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Items: 1 to 50 of 734

1.

Energy-dependent endocytosis is responsible for drug transcorneal penetration following the instillation of ophthalmic formulations containing indomethacin nanoparticles.

Nagai N, Ogata F, Otake H, Nakazawa Y, Kawasaki N.

Int J Nanomedicine. 2019 Feb 18;14:1213-1227. doi: 10.2147/IJN.S196681. eCollection 2019.

2.

Preventive effects of tyrosol, a natural phenolic compound, on anterior uveitis induced by anterior chamber paracentesis in healthy beagle dogs.

Sato K, Kanai K, Ozaki M, Kagawa T, Kita M, Yamashita Y, Nagai N, Tajima K.

J Vet Med Sci. 2019 Feb 25. doi: 10.1292/jvms.18-0723. [Epub ahead of print]

3.

Structure of two purple pigments, catechiopyranocyanidins A and B from the seed-coat of the small red bean, Vigna angularis.

Yoshida K, Nagai N, Ichikawa Y, Goto M, Kazuma K, Oyama KI, Koga K, Hashimoto M, Iuchi S, Takaya Y, Kondo T.

Sci Rep. 2019 Feb 6;9(1):1484. doi: 10.1038/s41598-018-37641-0.

4.

Comparison of early posttreatment effects of two steroidal anti-inflammatory ophthalmic drugs on the ocular inflammatory response induced by paracentesis in healthy canine eyes.

Sato K, Iwasaki K, Nagai N, Yamashita Y, Chikazawa S, Hoshi F, Kanai K.

Vet Ophthalmol. 2019 Feb 4. doi: 10.1111/vop.12629. [Epub ahead of print]

PMID:
30716193
5.

Evaluation of Dissolution Profile between Original and Generic Products of Zolpidem Tartrate by Microdialysis-HPLC.

Inaba K, Oie T, Otake H, Kotake T, Nagai N.

Chem Pharm Bull (Tokyo). 2019;67(2):120-124. doi: 10.1248/cpb.c18-00642.

6.

QD laser eyewear as a visual field aid in a visual field defect model.

Iyama C, Shigeno Y, Hirano E, Kamoshita M, Nagai N, Suzuki M, Minami S, Kurihara T, Sonobe H, Watanabe K, Shinoda H, Tsubota K, Ozawa Y.

Sci Rep. 2019 Jan 30;9(1):1010. doi: 10.1038/s41598-018-37744-8.

7.

A drug refillable device for transscleral sustained drug delivery to the retina.

Nagai N, Saijo S, Song Y, Kaji H, Abe T.

Eur J Pharm Biopharm. 2019 Mar;136:184-191. doi: 10.1016/j.ejpb.2019.01.024. Epub 2019 Jan 25.

PMID:
30690065
8.

Retinal inflammation diagnosed as an idiopathic macular hole with multiple recurrences and spontaneous closures: A case report.

Hayashi I, Shinoda H, Nagai N, Tsubota K, Ozawa Y.

Medicine (Baltimore). 2019 Jan;98(4):e14230. doi: 10.1097/MD.0000000000014230.

9.

Coffee brew intake can prevent the reduction of lens glutathione and ascorbic acid levels in HFD-fed animals.

Nakazawa Y, Ishimori N, Oguchi J, Nagai N, Kimura M, Funakoshi-Tago M, Tamura H.

Exp Ther Med. 2019 Feb;17(2):1420-1425. doi: 10.3892/etm.2018.7092. Epub 2018 Dec 13.

10.

Energy-Dependent Endocytosis is Involved in the Absorption of Indomethacin Nanoparticles in the Small Intestine.

Ishii M, Fukuoka Y, Deguchi S, Otake H, Tanino T, Nagai N.

Int J Mol Sci. 2019 Jan 22;20(3). pii: E476. doi: 10.3390/ijms20030476.

11.

[Effect of Methylcellulose (Cellulose Derivatives) on Ibuprofen-crushing Efficiency in Nano Pulverizer NP-100].

Nagai N, Yamasaki Y, Nakamura T, Otake H, Okamoto N.

Yakugaku Zasshi. 2019;139(1):123-130. doi: 10.1248/yakushi.18-00176. Japanese.

12.

Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition.

Nagai N, Ohguchi H, Nakaki R, Matsumura Y, Kanki Y, Sakai J, Aburatani H, Minami T.

PLoS Genet. 2018 Nov 30;14(11):e1007826. doi: 10.1371/journal.pgen.1007826. eCollection 2018 Nov.

13.

A Proteomic Approach for Understanding the Mechanisms of Delayed Corneal Wound Healing in Diabetic Keratopathy Using Diabetic Model Rat.

Yamamoto T, Otake H, Hiramatsu N, Yamamoto N, Taga A, Nagai N.

Int J Mol Sci. 2018 Nov 18;19(11). pii: E3635. doi: 10.3390/ijms19113635.

14.

Tolvaptan Efficiently Reduces Intracellular Fluid: Working Toward a Potential Treatment Option for Cellular Edema.

Kawabata H, Iwatani H, Yamamichi Y, Shirahase K, Nagai N, Isaka Y.

Intern Med. 2019 Mar 1;58(5):639-642. doi: 10.2169/internalmedicine.0993-18. Epub 2018 Nov 19.

15.

Prevalence and Risk Factors of Elevated Liver Enzymes in Japanese Women With Polycystic Ovary Syndrome.

Minato S, Sakane N, Kotani K, Nirengi S, Hayashi I, Suganuma A, Yamaguchi K, Takakura K, Nagai N.

J Clin Med Res. 2018 Dec;10(12):904-910. doi: 10.14740/jocmr3639. Epub 2018 Oct 30.

16.

Hepatic cytochrome P450 metabolism suppressed by mast cells in type 1 allergic mice.

Tanino T, Bando T, Nojiri Y, Okada Y, Nagai N, Ueda Y, Sakurai E.

Biochem Pharmacol. 2018 Dec;158:318-326. doi: 10.1016/j.bcp.2018.11.001. Epub 2018 Nov 2.

PMID:
30395837
17.

Comparison of cervical vestibular evoked potentials evoked by air-conducted sound and bone-conducted vibration in vestibular Schwannoma patients.

Ogawa Y, Otsuka K, Inagaki T, Nagai N, Itani S, Kondo T, Kohno M, Suzuki M.

Acta Otolaryngol. 2018 Oct;138(10):898-903. doi: 10.1080/00016489.2018.1490815. Epub 2018 Sep 27.

PMID:
30261801
18.

Design of a transdermal formulation containing raloxifene nanoparticles for osteoporosis treatment.

Nagai N, Ogata F, Otake H, Nakazawa Y, Kawasaki N.

Int J Nanomedicine. 2018 Sep 6;13:5215-5229. doi: 10.2147/IJN.S173216. eCollection 2018.

19.

Single-electron charge sensing in self-assembled quantum dots.

Kiyama H, Korsch A, Nagai N, Kanai Y, Matsumoto K, Hirakawa K, Oiwa A.

Sci Rep. 2018 Sep 18;8(1):13188. doi: 10.1038/s41598-018-31268-x.

20.

[Establishment of disaster health management programs by public health centers in Japan with the introduction of the Disaster Health Emergency Assistance Team].

Takayama Y, Ikeda K, Hasegawa M, Furuhata M, Nagai N, Tsuchiya H, Yamada M, Takechi H, Nakazato E, Maeda H, Miyazono M, Inuzuka K, Matsuoka H, Seiko A, Yamanaka T, Uda H, Furuya Y, Tagami T.

Nihon Koshu Eisei Zasshi. 2018;65(8):399-410. doi: 10.11236/jph.65.8_399. Japanese. No abstract available.

21.

Effect of combined bifidobacteria supplementation and resistance training on cognitive function, body composition and bowel habits of healthy elderly subjects.

Inoue T, Kobayashi Y, Mori N, Sakagawa M, Xiao JZ, Moritani T, Sakane N, Nagai N.

Benef Microbes. 2018 Sep 10:1-12. doi: 10.3920/BM2017.0193. [Epub ahead of print]

PMID:
30198326
22.

Reactivation of human herpesviruses 6 and 7 in Kawasaki disease.

Kawano Y, Kawada JI, Nagai N, Ito Y.

Mod Rheumatol. 2018 Sep 5:1-5. doi: 10.1080/14397595.2018.1510758. [Epub ahead of print]

PMID:
30092156
23.

[Design of Microdialysis-CLC Method for Measurement of Drug Behavior in Lacrimal Fluid after Instillation].

Nagai N, Ueno A, Ishii M, Fukuoka Y, Otake H.

Yakugaku Zasshi. 2018;138(8):1111-1117. doi: 10.1248/yakushi.18-00025. Japanese.

24.

Involvement of Endocytosis in the Transdermal Penetration Mechanism of Ketoprofen Nanoparticles.

Nagai N, Ogata F, Ishii M, Fukuoka Y, Otake H, Nakazawa Y, Kawasaki N.

Int J Mol Sci. 2018 Jul 23;19(7). pii: E2138. doi: 10.3390/ijms19072138.

25.

Effect of hesperetin derivatives on the development of selenite‑induced cataracts in rats.

Nakazawa Y, Pauze M, Fukuyama K, Nagai N, Funakoshi-Tago M, Sugai T, Tamura H.

Mol Med Rep. 2018 Jul;18(1):1043-1050. doi: 10.3892/mmr.2018.9045. Epub 2018 May 22.

PMID:
29845214
26.

Increase in blood-brain barrier permeability does not directly induce neuronal death but may accelerate ischemic neuronal damage.

Ohmori C, Sakai Y, Matano Y, Suzuki Y, Umemura K, Nagai N.

Exp Anim. 2018 Nov 1;67(4):479-486. doi: 10.1538/expanim.18-0038. Epub 2018 May 28.

27.

Tracking Infiltration Front Depth Using Time-lapse Multi-offset Gathers Collected with Array Antenna Ground Penetrating Radar.

Saito H, Kuroda S, Iwasaki T, Fujimaki H, Nagai N, Sala J.

J Vis Exp. 2018 May 1;(135). doi: 10.3791/56847.

28.

Relationship Between the Review Time and Various PMDA Consultations in Recent New Drug Approval Cases in Japan.

Nishiyama K, Toyoshima S, Yamada H, Suzuki H, Nagai N.

Ther Innov Regul Sci. 2018 Nov;52(6):731-738. doi: 10.1177/2168479018762795. Epub 2018 Mar 26.

PMID:
29714577
29.

Optic neuropathy causing vertical unilateral hemianopsia after pars plana vitrectomy for a macular hole: A case report.

Kawashima H, Nagai N, Shinoda H, Tsubota K, Ozawa Y.

Medicine (Baltimore). 2018 Apr;97(17):e0321. doi: 10.1097/MD.0000000000010321.

30.

Instillation of Sericin Enhances Corneal Wound Healing through the ERK Pathway in Rat Debrided Corneal Epithelium.

Nagai N, Fukuoka Y, Ishii M, Otake H, Yamamoto T, Taga A, Okamoto N, Shimomura Y.

Int J Mol Sci. 2018 Apr 9;19(4). pii: E1123. doi: 10.3390/ijms19041123.

31.

In situ formation of injectable chitosan-gelatin hydrogels through double crosslinking for sustained intraocular drug delivery.

Song Y, Nagai N, Saijo S, Kaji H, Nishizawa M, Abe T.

Mater Sci Eng C Mater Biol Appl. 2018 Jul 1;88:1-12. doi: 10.1016/j.msec.2018.02.022. Epub 2018 Mar 6.

PMID:
29636124
32.

Adsorption of Nitrite and Nitrate Ions from an Aqueous Solution by Fe-Mg-Type Hydrotalcites at Different Molar Ratios.

Ogata F, Nagai N, Kariya Y, Nagahashi E, Kobayashi Y, Nakamura T, Kawasaki N.

Chem Pharm Bull (Tokyo). 2018;66(4):458-465. doi: 10.1248/cpb.c17-01044.

33.

Enhanced percutaneous absorption of cilostazol nanocrystals using aqueous gel patch systems and clarification of the absorption mechanism.

Yoshioka C, Ito Y, Nagai N.

Exp Ther Med. 2018 Apr;15(4):3501-3508. doi: 10.3892/etm.2018.5820. Epub 2018 Jan 31.

34.

Biomass Potential of Virgin and Calcined Tapioca (Cassava Starch) for the Removal of Sr(II) and Cs(I) from Aqueous Solutions.

Ogata F, Nagai N, Ueta E, Nakamura T, Kawasaki N.

Chem Pharm Bull (Tokyo). 2018;66(3):295-302. doi: 10.1248/cpb.c17-00873.

35.

Interaction of receptor type of protein tyrosine phosphatase sigma (RPTPσ) with a glycosaminoglycan library.

Tadai K, Shioiri T, Tsuchimoto J, Nagai N, Watanabe H, Sugiura N.

J Biochem. 2018 Jul 1;164(1):41-51. doi: 10.1093/jb/mvy027.

PMID:
29420785
36.

Pharmacokinetic and Safety Evaluation of a Transscleral Sustained Unoprostone Release Device in Monkey Eyes.

Nagai N, Yamada S, Kawasaki J, Koyanagi E, Saijo S, Kaji H, Nishizawa M, Nakazawa T, Abe T.

Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):644-652. doi: 10.1167/iovs.17-22429.

PMID:
29392308
37.

An oral formulation of cilostazol nanoparticles enhances intestinal drug absorption in rats.

Yoshioka C, Ito Y, Nagai N.

Exp Ther Med. 2018 Jan;15(1):454-460. doi: 10.3892/etm.2017.5373. Epub 2017 Oct 24.

38.

Measurement of endometrial thickness in premenopausal women in office gynecology.

Tsuda H, Ito YM, Todo Y, Iba T, Tasaka K, Sutou Y, Hirai K, Dozono K, Dobashi Y, Manabe M, Sakamoto T, Yamamoto R, Ueda K, Akatsuka M, Kiyozuka Y, Nagai N, Imai M, Kobiki K, Fujita H, Itamochi H, Oshita T, Kawarada T, Hatae M, Yokoyama Y.

Reprod Med Biol. 2017 Sep 16;17(1):29-35. doi: 10.1002/rmb2.12062. eCollection 2018 Jan.

39.

Enhancement in Corneal Permeability of Dissolved Carteolol by Its Combination with Magnesium Hydroxide Nanoparticles.

Nagai N, Yamaoka S, Fukuoka Y, Ishii M, Otake H, Kanai K, Okamoto N, Shimomura Y.

Int J Mol Sci. 2018 Jan 17;19(1). pii: E282. doi: 10.3390/ijms19010282.

40.

Benefits of aflibercept treatment for age-related macular degeneration patients with good best-corrected visual acuity at baseline.

Minami S, Nagai N, Suzuki M, Kurihara T, Sonobe H, Kamoshita M, Uchida A, Shinoda H, Takagi H, Sonoda S, Sakamoto T, Tsubota K, Ozawa Y.

Sci Rep. 2018 Jan 8;8(1):58. doi: 10.1038/s41598-017-18255-4.

41.

Ophthalmic Formulation Containing Nilvadipine Nanoparticles Prevents Retinal Dysfunction in Rats Injected with Streptozotocin.

Deguchi S, Otake H, Nakazawa Y, Hiramatsu N, Yamamoto N, Nagai N.

Int J Mol Sci. 2017 Dec 15;18(12). pii: E2720. doi: 10.3390/ijms18122720.

42.

Proteomic profile of the lens in a streptozotocin-induced diabetic rat model using shotgun proteomics.

Nagai N, Yamamoto T, Mitamura K, Taga A.

Biomed Rep. 2017 Nov;7(5):445-450. doi: 10.3892/br.2017.988. Epub 2017 Sep 22.

43.

The CLOCK 3111T/C single nucleotide polymorphism and daytime fluctuations of gastric motility in healthy young women: A preliminary study.

Yamaguchi M, Kotani K, Tsuzaki K, Motokubota N, Komai N, Sakane N, Moritani T, Nagai N.

Chronobiol Int. 2017;34(10):1478-1482. doi: 10.1080/07420528.2017.1373660. Epub 2017 Oct 24.

PMID:
29064730
44.

Co-instillation of nano-solid magnesium hydroxide enhances corneal permeability of dissolved timolol.

Nagai N, Ogata F, Otake H, Kawasaki N, Nakazawa Y, Kanai K, Okamoto N, Shimomura Y.

Exp Eye Res. 2017 Dec;165:118-124. doi: 10.1016/j.exer.2017.10.002. Epub 2017 Oct 5.

PMID:
28987318
45.

Therapeutic Effect of Cilostazol Ophthalmic Nanodispersions on Retinal Dysfunction in Streptozotocin-Induced Diabetic Rats.

Nagai N, Deguchi S, Otake H, Hiramatsu N, Yamamoto N.

Int J Mol Sci. 2017 Sep 14;18(9). pii: E1971. doi: 10.3390/ijms18091971.

46.

Evaluation of Retinal Function in Streptozotocin-induced Diabetic Rats by Using the Electroretinography and Immunohistochemistry Methods.

Hiramatsu N, Deguchi S, Yoshioka C, Otake H, Yamamoto N, Nagai N.

Yakugaku Zasshi. 2017;137(9):1169-1175. doi: 10.1248/yakushi.17-00115. Japanese.

47.

Absolute and estimated values of macular pigment optical density in young and aged Asian participants with or without age-related macular degeneration.

Ozawa Y, Shigeno Y, Nagai N, Suzuki M, Kurihara T, Minami S, Hirano E, Shinoda H, Kobayashi S, Tsubota K.

BMC Ophthalmol. 2017 Aug 29;17(1):161. doi: 10.1186/s12886-017-0557-5.

48.

Administration of antioxidant compounds affects the lens chaperone activity and prevents the onset of cataracts.

Nakazawa Y, Nagai N, Ishimori N, Oguchi J, Tamura H.

Biomed Pharmacother. 2017 Nov;95:137-143. doi: 10.1016/j.biopha.2017.08.055. Epub 2017 Sep 12.

PMID:
28837880
49.

Oral Carbonation Attenuates Feeling of Hunger and Gastric Myoelectrical Activity in Young Women.

Suzuki M, Mura E, Taniguchi A, Moritani T, Nagai N.

J Nutr Sci Vitaminol (Tokyo). 2017;63(3):186-192. doi: 10.3177/jnsv.63.186.

50.

Controlled basic fibroblast growth factor release device made of poly(ethyleneglycol) dimethacrylates for creating a subcutaneous neovascular bed for cell transplantation.

Yamada S, Nagai N, Saijo S, Kaji H, Nishizawa M, Imura K, Goto M, Abe T.

J Biomed Mater Res A. 2017 Nov;105(11):3017-3024. doi: 10.1002/jbm.a.36153. Epub 2017 Aug 10.

PMID:
28707305

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