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Items: 14


New mechanistic insights into modifiable risk factors that promote pancreatic cancer.

Srinivasan S, Dosch AR, Nagathihalli NS.

Oncotarget. 2019 Mar 29;10(25):2417-2418. doi: 10.18632/oncotarget.26813. eCollection 2019 Mar 29. No abstract available.


Src kinase inhibition restores E-cadherin expression in dasatinib-sensitive pancreatic cancer cells.

Dosch AR, Dai X, Gaidarski Iii AA, Shi C, Castellanos JA, VanSaun MN, Merchant NB, Nagathihalli NS.

Oncotarget. 2019 Feb 1;10(10):1056-1069. doi: 10.18632/oncotarget.26621. eCollection 2019 Feb 1.


Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer.

Totiger TM, Srinivasan S, Jala VR, Lamichhane P, Dosch AR, Gaidarski AA 3rd, Joshi C, Rangappa S, Castellanos J, Vemula PK, Chen X, Kwon D, Kashikar N, VanSaun M, Merchant NB, Nagathihalli NS.

Mol Cancer Ther. 2019 Feb;18(2):301-311. doi: 10.1158/1535-7163.MCT-18-0464. Epub 2018 Nov 7.


Tobacco Carcinogen-Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer.

Srinivasan S, Totiger T, Shi C, Castellanos J, Lamichhane P, Dosch AR, Messaggio F, Kashikar N, Honnenahally K, Ban Y, Merchant NB, VanSaun M, Nagathihalli NS.

Cancer Res. 2018 Nov 1;78(21):6146-6158. doi: 10.1158/0008-5472.CAN-18-0579. Epub 2018 Sep 19.


Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer.

Nagathihalli NS, Castellanos JA, Lamichhane P, Messaggio F, Shi C, Dai X, Rai P, Chen X, VanSaun MN, Merchant NB.

Cancer Res. 2018 Nov 1;78(21):6235-6246. doi: 10.1158/0008-5472.CAN-18-0634. Epub 2018 Aug 28.


Adiponectin receptor agonists inhibit leptin induced pSTAT3 and in vivo pancreatic tumor growth.

Messaggio F, Mendonsa AM, Castellanos J, Nagathihalli NS, Gorden L, Merchant NB, VanSaun MN.

Oncotarget. 2017 Aug 3;8(49):85378-85391. doi: 10.18632/oncotarget.19905. eCollection 2017 Oct 17.


Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells.

Nagathihalli NS, Castellanos JA, VanSaun MN, Dai X, Ambrose M, Guo Q, Xiong Y, Merchant NB.

Oncotarget. 2016 Oct 4;7(40):65982-65992. doi: 10.18632/oncotarget.11786.


Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response.

Walsh AJ, Castellanos JA, Nagathihalli NS, Merchant NB, Skala MC.

Pancreas. 2016 Jul;45(6):863-9. doi: 10.1097/MPA.0000000000000543.


Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer.

Nagathihalli NS, Castellanos JA, Shi C, Beesetty Y, Reyzer ML, Caprioli R, Chen X, Walsh AJ, Skala MC, Moses HL, Merchant NB.

Gastroenterology. 2015 Dec;149(7):1932-1943.e9. doi: 10.1053/j.gastro.2015.07.058. Epub 2015 Aug 7.


Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids.

Nagathihalli NS, Beesetty Y, Lee W, Washington MK, Chen X, Lockhart AC, Merchant NB.

Cancer Res. 2014 Apr 1;74(7):2062-72. doi: 10.1158/0008-5472.CAN-13-2329. Epub 2014 Feb 11.


Emerging targets in pancreatic cancer: epithelial-mesenchymal transition and cancer stem cells.

Castellanos JA, Merchant NB, Nagathihalli NS.

Onco Targets Ther. 2013 Sep 13;6:1261-7. doi: 10.2147/OTT.S34670. Review.


Smoking induces epithelial-to-mesenchymal transition in non-small cell lung cancer through HDAC-mediated downregulation of E-cadherin.

Nagathihalli NS, Massion PP, Gonzalez AL, Lu P, Datta PK.

Mol Cancer Ther. 2012 Nov;11(11):2362-72. doi: 10.1158/1535-7163.MCT-12-0107. Epub 2012 Aug 29.


Src-mediated regulation of E-cadherin and EMT in pancreatic cancer.

Nagathihalli NS, Merchant NB.

Front Biosci (Landmark Ed). 2012 Jun 1;17:2059-69. Review.


RAD51 as a potential biomarker and therapeutic target for pancreatic cancer.

Nagathihalli NS, Nagaraju G.

Biochim Biophys Acta. 2011 Dec;1816(2):209-18. doi: 10.1016/j.bbcan.2011.07.004. Epub 2011 Jul 23. Review.


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