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Items: 18

1.

Evaluation of the Microbiological Efficacy of a Single 2-Gram Dose of Extended-Release Azithromycin by Population Pharmacokinetics and Simulation in Japanese Patients with Gonococcal Urethritis.

Soda M, Ito S, Matsumaru N, Nakamura S, Nagase I, Takahashi H, Ohno Y, Yasuda M, Yamamoto M, Tsukamoto K, Itoh Y, Deguchi T, Kitaichi K.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01409-17. doi: 10.1128/AAC.01409-17. Print 2018 Jan.

2.
3.

Pharmacokinetic and pharmacodynamic study of ipragliflozin in Japanese patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study.

Kadokura T, Akiyama N, Kashiwagi A, Utsuno A, Kazuta K, Yoshida S, Nagase I, Smulders R, Kageyama S.

Diabetes Res Clin Pract. 2014 Oct;106(1):50-6. doi: 10.1016/j.diabres.2014.07.020. Epub 2014 Jul 26.

PMID:
25149596
4.

Synthesis and evaluation of N-phenyl-(2-aminothiazol-4-yl)acetamides with phenoxypropanolamine moiety as selective β3-adrenergic receptor agonists.

Maruyama T, Onda K, Suzuki T, Hayakawa M, Takahashi T, Matsui T, Takasu T, Nagase I, Ohta M.

Chem Pharm Bull (Tokyo). 2012;60(5):647-58.

5.

Synthesis and evaluation of novel phenylethanolamine derivatives containing acetanilides as potent and selective beta3-adrenergic receptor agonists.

Maruyama T, Onda K, Hayakawa M, Suzuki T, Kimizuka T, Matsui T, Takasu T, Nagase I, Hamada N, Ohta M.

Chem Pharm Bull (Tokyo). 2010 Apr;58(4):533-45.

6.

Effects of the dipeptidyl peptidase-IV inhibitor ASP8497 on glucose tolerance in animal models of secondary failure.

Someya Y, Nakano R, Tahara A, Takasu T, Takeuchi A, Nagase I, Matsuyama-Yokono A, Hayakawa M, Sasamata M, Miyata K, Uchiyama Y.

Eur J Pharmacol. 2009 Nov 10;622(1-3):71-7. doi: 10.1016/j.ejphar.2009.09.024. Epub 2009 Sep 17.

PMID:
19766107
7.

Synthesis and evaluation of novel phenoxypropanolamine derivatives containing acetanilides as potent and selective beta3-adrenergic receptor agonists.

Maruyama T, Onda K, Hayakawa M, Seki N, Takahashi T, Moritomo H, Suzuki T, Matsui T, Takasu T, Nagase I, Ohta M.

Bioorg Med Chem. 2009 May 1;17(9):3283-94. doi: 10.1016/j.bmc.2009.03.044. Epub 2009 Mar 27.

PMID:
19362005
8.

ASP8497 is a novel selective and competitive dipeptidyl peptidase-IV inhibitor with antihyperglycemic activity.

Matsuyama-Yokono A, Tahara A, Nakano R, Someya Y, Nagase I, Hayakawa M, Shibasaki M.

Biochem Pharmacol. 2008 Jul 1;76(1):98-107. doi: 10.1016/j.bcp.2008.03.021. Epub 2008 Apr 6.

PMID:
18468582
9.

Pharmacological profile of ASP8497, a novel, selective, and competitive dipeptidyl peptidase-IV inhibitor, in vitro and in vivo.

Someya Y, Tahara A, Nakano R, Matsuyama-Yokono A, Nagase I, Fukunaga Y, Takasu T, Hayakawa M, Shibasaki M.

Naunyn Schmiedebergs Arch Pharmacol. 2008 May;377(3):209-17. doi: 10.1007/s00210-008-0277-8. Epub 2008 Apr 9.

PMID:
18398600
10.

Wogonin prevents glucocorticoid-induced thymocyte apoptosis without diminishing its anti-inflammatory action.

Enomoto R, Sugahara C, Suzuki C, Nagase I, Takamura Y, Yoshikawa A, Hosoda A, Hirano H, Yokoi T, Lee E.

J Pharmacol Sci. 2007 Aug;104(4):355-65. Epub 2007 Aug 10.

11.

Effect of (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl} acetanilide (YM178), a novel selective beta3-adrenoceptor agonist, on bladder function.

Takasu T, Ukai M, Sato S, Matsui T, Nagase I, Maruyama T, Sasamata M, Miyata K, Uchida H, Yamaguchi O.

J Pharmacol Exp Ther. 2007 May;321(2):642-7. Epub 2007 Feb 9.

PMID:
17293563
12.

Up-regulation of uncoupling proteins by beta-adrenergic stimulation in L6 myotubes.

Nagase I, Yoshida T, Saito M.

FEBS Lett. 2001 Apr 13;494(3):175-80.

13.

Beta 3-adrenergic agonist up-regulates uncoupling proteins 2 and 3 in skeletal muscle of the mouse.

Nakamura Y, Nagase I, Asano A, Sasaki N, Yoshida T, Umekawa T, Sakane N, Saito M.

J Vet Med Sci. 2001 Mar;63(3):309-14.

14.

Up-regulation of uncoupling protein 3 by thyroid hormone, peroxisome proliferator-activated receptor ligands and 9-cis retinoic acid in L6 myotubes.

Nagase I, Yoshida S, Canas X, Irie Y, Kimura K, Yoshida T, Saito M.

FEBS Lett. 1999 Nov 19;461(3):319-22.

15.

Nicotine induces uncoupling protein 1 in white adipose tissue of obese mice.

Yoshida T, Sakane N, Umekawa T, Kogure A, Kondo M, Kumamoto K, Kawada T, Nagase I, Saito M.

Int J Obes Relat Metab Disord. 1999 Jun;23(6):570-5.

PMID:
10411229
16.

beta 3-Adrenergic agonist induces a functionally active uncoupling protein in fat and slow-twitch muscle fibers.

Yoshida T, Umekawa T, Kumamoto K, Sakane N, Kogure A, Kondo M, Wakabayashi Y, Kawada T, Nagase I, Saito M.

Am J Physiol. 1998 Mar;274(3):E469-75. doi: 10.1152/ajpendo.1998.274.3.E469.

PMID:
9530130
17.

Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic beta 3-adrenergic agonist.

Nagase I, Yoshida T, Kumamoto K, Umekawa T, Sakane N, Nikami H, Kawada T, Saito M.

J Clin Invest. 1996 Jun 15;97(12):2898-904.

18.

Hyperplasia of brown adipose tissue after chronic stimulation of beta 3-adrenergic receptor in rats.

Nagase I, Sasaki N, Tsukazaki K, Yoshida T, Morimatsu M, Saito M.

Jpn J Vet Res. 1994 Dec;42(3-4):137-45.

PMID:
7745877

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