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Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism.

Coloma R, Arranz R, de la Rosa-Trevín JM, Sorzano COS, Munier S, Carlero D, Naffakh N, Ortín J, Martín-Benito J.

Nat Microbiol. 2020 Mar 9. doi: 10.1038/s41564-020-0675-3. [Epub ahead of print]


Influenza virus polymerase subunits co-evolve to ensure proper levels of dimerization of the heterotrimer.

Chen KY, Santos Afonso ED, Enouf V, Isel C, Naffakh N.

PLoS Pathog. 2019 Oct 3;15(10):e1008034. doi: 10.1371/journal.ppat.1008034. eCollection 2019 Oct.


Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.

Ashraf U, Tengo L, Le Corre L, Fournier G, Busca P, McCarthy AA, Rameix-Welti MA, Gravier-Pelletier C, Ruigrok RWH, Jacob Y, Vidalain PO, Pietrancosta N, Crépin T, Naffakh N.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10968-10977. doi: 10.1073/pnas.1901214116. Epub 2019 May 10.


Advances in Analyzing Virus-Induced Alterations of Host Cell Splicing.

Ashraf U, Benoit-Pilven C, Lacroix V, Navratil V, Naffakh N.

Trends Microbiol. 2019 Mar;27(3):268-281. doi: 10.1016/j.tim.2018.11.004. Epub 2018 Dec 19. Review.


Metal-Tagging Transmission Electron Microscopy and Immunogold Labeling on Tokuyasu Cryosections to Image Influenza A Virus Ribonucleoprotein Transport and Packaging.

Sachse M, de Castro IF, Fournier G, Naffakh N, Risco C.

Methods Mol Biol. 2018;1836:281-301. doi: 10.1007/978-1-4939-8678-1_14.


Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009.

Pagani I, Di Pietro A, Oteiza A, Ghitti M, Mechti N, Naffakh N, Vicenzi E.

mSphere. 2018 Apr 4;3(2). pii: e00110-18. doi: 10.1128/mSphere.00110-18. Print 2018 Apr 25.


Comparative Profiling of Ubiquitin Proteasome System Interplay with Influenza A Virus PB2 Polymerase Protein Recapitulating Virus Evolution in Humans.

Biquand E, Poirson J, Karim M, Declercq M, Malausse N, Cassonnet P, Barbezange C, Straub ML, Jones L, Munier S, Naffakh N, van der Werf S, Jacob Y, Masson M, Demeret C.

mSphere. 2017 Nov 22;2(6). pii: e00330-17. doi: 10.1128/mSphere.00330-17. eCollection 2017 Nov-Dec.


Influenza virus genome reaches the plasma membrane via a modified endoplasmic reticulum and Rab11-dependent vesicles.

de Castro Martin IF, Fournier G, Sachse M, Pizarro-Cerda J, Risco C, Naffakh N.

Nat Commun. 2017 Nov 9;8(1):1396. doi: 10.1038/s41467-017-01557-6.


Structural basis of an essential interaction between influenza polymerase and Pol II CTD.

Lukarska M, Fournier G, Pflug A, Resa-Infante P, Reich S, Naffakh N, Cusack S.

Nature. 2017 Jan 5;541(7635):117-121. doi: 10.1038/nature20594. Epub 2016 Dec 21.


Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations.

Quach H, Rotival M, Pothlichet J, Loh YE, Dannemann M, Zidane N, Laval G, Patin E, Harmant C, Lopez M, Deschamps M, Naffakh N, Duffy D, Coen A, Leroux-Roels G, Clément F, Boland A, Deleuze JF, Kelso J, Albert ML, Quintana-Murci L.

Cell. 2016 Oct 20;167(3):643-656.e17. doi: 10.1016/j.cell.2016.09.024.


Influenza A Virus Polymerase Recruits the RNA Helicase DDX19 to Promote the Nuclear Export of Viral mRNAs.

Diot C, Fournier G, Dos Santos M, Magnus J, Komarova A, van der Werf S, Munier S, Naffakh N.

Sci Rep. 2016 Sep 22;6:33763. doi: 10.1038/srep33763.


Experimental Approaches to Study Genome Packaging of Influenza A Viruses.

Isel C, Munier S, Naffakh N.

Viruses. 2016 Aug 9;8(8). pii: E218. doi: 10.3390/v8080218. Review.


Time-Resolved Visualisation of Nearly-Native Influenza A Virus Progeny Ribonucleoproteins and Their Individual Components in Live Infected Cells.

Avilov S, Magnus J, Cusack S, Naffakh N.

PLoS One. 2016 Mar 15;11(3):e0149986. doi: 10.1371/journal.pone.0149986. eCollection 2016.


Targeting host calpain proteases decreases influenza A virus infection.

Blanc F, Furio L, Moisy D, Yen HL, Chignard M, Letavernier E, Naffakh N, Mok CK, Si-Tahar M.

Am J Physiol Lung Cell Mol Physiol. 2016 Apr 1;310(7):L689-99. doi: 10.1152/ajplung.00314.2015. Epub 2016 Jan 8.


Temperature-Sensitive Mutants in the Influenza A Virus RNA Polymerase: Alterations in the PA Linker Reduce Nuclear Targeting of the PB1-PA Dimer and Result in Viral Attenuation.

Da Costa B, Sausset A, Munier S, Ghounaris A, Naffakh N, Le Goffic R, Delmas B.

J Virol. 2015 Jun;89(12):6376-90. doi: 10.1128/JVI.00589-15. Epub 2015 Apr 8.


Recruitment of RED-SMU1 complex by Influenza A Virus RNA polymerase to control Viral mRNA splicing.

Fournier G, Chiang C, Munier S, Tomoiu A, Demeret C, Vidalain PO, Jacob Y, Naffakh N.

PLoS Pathog. 2014 Jun 12;10(6):e1004164. doi: 10.1371/journal.ppat.1004164. eCollection 2014 Jun. Erratum in: PLoS Pathog. 2014 Jul;10(7):e1004317.


Shortening the unstructured, interdomain region of the non-structural protein NS1 of an avian H1N1 influenza virus increases its replication and pathogenicity in chickens.

Trapp S, Soubieux D, Marty H, Esnault E, Hoffmann TW, Chandenier M, Lion A, Kut E, Quéré P, Larcher T, Ledevin M, Munier S, Naffakh N, Marc D.

J Gen Virol. 2014 Jun;95(Pt 6):1233-1243. doi: 10.1099/vir.0.063776-0. Epub 2014 Apr 2.


Multiple hosts and Influenza A viruses genetic mixing.

Rivailler P, Moisy D, Naffakh N.

Virologie (Montrouge). 2013 Dec 1;17(6):387-400. doi: 10.1684/vir.2013.0540.


Productive infection of human skeletal muscle cells by pandemic and seasonal influenza A(H1N1) viruses.

Desdouits M, Munier S, Prevost MC, Jeannin P, Butler-Browne G, Ozden S, Gessain A, Van Der Werf S, Naffakh N, Ceccaldi PE.

PLoS One. 2013 Nov 5;8(11):e79628. doi: 10.1371/journal.pone.0079628. eCollection 2013.


CD36-specific antibodies block release of HIV-1 from infected primary macrophages and its transmission to T cells.

Berre S, Gaudin R, Cunha de Alencar B, Desdouits M, Chabaud M, Naffakh N, Rabaza-Gairi M, Gobert FX, Jouve M, Benaroch P.

J Exp Med. 2013 Nov 18;210(12):2523-38. doi: 10.1084/jem.20130566. Epub 2013 Oct 21.


Interactions moléculaires entre les ribonucléoprotéines des virus influenza de type A et la cellule hôte.

Moisy D, Naffakh N.

Virologie (Montrouge). 2013 Aug 1;17(4):278-293. doi: 10.1684/vir.2013.0510.


Exploration of binary virus-host interactions using an infectious protein complementation assay.

Munier S, Rolland T, Diot C, Jacob Y, Naffakh N.

Mol Cell Proteomics. 2013 Oct;12(10):2845-55. doi: 10.1074/mcp.M113.028688. Epub 2013 Jul 1.


Influenza A virus progeny vRNP trafficking in live infected cells studied with the virus-encoded fluorescently tagged PB2 protein.

Avilov SV, Moisy D, Naffakh N, Cusack S.

Vaccine. 2012 Dec 7;30(51):7411-7. doi: 10.1016/j.vaccine.2012.09.077. Epub 2012 Oct 10.


Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility.

Rudrawar S, Kerry PS, Rameix-Welti MA, Maggioni A, Dyason JC, Rose FJ, van der Werf S, Thomson RJ, Naffakh N, Russell RJ, von Itzstein M.

Org Biomol Chem. 2012 Nov 21;10(43):8628-39. doi: 10.1039/c2ob25627d.


The influenza fingerprints: NS1 and M1 proteins contribute to specific host cell ultrastructure signatures upon infection by different influenza A viruses.

Terrier O, Moules V, Carron C, Cartet G, Frobert E, Yver M, Traversier A, Wolff T, Riteau B, Naffakh N, Lina B, Diaz JJ, Rosa-Calatrava M.

Virology. 2012 Oct 10;432(1):204-18. doi: 10.1016/j.virol.2012.05.019. Epub 2012 Jul 6.


HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replication.

Moisy D, Avilov SV, Jacob Y, Laoide BM, Ge X, Baudin F, Naffakh N, Jestin JL.

J Virol. 2012 Sep;86(17):9122-33. doi: 10.1128/JVI.00789-12. Epub 2012 Jun 13.


Replication-competent influenza A virus that encodes a split-green fluorescent protein-tagged PB2 polymerase subunit allows live-cell imaging of the virus life cycle.

Avilov SV, Moisy D, Munier S, Schraidt O, Naffakh N, Cusack S.

J Virol. 2012 Feb;86(3):1433-48. doi: 10.1128/JVI.05820-11. Epub 2011 Nov 23.


Highly heterogeneous temperature sensitivity of 2009 pandemic influenza A(H1N1) viral isolates, northern France.

Pelletier I, Rousset D, Enouf V; GROG, Colbere-Garapin F, van der Werf S, Naffakh N.

Euro Surveill. 2011 Oct 27;16(43). pii: 19999.


Length variations in the NA stalk of an H7N1 influenza virus have opposite effects on viral excretion in chickens and ducks.

Hoffmann TW, Munier S, Larcher T, Soubieux D, Ledevin M, Esnault E, Tourdes A, Croville G, Guérin JL, Quéré P, Volmer R, Naffakh N, Marc D.

J Virol. 2012 Jan;86(1):584-8. doi: 10.1128/JVI.05474-11. Epub 2011 Oct 19.


Influenza virus ribonucleoprotein complexes gain preferential access to cellular export machinery through chromatin targeting.

Chase GP, Rameix-Welti MA, Zvirbliene A, Zvirblis G, Götz V, Wolff T, Naffakh N, Schwemmle M.

PLoS Pathog. 2011 Sep;7(9):e1002187. doi: 10.1371/journal.ppat.1002187. Epub 2011 Sep 1.


Influenza virus infection induces the nuclear relocalization of the Hsp90 co-chaperone p23 and inhibits the glucocorticoid receptor response.

Ge X, Rameix-Welti MA, Gault E, Chase G, dos Santos Afonso E, Picard D, Schwemmle M, Naffakh N.

PLoS One. 2011;6(8):e23368. doi: 10.1371/journal.pone.0023368. Epub 2011 Aug 10.


Neuraminidase of 2007-2008 influenza A(H1N1) viruses shows increased affinity for sialic acids due to the D344N substitution.

Rameix-Welti MA, Munier S, Le Gal S, Cuvelier F, Agou F, Enouf V, Naffakh N, van der Werf S.

Antivir Ther. 2011;16(4):597-603. doi: 10.3851/IMP1804.


The influenza A virus NS1 protein interacts with the nucleoprotein of viral ribonucleoprotein complexes.

Robb NC, Chase G, Bier K, Vreede FT, Shaw PC, Naffakh N, Schwemmle M, Fodor E.

J Virol. 2011 May;85(10):5228-31. doi: 10.1128/JVI.02562-10. Epub 2011 Mar 16.


Confronting influenza virus: a common but ever-changing pathogen.

Naffakh N, Shih SR.

Microbes Infect. 2011 May;13(5):468-9. doi: 10.1016/j.micinf.2011.01.011. Epub 2011 Jan 27. No abstract available.


Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase.

Rudrawar S, Dyason JC, Rameix-Welti MA, Rose FJ, Kerry PS, Russell RJ, van der Werf S, Thomson RJ, Naffakh N, von Itzstein M.

Nat Commun. 2010 Nov 16;1:113.


In vitro characterization of naturally occurring influenza H3NA- viruses lacking the NA gene segment: toward a new mechanism of viral resistance?

Moules V, Ferraris O, Terrier O, Giudice E, Yver M, Rolland JP, Bouscambert-Duchamp M, Bergeron C, Ottmann M, Fournier E, Traversier A, Boule C, Rivoire A, Lin Y, Hay A, Valette M, Marquet R, Rosa-Calatrava M, Naffakh N, Schoehn G, Thomas D, Lina B.

Virology. 2010 Sep 1;404(2):215-24. doi: 10.1016/j.virol.2010.04.030.


[Interspecies transmission, adaptation to humans and pathogenicity of animal influenza viruses].

Munier S, Moisy D, Marc D, Naffakh N.

Pathol Biol (Paris). 2010 Apr;58(2):e59-68. doi: 10.1016/j.patbio.2010.01.012. Epub 2010 Mar 19. Review. French.


Enhancement of the influenza A hemagglutinin (HA)-mediated cell-cell fusion and virus entry by the viral neuraminidase (NA).

Su B, Wurtzer S, Rameix-Welti MA, Dwyer D, van der Werf S, Naffakh N, Clavel F, Labrosse B.

PLoS One. 2009 Dec 30;4(12):e8495. doi: 10.1371/journal.pone.0008495.


A genetically engineered waterfowl influenza virus with a deletion in the stalk of the neuraminidase has increased virulence for chickens.

Munier S, Larcher T, Cormier-Aline F, Soubieux D, Su B, Guigand L, Labrosse B, Cherel Y, Quéré P, Marc D, Naffakh N.

J Virol. 2010 Jan;84(2):940-52. doi: 10.1128/JVI.01581-09. Epub 2009 Nov 4.


Influenza A virus neuraminidase enhances meningococcal adhesion to epithelial cells through interaction with sialic acid-containing meningococcal capsules.

Rameix-Welti MA, Zarantonelli ML, Giorgini D, Ruckly C, Marasescu M, van der Werf S, Alonso JM, Naffakh N, Taha MK.

Infect Immun. 2009 Sep;77(9):3588-95. doi: 10.1128/IAI.00155-09. Epub 2009 Jun 15.


April 2009: an outbreak of swine-origin influenza A(H1N1) virus with evidence for human-to-human transmission.

Naffakh N, van der Werf S.

Microbes Infect. 2009 Jul-Aug;11(8-9):725-8. doi: 10.1016/j.micinf.2009.05.002. Epub 2009 May 13. Review.


Neuraminidase stalk length and additional glycosylation of the hemagglutinin influence the virulence of influenza H5N1 viruses for mice.

Matsuoka Y, Swayne DE, Thomas C, Rameix-Welti MA, Naffakh N, Warnes C, Altholtz M, Donis R, Subbarao K.

J Virol. 2009 May;83(9):4704-8. doi: 10.1128/JVI.01987-08. Epub 2009 Feb 18.


Avian Influenza A virus polymerase association with nucleoprotein, but not polymerase assembly, is impaired in human cells during the course of infection.

Rameix-Welti MA, Tomoiu A, Dos Santos Afonso E, van der Werf S, Naffakh N.

J Virol. 2009 Feb;83(3):1320-31. doi: 10.1128/JVI.00977-08. Epub 2008 Nov 19.


Host restriction of avian influenza viruses at the level of the ribonucleoproteins.

Naffakh N, Tomoiu A, Rameix-Welti MA, van der Werf S.

Annu Rev Microbiol. 2008;62:403-24. doi: 10.1146/annurev.micro.62.081307.162746. Review.


Failure of zanamivir therapy for pneumonia in a bone-marrow transplant recipient infected by a zanamivir-sensitive influenza A (H1N1) virus.

Medeiros R, Rameix-Welti MA, Lorin V, Ribaud P, Manuguerra JC, Socie G, Scieux C, Naffakh N, van der Werf S.

Antivir Ther. 2007;12(4):571-6.


Codon conservation in the influenza A virus genome defines RNA packaging signals.

Gog JR, Afonso Edos S, Dalton RM, Leclercq I, Tiley L, Elton D, von Kirchbach JC, Naffakh N, Escriou N, Digard P.

Nucleic Acids Res. 2007;35(6):1897-907. Epub 2007 Mar 1.


Host-range determinants on the PB2 protein of influenza A viruses control the interaction between the viral polymerase and nucleoprotein in human cells.

Labadie K, Dos Santos Afonso E, Rameix-Welti MA, van der Werf S, Naffakh N.

Virology. 2007 Jun 5;362(2):271-82. Epub 2007 Jan 31.


Natural variation can significantly alter the sensitivity of influenza A (H5N1) viruses to oseltamivir.

Rameix-Welti MA, Agou F, Buchy P, Mardy S, Aubin JT, Véron M, van der Werf S, Naffakh N.

Antimicrob Agents Chemother. 2006 Nov;50(11):3809-15. Epub 2006 Aug 28.


Cloning of the chicken RNA polymerase I promoter and use for reverse genetics of influenza A viruses in avian cells.

Massin P, Rodrigues P, Marasescu M, van der Werf S, Naffakh N.

J Virol. 2005 Nov;79(21):13811-6.

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