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Items: 33


Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH.

Nadtochiy SM, Wang YT, Nehrke K, Munger J, Brookes PS.

J Mol Cell Cardiol. 2018 Aug;121:155-162. doi: 10.1016/j.yjmcc.2018.06.007. Epub 2018 Jun 26.


Cardiac metabolic effects of KNa1.2 channel deletion and evidence for its mitochondrial localization.

Smith CO, Wang YT, Nadtochiy SM, Miller JH, Jonas EA, Dirksen RT, Nehrke K, Brookes PS.

FASEB J. 2018 Jun 4:fj201800139R. doi: 10.1096/fj.201800139R. [Epub ahead of print]


Metabolomics reveals critical adrenergic regulatory checkpoints in glycolysis and pentose-phosphate pathways in embryonic heart.

Peoples JNR, Maxmillian T, Le Q, Nadtochiy SM, Brookes PS, Porter GA Jr, Davidson VL, Ebert SN.

J Biol Chem. 2018 May 4;293(18):6925-6941. doi: 10.1074/jbc.RA118.002566. Epub 2018 Mar 14.


Potential mechanisms linking SIRT activity and hypoxic 2-hydroxyglutarate generation: no role for direct enzyme (de)acetylation.

Nadtochiy SM, Wang YT, Zhang J, Nehrke K, Schafer X, Welle K, Ghaemmaghami S, Munger J, Brookes PS.

Biochem J. 2017 Aug 10;474(16):2829-2839. doi: 10.1042/BCJ20170389.


Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling.

Nadtochiy SM, Schafer X, Fu D, Nehrke K, Munger J, Brookes PS.

J Biol Chem. 2016 Sep 16;291(38):20188-97. doi: 10.1074/jbc.M116.738799. Epub 2016 Aug 10.


Cyclophilin D Knock-Out Mice Show Enhanced Resistance to Osteoporosis and to Metabolic Changes Observed in Aging Bone.

Shum LC, White NS, Nadtochiy SM, Bentley KL, Brookes PS, Jonason JH, Eliseev RA.

PLoS One. 2016 May 16;11(5):e0155709. doi: 10.1371/journal.pone.0155709. eCollection 2016.


Nitroalkenes confer acute cardioprotection via adenine nucleotide translocase 1.

Nadtochiy SM, Zhu QM, Urciuoli W, Rafikov R, Black SM, Brookes PS.

J Biol Chem. 2015 Dec 18;290(51):30267. doi: 10.1074/jbc.A111.298406. No abstract available.


The cardioprotective compound cloxyquin uncouples mitochondria and induces autophagy.

Zhang J, Nadtochiy SM, Urciuoli WR, Brookes PS.

Am J Physiol Heart Circ Physiol. 2016 Jan 1;310(1):H29-38. doi: 10.1152/ajpheart.00926.2014. Epub 2015 Oct 30.


Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation.

Nadtochiy SM, Urciuoli W, Zhang J, Schafer X, Munger J, Brookes PS.

J Mol Cell Cardiol. 2015 Nov;88:64-72. doi: 10.1016/j.yjmcc.2015.09.008. Epub 2015 Sep 24.


Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.

Chouchani ET, Pell VR, Gaude E, Aksentijevińá D, Sundier SY, Robb EL, Logan A, Nadtochiy SM, Ord ENJ, Smith AC, Eyassu F, Shirley R, Hu CH, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa ASH, Brookes PS, Davidson SM, Duchen MR, Saeb-Parsy K, Shattock MJ, Robinson AJ, Work LM, Frezza C, Krieg T, Murphy MP.

Nature. 2014 Nov 20;515(7527):431-435. doi: 10.1038/nature13909. Epub 2014 Nov 5.


SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts.

Porter GA, Urciuoli WR, Brookes PS, Nadtochiy SM.

Am J Physiol Heart Circ Physiol. 2014 Jun 15;306(12):H1602-9. doi: 10.1152/ajpheart.00027.2014. Epub 2014 Apr 18.


Mitochondrially targeted nitro-linoleate: a new tool for the study of cardioprotection.

Nadtochiy SM, Madukwe J, Hagen F, Brookes PS.

Br J Pharmacol. 2014 Apr;171(8):2091-8. doi: 10.1111/bph.12405.


Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I.

Chouchani ET, Methner C, Nadtochiy SM, Logan A, Pell VR, Ding S, James AM, Cochemé HM, Reinhold J, Lilley KS, Partridge L, Fearnley IM, Robinson AJ, Hartley RC, Smith RA, Krieg T, Brookes PS, Murphy MP.

Nat Med. 2013 Jun;19(6):753-9. doi: 10.1038/nm.3212. Epub 2013 May 26.


A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel.

Wojtovich AP, Nadtochiy SM, Urciuoli WR, Smith CO, Grunnet M, Nehrke K, Brookes PS.

PeerJ. 2013 Mar 5;1:e48. doi: 10.7717/peerj.48. Print 2013.


A cell-based phenotypic assay to identify cardioprotective agents.

Guo S, Olm-Shipman A, Walters A, Urciuoli WR, Devito S, Nadtochiy SM, Wojtovich AP, Brookes PS.

Circ Res. 2012 Mar 30;110(7):948-57. doi: 10.1161/CIRCRESAHA.111.263715. Epub 2012 Mar 6.


Nitroalkenes confer acute cardioprotection via adenine nucleotide translocase 1.

Nadtochiy SM, Zhu QM, Urciuoli W, Rafikov R, Black SM, Brookes PS.

J Biol Chem. 2012 Jan 27;287(5):3573-80. doi: 10.1074/jbc.M111.298406. Epub 2011 Dec 9. Erratum in: J Biol Chem. 2015 Dec 18;290(51):30267. Zhu, Qiuyu [corrected to Zhu, Qiuyu Martin].


SLO-2 is cytoprotective and contributes to mitochondrial potassium transport.

Wojtovich AP, Sherman TA, Nadtochiy SM, Urciuoli WR, Brookes PS, Nehrke K.

PLoS One. 2011;6(12):e28287. doi: 10.1371/journal.pone.0028287. Epub 2011 Dec 1.


Ischemic preconditioning: the role of mitochondria and aging.

Wojtovich AP, Nadtochiy SM, Brookes PS, Nehrke K.

Exp Gerontol. 2012 Jan;47(1):1-7. doi: 10.1016/j.exger.2011.11.001. Epub 2011 Nov 10. Review.


SIRT1-mediated acute cardioprotection.

Nadtochiy SM, Yao H, McBurney MW, Gu W, Guarente L, Rahman I, Brookes PS.

Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1506-12. doi: 10.1152/ajpheart.00587.2011. Epub 2011 Aug 19.


p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: a pathogenic mechanism for ischemia-reperfusion injury.

Shi X, Yan C, Nadtochiy SM, Abe J, Brookes PS, Berk BC.

J Mol Cell Cardiol. 2011 Aug;51(2):272-5. doi: 10.1016/j.yjmcc.2011.05.005. Epub 2011 May 14. Erratum in: J Mol Cell Cardiol. 2012 Jan;52(1):292.


Mediterranean diet and cardioprotection: the role of nitrite, polyunsaturated fatty acids, and polyphenols.

Nadtochiy SM, Redman EK.

Nutrition. 2011 Jul-Aug;27(7-8):733-44. doi: 10.1016/j.nut.2010.12.006. Epub 2011 Mar 30. Review.


Redox regulation of the mitochondrial K(ATP) channel in cardioprotection.

Queliconi BB, Wojtovich AP, Nadtochiy SM, Kowaltowski AJ, Brookes PS.

Biochim Biophys Acta. 2011 Jul;1813(7):1309-15. doi: 10.1016/j.bbamcr.2010.11.005. Epub 2010 Nov 20.


Lysine deacetylation in ischaemic preconditioning: the role of SIRT1.

Nadtochiy SM, Redman E, Rahman I, Brookes PS.

Cardiovasc Res. 2011 Feb 15;89(3):643-9. doi: 10.1093/cvr/cvq287. Epub 2010 Sep 7.


Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation.

Chouchani ET, Hurd TR, Nadtochiy SM, Brookes PS, Fearnley IM, Lilley KS, Smith RA, Murphy MP.

Biochem J. 2010 Aug 15;430(1):49-59. doi: 10.1042/BJ20100633.


Modulation of cell surface protein free thiols: a potential novel mechanism of action of the sesquiterpene lactone parthenolide.

Skalska J, Brookes PS, Nadtochiy SM, Hilchey SP, Jordan CT, Guzman ML, Maggirwar SB, Briehl MM, Bernstein SH.

PLoS One. 2009 Dec 2;4(12):e8115. doi: 10.1371/journal.pone.0008115.


A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury.

Prime TA, Blaikie FH, Evans C, Nadtochiy SM, James AM, Dahm CC, Vitturi DA, Patel RP, Hiley CR, Abakumova I, Requejo R, Chouchani ET, Hurd TR, Garvey JF, Taylor CT, Brookes PS, Smith RA, Murphy MP.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10764-9. doi: 10.1073/pnas.0903250106. Epub 2009 Jun 15.


In vivo cardioprotection by S-nitroso-2-mercaptopropionyl glycine.

Nadtochiy SM, Burwell LS, Ingraham CA, Spencer CM, Friedman AE, Pinkert CA, Brookes PS.

J Mol Cell Cardiol. 2009 Jun;46(6):960-8. doi: 10.1016/j.yjmcc.2009.01.012. Epub 2009 Feb 3.


Cardioprotection by metabolic shut-down and gradual wake-up.

Burwell LS, Nadtochiy SM, Brookes PS.

J Mol Cell Cardiol. 2009 Jun;46(6):804-10. doi: 10.1016/j.yjmcc.2009.02.026. Epub 2009 Mar 10. Review.


Purine release: a protective signaling mechanism of the mitochondrial permeability transition pore in ischemia.

Nadtochiy SM, Nauduri D, Shimanskaya TV, Sagach VF, Brookes PS.

Fiziol Zh. 2008;54(6):5-14.


Mitochondrial nitroalkene formation and mild uncoupling in ischaemic preconditioning: implications for cardioprotection.

Nadtochiy SM, Baker PR, Freeman BA, Brookes PS.

Cardiovasc Res. 2009 May 1;82(2):333-40. doi: 10.1093/cvr/cvn323. Epub 2008 Dec 2.


Direct evidence for S-nitrosation of mitochondrial complex I.

Burwell LS, Nadtochiy SM, Tompkins AJ, Young S, Brookes PS.

Biochem J. 2006 Mar 15;394(Pt 3):627-34.

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