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The impact of obesity on insulin sensitivity and secretion during pubertal progression: a longitudinal study.

Kelsey MM, Pyle L, Hilkin A, Severn CD, Utzschneider K, Van Pelt RE, Nadeau KJ, Zeitler PS.

J Clin Endocrinol Metab. 2020 Jan 30. pii: dgaa043. doi: 10.1210/clinem/dgaa043. [Epub ahead of print]


Obese adolescents with PCOS have altered biodiversity and relative abundance in gastrointestinal microbiota.

Jobira B, Frank DN, Pyle L, Silveira LJ, Kelsey MM, Garcia-Reyes Y, Robertson CE, Ir D, Nadeau KJ, Cree-Green M.

J Clin Endocrinol Metab. 2020 Jan 23. pii: dgz263. doi: 10.1210/clinem/dgz263. [Epub ahead of print]


Poor Sleep is Related to Metabolic Syndrome Severity in Adolescents with PCOS and Obesity.

Simon S, Rahat H, Carreau AM, Garcia-Reyes Y, Halbower A, Pyle L, Nadeau KJ, Cree-Green M.

J Clin Endocrinol Metab. 2020 Jan 4. pii: dgz285. doi: 10.1210/clinem/dgz285. [Epub ahead of print]


The changing face of paediatric diabetes.

Shah AS, Nadeau KJ.

Diabetologia. 2020 Jan 2. doi: 10.1007/s00125-019-05075-6. [Epub ahead of print] Review.


High residual C-peptide likely contributes to glycemic control in type 1 diabetes.

Rickels MR, Evans-Molina C, Bahnson HT, Ylescupidez A, Nadeau KJ, Hao W, Clements MA, Sherr JL, Pratley RE, Hannon TS, Shah VN, Miller KM, Greenbaum CJ.

J Clin Invest. 2020 Jan 2. pii: 134057. doi: 10.1172/JCI134057. [Epub ahead of print]


Muscle Insulin Resistance in Youth with Obesity and Normoglycemia is Associated with Altered Fat Metabolism.

Cree-Green M, Wiromrat P, Stuppy JJ, Thurston J, Bergman BC, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ.

Obesity (Silver Spring). 2019 Dec;27(12):2046-2054. doi: 10.1002/oby.22658. Epub 2019 Oct 28.


Body Composition and Markers of Cardiometabolic Health in Transgender Youth Compared With Cisgender Youth.

Nokoff NJ, Scarbro SL, Moreau KL, Zeitler P, Nadeau KJ, Juarez-Colunga E, Kelsey MM.

J Clin Endocrinol Metab. 2020 Mar 1;105(3). pii: dgz029. doi: 10.1210/clinem/dgz029.


The association of sleep disturbances with glycemia and obesity in youth at risk for or with recently diagnosed type 2 diabetes.

Mokhlesi B, Temple KA, Tjaden AH, Edelstein SL, Nadeau KJ, Hannon TS, Manchanda S, Sam S, Barengolts E, Utzschneider KM, Ehrmann DA, Van Cauter E; RISE Consortium.

Pediatr Diabetes. 2019 Dec;20(8):1056-1063. doi: 10.1111/pedi.12917. Epub 2019 Sep 15.


Screening for cystic fibrosis-related diabetes and prediabetes: Evaluating 1,5-anhydroglucitol, fructosamine, glycated albumin, and hemoglobin A1c.

Tommerdahl KL, Brinton JT, Vigers T, Nadeau KJ, Zeitler PS, Chan CL.

Pediatr Diabetes. 2019 Dec;20(8):1080-1086. doi: 10.1111/pedi.12914. Epub 2019 Oct 2.


Clinical prediction score of nonalcoholic fatty liver disease in adolescent girls with polycystic ovary syndrome (PCOS-HS index).

Carreau AM, Pyle L, Garcia-Reyes Y, Rahat H, Vigers T, Jensen T, Scherzinger A, Nadeau KJ, Cree-Green M.

Clin Endocrinol (Oxf). 2019 Oct;91(4):544-552. doi: 10.1111/cen.14062. Epub 2019 Aug 16.


Sleep & Circadian Health are Associated with Mood & Behavior in Adolescents with Overweight/Obesity.

Simon SL, Diniz Behn C, Laikin A, Kaar JL, Rahat H, Cree-Green M, Wright KP Jr, Nadeau KJ.

Behav Sleep Med. 2019 Jun 20:1-10. doi: 10.1080/15402002.2019.1629444. [Epub ahead of print]


Changes in Visceral and Subcutaneous Fat in Youth With Type 2 Diabetes in the TODAY Study.

Dhaliwal R, Shepherd JA, El Ghormli L, Copeland KC, Geffner ME, Higgins J, Levitsky LL, Nadeau KJ, Weinstock RS, White NH; TODAY Study Group.

Diabetes Care. 2019 Aug;42(8):1549-1559. doi: 10.2337/dc18-1935. Epub 2019 Jun 5.


Association of Self-Reported Sleep and Circadian Measures With Glycemia in Adults With Prediabetes or Recently Diagnosed Untreated Type 2 Diabetes.

Mokhlesi B, Temple KA, Tjaden AH, Edelstein SL, Utzschneider KM, Nadeau KJ, Hannon TS, Sam S, Barengolts E, Manchanda S, Ehrmann DA, Van Cauter E; RISE Consortium.

Diabetes Care. 2019 Jul;42(7):1326-1332. doi: 10.2337/dc19-0298. Epub 2019 May 2.


A simple method to monitor hepatic gluconeogenesis and triglyceride synthesis following oral sugar tolerance test in obese adolescents.

Carreau AM, Jin ES, Garcia-Reyes Y, Rahat H, Nadeau KJ, Malloy CR, Cree-Green M.

Am J Physiol Regul Integr Comp Physiol. 2019 Jul 1;317(1):R134-R142. doi: 10.1152/ajpregu.00047.2019. Epub 2019 May 1.


Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study.

Wiromrat P, Bjornstad P, Roncal C, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schäfer M, Truong U, Pyle L, Johnson RJ, Nadeau KJ.

J Diabetes Complications. 2019 Jun;33(6):434-436. doi: 10.1016/j.jdiacomp.2019.03.001. Epub 2019 Mar 21.


Sex Differences in Effects of Obesity on Reproductive Hormones and Glucose Metabolism in Early Puberty.

Nokoff N, Thurston J, Hilkin A, Pyle L, Zeitler PS, Nadeau KJ, Santoro N, Kelsey MM.

J Clin Endocrinol Metab. 2019 Oct 1;104(10):4390-4397. doi: 10.1210/jc.2018-02747.


Elevated Serum Uric Acid Is Associated With Greater Risk for Hypertension and Diabetic Kidney Diseases in Obese Adolescents With Type 2 Diabetes: An Observational Analysis From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study.

Bjornstad P, Laffel L, Lynch J, El Ghormli L, Weinstock RS, Tollefsen SE, Nadeau KJ; TODAY Study Group.

Diabetes Care. 2019 Jun;42(6):1120-1128. doi: 10.2337/dc18-2147. Epub 2019 Apr 9.


Metformin Improves Peripheral Insulin Sensitivity in Youth With Type 1 Diabetes.

Cree-Green M, Bergman BC, Cengiz E, Fox LA, Hannon TS, Miller K, Nathan B, Pyle L, Kahn D, Tansey M, Tichy E, Tsalikian E, Libman I, Nadeau KJ.

J Clin Endocrinol Metab. 2019 Aug 1;104(8):3265-3278. doi: 10.1210/jc.2019-00129.


Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome.

Simon SL, McWhirter L, Diniz Behn C, Bubar KM, Kaar JL, Pyle L, Rahat H, Garcia-Reyes Y, Carreau AM, Wright KP, Nadeau KJ, Cree-Green M.

J Clin Endocrinol Metab. 2019 Aug 1;104(8):3525-3534. doi: 10.1210/jc.2018-02385.


Amino acid and fatty acid metabolomic profile during fasting and hyperinsulinemia in girls with polycystic ovarian syndrome.

Cree-Green M, Carreau AM, Rahat H, Garcia-Reyes Y, Bergman BC, Pyle L, Nadeau KJ.

Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E707-E718. doi: 10.1152/ajpendo.00532.2018. Epub 2019 Feb 12.


Metformin Improves Insulin Sensitivity and Vascular Health in Youth With Type 1 Diabetes Mellitus.

Bjornstad P, Schäfer M, Truong U, Cree-Green M, Pyle L, Baumgartner A, Garcia Reyes Y, Maniatis A, Nayak S, Wadwa RP, Browne LP, Reusch JEB, Nadeau KJ.

Circulation. 2018 Dec 18;138(25):2895-2907. doi: 10.1161/CIRCULATIONAHA.118.035525.


Youth with type 2 diabetes have hepatic, peripheral, and adipose insulin resistance.

Cree-Green M, Wiromrat P, Stuppy JJ, Thurston J, Bergman BC, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ.

Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E186-E195. doi: 10.1152/ajpendo.00258.2018. Epub 2018 Dec 18.


Too Late and Not Enough: School Year Sleep Duration, Timing, and Circadian Misalignment Are Associated with Reduced Insulin Sensitivity in Adolescents with Overweight/Obesity.

Simon SL, Behn CD, Cree-Green M, Kaar JL, Pyle L, Hawkins SMM, Rahat H, Garcia-Reyes Y, Wright KP Jr, Nadeau KJ.

J Pediatr. 2019 Feb;205:257-264.e1. doi: 10.1016/j.jpeds.2018.10.027. Epub 2018 Nov 26.


Design of a randomized controlled trial to decrease depression and improve insulin sensitivity in adolescents: Mood and INsulin sensitivity to prevent Diabetes (MIND).

Shomaker LB, Gulley L, Hilkin AM, Clark E, Annameier S, Rao S, Rockette-Wagner B, Kriska A, Wright KP Jr, Stice E, Nadeau KJ, Kelsey MM.

Contemp Clin Trials. 2018 Dec;75:19-28. doi: 10.1016/j.cct.2018.10.007. Epub 2018 Oct 17.


Using simple clinical measures to predict insulin resistance or hyperglycemia in girls with polycystic ovarian syndrome.

Cree-Green M, Cai N, Thurston JE, Coe GV, Newnes L, Garcia-Reyes Y, Baumgartner AD, Pyle L, Nadeau KJ.

Pediatr Diabetes. 2018 Dec;19(8):1370-1378. doi: 10.1111/pedi.12778. Epub 2018 Oct 9.


Reduced insulin sensitivity is correlated with impaired sleep in adolescents with cystic fibrosis.

Simon SL, Vigers T, Campbell K, Pyle L, Branscomb R, Nadeau KJ, Chan CL.

Pediatr Diabetes. 2018 Nov;19(7):1183-1190. doi: 10.1111/pedi.12727. Epub 2018 Aug 1.


Youth With Type 1 Diabetes Have Adipose, Hepatic, and Peripheral Insulin Resistance.

Cree-Green M, Stuppy JJ, Thurston J, Bergman BC, Coe GV, Baumgartner AD, Bacon S, Scherzinger A, Pyle L, Nadeau KJ.

J Clin Endocrinol Metab. 2018 Oct 1;103(10):3647-3657. doi: 10.1210/jc.2018-00433.


Bone mineral content and bone density is lower in adolescents with type 1 diabetes: A brief report from the RESISTANT and EMERALD studies.

Kaur H, Joshee P, Franquemont S, Baumgartner A, Thurston J, Pyle L, Nadeau KJ, Shah VN.

J Diabetes Complications. 2018 Oct;32(10):931-933. doi: 10.1016/j.jdiacomp.2018.06.004. Epub 2018 Jun 15.


Oral Glucose Tolerance Test Glucose Peak Time Is Most Predictive of Prediabetes and Hepatic Steatosis in Obese Girls.

Cree-Green M, Xie D, Rahat H, Garcia-Reyes Y, Bergman BC, Scherzinger A, Diniz Behn C, Chan CL, Kelsey MM, Pyle L, Nadeau KJ.

J Endocr Soc. 2018 May 7;2(6):547-562. doi: 10.1210/js.2018-00041. eCollection 2018 Jun 1.


Prevalence of arterial stiffness in adolescents with type 2 diabetes in the TODAY cohort: Relationships to glycemic control and other risk factors.

Shah AS, El Ghormli L, Gidding SS, Bacha F, Nadeau KJ, Levitt Katz LE, Tryggestad JB, Leibel N, Hale DE, Urbina EM.

J Diabetes Complications. 2018 Aug;32(8):740-745. doi: 10.1016/j.jdiacomp.2018.05.013. Epub 2018 May 25.


Hemoglobin A1c Accurately Predicts Continuous Glucose Monitoring-Derived Average Glucose in Youth and Young Adults With Cystic Fibrosis.

Chan CL, Hope E, Thurston J, Vigers T, Pyle L, Zeitler PS, Nadeau KJ.

Diabetes Care. 2018 Jul;41(7):1406-1413. doi: 10.2337/dc17-2419. Epub 2018 Apr 19.


Supplemental Oxygen Improves In Vivo Mitochondrial Oxidative Phosphorylation Flux in Sedentary Obese Adults With Type 2 Diabetes.

Cree-Green M, Scalzo RL, Harrall K, Newcomer BR, Schauer IE, Huebschmann AG, McMillin S, Brown MS, Orlicky D, Knaub L, Nadeau KJ, McClatchey PM, Bauer TA, Regensteiner JG, Reusch JEB.

Diabetes. 2018 Jul;67(7):1369-1379. doi: 10.2337/db17-1124. Epub 2018 Apr 11.


Continuous glucose monitoring abnormalities in cystic fibrosis youth correlate with pulmonary function decline.

Chan CL, Vigers T, Pyle L, Zeitler PS, Sagel SD, Nadeau KJ.

J Cyst Fibros. 2018 Nov;17(6):783-790. doi: 10.1016/j.jcf.2018.03.008. Epub 2018 Mar 23.


Role of bicarbonate supplementation on urine uric acid crystals and diabetic tubulopathy in adults with type 1 diabetes.

Bjornstad P, Maahs DM, Roncal CA, Snell-Bergeon JK, Shah VN, Milagres T, Ellis SL, Hatch M, Chung LT, Rewers MJ, Garg S, Cherney DZ, Pyle L, Nadeau KJ, Johnson RJ.

Diabetes Obes Metab. 2018 Jul;20(7):1776-1780. doi: 10.1111/dom.13274. Epub 2018 Mar 24.


Fructose and sugar: A major mediator of non-alcoholic fatty liver disease.

Jensen T, Abdelmalek MF, Sullivan S, Nadeau KJ, Green M, Roncal C, Nakagawa T, Kuwabara M, Sato Y, Kang DH, Tolan DR, Sanchez-Lozada LG, Rosen HR, Lanaspa MA, Diehl AM, Johnson RJ.

J Hepatol. 2018 May;68(5):1063-1075. doi: 10.1016/j.jhep.2018.01.019. Epub 2018 Feb 2. Review.


Lipid Profiles, Inflammatory Markers, and Insulin Therapy in Youth with Type 2 Diabetes.

Levitt Katz LE, Bacha F, Gidding SS, Weinstock RS, El Ghormli L, Libman I, Nadeau KJ, Porter K, Marcovina S; TODAY Study Group.

J Pediatr. 2018 May;196:208-216.e2. doi: 10.1016/j.jpeds.2017.12.052. Epub 2018 Feb 2.


Insulin Resistance, Hyperinsulinemia, and Mitochondria Dysfunction in Nonobese Girls With Polycystic Ovarian Syndrome.

Cree-Green M, Rahat H, Newcomer BR, Bergman BC, Brown MS, Coe GV, Newnes L, Garcia-Reyes Y, Bacon S, Thurston JE, Pyle L, Scherzinger A, Nadeau KJ.

J Endocr Soc. 2017 Jun 1;1(7):931-944. doi: 10.1210/js.2017-00192. eCollection 2017 Jul 1.


Insulin Sensitivity and Diabetic Kidney Disease in Children and Adolescents With Type 2 Diabetes: An Observational Analysis of Data From the TODAY Clinical Trial.

Bjornstad P, Nehus E, El Ghormli L, Bacha F, Libman IM, McKay S, Willi SM, Laffel L, Arslanian S, Nadeau KJ; TODAY Study Group.

Am J Kidney Dis. 2018 Jan;71(1):65-74. doi: 10.1053/j.ajkd.2017.07.015. Epub 2017 Nov 20. Erratum in: Am J Kidney Dis. 2019 Apr;73(4):580.


Longitudinal follow up of dysglycemia in overweight and obese pediatric patients.

Love-Osborne KA, Sheeder JL, Nadeau KJ, Zeitler P.

Pediatr Diabetes. 2018 Mar;19(2):199-204. doi: 10.1111/pedi.12570. Epub 2017 Aug 30.


Adolescent's Health Behaviors and Risk for Insulin Resistance: A Review of the Literature.

Kaar JL, Simon SL, Schmiege SJ, Nadeau KJ, Kelsey MM.

Curr Diab Rep. 2017 Jul;17(7):49. doi: 10.1007/s11892-017-0881-4. Review.


Review of methods for measuring β-cell function: Design considerations from the Restoring Insulin Secretion (RISE) Consortium.

Hannon TS, Kahn SE, Utzschneider KM, Buchanan TA, Nadeau KJ, Zeitler PS, Ehrmann DA, Arslanian SA, Caprio S, Edelstein SL, Savage PJ, Mather KJ; RISE Consortium.

Diabetes Obes Metab. 2018 Jan;20(1):14-24. doi: 10.1111/dom.13005. Epub 2017 Jun 22. Review.


Leptin is associated with cardiopulmonary fitness independent of body-mass index and insulin sensitivity in adolescents with type 1 diabetes: a brief report from the EMERALD study.

Bjornstad P, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schafer M, Pyle L, Regensteiner JG, Reusch JEB, Nadeau KJ.

J Diabetes Complications. 2017 May;31(5):850-853. doi: 10.1016/j.jdiacomp.2017.02.019. Epub 2017 Mar 14.


Insulin Resistance in Youth Without Diabetes Is Not Related to Muscle Mitochondrial Dysfunction.

Cree-Green M, Cai N, Pyle L, Ringham B, Brown MS, Newcomer BR, Nadeau KJ, Dabelea D.

J Clin Endocrinol Metab. 2017 May 1;102(5):1652-1660. doi: 10.1210/jc.2016-3912.


Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers.

Patel SS, Truong U, King M, Ferland A, Moreau KL, Dorosz J, Hokanson JE, Wang H, Kinney GL, Maahs DM, Eckel RH, Nadeau KJ, Cree-Green M.

Vasc Med. 2017 Apr;22(2):85-95. doi: 10.1177/1358863X16682107. Epub 2017 Jan 17.


Alternate glycemic markers reflect glycemic variability in continuous glucose monitoring in youth with prediabetes and type 2 diabetes.

Chan CL, Pyle L, Kelsey MM, Newnes L, Baumgartner A, Zeitler PS, Nadeau KJ.

Pediatr Diabetes. 2017 Nov;18(7):629-636. doi: 10.1111/pedi.12475. Epub 2016 Nov 22.


Insulin resistance in type 2 diabetes youth relates to serum free fatty acids and muscle mitochondrial dysfunction.

Cree-Green M, Gupta A, Coe GV, Baumgartner AD, Pyle L, Reusch JE, Brown MS, Newcomer BR, Nadeau KJ.

J Diabetes Complications. 2017 Jan;31(1):141-148. doi: 10.1016/j.jdiacomp.2016.10.014. Epub 2016 Oct 17.


Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin Resistance.

Cree-Green M, Bergman BC, Coe GV, Newnes L, Baumgartner AD, Bacon S, Sherzinger A, Pyle L, Nadeau KJ.

Obesity (Silver Spring). 2016 Nov;24(11):2399-2406. doi: 10.1002/oby.21651.


Adiponectin, Insulin Sensitivity, β-Cell Function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY.

Arslanian S, El Ghormli L, Bacha F, Caprio S, Goland R, Haymond MW, Levitsky L, Nadeau KJ, White NH, Willi SM; TODAY Study Group.

Diabetes Care. 2017 Jan;40(1):85-93. doi: 10.2337/dc16-0455. Epub 2016 Nov 1.


Ethnic and Sex Differences in Adiponectin: From Childhood to Adulthood.

Ohman-Hanson RA, Cree-Green M, Kelsey MM, Bessesen DH, Sharp TA, Pyle L, Pereira RI, Nadeau KJ.

J Clin Endocrinol Metab. 2016 Dec;101(12):4808-4815. Epub 2016 Sep 7.

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