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Items: 23


Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.

Tsushima H, Tang YJ, Puviindran V, Hsu SC, Nadesan P, Yu C, Zhang H, Mirando AJ, Hilton MJ, Alman BA.

Development. 2018 Jun 13. pii: dev.162396. doi: 10.1242/dev.162396. [Epub ahead of print]


Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage.

Hsu SC, Nadesan P, Puviindran V, Stallcup WB, Kirsch DG, Alman BA.

J Biol Chem. 2018 Feb 16;293(7):2466-2475. doi: 10.1074/jbc.M117.805051. Epub 2017 Dec 1.


Pharmacologically targeting beta-catenin for NF1 associated deficiencies in fracture repair.

Baht GS, Nadesan P, Silkstone D, Alman BA.

Bone. 2017 May;98:31-36. doi: 10.1016/j.bone.2017.02.012. Epub 2017 Feb 22.


Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.

Sato S, Tang YJ, Wei Q, Hirata M, Weng A, Han I, Okawa A, Takeda S, Whetstone H, Nadesan P, Kirsch DG, Wunder JS, Alman BA.

Cell Rep. 2016 Jul 26;16(4):917-927. doi: 10.1016/j.celrep.2016.06.058. Epub 2016 Jul 14.


Erratum: Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin.

Baht GS, Silkstone D, Vi L, Nadesan P, Amani Y, Whetstone H, Wei Q, Alman BA.

Nat Commun. 2015 Aug 26;6:7761. doi: 10.1038/ncomms8761. No abstract available.


Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin.

Baht GS, Silkstone D, Vi L, Nadesan P, Amani Y, Whetstone H, Wei Q, Alman BA.

Nat Commun. 2015 May 19;6:7131. doi: 10.1038/ncomms8131. Erratum in: Nat Commun. 2015;6:7761.


Mutant IDH is sufficient to initiate enchondromatosis in mice.

Hirata M, Sasaki M, Cairns RA, Inoue S, Puviindran V, Li WY, Snow BE, Jones LD, Wei Q, Sato S, Tang YJ, Nadesan P, Rockel J, Whetstone H, Poon R, Weng A, Gross S, Straley K, Gliser C, Xu Y, Wunder J, Mak TW, Alman BA.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2829-34. doi: 10.1073/pnas.1424400112. Epub 2015 Feb 17.


β-Catenin-regulated myeloid cell adhesion and migration determine wound healing.

Amini-Nik S, Cambridge E, Yu W, Guo A, Whetstone H, Nadesan P, Poon R, Hinz B, Alman BA.

J Clin Invest. 2014 Jun;124(6):2599-610. doi: 10.1172/JCI62059. Epub 2014 May 16.


Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth.

Campbell VT, Nadesan P, Ali SA, Wang CY, Whetstone H, Poon R, Wei Q, Keilty J, Proctor J, Wang LW, Apte SS, McGovern K, Alman BA, Wunder JS.

Mol Cancer Ther. 2014 May;13(5):1259-69. doi: 10.1158/1535-7163.MCT-13-0731. Epub 2014 Mar 14.


Activation of hedgehog signaling during fracture repair enhances osteoblastic-dependent matrix formation.

Baht GS, Silkstone D, Nadesan P, Whetstone H, Alman BA.

J Orthop Res. 2014 Apr;32(4):581-6. doi: 10.1002/jor.22562. Epub 2013 Dec 17.


Testosterone regulates cell proliferation in aggressive fibromatosis (desmoid tumour).

Hong H, Nadesan P, Poon R, Alman BA.

Br J Cancer. 2011 Apr 26;104(9):1452-8. doi: 10.1038/bjc.2011.107. Epub 2011 Apr 5.


Ultrafast mid-IR laser scalpel: protein signals of the fundamental limits to minimally invasive surgery.

Amini-Nik S, Kraemer D, Cowan ML, Gunaratne K, Nadesan P, Alman BA, Miller RJ.

PLoS One. 2010 Sep 28;5(9). pii: e13053. doi: 10.1371/journal.pone.0013053.


Aggressive fibromatosis (desmoid tumor) is derived from mesenchymal progenitor cells.

Wu C, Amini-Nik S, Nadesan P, Stanford WL, Alman BA.

Cancer Res. 2010 Oct 1;70(19):7690-8. doi: 10.1158/0008-5472.CAN-10-1656. Epub 2010 Sep 14. Erratum in: Cancer Res. 2011 Sep 15;71(18):6084. Nik-Amini, Saied [corrected to Amini-Nik, Saeid].


Side population cells isolated from mesenchymal neoplasms have tumor initiating potential.

Wu C, Wei Q, Utomo V, Nadesan P, Whetstone H, Kandel R, Wunder JS, Alman BA.

Cancer Res. 2007 Sep 1;67(17):8216-22.


Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing.

Chen Y, Whetstone HC, Lin AC, Nadesan P, Wei Q, Poon R, Alman BA.

PLoS Med. 2007 Jul 31;4(7):e249.


IFN-{beta} signaling positively regulates tumorigenesis in aggressive fibromatosis, potentially by modulating mesenchymal progenitors.

Tjandra SS, Hsu C, Goh YI, Gurung A, Poon R, Nadesan P, Alman BA.

Cancer Res. 2007 Aug 1;67(15):7124-31. Erratum in: Cancer Res. 2008 Feb 1;68(3):956. Goh, Ingrid [corrected to Goh, Y Ingrid].


Beta-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation.

Chen Y, Whetstone HC, Youn A, Nadesan P, Chow EC, Lin AC, Alman BA.

J Biol Chem. 2007 Jan 5;282(1):526-33. Epub 2006 Nov 3.


Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation.

Tiet TD, Hopyan S, Nadesan P, Gokgoz N, Poon R, Lin AC, Yan T, Andrulis IL, Alman BA, Wunder JS.

Am J Pathol. 2006 Jan;168(1):321-30.


Dysregulation of hedgehog signalling predisposes to synovial chondromatosis.

Hopyan S, Nadesan P, Yu C, Wunder J, Alman BA.

J Pathol. 2005 Jun;206(2):143-50.


Plasminogen activator inhibitor-1 (PAI-1) modifies the formation of aggressive fibromatosis (desmoid tumor).

Fen Li C, Kandel C, Baliko F, Nadesan P, Brünner N, Alman BA.

Oncogene. 2005 Feb 24;24(9):1615-24.


Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis.

Kong Y, Poon R, Nadesan P, Di Muccio T, Fodde R, Khokha R, Alman BA.

Cancer Res. 2004 Aug 15;64(16):5795-803.


beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds.

Cheon SS, Cheah AY, Turley S, Nadesan P, Poon R, Clevers H, Alman BA.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6973-8. Epub 2002 Apr 30.

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