PLoS One. 2019 Feb 27;14(2):e0208341. doi: 10.1371/journal.pone.0208341. eCollection 2019.

6.

The CHD6 chromatin remodeler is an oxidative DNA damage response factor.

Moore S, Berger ND, Luijsterburg MS, Piett CG, Stanley FKT, Schräder CU, Fang S, Chan JA, Schriemer DC, Nagel ZD, van Attikum H, Goodarzi AA.

Nat Commun. 2019 Jan 16;10(1):241. doi: 10.1038/s41467-018-08111-y.

7.

Nitric oxide induced S-nitrosation causes base excision repair imbalance.

Parrish MC, Chaim IA, Nagel ZD, Tannenbaum SR, Samson LD, Engelward BP.

DNA Repair (Amst). 2018 Aug;68:25-33. doi: 10.1016/j.dnarep.2018.04.008. Epub 2018 May 5.

8.

ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade.

Shen J, Ju Z, Zhao W, Wang L, Peng Y, Ge Z, Nagel ZD, Zou J, Wang C, Kapoor P, Ma X, Ma D, Liang J, Song S, Liu J, Samson LD, Ajani JA, Li GM, Liang H, Shen X, Mills GB, Peng G.

Nat Med. 2018 May;24(5):556-562. doi: 10.1038/s41591-018-0012-z. Epub 2018 May 7.

9.

In vivo measurements of interindividual differences in DNA glycosylases and APE1 activities.

Chaim IA, Nagel ZD, Jordan JJ, Mazzucato P, Ngo LP, Samson LD.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10379-E10388. doi: 10.1073/pnas.1712032114. Epub 2017 Nov 9.

10.

Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease.

Nagel ZD, Engelward BP, Brenner DJ, Begley TJ, Sobol RW, Bielas JH, Stambrook PJ, Wei Q, Hu JJ, Terry MB, Dilworth C, McAllister KA, Reinlib L, Worth L, Shaughnessy DT.

Mutat Res. 2017 Aug;800-802:14-28. doi: 10.1016/j.mrfmmm.2017.03.007. Epub 2017 Apr 6. Review.

11.

DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme.

Nagel ZD, Kitange GJ, Gupta SK, Joughin BA, Chaim IA, Mazzucato P, Lauffenburger DA, Sarkaria JN, Samson LD.

Cancer Res. 2017 Jan 1;77(1):198-206. doi: 10.1158/0008-5472.CAN-16-1151. Epub 2016 Oct 28.

12.

Fluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor Drug Response.

Beharry AA, Nagel ZD, Samson LD, Kool ET.

PLoS One. 2016 Apr 1;11(4):e0152684. doi: 10.1371/journal.pone.0152684. eCollection 2016.

13.

Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide.

McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD.

Cancer Res. 2015 Aug 1;75(15):3127-38. doi: 10.1158/0008-5472.CAN-14-3616. Epub 2015 May 29.

14.

Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research.

Nagel ZD, Chaim IA, Samson LD.

DNA Repair (Amst). 2014 Jul;19:199-213. doi: 10.1016/j.dnarep.2014.03.009. Epub 2014 Apr 26.

15.

Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis.

Nagel ZD, Margulies CM, Chaim IA, McRee SK, Mazzucato P, Ahmad A, Abo RP, Butty VL, Forget AL, Samson LD.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1823-32. doi: 10.1073/pnas.1401182111. Epub 2014 Apr 22.

16.

Identification of a long-range protein network that modulates active site dynamics in extremophilic alcohol dehydrogenases.

Nagel ZD, Cun S, Klinman JP.

J Biol Chem. 2013 May 17;288(20):14087-97. doi: 10.1074/jbc.M113.453951. Epub 2013 Mar 22.

17.

Active site hydrophobic residues impact hydrogen tunneling differently in a thermophilic alcohol dehydrogenase at optimal versus nonoptimal temperatures.

Nagel ZD, Meadows CW, Dong M, Bahnson BJ, Klinman JP.

Biochemistry. 2012 May 22;51(20):4147-56. doi: 10.1021/bi3001352. Epub 2012 May 8.

18.

Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors.

Nagel ZD, Dong M, Bahnson BJ, Klinman JP.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10520-5. doi: 10.1073/pnas.1104989108. Epub 2011 Jun 13.

19.

Update 1 of: Tunneling and dynamics in enzymatic hydride transfer.

Nagel ZD, Klinman JP.

Chem Rev. 2010 Dec 8;110(12):PR41-67. doi: 10.1021/cr1001035. No abstract available.

20.

A 21st century revisionist's view at a turning point in enzymology.

Nagel ZD, Klinman JP.

Nat Chem Biol. 2009 Aug;5(8):543-50. doi: 10.1038/nchembio.204. Erratum in: Nat Chem Biol. 2009 Sep;5(9):696.

PMID:
19620995
21.

Tunneling and dynamics in enzymatic hydride transfer.

Nagel ZD, Klinman JP.

Chem Rev. 2006 Aug;106(8):3095-118. Review. No abstract available.

PMID:
16895320

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