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Precision medicine and Mammalian Genome.

Brown SDM, Nadeau JH.

Mamm Genome. 2019 Jun;30(5-6):89. doi: 10.1007/s00335-019-09801-8. No abstract available.


The virtuous cycle of human genetics and mouse models in drug discovery.

Nadeau JH, Auwerx J.

Nat Rev Drug Discov. 2019 Apr;18(4):255-272. doi: 10.1038/s41573-018-0009-9. Review.


Apobec1 complementation factor (A1CF) and RBM47 interact in tissue-specific regulation of C to U RNA editing in mouse intestine and liver.

Blanc V, Xie Y, Kennedy S, Riordan JD, Rubin DC, Madison BB, Mills JC, Nadeau JH, Davidson NO.

RNA. 2019 Jan;25(1):70-81. doi: 10.1261/rna.068395.118. Epub 2018 Oct 11.


Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors.

Tschida BR, Temiz NA, Kuka TP, Lee LA, Riordan JD, Tierrablanca CA, Hullsiek R, Wagner S, Hudson WA, Linden MA, Amin K, Beckmann PJ, Heuer RA, Sarver AL, Yang JD, Roberts LR, Nadeau JH, Dupuy AJ, Keng VW, Largaespada DA.

Cancer Res. 2017 Dec 1;77(23):6576-6588. doi: 10.1158/0008-5472.CAN-17-2281. Epub 2017 Oct 9.


Do Gametes Woo? Evidence for Their Nonrandom Union at Fertilization.

Nadeau JH.

Genetics. 2017 Oct;207(2):369-387. doi: 10.1534/genetics.117.300109. Review.


From Peas to Disease: Modifier Genes, Network Resilience, and the Genetics of Health.

Riordan JD, Nadeau JH.

Am J Hum Genet. 2017 Aug 3;101(2):177-191. doi: 10.1016/j.ajhg.2017.06.004. Review.


Canalization Leads to Similar Whole Bone Mechanical Function at Maturity in Two Inbred Strains of Mice.

Schlecht SH, Smith LM, Ramcharan MA, Bigelow EM, Nolan BT, Mathis NJ, Cathey A, Manley E Jr, Menon R, McEachin RC, Nadeau JH, Jepsen KJ.

J Bone Miner Res. 2017 May;32(5):1002-1013. doi: 10.1002/jbmr.3093. Epub 2017 Feb 27.


The State of Systems Genetics in 2017.

Baliga NS, Björkegren JL, Boeke JD, Boutros M, Crawford NP, Dudley AM, Farber CR, Jones A, Levey AI, Lusis AJ, Mak HC, Nadeau JH, Noyes MB, Petretto E, Seyfried NT, Steinmetz LM, Vonesch SC.

Cell Syst. 2017 Jan 25;4(1):7-15. doi: 10.1016/j.cels.2017.01.005.


How mice are indispensable for understanding obesity and diabetes genetics.

Attie AD, Churchill GA, Nadeau JH.

Curr Opin Endocrinol Diabetes Obes. 2017 Apr;24(2):83-91. doi: 10.1097/MED.0000000000000321. Review.


Honoring the work and life of Leroy C. Stevens. A symposium as part of the International Stem Cell Initiative Workshop.

Graham CF, Solter D, Gearhart JD, Nadeau JH, Knowles BB.

Int J Dev Biol. 2016;60(10-11-12):327-336. doi: 10.1387/ijdb.160420bk.


Parent-of-origin effects of A1CF and AGO2 on testicular germ-cell tumors, testicular abnormalities, and fertilization bias.

Carouge D, Blanc V, Knoblaugh SE, Hunter RJ, Davidson NO, Nadeau JH.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5425-33. doi: 10.1073/pnas.1604773113. Epub 2016 Aug 31.


High-Fat Diet-Induced Complement Activation Mediates Intestinal Inflammation and Neoplasia, Independent of Obesity.

Doerner SK, Reis ES, Leung ES, Ko JS, Heaney JD, Berger NA, Lambris JD, Nadeau JH.

Mol Cancer Res. 2016 Oct;14(10):953-965. Epub 2016 Aug 17.



Schaefer S, Nadeau JH.

Q Rev Biol. 2015 Dec;90(4):381-415. Review.


A pre-modern and post-modern perspective of epigenetic inheritance.

Nadeau JH.

Semin Cell Dev Biol. 2015 Jul;43:65. doi: 10.1016/j.semcdb.2015.10.006. No abstract available.


Genetic control of obesity, glucose homeostasis, dyslipidemia and fatty liver in a mouse model of diet-induced metabolic syndrome.

Sinasac DS, Riordan JD, Spiezio SH, Yandell BS, Croniger CM, Nadeau JH.

Int J Obes (Lond). 2016 Feb;40(2):346-55. doi: 10.1038/ijo.2015.184. Epub 2015 Sep 18.


The nature of evidence for and against epigenetic inheritance.

Nadeau JH.

Genome Biol. 2015 Jul 11;16:137. doi: 10.1186/s13059-015-0709-y.


Contrasting genetic architectures in different mouse reference populations used for studying complex traits.

Buchner DA, Nadeau JH.

Genome Res. 2015 Jun;25(6):775-91. doi: 10.1101/gr.187450.114. Epub 2015 May 7. Review.


IL-33 activates tumor stroma to promote intestinal polyposis.

Maywald RL, Doerner SK, Pastorelli L, De Salvo C, Benton SM, Dawson EP, Lanza DG, Berger NA, Markowitz SD, Lenz HJ, Nadeau JH, Pizarro TT, Heaney JD.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2487-96. doi: 10.1073/pnas.1422445112. Epub 2015 Apr 27.


Turn up the heat: circulating serotonin tunes our internal heating system.

Schneider JG, Nadeau JH.

Cell Metab. 2015 Feb 3;21(2):156-158. doi: 10.1016/j.cmet.2015.01.011.


Genetic perturbations that impair functional trait interactions lead to reduced bone strength and increased fragility in mice.

Smith LM, Bigelow EM, Nolan BT, Faillace ME, Nadeau JH, Jepsen KJ.

Bone. 2014 Oct;67:130-8. doi: 10.1016/j.bone.2014.06.035. Epub 2014 Jul 6.


Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice.

Spiezio SH, Amon LM, McMillen TS, Vick CM, Houston BA, Caldwell M, Ogimoto K, Morton GJ, Kirk EA, Schwartz MW, Nadeau JH, LeBoeuf RC.

Mamm Genome. 2014 Dec;25(11-12):549-63. doi: 10.1007/s00335-014-9530-2. Epub 2014 Jul 8.


Genome-wide identification and functional analysis of Apobec-1-mediated C-to-U RNA editing in mouse small intestine and liver.

Blanc V, Park E, Schaefer S, Miller M, Lin Y, Kennedy S, Billing AM, Ben Hamidane H, Graumann J, Mortazavi A, Nadeau JH, Davidson NO.

Genome Biol. 2014 Jun 19;15(6):R79. doi: 10.1186/gb-2014-15-6-r79.


Modeling progressive non-alcoholic fatty liver disease in the laboratory mouse.

Riordan JD, Nadeau JH.

Mamm Genome. 2014 Oct;25(9-10):473-86. doi: 10.1007/s00335-014-9521-3. Epub 2014 May 7. Review.


Maternal nutrition induces pervasive gene expression changes but no detectable DNA methylation differences in the liver of adult offspring.

Cannon MV, Buchner DA, Hester J, Miller H, Sehayek E, Nadeau JH, Serre D.

PLoS One. 2014 Mar 3;9(3):e90335. doi: 10.1371/journal.pone.0090335. eCollection 2014.


A novel intergenic ETnII-β insertion mutation causes multiple malformations in polypodia mice.

Lehoczky JA, Thomas PE, Patrie KM, Owens KM, Villarreal LM, Galbraith K, Washburn J, Johnson CN, Gavino B, Borowsky AD, Millen KJ, Wakenight P, Law W, Van Keuren ML, Gavrilina G, Hughes ED, Saunders TL, Brihn L, Nadeau JH, Innis JW.

PLoS Genet. 2013;9(12):e1003967. doi: 10.1371/journal.pgen.1003967. Epub 2013 Dec 5.


Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis.

Zechel JL, Doerner SK, Lager A, Tesar PJ, Heaney JD, Nadeau JH.

BMC Genet. 2013 Jun 17;14:54. doi: 10.1186/1471-2156-14-54.


Genetic resistance to liver fibrosis on A/J mouse chromosome 17.

DeSantis DA, Lee P, Doerner SK, Ko CW, Kawasoe JH, Hill-Baskin AE, Ernest SR, Bhargava P, Hur KY, Cresci GA, Pritchard MT, Lee CH, Nagy LE, Nadeau JH, Croniger CM.

Alcohol Clin Exp Res. 2013 Oct;37(10):1668-79. doi: 10.1111/acer.12157. Epub 2013 Jun 13.


Chromosome substitution strains: gene discovery, functional analysis, and systems studies.

Nadeau JH, Forejt J, Takada T, Shiroishi T.

Mamm Genome. 2012 Oct;23(9-10):693-705. doi: 10.1007/s00335-012-9426-y. Epub 2012 Sep 8. Review.


Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability.

Nelson VR, Heaney JD, Tesar PJ, Davidson NO, Nadeau JH.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):E2766-73. doi: 10.1073/pnas.1207169109. Epub 2012 Aug 24.


Inflammatory priming predisposes mice to age-related retinal degeneration.

Mustafi D, Maeda T, Kohno H, Nadeau JH, Palczewski K.

J Clin Invest. 2012 Aug;122(8):2989-3001. doi: 10.1172/JCI64427. Epub 2012 Jul 17.


The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity.

Buchner DA, Geisinger JM, Glazebrook PA, Morgan MG, Spiezio SH, Kaiyala KJ, Schwartz MW, Sakurai T, Furley AJ, Kunze DL, Croniger CM, Nadeau JH.

Mamm Genome. 2012 Aug;23(7-8):431-42. doi: 10.1007/s00335-012-9400-8. Epub 2012 Jul 1.


Genetic divergence and the genetic architecture of complex traits in chromosome substitution strains of mice.

Spiezio SH, Takada T, Shiroishi T, Nadeau JH.

BMC Genet. 2012 May 18;13:38. doi: 10.1186/1471-2156-13-38.


Germ cell pluripotency, premature differentiation and susceptibility to testicular teratomas in mice.

Heaney JD, Anderson EL, Michelson MV, Zechel JL, Conrad PA, Page DC, Nadeau JH.

Development. 2012 May;139(9):1577-86. doi: 10.1242/dev.076851. Epub 2012 Mar 21.


Report of the National Heart, Lung, and Blood Institute Working Group on epigenetics and hypertension.

Cowley AW Jr, Nadeau JH, Baccarelli A, Berecek K, Fornage M, Gibbons GH, Harrison DG, Liang M, Nathanielsz PW, O'Connor DT, Ordovas J, Peng W, Soares MB, Szyf M, Tolunay HE, Wood KC, Zhao K, Galis ZS.

Hypertension. 2012 May;59(5):899-905. doi: 10.1161/HYPERTENSIONAHA.111.190116. Epub 2012 Mar 19. Review. No abstract available.


Transgenerational genetic effects.

Nelson VR, Nadeau JH.

Epigenomics. 2010 Dec;2(6):797-806. doi: 10.2217/epi.10.57. Review.


Systems medicine and integrated care to combat chronic noncommunicable diseases.

Bousquet J, Anto JM, Sterk PJ, Adcock IM, Chung KF, Roca J, Agusti A, Brightling C, Cambon-Thomsen A, Cesario A, Abdelhak S, Antonarakis SE, Avignon A, Ballabio A, Baraldi E, Baranov A, Bieber T, Bockaert J, Brahmachari S, Brambilla C, Bringer J, Dauzat M, Ernberg I, Fabbri L, Froguel P, Galas D, Gojobori T, Hunter P, Jorgensen C, Kauffmann F, Kourilsky P, Kowalski ML, Lancet D, Pen CL, Mallet J, Mayosi B, Mercier J, Metspalu A, Nadeau JH, Ninot G, Noble D, Oztürk M, Palkonen S, Préfaut C, Rabe K, Renard E, Roberts RG, Samolinski B, Schünemann HJ, Simon HU, Soares MB, Superti-Furga G, Tegner J, Verjovski-Almeida S, Wellstead P, Wolkenhauer O, Wouters E, Balling R, Brookes AJ, Charron D, Pison C, Chen Z, Hood L, Auffray C.

Genome Med. 2011 Jul 6;3(7):43. doi: 10.1186/gm259.


Spontaneous metastasis in mouse models of testicular germ-cell tumours.

Zechel JL, MacLennan GT, Heaney JD, Nadeau JH.

Int J Androl. 2011 Aug;34(4 Pt 2):e278-87. doi: 10.1111/j.1365-2605.2011.01160.x. Epub 2011 Jun 9.


Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis.

Yazbek SN, Buchner DA, Geisinger JM, Burrage LC, Spiezio SH, Zentner GE, Hsieh CW, Scacheri PC, Croniger CM, Nadeau JH.

Genome Res. 2011 Jul;21(7):1065-73. doi: 10.1101/gr.120741.111. Epub 2011 Apr 19.


Pathways, networks, and systems medicine--the meeting place of the Aegean and the mind.

Subramaniam S, Nadeau JH.

Wiley Interdiscip Rev Syst Biol Med. 2011 May-Jun;3(3):253-4. doi: 10.1002/wsbm.153. Epub 2011 Apr 1. No abstract available.


Isolation of epiblast stem cells from preimplantation mouse embryos.

Najm FJ, Chenoweth JG, Anderson PD, Nadeau JH, Redline RW, McKay RD, Tesar PJ.

Cell Stem Cell. 2011 Mar 4;8(3):318-25. doi: 10.1016/j.stem.2011.01.016.


Genetics. Systems genetics.

Nadeau JH, Dudley AM.

Science. 2011 Feb 25;331(6020):1015-6. doi: 10.1126/science.1203869. No abstract available.


Systems physiology--the heart of the matter or a bone of contention?

Subramaniam S, Nadeau JH.

Wiley Interdiscip Rev Syst Biol Med. 2011 Mar-Apr;3(2):127-8. doi: 10.1002/wsbm.146. No abstract available.


Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background.

Cook MS, Munger SC, Nadeau JH, Capel B.

Development. 2011 Jan;138(1):23-32. doi: 10.1242/dev.057000. Epub 2010 Nov 29.


Increased mitochondrial oxidative phosphorylation in the liver is associated with obesity and insulin resistance.

Buchner DA, Yazbek SN, Solinas P, Burrage LC, Morgan MG, Hoppel CL, Nadeau JH.

Obesity (Silver Spring). 2011 May;19(5):917-24. doi: 10.1038/oby.2010.214. Epub 2010 Sep 30. Erratum in: Obesity (Silver Spring). 2011 Nov;19(11):2286.


Functional interactions between the LRP6 WNT co-receptor and folate supplementation.

Gray JD, Nakouzi G, Slowinska-Castaldo B, Dazard JE, Rao JS, Nadeau JH, Ross ME.

Hum Mol Genet. 2010 Dec 1;19(23):4560-72. doi: 10.1093/hmg/ddq384. Epub 2010 Sep 15.


Systems medicine--viewed through the real and computing lenses.

Subramaniam S, Nadeau JH.

Wiley Interdiscip Rev Syst Biol Med. 2010 Jul-Aug;2(4):383-384. doi: 10.1002/wsbm.103.


Systems biology and medicine--metazoan life and processes.

Subramaniam S, Nadeau JH.

Wiley Interdiscip Rev Syst Biol Med. 2010 May-Jun;2(3):253-254. doi: 10.1002/wsbm.99.


Systems biology and medicine--meta-issues and frameworks.

Subramaniam S, Nadeau JH.

Wiley Interdiscip Rev Syst Biol Med. 2010 Mar-Apr;2(2):i-ii. doi: 10.1002/wsbm.98.


Systems biology--old wine in a new bottle or is the bottle changing the wine?

Nadeau JH, Subramaniam S.

Wiley Interdiscip Rev Syst Biol Med. 2010 Jan-Feb;2(1):1-2. doi: 10.1002/wsbm.91.


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