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The Future Of Omics For Clinical Practice.

Long A, Bunning B, Borro M, Sampath V, Nadeau KC.

Ann Allergy Asthma Immunol. 2019 Jul 25. pii: S1081-1206(19)30534-4. doi: 10.1016/j.anai.2019.07.016. [Epub ahead of print]


Almond (Prunus dulcis) Allergen Pru du 8, the First Member of a New Family of Food Allergens.

Che H, Zhang Y, Jiang S, Jin T, Lyu SC, Nadeau KC, McHugh T.

J Agric Food Chem. 2019 Aug 7;67(31):8626-8631. doi: 10.1021/acs.jafc.9b02781. Epub 2019 Jul 29.


Modeling Cardiovascular Risks of E-Cigarettes With Human-Induced Pluripotent Stem Cell-Derived Endothelial Cells.

Lee WH, Ong SG, Zhou Y, Tian L, Bae HR, Baker N, Whitlatch A, Mohammadi L, Guo H, Nadeau KC, Springer ML, Schick SF, Bhatnagar A, Wu JC.

J Am Coll Cardiol. 2019 Jun 4;73(21):2722-2737. doi: 10.1016/j.jacc.2019.03.476.


Legends of Allergy: Stephen J. Galli.

Tsai M, Chinthrajah S, Nadeau KC.

Allergy. 2019 Apr 9. doi: 10.1111/all.13815. [Epub ahead of print]


Newly identified T cell subsets in mechanistic studies of food immunotherapy.

Sampath V, Nadeau KC.

J Clin Invest. 2019 Apr 1;129(4):1431-1440. doi: 10.1172/JCI124605. Epub 2019 Apr 1. Review.


Changing Patient Mindsets about Non-Life-Threatening Symptoms During Oral Immunotherapy: A Randomized Clinical Trial.

Howe LC, Leibowitz KA, Perry MA, Bitler JM, Block W, Kaptchuk TJ, Nadeau KC, Crum AJ.

J Allergy Clin Immunol Pract. 2019 May - Jun;7(5):1550-1559. doi: 10.1016/j.jaip.2019.01.022. Epub 2019 Jan 23.


Prevalence and Severity of Food Allergies Among US Adults.

Gupta RS, Warren CM, Smith BM, Jiang J, Blumenstock JA, Davis MM, Schleimer RP, Nadeau KC.

JAMA Netw Open. 2019 Jan 4;2(1):e185630. doi: 10.1001/jamanetworkopen.2018.5630.


Report from the National Institute of Allergy and Infectious Diseases workshop on "Atopic dermatitis and the atopic march: Mechanisms and interventions".

Davidson WF, Leung DYM, Beck LA, Berin CM, Boguniewicz M, Busse WW, Chatila TA, Geha RS, Gern JE, Guttman-Yassky E, Irvine AD, Kim BS, Kong HH, Lack G, Nadeau KC, Schwaninger J, Simpson A, Simpson EL, Spergel JM, Togias A, Wahn U, Wood RA, Woodfolk JA, Ziegler SF, Plaut M.

J Allergy Clin Immunol. 2019 Mar;143(3):894-913. doi: 10.1016/j.jaci.2019.01.003. Epub 2019 Jan 9.


High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes.

Croote D, Darmanis S, Nadeau KC, Quake SR.

Science. 2018 Dec 14;362(6420):1306-1309. doi: 10.1126/science.aau2599.


Baseline Gastrointestinal Eosinophilia Is Common in Oral Immunotherapy Subjects With IgE-Mediated Peanut Allergy.

Wright BL, Fernandez-Becker NQ, Kambham N, Purington N, Tupa D, Zhang W, Rank MA, Kita H, Shim KP, Bunning BJ, Doyle AD, Jacobsen EA, Boyd SD, Tsai M, Maecker H, Manohar M, Galli SJ, Nadeau KC, Chinthrajah RS.

Front Immunol. 2018 Nov 22;9:2624. doi: 10.3389/fimmu.2018.02624. eCollection 2018.


Analysis of a Large Standardized Food Challenge Data Set to Determine Predictors of Positive Outcome Across Multiple Allergens.

Sindher S, Long AJ, Purington N, Chollet M, Slatkin S, Andorf S, Tupa D, Kumar D, Woch MA, O'Laughlin KL, Assaad A, Pongracic J, Spergel JM, Tam J, Tilles S, Wang J, Galli SJ, Nadeau KC, Chinthrajah RS.

Front Immunol. 2018 Nov 27;9:2689. doi: 10.3389/fimmu.2018.02689. eCollection 2018.


Identification of Almond ( Prunus dulcis) Vicilin As a Food Allergen.

Che H, Zhang Y, Lyu SC, Nadeau KC, McHugh T.

J Agric Food Chem. 2019 Jan 9;67(1):425-432. doi: 10.1021/acs.jafc.8b05290. Epub 2018 Dec 20.


Laundry detergents and detergent residue after rinsing directly disrupt tight junction barrier integrity in human bronchial epithelial cells.

Wang M, Tan G, Eljaszewicz A, Meng Y, Wawrzyniak P, Acharya S, Altunbulakli C, Westermann P, Dreher A, Yan L, Wang C, Akdis M, Zhang L, Nadeau KC, Akdis CA.

J Allergy Clin Immunol. 2019 May;143(5):1892-1903. doi: 10.1016/j.jaci.2018.11.016. Epub 2018 Nov 27.


The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States.

Gupta RS, Warren CM, Smith BM, Blumenstock JA, Jiang J, Davis MM, Nadeau KC.

Pediatrics. 2018 Dec;142(6). pii: e20181235. doi: 10.1542/peds.2018-1235. Epub 2018 Nov 19. Erratum in: Pediatrics. 2019 Mar;143(3):.


Differences in multiple immune parameters between Indian and U.S. infants.

Rathore DK, Holmes TH, Nadeau KC, Mittal P, Batra A, Rosenberg-Hasson Y, Sopory S, Gupta R, Chellani HK, Aggarwal KC, Bal V, Natchu UCM, Bhatnagar S, Tavassoli M, Lyell DJ, Rath S, Wadhwa N, Maecker HT.

PLoS One. 2018 Nov 16;13(11):e0207297. doi: 10.1371/journal.pone.0207297. eCollection 2018. Erratum in: PLoS One. 2019 Mar 28;14(3):e0214749.


Immunoglobulin E blockade during food allergen ingestion enhances the induction of inhibitory immunoglobulin G antibodies.

Stranks AJ, Minnicozzi SC, Miller SJ, Burton OT, Logsdon SL, Spergel JM, Nadeau KC, Pongracic JA, Umetsu DT, Rachid R, MacGinnitie AJ, Schneider LC, Oettgen HC.

Ann Allergy Asthma Immunol. 2019 Feb;122(2):213-215. doi: 10.1016/j.anai.2018.10.024. Epub 2018 Nov 4. No abstract available.


Multicenter, randomized, double-blind, placebo-controlled clinical trial of vital wheat gluten oral immunotherapy.

Nowak-Węgrzyn A, Wood RA, Nadeau KC, Pongracic JA, Henning AK, Lindblad RW, Beyer K, Sampson HA.

J Allergy Clin Immunol. 2019 Feb;143(2):651-661.e9. doi: 10.1016/j.jaci.2018.08.041. Epub 2018 Oct 30.


Peanut-specific T cell responses in patients with different clinical reactivity.

Birrueta G, Tripple V, Pham J, Manohar M, James EA, Kwok WW, Nadeau KC, Sette A, Peters B, Schulten V.

PLoS One. 2018 Oct 10;13(10):e0204620. doi: 10.1371/journal.pone.0204620. eCollection 2018.


Eliciting Dose and Safety Outcomes From a Large Dataset of Standardized Multiple Food Challenges.

Purington N, Chinthrajah RS, Long A, Sindher S, Andorf S, O'Laughlin K, Woch MA, Scheiber A, Assa'ad A, Pongracic J, Spergel JM, Tam J, Tilles S, Wang J, Galli SJ, Desai M, Nadeau KC.

Front Immunol. 2018 Sep 21;9:2057. doi: 10.3389/fimmu.2018.02057. eCollection 2018.


Heterogeneity of Ara h Component-Specific CD4 T Cell Responses in Peanut-Allergic Subjects.

Renand A, Farrington M, Whalen E, Wambre E, Bajzik V, Chinthrajah S, Nadeau KC, Kwok WW.

Front Immunol. 2018 Jun 25;9:1408. doi: 10.3389/fimmu.2018.01408. eCollection 2018.


Development of a tool predicting severity of allergic reaction during peanut challenge.

Chinthrajah RS, Purington N, Andorf S, Rosa JS, Mukai K, Hamilton R, Smith BM, Gupta R, Galli SJ, Desai M, Nadeau KC.

Ann Allergy Asthma Immunol. 2018 Jul;121(1):69-76.e2. doi: 10.1016/j.anai.2018.04.020. Epub 2018 Apr 27.


High dimensional immune biomarkers demonstrate differences in phenotypes and endotypes in food allergy and asthma.

Chinthrajah RS, Purington N, Sampath V, Andorf S, Manohar M, Prunicki M, Zhou X, Tupa D, Nadeau KC.

Ann Allergy Asthma Immunol. 2018 Jul;121(1):117-119.e1. doi: 10.1016/j.anai.2018.04.022. Epub 2018 Apr 26. No abstract available.


Realizing the Paris Climate Agreement to Improve Cardiopulmonary Health. Where Science Meets Policy.

Rice MB, Motto Malea N, Pinkerton KE, Schwartz J, Nadeau KC, Browner CM, Whitehouse S, Thurston GD.

Ann Am Thorac Soc. 2018 Jul;15(7):791-798. doi: 10.1513/AnnalsATS.201803-203PS. No abstract available.


New treatment directions in food allergy.

Sampath V, Sindher SB, Zhang W, Nadeau KC.

Ann Allergy Asthma Immunol. 2018 Mar;120(3):254-262. doi: 10.1016/j.anai.2018.01.004. Review. No abstract available.


The Use of Biomarkers to Predict Aero-Allergen and Food Immunotherapy Responses.

Sindher SB, Long A, Acharya S, Sampath V, Nadeau KC.

Clin Rev Allergy Immunol. 2018 Oct;55(2):190-204. doi: 10.1007/s12016-018-8678-z. Review.


Exposure to NO2, CO, and PM2.5 is linked to regional DNA methylation differences in asthma.

Prunicki M, Stell L, Dinakarpandian D, de Planell-Saguer M, Lucas RW, Hammond SK, Balmes JR, Zhou X, Paglino T, Sabatti C, Miller RL, Nadeau KC.

Clin Epigenetics. 2018 Jan 5;10:2. doi: 10.1186/s13148-017-0433-4. eCollection 2018.


Food allergy and omics.

Dhondalay GK, Rael E, Acharya S, Zhang W, Sampath V, Galli SJ, Tibshirani R, Boyd SD, Maecker H, Nadeau KC, Andorf S.

J Allergy Clin Immunol. 2018 Jan;141(1):20-29. doi: 10.1016/j.jaci.2017.11.007. Review.


Feasibility of sustained response through long-term dosing in food allergy immunotherapy.

Andorf S, Manohar M, Dominguez T, Block W, Tupa D, Kshirsagar RA, Sampath V, Chinthrajah RS, Nadeau KC.

Allergy Asthma Clin Immunol. 2017 Dec 21;13:52. doi: 10.1186/s13223-017-0224-7. eCollection 2017.


Observational long-term follow-up study of rapid food oral immunotherapy with omalizumab.

Andorf S, Manohar M, Dominguez T, Block W, Tupa D, Kshirsagar RA, Sampath V, Chinthrajah RS, Nadeau KC.

Allergy Asthma Clin Immunol. 2017 Dec 21;13:51. doi: 10.1186/s13223-017-0223-8. eCollection 2017.


Isotype-specific agglutination-PCR (ISAP): A sensitive and multiplex method for measuring allergen-specific IgE.

Tsai CT, Mukai K, Robinson PV, Gray MA, Waschmann MB, Lyu SC, Tsai M, Chinthrajah RS, Nadeau KC, Bertozzi CR, Galli SJ.

J Allergy Clin Immunol. 2018 May;141(5):1901-1904.e15. doi: 10.1016/j.jaci.2017.11.021. Epub 2017 Dec 14. No abstract available.


Anti-IgE treatment with oral immunotherapy in multifood allergic participants: a double-blind, randomised, controlled trial.

Andorf S, Purington N, Block WM, Long AJ, Tupa D, Brittain E, Rudman Spergel A, Desai M, Galli SJ, Nadeau KC, Chinthrajah RS.

Lancet Gastroenterol Hepatol. 2018 Feb;3(2):85-94. doi: 10.1016/S2468-1253(17)30392-8. Epub 2017 Dec 12.


EAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy.

Pajno GB, Fernandez-Rivas M, Arasi S, Roberts G, Akdis CA, Alvaro-Lozano M, Beyer K, Bindslev-Jensen C, Burks W, Ebisawa M, Eigenmann P, Knol E, Nadeau KC, Poulsen LK, van Ree R, Santos AF, du Toit G, Dhami S, Nurmatov U, Boloh Y, Makela M, O'Mahony L, Papadopoulos N, Sackesen C, Agache I, Angier E, Halken S, Jutel M, Lau S, Pfaar O, Ryan D, Sturm G, Varga EM, van Wijk RG, Sheikh A, Muraro A; EAACI Allergen Immunotherapy Guidelines Group.

Allergy. 2018 Apr;73(4):799-815. doi: 10.1111/all.13319. Epub 2017 Dec 5.


Identification, characterization, and initial epitope mapping of pine nut allergen Pin k 2.

Zhang Y, Du WX, Fan Y, Yi J, Lyu SC, Nadeau KC, McHugh TH.

Food Res Int. 2016 Dec;90:268-274. doi: 10.1016/j.foodres.2016.10.043. Epub 2016 Oct 26.


Effect of Varying Doses of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Exposure Among Patients With Peanut Sensitivity: A Randomized Clinical Trial.

Sampson HA, Shreffler WG, Yang WH, Sussman GL, Brown-Whitehorn TF, Nadeau KC, Cheema AS, Leonard SA, Pongracic JA, Sauvage-Delebarre C, Assa'ad AH, de Blay F, Bird JA, Tilles SA, Boralevi F, Bourrier T, Hébert J, Green TD, Gerth van Wijk R, Knulst AC, Kanny G, Schneider LC, Kowalski ML, Dupont C.

JAMA. 2017 Nov 14;318(18):1798-1809. doi: 10.1001/jama.2017.16591.


Erratum to: Allergen immunotherapy for IgE-mediated food allergy: protocol for a systematic review.

Dhami S, Nurmatov U, Pajno GB, Fernandez-Rivas M, Muraro A, Roberts G, Akdis C, Alvaro-Lozano M, Beyer K, Bindslev-Jensen C, Burks W, du Toit G, Ebisawa M, Eigenmann P, Knol E, Makela M, Nadeau KC, O'Mahony L, Papadopoulos N, Poulsen L, Sackesen C, Sampson H, Santos A, van Ree R, Timmermans F, Sheikh A.

Clin Transl Allergy. 2017 Sep 15;7:31. doi: 10.1186/s13601-017-0166-7. eCollection 2017.


Immune monitoring for precision medicine in allergy and asthma.

Boyd SD, Hoh RA, Nadeau KC, Galli SJ.

Curr Opin Immunol. 2017 Oct;48:82-91. doi: 10.1016/j.coi.2017.08.007. Epub 2017 Sep 7. Review.


Oral immunotherapy for food allergy.

Freeland DMH, Manohar M, Andorf S, Hobson BD, Zhang W, Nadeau KC.

Semin Immunol. 2017 Apr;30:36-44. doi: 10.1016/j.smim.2017.08.008. Epub 2017 Aug 31. Review.


Combining anti-IgE with oral immunotherapy.

Lin C, Lee IT, Sampath V, Dinakar C, DeKruyff RH, Schneider LC, Nadeau KC.

Pediatr Allergy Immunol. 2017 Nov;28(7):619-627. doi: 10.1111/pai.12767. Epub 2017 Sep 7. Review.


IL-4Rα Inhibitor for Atopic Disease.

Chang HY, Nadeau KC.

Cell. 2017 Jul 13;170(2):222. doi: 10.1016/j.cell.2017.06.046.


Peanut-specific type 1 regulatory T cells induced in vitro from allergic subjects are functionally impaired.

Pellerin L, Jenks JA, Chinthrajah S, Dominguez T, Block W, Zhou X, Noshirvan A, Gregori S, Roncarolo MG, Nadeau KC, Bacchetta R.

J Allergy Clin Immunol. 2018 Jan;141(1):202-213.e8. doi: 10.1016/j.jaci.2017.05.045. Epub 2017 Jul 6.


Cord blood T cell subpopulations and associations with maternal cadmium and arsenic exposures.

Nygaard UC, Li Z, Palys T, Jackson B, Subbiah M, Malipatlolla M, Sampath V, Maecker H, Karagas MR, Nadeau KC.

PLoS One. 2017 Jun 29;12(6):e0179606. doi: 10.1371/journal.pone.0179606. eCollection 2017.


A new fluorescent-avidin-based method for quantifying basophil activation in whole blood.

Mukai K, Chinthrajah RS, Nadeau KC, Tsai M, Gaudenzio N, Galli SJ.

J Allergy Clin Immunol. 2017 Oct;140(4):1202-1206.e3. doi: 10.1016/j.jaci.2017.03.052. Epub 2017 Jun 9. No abstract available.


Traffic-Related Air Pollution and Telomere Length in Children and Adolescents Living in Fresno, CA: A Pilot Study.

Lee EY, Lin J, Noth EM, Hammond SK, Nadeau KC, Eisen EA, Balmes JR.

J Occup Environ Med. 2017 May;59(5):446-452. doi: 10.1097/JOM.0000000000000996.


Biologic Therapies for Immunoglobulin E-mediated Food Allergy and Eosinophilic Esophagitis.

Otani IM, Nadeau KC.

Immunol Allergy Clin North Am. 2017 May;37(2):369-396. doi: 10.1016/j.iac.2017.01.010. Review.


Association of Clinical Reactivity with Sensitization to Allergen Components in Multifood-Allergic Children.

Andorf S, Borres MP, Block W, Tupa D, Bollyky JB, Sampath V, Elizur A, Lidholm J, Jones JE, Galli SJ, Chinthrajah RS, Nadeau KC.

J Allergy Clin Immunol Pract. 2017 Sep - Oct;5(5):1325-1334.e4. doi: 10.1016/j.jaip.2017.01.016. Epub 2017 Mar 27.


Precision medicine in allergic disease-food allergy, drug allergy, and anaphylaxis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology.

Muraro A, Lemanske RF Jr, Castells M, Torres MJ, Khan D, Simon HU, Bindslev-Jensen C, Burks W, Poulsen LK, Sampson HA, Worm M, Nadeau KC.

Allergy. 2017 Jul;72(7):1006-1021. doi: 10.1111/all.13132. Epub 2017 Apr 12. Review.


Allergen immunotherapy for IgE-mediated food allergy: a systematic review and meta-analysis.

Nurmatov U, Dhami S, Arasi S, Pajno GB, Fernandez-Rivas M, Muraro A, Roberts G, Akdis C, Alvaro-Lozano M, Beyer K, Bindslev-Jensen C, Burks W, du Toit G, Ebisawa M, Eigenmann P, Knol E, Makela M, Nadeau KC, O'Mahony L, Papadopoulos N, Poulsen LK, Sackesen C, Sampson H, Santos AF, van Ree R, Timmermans F, Sheikh A.

Allergy. 2017 Aug;72(8):1133-1147. doi: 10.1111/all.13124. Epub 2017 May 11. Review.


Deciphering the black box of food allergy mechanisms.

Sampath V, Tupa D, Graham MT, Chatila TA, Spergel JM, Nadeau KC.

Ann Allergy Asthma Immunol. 2017 Jan;118(1):21-27. doi: 10.1016/j.anai.2016.10.017. Review.


Epigenetic Changes During Food-Specific Immunotherapy.

Bunning BJ, DeKruyff RH, Nadeau KC.

Curr Allergy Asthma Rep. 2016 Nov;16(12):87. Review.


Purification and Characterization of a Black Walnut (Juglans nigra) Allergen, Jug n 4.

Zhang YZ, Du WX, Fan Y, Yi J, Lyu SC, Nadeau KC, Thomas AL, McHugh T.

J Agric Food Chem. 2017 Jan 18;65(2):454-462. doi: 10.1021/acs.jafc.6b04387. Epub 2017 Jan 5.


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