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Items: 1 to 50 of 375

1.

Lanthionine ketimine ester improves outcome in an MPTP-induced mouse model of Parkinson's disease via suppressions of CRMP2 phosphorylation and microglial activation.

Togashi K, Hasegawa M, Nagai J, Kotaka K, Yazawa A, Takahashi M, Masukawa D, Goshima Y, Hensley K, Ohshima T.

J Neurol Sci. 2020 Mar 26;413:116802. doi: 10.1016/j.jns.2020.116802. [Epub ahead of print]

PMID:
32244093
2.

Establishment of Novel High-Standard Chemiluminescent Assay for NTPase in Two Protozoans and Its High-Throughput Screening.

Harada M, Nagai J, Kurata R, Shimizu K, Cui X, Isagawa T, Semba H, Ishihara J, Yoshida Y, Takeda N, Maemura K, Yonezawa T.

Mar Drugs. 2020 Mar 13;18(3). pii: E161. doi: 10.3390/md18030161.

3.

Phosphorylation of CRMP2 is required for migration and positioning of Purkinje cells: Redundant roles of CRMP1 and CRMP4.

Yamazaki Y, Nagai J, Akinaga S, Koga Y, Hasegawa M, Takahashi M, Yamashita N, Kolattukudy P, Goshima Y, Ohshima T.

Brain Res. 2020 Jun 1;1736:146762. doi: 10.1016/j.brainres.2020.146762. Epub 2020 Mar 7.

PMID:
32156571
4.

Aurora B kinase as a therapeutic target in acute lymphoblastic leukemia.

Goto H, Yoshino Y, Ito M, Nagai J, Kumamoto T, Inukai T, Sakurai Y, Miyagawa N, Keino D, Yokosuka T, Iwasaki F, Hamanoue S, Shiomi M, Goto S.

Cancer Chemother Pharmacol. 2020 Apr;85(4):773-783. doi: 10.1007/s00280-020-04045-9. Epub 2020 Mar 6.

PMID:
32144432
5.

Improved tools to study astrocytes.

Yu X, Nagai J, Khakh BS.

Nat Rev Neurosci. 2020 Mar;21(3):121-138. doi: 10.1038/s41583-020-0264-8. Epub 2020 Feb 10. Review.

PMID:
32042146
6.

Novel Reporter System Monitoring IL-18 Specific Signaling Can Be Applied to High-Throughput Screening.

Kurata R, Shimizu K, Cui X, Harada M, Isagawa T, Semba H, Ishihara J, Yamada K, Nagai J, Yoshida Y, Takeda N, Maemura K, Yonezawa T.

Mar Drugs. 2020 Jan 17;18(1). pii: E60. doi: 10.3390/md18010060.

7.

An efficient genetic test flow for multiple congenital anomaly and intellectual disability.

Yokoi T, Enomoto Y, Tsurusaki Y, Harada N, Saito T, Nagai JI, Takuya N, Kurosawa K.

Pediatr Int. 2020 Jan 18. doi: 10.1111/ped.14159. [Epub ahead of print]

PMID:
31955471
8.

Further Quantitative Structure-Cytotoxicity Relationship Analysis of 3-Styrylchromones.

Takao K, Hoshi K, Sakagami H, Shi H, Bandow K, Nagai J, Uesawa Y, Tomomura A, Tomomura M, Sugita Y.

Anticancer Res. 2020 Jan;40(1):87-95. doi: 10.21873/anticanres.13929.

PMID:
31892556
9.

Quantitative Structure-Cytotoxicity Relationship of 2-Styrylchromones.

Uesawa Y, Nagai J, Shi H, Sakagami H, Bandow K, Tomomura A, Tomomura M, Endo S, Takao K, Sugita Y.

Anticancer Res. 2019 Dec;39(12):6489-6498. doi: 10.21873/anticanres.13863.

PMID:
31810913
10.

Quantitative Structure-Cytotoxicity Relationship of 2-Arylazolylchromones and 2-Triazolylchromones.

Nagai J, Shi H, Sezaki N, Yoshida N, Bandow K, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.

Anticancer Res. 2019 Dec;39(12):6479-6488. doi: 10.21873/anticanres.13862.

PMID:
31810912
11.

Diamond-Blackfan anemia caused by chromosome 1p22 deletion encompassing RPL5.

Tominaga M, Hamanoue S, Goto H, Saito T, Nagai JI, Masuno M, Umeda Y, Kurosawa K.

Hum Genome Var. 2019 Aug 8;6:36. doi: 10.1038/s41439-019-0067-5. eCollection 2019.

12.

P2Y6 signaling in alveolar macrophages prevents leukotriene-dependent type 2 allergic lung inflammation.

Nagai J, Balestrieri B, Fanning LB, Kyin T, Cirka H, Lin J, Idzko M, Zech A, Kim EY, Brennan PJ, Boyce JA.

J Clin Invest. 2019 Dec 2;129(12):5169-5186. doi: 10.1172/JCI129761.

13.

2-Styrylchromone derivatives as potent and selective monoamine oxidase B inhibitors.

Takao K, Endo S, Nagai J, Kamauchi H, Takemura Y, Uesawa Y, Sugita Y.

Bioorg Chem. 2019 Nov;92:103285. doi: 10.1016/j.bioorg.2019.103285. Epub 2019 Sep 18.

PMID:
31561103
14.

Whole-exome sequencing reveals the subclonal expression of NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia.

Tsurusaki Y, Nagai JI, Fujita S, Sugiyama M, Nakamura W, Hayashi A, Miyagawa N, Keino D, Yokosuka T, Iwasaki F, Hamanoue S, Shiomi M, Goto S, Kurosawa K, Goto H.

Pediatr Blood Cancer. 2020 Jan;67(1):e28019. doi: 10.1002/pbc.28019. Epub 2019 Sep 25. No abstract available.

PMID:
31556219
15.

Abrogation of lysophosphatidic acid receptor 1 ameliorates murine vasculitis.

Miyabe C, Miyabe Y, Nagai J, Miura NN, Ohno N, Chun J, Tsuboi R, Ueda H, Miyasaka M, Miyasaka N, Nanki T.

Arthritis Res Ther. 2019 Aug 20;21(1):191. doi: 10.1186/s13075-019-1973-0.

16.

[Aplastic anemia following drug-induced liver injury].

Nagai J, Matsukawa T, Suto K, Oshimi K, Miyagishima T.

Rinsho Ketsueki. 2019;60(7):779-784. doi: 10.11406/rinketsu.60.779. Japanese.

PMID:
31391366
17.

Quantitative Structure-Cytotoxicity Relationship of Azulene Amide Derivatives.

Imanari K, Hashimoto M, Wakabayashi H, Okudaira N, Bandow K, Nagai J, Tomomura M, Tomomura A, Uesawa Y, Sakagami H.

Anticancer Res. 2019 Jul;39(7):3507-3518. doi: 10.21873/anticanres.13497.

PMID:
31262875
18.

Hemoglobin beta Kanagawa [c.443A>C; p.(Ter148Serext*21)]: A novel β-globin gene mutation causing dominantly inherited β-thalassemia.

Sugiyama M, Hamanoue S, Nagai JI, Tsurusaki Y, Kurosawa K, Tanaka M, Tanaka Y, Goto H.

Pediatr Blood Cancer. 2019 Sep;66(9):e27871. doi: 10.1002/pbc.27871. Epub 2019 Jun 3. No abstract available.

PMID:
31157496
19.

Genetic inhibition of CRMP2 phosphorylation delays Wallerian degeneration after optic nerve injury.

Kinoshita Y, Kondo S, Takahashi K, Nagai J, Wakatsuki S, Araki T, Goshima Y, Ohshima T.

Biochem Biophys Res Commun. 2019 Jul 5;514(4):1037-1039. doi: 10.1016/j.bbrc.2019.05.060. Epub 2019 May 13.

PMID:
31097218
20.

Genetic inhibition of CRMP2 phosphorylation at serine 522 promotes axonal regeneration after optic nerve injury.

Kondo S, Takahashi K, Kinoshita Y, Nagai J, Wakatsuki S, Araki T, Goshima Y, Ohshima T.

Sci Rep. 2019 May 10;9(1):7188. doi: 10.1038/s41598-019-43658-w.

21.

Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue.

Nagai J, Rajbhandari AK, Gangwani MR, Hachisuka A, Coppola G, Masmanidis SC, Fanselow MS, Khakh BS.

Cell. 2019 May 16;177(5):1280-1292.e20. doi: 10.1016/j.cell.2019.03.019. Epub 2019 Apr 25.

PMID:
31031006
22.

QSAR Prediction Model to Search for Compounds with Selective Cytotoxicity Against Oral Cell Cancer.

Nagai J, Imamura M, Sakagami H, Uesawa Y.

Medicines (Basel). 2019 Apr 1;6(2). pii: E45. doi: 10.3390/medicines6020045.

23.

A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP.

Lobas MA, Tao R, Nagai J, Kronschläger MT, Borden PM, Marvin JS, Looger LL, Khakh BS.

Nat Commun. 2019 Feb 12;10(1):711. doi: 10.1038/s41467-019-08441-5.

24.

Establishment of Novel Cells Stably Secreting Various Human IL-18 Recombinant Proteins.

Kumagai A, Shimizu K, Kurata R, Cui X, Isagawa T, Harada M, Nagai J, Yoshida Y, Ozaki KI, Takeda N, Semba H, Yonezawa T.

Curr Pharm Biotechnol. 2019;20(1):47-55. doi: 10.2174/1389201020666190206203640.

PMID:
30727885
25.

Recent Progress of Basic Studies of Natural Products and Their Dental Application.

Sakagami H, Watanabe T, Hoshino T, Suda N, Mori K, Yasui T, Yamauchi N, Kashiwagi H, Gomi T, Oizumi T, Nagai J, Uesawa Y, Takao K, Sugita Y.

Medicines (Basel). 2018 Dec 25;6(1). pii: E4. doi: 10.3390/medicines6010004. Review.

26.

Genetic suppression of collapsin response mediator protein 2 phosphorylation improves outcome in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's model mice.

Togashi K, Hasegawa M, Nagai J, Tonouchi A, Masukawa D, Hensley K, Goshima Y, Ohshima T.

Genes Cells. 2019 Jan;24(1):31-40. doi: 10.1111/gtc.12651. Epub 2018 Nov 18.

27.

Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior.

Yu X, Taylor AMW, Nagai J, Golshani P, Evans CJ, Coppola G, Khakh BS.

Neuron. 2018 Sep 19;99(6):1170-1187.e9. doi: 10.1016/j.neuron.2018.08.015. Epub 2018 Aug 30.

28.

Familial total anomalous pulmonary venous return with 15q11.2 (BP1-BP2) microdeletion.

Kuroda Y, Ohashi I, Naruto T, Ida K, Enomoto Y, Saito T, Nagai JI, Yanagi S, Ueda H, Kurosawa K.

J Hum Genet. 2018 Nov;63(11):1185-1188. doi: 10.1038/s10038-018-0499-7. Epub 2018 Aug 14.

PMID:
30108319
29.

Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives.

Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.

Anticancer Res. 2018 Aug;38(8):4459-4467. doi: 10.21873/anticanres.12748.

PMID:
30061210
30.

Quantitative Structure-Cytotoxicity Relationship of Pyrano[4,3-b]chromones.

Nagai J, Shi H, Kubota Y, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.

Anticancer Res. 2018 Aug;38(8):4449-4457. doi: 10.21873/anticanres.12747.

PMID:
30061209
31.

Pioglitazone induces hypoxia-inducible factor 1 activation in human renal proximal tubular epithelial cell line HK-2.

Urakami-Takebayashi Y, Kuroda Y, Murata T, Miyazaki M, Nagai J.

Biochem Biophys Res Commun. 2018 Sep 10;503(3):1682-1688. doi: 10.1016/j.bbrc.2018.07.099. Epub 2018 Jul 27.

PMID:
30057316
32.

Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives.

Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Sakagami H, Tomomura M, Tomomura A, Uesawa Y, Takao K, Sugita Y.

Anticancer Res. 2018 Jul;38(7):3897-3906. doi: 10.21873/anticanres.12674.

PMID:
29970510
33.

Involvement of lysophosphatidic acid-induced astrocyte activation underlying the maintenance of partial sciatic nerve injury-induced neuropathic pain.

Ueda H, Neyama H, Nagai J, Matsushita Y, Tsukahara T, Tsukahara R.

Pain. 2018 Nov;159(11):2170-2178. doi: 10.1097/j.pain.0000000000001316.

PMID:
29939962
34.

17q21.32-q22 Deletion in a girl with osteogenesis imperfecta, tricho-dento-osseous syndrome, and intellectual disability.

Yokoi T, Saito T, Nagai JI, Kurosawa K.

Congenit Anom (Kyoto). 2019 Mar;59(2):51-52. doi: 10.1111/cga.12292. Epub 2018 Jul 4. No abstract available.

PMID:
29896840
35.

Acute lymphoblastic leukemia in a male with Simpson-Golabi-Behmel syndrome.

Minatogawa M, Iwasaki F, Yokoi T, Nagai J, Sakazume S, Goto H, Kurosawa K.

Am J Med Genet A. 2018 Jul;176(7):1680-1682. doi: 10.1002/ajmg.a.38664. Epub 2018 May 7. No abstract available.

PMID:
29737011
36.

Establishment of Novel Reporter Cells Stably Maintaining Transcription Factor-driven Human Secreted Alkaline Phosphatase Expression.

Kurata R, Kumagai A, Cui X, Harada M, Nagai J, Yoshida Y, Ozaki KI, Tanaka Y, Yonezawa T.

Curr Pharm Biotechnol. 2018;19(3):224-231. doi: 10.2174/1389201019666180418093334.

PMID:
29667554
37.

Evaluation of a patient with classical Ehlers-Danlos syndrome due to a 9q34 duplication affecting COL5A1.

Kuroda Y, Ohashi I, Naruto T, Ida K, Enomoto Y, Saito T, Nagai JI, Kurosawa K.

Congenit Anom (Kyoto). 2018 Nov;58(6):191-193. doi: 10.1111/cga.12277. Epub 2018 Mar 25.

PMID:
29520887
38.

Association of isochromosome (7)(q10) in Shwachman-Diamond syndrome with the severity of cytopenia.

Shimosato Y, Tanoshima R, Tsujimoto SI, Takeuchi M, Sasaki K, Kajiwara R, Goto H, Nagai J, Yanagimachi MD, Ito S, Yokota S.

Clin Case Rep. 2017 Dec 5;6(1):125-128. doi: 10.1002/ccr3.1249. eCollection 2018 Jan.

39.

Haploinsufficiency of BCL11A associated with cerebellar abnormalities in 2p15p16.1 deletion syndrome.

Shimbo H, Yokoi T, Aida N, Mizuno S, Suzumura H, Nagai J, Ida K, Enomoto Y, Hatano C, Kurosawa K.

Mol Genet Genomic Med. 2017 May 22;5(4):429-437. doi: 10.1002/mgg3.289. eCollection 2017 Jul.

40.

Conservative Treatment for Idiopathic Adrenal Hemorrhage Tracked by a Long-term Series of CT Images.

Yamada T, Yamakawa F, Cao X, Fukui A, Tajitsu M, Nagai J, Yambe Y, Murase T, Saito M, Tsuzuki T.

Intern Med. 2017;56(6):673-676. doi: 10.2169/internalmedicine.56.7685. Epub 2017 Mar 17.

41.

Cobalt Chloride Induces Expression and Function of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Renal Proximal Tubular Epithelial Cell Line HK-2.

Nishihashi K, Kawashima K, Nomura T, Urakami-Takebayashi Y, Miyazaki M, Takano M, Nagai J.

Biol Pharm Bull. 2017;40(1):82-87. doi: 10.1248/bpb.b16-00684.

42.

Lanthionine ketimine ester promotes locomotor recovery after spinal cord injury by reducing neuroinflammation and promoting axon growth.

Kotaka K, Nagai J, Hensley K, Ohshima T.

Biochem Biophys Res Commun. 2017 Jan 29;483(1):759-764. doi: 10.1016/j.bbrc.2016.12.069. Epub 2016 Dec 11.

PMID:
27965088
43.

High-Throughput Screening and Prediction Model Building for Novel Hemozoin Inhibitors Using Physicochemical Properties.

Huy NT, Chi PL, Nagai J, Dang TN, Mbanefo EC, Ahmed AM, Long NP, Thoa LT, Hung LP, Titouna A, Kamei K, Ueda H, Hirayama K.

Antimicrob Agents Chemother. 2017 Jan 24;61(2). pii: e01607-16. doi: 10.1128/AAC.01607-16. Print 2017 Feb.

44.
45.

CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain.

Takaya R, Nagai J, Piao W, Niisato E, Nakabayashi T, Yamazaki Y, Nakamura F, Yamashita N, Kolattukudy P, Goshima Y, Ohshima T.

Brain Res. 2017 Jan 15;1655:161-167. doi: 10.1016/j.brainres.2016.11.003. Epub 2016 Nov 9.

PMID:
27836492
46.

Cdk5 is required for the positioning and survival of GABAergic neurons in developing mouse striatum.

Sasamoto K, Nagai J, Nakabayashi T, He X, Ohshima T.

Dev Neurobiol. 2017 Apr;77(4):483-492. doi: 10.1002/dneu.22424. Epub 2016 Aug 2.

47.

CRMPs Function in Neurons and Glial Cells: Potential Therapeutic Targets for Neurodegenerative Diseases and CNS Injury.

Nagai J, Baba R, Ohshima T.

Mol Neurobiol. 2017 Aug;54(6):4243-4256. doi: 10.1007/s12035-016-0005-1. Epub 2016 Jun 23. Review.

PMID:
27339876
48.

Deletion of Crmp4 attenuates CSPG-induced inhibition of axonal growth and induces nociceptive recovery after spinal cord injury.

Nagai J, Takaya R, Piao W, Goshima Y, Ohshima T.

Mol Cell Neurosci. 2016 Jul;74:42-8. doi: 10.1016/j.mcn.2016.03.006. Epub 2016 Mar 17.

PMID:
26995506
49.

Loss of collapsin response mediator protein 4 suppresses dopaminergic neuron death in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease.

Tonouchi A, Nagai J, Togashi K, Goshima Y, Ohshima T.

J Neurochem. 2016 Jun;137(5):795-805. doi: 10.1111/jnc.13617. Epub 2016 Apr 12.

50.

Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus.

Jin X, Sasamoto K, Nagai J, Yamazaki Y, Saito K, Goshima Y, Inoue T, Ohshima T.

Neural Plast. 2016;2016:6790743. doi: 10.1155/2016/6790743. Epub 2015 Dec 27.

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