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Items: 1 to 50 of 268

1.

Evaluation of the 5-fluorouracil plasma level in patients with colorectal cancer undergoing continuous infusion chemotherapy.

Abe Y, Sakuyama N, Sato T, Kishine K, Nagayasu K, Nakatani A, Kitajima M, Watanabe T, Nishimura K, Ochiai T, Nagaoka I.

Mol Clin Oncol. 2019 Sep;11(3):289-295. doi: 10.3892/mco.2019.1893. Epub 2019 Jul 3.

2.

Bacterial lipopolysaccharide and antimicrobial LL-37 enhance ICAM-1 expression and NF-κB p65 phosphorylation in senescent endothelial cells.

Suzuki K, Ohkuma M, Nagaoka I.

Int J Mol Med. 2019 Oct;44(4):1187-1196. doi: 10.3892/ijmm.2019.4294. Epub 2019 Jul 31.

3.

The Potential Use of Grape Phytochemicals for Preventing the Development of Intestine-Related and Subsequent Inflammatory Diseases.

Santa K, Kumazawa Y, Nagaoka I.

Endocr Metab Immune Disord Drug Targets. 2019;19(6):794-802. doi: 10.2174/1871530319666190529105226.

PMID:
31142251
4.

Effect of aging on the tendon structure and tendon-associated gene expression in mouse foot flexor tendon.

Sugiyama Y, Naito K, Goto K, Kojima Y, Furuhata A, Igarashi M, Nagaoka I, Kaneko K.

Biomed Rep. 2019 Apr;10(4):238-244. doi: 10.3892/br.2019.1200. Epub 2019 Mar 13.

5.

Chondroprotective action of glucosamine, a chitosan monomer, on the joint health of athletes.

Nagaoka I, Tsuruta A, Yoshimura M.

Int J Biol Macromol. 2019 Jul 1;132:795-800. doi: 10.1016/j.ijbiomac.2019.03.234. Epub 2019 Mar 30. Review.

PMID:
30940583
6.

Low Endotoxin Recovery-Masking of Naturally Occurring Endotoxin.

Reich J, Weyer FA, Tamura H, Nagaoka I, Motschmann H.

Int J Mol Sci. 2019 Feb 15;20(4). pii: E838. doi: 10.3390/ijms20040838.

7.

Impact of primary tumor location as a predictive factor in patients suffering from colorectal cancer treated with cytotoxic anticancer agents based on the collagen gel droplet-embedded drug sensitivity test.

Ochiai T, Nishimura K, Watanabe T, Kitajima M, Nakatani A, Nagayasu K, Sakuyama N, Sato T, Kishine K, Abe Y, Nagaoka I.

Oncol Lett. 2019 Feb;17(2):1842-1850. doi: 10.3892/ol.2018.9805. Epub 2018 Dec 6.

8.

MrgX2‑mediated internalization of LL‑37 and degranulation of human LAD2 mast cells.

Murakami T, Suzuki K, Niyonsaba F, Tada H, Reich J, Tamura H, Nagaoka I.

Mol Med Rep. 2018 Dec;18(6):4951-4959. doi: 10.3892/mmr.2018.9532. Epub 2018 Oct 2.

9.

Protection of the endothelial glycocalyx by antithrombin in an endotoxin-induced rat model of sepsis.

Iba T, Levy JH, Hirota T, Hiki M, Sato K, Murakami T, Nagaoka I.

Thromb Res. 2018 Nov;171:1-6. doi: 10.1016/j.thromres.2018.09.042. Epub 2018 Sep 6.

PMID:
30216821
10.

Evaluation of the effect of the administration of a glucosamine‑containing supplement on biomarkers for cartilage metabolism in soccer players: A randomized double‑blind placebo‑controlled study.

Tsuruta A, Horiike T, Yoshimura M, Nagaoka I.

Mol Med Rep. 2018 Oct;18(4):3941-3948. doi: 10.3892/mmr.2018.9396. Epub 2018 Aug 17.

PMID:
30132529
11.

Investigation of the kinetics and mechanism of low endotoxin recovery in a matrix for biopharmaceutical drug products.

Reich J, Tamura H, Nagaoka I, Motschmann H.

Biologicals. 2018 May;53:1-9. doi: 10.1016/j.biologicals.2018.04.001. Epub 2018 Apr 21.

12.

JAK2/STAT3 pathway as a therapeutic target in ovarian cancers.

Yoshikawa T, Miyamoto M, Aoyama T, Soyama H, Goto T, Hirata J, Suzuki A, Nagaoka I, Tsuda H, Furuya K, Takano M.

Oncol Lett. 2018 Apr;15(4):5772-5780. doi: 10.3892/ol.2018.8028. Epub 2018 Feb 12.

13.

Effect of intermittent administration of teriparatide on the mechanical and histological changes in bone grafted with β-tricalcium phosphate using a rabbit bone defect model.

Komatsu J, Nagura N, Iwase H, Igarashi M, Ohbayashi O, Nagaoka I, Kaneko K.

Exp Ther Med. 2018 Jan;15(1):19-30. doi: 10.3892/etm.2017.5424. Epub 2017 Nov 1.

14.

Protective effect of a newly developed fucose-deficient recombinant antithrombin against histone-induced endothelial damage.

Iba T, Hirota T, Sato K, Nagaoka I.

Int J Hematol. 2018 May;107(5):528-534. doi: 10.1007/s12185-018-2402-x. Epub 2018 Jan 20.

PMID:
29353463
15.

Impact of the individualization of the first-line chemotherapy for advanced colorectal cancer based on collagen gel droplet-embedded drug sensitivity test.

Ochiai T, Nishimura K, Watanabe T, Kitajima M, Nakatani A, Nagayasu K, Naito S, Sato T, Kishine K, Abe Y, Hara C, Yamada S, Mashiko S, Nagaoka I.

Oncol Lett. 2017 Nov;14(5):6045-6052. doi: 10.3892/ol.2017.6960. Epub 2017 Sep 15.

16.

Evaluation of the efficacy of Ajuga decumbens extract supplement in individuals with knee discomfort associated with physical activity: A randomized, double-blind, placebo-controlled study.

Sawada Y, Sugimoto A, Hananouchi T, Sato N, Nagaoka I.

Exp Ther Med. 2017 Nov;14(5):4561-4571. doi: 10.3892/etm.2017.5064. Epub 2017 Aug 29.

17.

Quantitative trait loci analysis of grain appearance in Oryza sativa L. 'Emi-no-kizuna'.

Nagaoka I, Sasahara H, Matsushita K, Maeda H, Fukuoka S, Yamaguchi M, Shigemune A, Miura K.

Breed Sci. 2017 Sep;67(4):421-426. doi: 10.1270/jsbbs.17025. Epub 2017 Aug 11.

18.

Evaluation of the chondroprotective action of N-acetylglucosamine in a rat experimental osteoarthritis model.

Kubomura D, Ueno T, Yamada M, Nagaoka I.

Exp Ther Med. 2017 Oct;14(4):3137-3144. doi: 10.3892/etm.2017.4849. Epub 2017 Jul 28.

19.

Anti‑inflammatory actions of gabapentin and pregabalin on the substance P‑induced mitogen‑activated protein kinase activation in U373 MG human glioblastoma astrocytoma cells.

Yamaguchi K, Kumakura S, Someya A, Iseki M, Inada E, Nagaoka I.

Mol Med Rep. 2017 Nov;16(5):6109-6115. doi: 10.3892/mmr.2017.7368. Epub 2017 Aug 28.

PMID:
28849160
20.

Improvement of seed shattering and dormancy in Oryza sativa L. 'Hokuriku 193' based on genetic information.

Nagaoka I, Sasahara H, Tabuchi H, Shigemune A, Matsushita K, Maeda H, Goto A, Fukuoka S, Ando T, Miura K.

Breed Sci. 2017 Jun;67(3):173-180. doi: 10.1270/jsbbs.16128. Epub 2017 May 10.

21.

Psoas muscle volume as a predictor of peripheral neurotoxicity induced by primary chemotherapy in ovarian cancers.

Yoshikawa T, Takano M, Miyamoto M, Yajima I, Shimizu Y, Aizawa Y, Suguchi Y, Moriiwa M, Aoyama T, Soyama H, Goto T, Hirata J, Suzuki A, Sasa H, Nagaoka I, Tsuda H, Furuya K.

Cancer Chemother Pharmacol. 2017 Sep;80(3):555-561. doi: 10.1007/s00280-017-3395-5. Epub 2017 Jul 19.

PMID:
28726081
22.

Evaluation of the effect of salmon nasal proteoglycan on biomarkers for cartilage metabolism in individuals with knee joint discomfort: A randomized double-blind placebo-controlled clinical study.

Tomonaga A, Takahashi T, Tanaka YT, Tsuboi M, Ito K, Nagaoka I.

Exp Ther Med. 2017 Jul;14(1):115-126. doi: 10.3892/etm.2017.4454. Epub 2017 May 11.

23.

The Comparison of the Protective Effects of α- and β-Antithrombin against Vascular Endothelial Cell Damage Induced by Histone in Vitro.

Iba T, Sasaki T, Ohshima K, Sato K, Nagaoka I, Thachil J.

TH Open. 2017 Jun 28;1(1):e3-e10. doi: 10.1055/s-0037-1603926. eCollection 2017 Jun.

24.

Quantitative trait loci analysis of blast resistance in Oryza sativa L. 'Hokuriku 193'.

Nagaoka I, Sasahara H, Tabuchi H, Shigemune A, Matsushita K, Maeda H, Goto A, Fukuoka S, Ando T, Miura K.

Breed Sci. 2017 Mar;67(2):159-164. doi: 10.1270/jsbbs.16099. Epub 2017 Feb 25.

25.

Evaluation of the effect of recombinant thrombomodulin on a lipopolysaccharide-induced murine sepsis model.

Takehara K, Murakami T, Kuwahara-Arai K, Iba T, Nagaoka I, Sakamoto K.

Exp Ther Med. 2017 Jun;13(6):2969-2974. doi: 10.3892/etm.2017.4308. Epub 2017 Apr 5.

26.

Evaluation of the effect of oral administration of collagen peptides on an experimental rat osteoarthritis model.

Isaka S, Someya A, Nakamura S, Naito K, Nozawa M, Inoue N, Sugihara F, Nagaoka I, Kaneko K.

Exp Ther Med. 2017 Jun;13(6):2699-2706. doi: 10.3892/etm.2017.4310. Epub 2017 Apr 5.

27.

Evaluation of the anti-inflammatory actions of various functional food materials including glucosamine on synovial cells.

Yamagishi Y, Someya A, Imai K, Nagao J, Nagaoka I.

Mol Med Rep. 2017 Aug;16(2):1353-1359. doi: 10.3892/mmr.2017.6691. Epub 2017 Jun 6.

PMID:
28586015
28.

Is there any predictor for hypersensitivity reactions in gynecologic cancer patients treated with paclitaxel-based therapy?

Aoyama T, Takano M, Miyamoto M, Yoshikawa T, Soyama H, Kato K, Ishibashi H, Iwahashi H, Nakatsuka M, Yajima I, Shimizu Y, Aizawa Y, Suguchi Y, Moriiwa M, Goto T, Sasa H, Nagaoka I, Tsuda H, Furuya K.

Cancer Chemother Pharmacol. 2017 Jul;80(1):65-69. doi: 10.1007/s00280-017-3332-7. Epub 2017 May 10.

PMID:
28493032
29.

Effect of aloe‑emodin on the proliferation and apoptosis of human synovial MH7A cells; a comparison with methotrexate.

Hashiguchi M, Suzuki K, Kaneko K, Nagaoka I.

Mol Med Rep. 2017 Jun;15(6):4398-4404. doi: 10.3892/mmr.2017.6541. Epub 2017 May 2.

PMID:
28487948
30.

Effect of N-acetylglucosamine administration on cartilage metabolism and safety in healthy subjects without symptoms of arthritis: A case report.

Kubomura D, Ueno T, Yamada M, Tomonaga A, Nagaoka I.

Exp Ther Med. 2017 Apr;13(4):1614-1621. doi: 10.3892/etm.2017.4140. Epub 2017 Feb 21.

31.

Neutrophil extracellular traps induce IL-1β production by macrophages in combination with lipopolysaccharide.

Hu Z, Murakami T, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Tabe Y, Nagaoka I.

Int J Mol Med. 2017 Mar;39(3):549-558. doi: 10.3892/ijmm.2017.2870. Epub 2017 Jan 27.

32.

Ketamine suppresses the substance P-induced production of IL-6 and IL-8 by human U373MG glioblastoma/astrocytoma cells.

Yamaguchi K, Kumakura S, Murakami T, Someya A, Inada E, Nagaoka I.

Int J Mol Med. 2017 Mar;39(3):687-692. doi: 10.3892/ijmm.2017.2875. Epub 2017 Feb 3.

PMID:
28204809
33.

Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells.

Tabe Y, Yamamoto S, Saitoh K, Sekihara K, Monma N, Ikeo K, Mogushi K, Shikami M, Ruvolo V, Ishizawa J, Hail N Jr, Kazuno S, Igarashi M, Matsushita H, Yamanaka Y, Arai H, Nagaoka I, Miida T, Hayashizaki Y, Konopleva M, Andreeff M.

Cancer Res. 2017 Mar 15;77(6):1453-1464. doi: 10.1158/0008-5472.CAN-16-1645. Epub 2017 Jan 20.

34.

Effect of glucosamine on expression of type II collagen, matrix metalloproteinase and sirtuin genes in a human chondrocyte cell line.

Igarashi M, Sakamoto K, Nagaoka I.

Int J Mol Med. 2017 Feb;39(2):472-478. doi: 10.3892/ijmm.2016.2842. Epub 2016 Dec 28.

PMID:
28035358
35.

High-temperature-required protein A2 as a predictive marker for response to chemotherapy and prognosis in patients with high-grade serous ovarian cancers.

Miyamoto M, Takano M, Iwaya K, Shinomiya N, Goto T, Kato M, Suzuki A, Aoyama T, Hitrata J, Nagaoka I, Tsuda H, Furuya K.

Br J Cancer. 2017 Mar 14;116(6):e2. doi: 10.1038/bjc.2016.371. Epub 2016 Nov 10. No abstract available.

36.

Glucosamine Downregulates the IL-1β-Induced Expression of Proinflammatory Cytokine Genes in Human Synovial MH7A Cells by O-GlcNAc Modification-Dependent and -Independent Mechanisms.

Someya A, Ikegami T, Sakamoto K, Nagaoka I.

PLoS One. 2016 Oct 24;11(10):e0165158. doi: 10.1371/journal.pone.0165158. eCollection 2016.

38.

Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells.

Tada H, Shimizu T, Nagaoka I, Takada H.

Biomed Res. 2016;37(3):199-205. doi: 10.2220/biomedres.37.199.

39.

Is Modified Radical Hysterectomy Needed for Patients with Clinical Stage I/II Endometrial Cancers? A Historical Control Study.

Miyamoto M, Takano M, Aoyama T, Soyama H, Kato M, Yoshikawa T, Shibutani T, Matsuura H, Goto T, Sasa H, Nagaoka I, Furuya K.

Oncology. 2016;90(4):179-85. doi: 10.1159/000444258. Epub 2016 Mar 18.

PMID:
26986224
40.

Release mechanism of high mobility group nucleosome binding domain 1 from lipopolysaccharide-stimulated macrophages.

Murakami T, Hu Z, Tamura H, Nagaoka I.

Mol Med Rep. 2016 Apr;13(4):3115-20. doi: 10.3892/mmr.2016.4893. Epub 2016 Feb 16.

PMID:
26935015
41.

Physiological Levels of Pentraxin 3 and Albumin Attenuate Vascular Endothelial Cell Damage Induced by Histone H3 In Vitro.

Iba T, Hamakubo T, Nagaoka I, Sato K, Thachil J.

Microcirculation. 2016 Apr;23(3):240-7. doi: 10.1111/micc.12269.

PMID:
26806786
42.

Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice.

Hu Z, Murakami T, Suzuki K, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Nagaoka I.

Int Immunol. 2016 May;28(5):245-53. doi: 10.1093/intimm/dxv113. Epub 2016 Jan 7.

43.

Human Host Defense Cathelicidin Peptide LL-37 Enhances the Lipopolysaccharide Uptake by Liver Sinusoidal Endothelial Cells without Cell Activation.

Suzuki K, Murakami T, Hu Z, Tamura H, Kuwahara-Arai K, Iba T, Nagaoka I.

J Immunol. 2016 Feb 1;196(3):1338-47. doi: 10.4049/jimmunol.1403203. Epub 2016 Jan 4.

44.

Heparins attenuated histone-mediated cytotoxicity in vitro and improved the survival in a rat model of histone-induced organ dysfunction.

Iba T, Hashiguchi N, Nagaoka I, Tabe Y, Kadota K, Sato K.

Intensive Care Med Exp. 2015 Dec;3(1):36. doi: 10.1186/s40635-015-0072-z. Epub 2015 Dec 29.

45.

Evaluation of the lipopolysaccharide-induced transcription of the human TREM-1 gene in vitamin D3-matured THP-1 macrophage-like cells.

Hosoda H, Tamura H, Nagaoka I.

Int J Mol Med. 2015 Nov;36(5):1300-10. doi: 10.3892/ijmm.2015.2349. Epub 2015 Sep 18.

PMID:
26397033
46.

Effects of the combination of vitamin K and teriparatide on the bone metabolism in ovariectomized rats.

Nagura N, Komatsu J, Iwase H, Hosoda H, Ohbayashi O, Nagaoka I, Kaneko K.

Biomed Rep. 2015 May;3(3):295-300. Epub 2015 Feb 18.

47.

High-temperature-required protein A2 as a predictive marker for response to chemotherapy and prognosis in patients with high-grade serous ovarian cancers.

Miyamoto M, Takano M, Iwaya K, Shinomiya N, Goto T, Kato M, Suzuki A, Aoyama T, Hirata J, Nagaoka I, Tsuda H, Furuya K.

Br J Cancer. 2015 Feb 17;112(4):739-44. doi: 10.1038/bjc.2015.1. Epub 2015 Jan 27. Erratum in: Br J Cancer. 2017 Mar 14;116(6):e2.

48.

Mechanism underlying the transient increase of serum iron during FOLFOX/FOLFIRI therapy.

Ochiai T, Nishimura K, Watanabe T, Kitajima M, Nakatani A, Sato T, Kishine K, Futagawa S, Mashiko S, Nagaoka I.

Mol Clin Oncol. 2014 Nov;2(6):968-972. Epub 2014 Aug 11.

49.

Is the neutrophil a 'prima donna' in the procoagulant process during sepsis?

Iba T, Miki T, Hashiguchi N, Tabe Y, Nagaoka I.

Crit Care. 2014 Jul 9;18(4):230. doi: 10.1186/cc13983. Review.

50.

Combination of antithrombin and recombinant thrombomodulin modulates neutrophil cell-death and decreases circulating DAMPs levels in endotoxemic rats.

Iba T, Miki T, Hashiguchi N, Tabe Y, Nagaoka I.

Thromb Res. 2014 Jul;134(1):169-73. doi: 10.1016/j.thromres.2014.04.015. Epub 2014 Apr 29.

PMID:
24816370

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