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Items: 36

1.

Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities.

Zhang D, Hop CE, Patilea-Vrana G, Gampa G, Seneviratne HK, Unadkat JD, Kenny JR, Nagapudi K, Di L, Zhou L, Zak M, Wright MR, Bumpus NN, Zang R, Liu X, Lai Y, Khojasteh SC.

Drug Metab Dispos. 2019 Jul 2. pii: dmd.119.086744. doi: 10.1124/dmd.119.086744. [Epub ahead of print]

2.

Impact of Surfactant and Surfactant-Polymer Interaction on Desupersaturation of Clotrimazole.

Zhang W, Hate SS, Russell DJ, Hou HH, Nagapudi K.

J Pharm Sci. 2019 Jun 14. pii: S0022-3549(19)30369-7. doi: 10.1016/j.xphs.2019.05.035. [Epub ahead of print]

PMID:
31207217
3.

Rapid Characterization of Formulated Pharmaceuticals Using Fast MAS 1H Solid-State NMR Spectroscopy.

Hirsh DA, Wijesekara AV, Carnahan SL, Hung I, Lubach JW, Nagapudi K, Rossini AJ.

Mol Pharm. 2019 Jul 1;16(7):3121-3132. doi: 10.1021/acs.molpharmaceut.9b00343. Epub 2019 Jun 4.

PMID:
31095913
4.

An Integrated Analysis of Solid Form Change Impact on Solubility and Permeability: Case Study of Oral Exposure in Rats of an RAR Related Orphan Receptor C Inhibitor.

Chiang PC, Nagapudi K, Liu J, Crawford JJ, Zbieg JR, Plise E, Deng Y.

J Pharm Sci. 2019 Jul;108(7):2256-2263. doi: 10.1016/j.xphs.2019.01.031. Epub 2019 Feb 7.

PMID:
30738851
5.

Impact of Method of Preparation of Amorphous Solid Dispersions on Mechanical Properties: Comparison of Coprecipitation and Spray Drying.

Hou HH, Rajesh A, Pandya KM, Lubach JW, Muliadi A, Yost E, Jia W, Nagapudi K.

J Pharm Sci. 2019 Feb;108(2):870-879. doi: 10.1016/j.xphs.2018.09.008. Epub 2018 Sep 19.

PMID:
30244013
6.

Understanding Phase Behavior of Nearly Energetically Equivalent Polymorphs To Achieve Controlled Crystallization for a Nav1.7 Pain Inhibitor Compound.

Chakravarty P, DiPasquale AG, Stumpf A, Lubach JW, Nagapudi K.

Mol Pharm. 2018 Nov 5;15(11):5072-5080. doi: 10.1021/acs.molpharmaceut.8b00658. Epub 2018 Sep 28.

PMID:
30216726
7.

Investigation of Drug Delivery in Rats via Subcutaneous Injection: Case Study of Pharmacokinetic Modeling of Suspension Formulations.

Chiang PC, Nagapudi K, Fan PW, Liu J.

J Pharm Sci. 2019 Jan;108(1):109-119. doi: 10.1016/j.xphs.2018.06.003. Epub 2018 Jun 14.

PMID:
29909029
8.

Evaluation of Accuracy of Amorphous Solubility Advantage Calculation by Comparison with Experimental Solubility Measurement in Buffer and Biorelevant Media.

Zhang W, Haser A, Hou HH, Nagapudi K.

Mol Pharm. 2018 Apr 2;15(4):1714-1723. doi: 10.1021/acs.molpharmaceut.8b00125. Epub 2018 Mar 21.

PMID:
29522344
9.

Determination of Fragility in Organic Small Molecular Glass Forming Liquids: Comparison of Calorimetric and Spectroscopic Data and Commentary on Pharmaceutical Importance.

Chakravarty P, Pandya K, Nagapudi K.

Mol Pharm. 2018 Mar 5;15(3):1248-1257. doi: 10.1021/acs.molpharmaceut.7b01068. Epub 2018 Feb 7.

PMID:
29384682
10.

Effect of Microenvironmental pH Modulation on the Dissolution Rate and Oral Absorption of the Salt of a Weak Acid - Case Study of GDC-0810.

Hou HH, Jia W, Liu L, Cheeti S, Li J, Nauka E, Nagapudi K.

Pharm Res. 2018 Jan 29;35(2):37. doi: 10.1007/s11095-018-2347-z.

PMID:
29380076
11.

Comparative Assessment of Miniaturized Screening Approaches for Selection of Polymers for Amorphous Drug Stabilization.

Banda A, Manchanda A, Zhang W, Alba GM, Nagapudi K.

J Pharm Sci. 2018 Mar;107(3):897-908. doi: 10.1016/j.xphs.2017.11.006. Epub 2017 Nov 16.

PMID:
29155235
12.

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products.

Silva Elipe MV, Li L, Nagapudi K, Kook AM, Cobas C, Iglesias I, Peng C.

J Vis Exp. 2017 Aug 22;(126). doi: 10.3791/55850.

13.

High-throughput screening and scale-up of cocrystals using resonant acoustic mixing.

Nagapudi K, Umanzor EY, Masui C.

Int J Pharm. 2017 Apr 15;521(1-2):337-345. doi: 10.1016/j.ijpharm.2017.02.027. Epub 2017 Feb 14.

PMID:
28229947
14.

Humidity induced phase transformation of poloxamer 188 and its effect on physical stability of amorphous solid dispersion of AMG 579, a PDE10A inhibitor.

Wu Q, Kennedy MT, Nagapudi K, Kiang YH.

Int J Pharm. 2017 Apr 15;521(1-2):1-7. doi: 10.1016/j.ijpharm.2017.01.059. Epub 2017 Feb 2.

PMID:
28163226
15.

Control Strategies for Drug Product Continuous Direct Compression-State of Control, Product Collection Strategies, and Startup/Shutdown Operations for the Production of Clinical Trial Materials and Commercial Products.

Almaya A, De Belder L, Meyer R, Nagapudi K, Lin HH, Leavesley I, Jayanth J, Bajwa G, DiNunzio J, Tantuccio A, Blackwood D, Abebe A.

J Pharm Sci. 2017 Apr;106(4):930-943. doi: 10.1016/j.xphs.2016.12.014. Epub 2017 Jan 6.

PMID:
28069357
16.

A rational approach towards development of amorphous solid dispersions: Experimental and computational techniques.

Chakravarty P, Lubach JW, Hau J, Nagapudi K.

Int J Pharm. 2017 Mar 15;519(1-2):44-57. doi: 10.1016/j.ijpharm.2017.01.003. Epub 2017 Jan 4.

PMID:
28063904
17.

Investigation of Phase Mixing in Amorphous Solid Dispersions of AMG 517 in HPMC-AS Using DSC, Solid-State NMR, and Solution Calorimetry.

Calahan JL, Azali SC, Munson EJ, Nagapudi K.

Mol Pharm. 2015 Nov 2;12(11):4115-23. doi: 10.1021/acs.molpharmaceut.5b00556. Epub 2015 Oct 23.

PMID:
26457879
18.

Conformational isomerism in solid state of AMG 853--structure studies using solid-state nuclear magnetic resonance and X-ray diffraction.

Kiang YH, Nagapudi K, Wu T, Peterson ML, Jona J, Staples RJ, Stephens PW.

J Pharm Sci. 2015 Jul;104(7):2161-8. doi: 10.1002/jps.24457. Epub 2015 Apr 24.

PMID:
25912152
19.

Application of (19)  F time-domain NMR to measure content in fluorine-containing drug products.

Silva Elipe MV, Li L, Nagapudi K, Kook AM, Cobas C, Iglesias I, Peng C.

Magn Reson Chem. 2016 Jun;54(6):531-8. doi: 10.1002/mrc.4223. Epub 2015 Mar 13.

PMID:
25773191
20.

Amorphous solid dispersions: a robust platform to address bioavailability challenges.

Newman A, Nagapudi K, Wenslow R.

Ther Deliv. 2015 Feb;6(2):247-61. doi: 10.4155/tde.14.101. Review.

PMID:
25690090
21.

Application of twin screw extrusion to the manufacture of cocrystals: scale-up of AMG 517-sorbic acid cocrystal production.

Daurio D, Nagapudi K, Li L, Quan P, Nunez FA.

Faraday Discuss. 2014;170:235-49. doi: 10.1039/c3fd00153a.

PMID:
25406487
22.

Sorbitol crystallization-induced aggregation in frozen mAb formulations.

Piedmonte DM, Hair A, Baker P, Brych L, Nagapudi K, Lin H, Cao W, Hershenson S, Ratnaswamy G.

J Pharm Sci. 2015 Feb;104(2):686-97. doi: 10.1002/jps.24141. Epub 2014 Sep 12.

PMID:
25219372
23.

Structural studies of a non-stoichiometric channel hydrate using high resolution X-ray powder diffraction, solid-state nuclear magnetic resonance, and moisture sorption methods.

Kiang YH, Cheung E, Stephens PW, Nagapudi K.

J Pharm Sci. 2014 Sep;103(9):2809-2818. doi: 10.1002/jps.23873. Epub 2014 Jan 27.

PMID:
24470123
24.

Effect of pH and excipients on structure, dynamics, and long-term stability of a model IgG1 monoclonal antibody upon freeze-drying.

Park J, Nagapudi K, Vergara C, Ramachander R, Laurence JS, Krishnan S.

Pharm Res. 2013 Apr;30(4):968-84. doi: 10.1007/s11095-012-0933-z. Epub 2012 Nov 27.

PMID:
23184227
25.

Crystal structure study and investigation of solid-state cyclization for AMG 222, a channel hydrate.

Kiang YH, Nagapudi K, Liu J, Staples RJ, Jona J.

Int J Pharm. 2013 Jan 30;441(1-2):299-306. doi: 10.1016/j.ijpharm.2012.11.029. Epub 2012 Nov 23.

PMID:
23182974
26.

High-throughput 96-well solvent mediated sonic blending synthesis and on-plate solid/solution stability characterization of pharmaceutical cocrystals.

Luu V, Jona J, Stanton MK, Peterson ML, Morrison HG, Nagapudi K, Tan H.

Int J Pharm. 2013 Jan 30;441(1-2):356-64. doi: 10.1016/j.ijpharm.2012.11.020. Epub 2012 Nov 23.

PMID:
23178596
27.

Manufacture and performance evaluation of a stable amorphous complex of an acidic drug molecule and Neusilin.

Maclean J, Medina C, Daurio D, Alvarez-Nunez F, Jona J, Munson E, Nagapudi K.

J Pharm Sci. 2011 Aug;100(8):3332-3344. doi: 10.1002/jps.22583. Epub 2011 Apr 25.

PMID:
21520086
28.

Application of twin screw extrusion in the manufacture of cocrystals, part I: four case studies.

Daurio D, Medina C, Saw R, Nagapudi K, Alvarez-Núñez F.

Pharmaceutics. 2011 Aug 31;3(3):582-600. doi: 10.3390/pharmaceutics3030582.

29.

Selective and potent Raf inhibitors paradoxically stimulate normal cell proliferation and tumor growth.

Carnahan J, Beltran PJ, Babij C, Le Q, Rose MJ, Vonderfecht S, Kim JL, Smith AL, Nagapudi K, Broome MA, Fernando M, Kha H, Belmontes B, Radinsky R, Kendall R, Burgess TL.

Mol Cancer Ther. 2010 Aug;9(8):2399-410. doi: 10.1158/1535-7163.MCT-10-0181. Epub 2010 Jul 27.

30.

Fast surface crystallization of amorphous griseofulvin below T g.

Zhu L, Jona J, Nagapudi K, Wu T.

Pharm Res. 2010 Aug;27(8):1558-67. doi: 10.1007/s11095-010-0140-8. Epub 2010 Apr 23.

PMID:
20414704
31.

Manufacture of pharmaceutical co-crystals using twin screw extrusion: a solvent-less and scalable process.

Medina C, Daurio D, Nagapudi K, Alvarez-Nunez F.

J Pharm Sci. 2010 Apr;99(4):1693-6. doi: 10.1002/jps.21942. No abstract available.

PMID:
19774652
32.

Quantification of compaction-induced crystallinity reduction of a pharmaceutical solid using 19F solid-state NMR and powder X-ray diffraction.

Liu J, Nagapudi K, Kiang YH, Martinez E, Jona J.

Drug Dev Ind Pharm. 2009 Aug;35(8):969-75. doi: 10.1080/03639040902729424.

PMID:
19360510
33.

Alterations in physical cross-linking modulate mechanical properties of two-phase protein polymer networks.

Wu X, Sallach R, Haller CA, Caves JA, Nagapudi K, Conticello VP, Levenston ME, Chaikof EL.

Biomacromolecules. 2005 Nov-Dec;6(6):3037-44.

PMID:
16283724
34.

Viscoelastic and mechanical behavior of recombinant protein elastomers.

Nagapudi K, Brinkman WT, Thomas BS, Park JO, Srinivasarao M, Wright E, Conticello VP, Chaikof EL.

Biomaterials. 2005 Aug;26(23):4695-706.

PMID:
15763249
35.

Photo-cross-linking of type I collagen gels in the presence of smooth muscle cells: mechanical properties, cell viability, and function.

Brinkman WT, Nagapudi K, Thomas BS, Chaikof EL.

Biomacromolecules. 2003 Jul-Aug;4(4):890-5.

PMID:
12857069
36.

Engineered collagen-PEO nanofibers and fabrics.

Huang L, Nagapudi K, Apkarian RP, Chaikof EL.

J Biomater Sci Polym Ed. 2001;12(9):979-93.

PMID:
11787524

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