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Items: 1 to 50 of 135

1.

MET-oncogenic and JAK2-inactivating alterations are independent factors that affect regulation of PD-L1 expression in lung cancer.

Saigi M, Alburquerque-Bejar JJ, McLEER-Florin A, Pereira C, Pros E, Romero OA, Baixeras N, Esteve-Codina A, Nadal E, Brambilla E, Sanchez-Cespedes M.

Clin Cancer Res. 2018 Jun 13. pii: clincanres.0267.2018. doi: 10.1158/1078-0432.CCR-18-0267. [Epub ahead of print]

PMID:
29898990
2.

SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo.

Mainardi S, Mulero-Sánchez A, Prahallad A, Germano G, Bosma A, Krimpenfort P, Lieftink C, Steinberg JD, de Wit N, Gonçalves-Ribeiro S, Nadal E, Bardelli A, Villanueva A, Bernards R.

Nat Med. 2018 May 28. doi: 10.1038/s41591-018-0023-9. [Epub ahead of print]

PMID:
29808006
3.

Genetic and cellular sensitivity of Caenorhabditis elegans to the chemotherapeutic agent cisplatin.

García-Rodríguez FJ, Martínez-Fernández C, Brena D, Kukhtar D, Serrat X, Nadal E, Boxem M, Honnen S, Miranda-Vizuete A, Villanueva A, Cerón J.

Dis Model Mech. 2018 May 10. pii: dmm.033506. doi: 10.1242/dmm.033506. [Epub ahead of print]

4.

Timing of gene expression in a cell-fate decision system.

Aymoz D, Solé C, Pierre JJ, Schmitt M, de Nadal E, Posas F, Pelet S.

Mol Syst Biol. 2018 Apr 25;14(4):e8024. doi: 10.15252/msb.20178024.

5.

Preoperative nutritional status assessment predicts postoperative outcomes in patients with surgically resected non-small cell lung cancer.

Ramos R, Nadal E, Peiró I, Masuet-Aumatell C, Macia I, Rivas F, Rosado G, Rodriguez P, Ureña A, Padrones S, Aso S, Deniz C, Navarro A, Escobar I.

Eur J Surg Oncol. 2018 Apr 11. pii: S0748-7983(18)30995-8. doi: 10.1016/j.ejso.2018.03.026. [Epub ahead of print]

PMID:
29685760
6.

Successful treatment with brigatinib in a patient with ALK-rearranged lung adenocarcinoma who developed crizotinib-induced interstitial lung disease.

Doménech M, Jové M, Aso S, Marín M, Nadal E.

Lung Cancer. 2018 May;119:99-102. doi: 10.1016/j.lungcan.2018.03.014. Epub 2018 Mar 17.

PMID:
29656760
7.

Plug-and-Play Multicellular Circuits with Time-Dependent Dynamic Responses.

Urrios A, Gonzalez-Flo E, Canadell D, de Nadal E, Macia J, Posas F.

ACS Synth Biol. 2018 Apr 20;7(4):1095-1104. doi: 10.1021/acssynbio.7b00463. Epub 2018 Apr 2.

PMID:
29584406
8.

Incidence, predictors and prognostic significance of thromboembolic disease in patients with advanced ALK-rearranged non-small cell lung cancer.

Zugazagoitia J, Biosca M, Oliveira J, Olmedo ME, Dómine M, Nadal E, Ruffinelli JC, Muñoz N, Luna AM, Hernández B, Martínez M, Gallego I, Martínez de Castro E, Font C, Calvo V, Martínez-Marín V, Corral J, Noguerón E, Mondéjar R, García Escobar I, Salvador-Coloma C, Juan Ó, Sánchez Cánovas M, Valdivia J, Ochoa MP, López Castro R, Obispo B, Pangua C, Sereno M, Fernández Franco L, Mielgo X, Calzas J, Blasco A, Aparisi F, Chara L, Grau JF, Soares M, Gómez A, Zenzola V, García-Morillo M, Cacho D, Díaz-Serrano A, Aguado C, Ponce-Aix S, González-Larriba JL, Muñoz AJ, Lora D, Paz-Ares L, Manzano A.

Eur Respir J. 2018 May 3;51(5). pii: 1702431. doi: 10.1183/13993003.02431-2017. Print 2018 May. No abstract available.

PMID:
29563169
9.

Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII-p38MAPK-pS249/T252RB Pathway.

Yu-Lee LY, Yu G, Lee YC, Lin SC, Pan J, Pan T, Yu KJ, Liu B, Creighton CJ, Rodriguez-Canales J, Villalobos PA, Wistuba II, de Nadal E, Posas F, Gallick GE, Lin SH.

Cancer Res. 2018 Jun 1;78(11):2911-2924. doi: 10.1158/0008-5472.CAN-17-1051. Epub 2018 Mar 7.

PMID:
29514796
10.

Optical Properties of Complex Plasmonic Materials Studied with Extended Effective Medium Theories Combined with Rigorous Coupled Wave Analysis.

Nadal E, Barros N, Glénat H, Kachakachi H.

Materials (Basel). 2018 Feb 27;11(3). pii: E351. doi: 10.3390/ma11030351.

11.

KRAS oncogene in non-small cell lung cancer: clinical perspectives on the treatment of an old target.

Román M, Baraibar I, López I, Nadal E, Rolfo C, Vicent S, Gil-Bazo I.

Mol Cancer. 2018 Feb 19;17(1):33. doi: 10.1186/s12943-018-0789-x. Review.

12.

Geriatric assessment may help decision-making in elderly patients with inoperable, locally advanced non-small-cell lung cancer.

Antonio M, Saldaña J, Linares J, Ruffinelli JC, Palmero R, Navarro A, Arnaiz MD, Brao I, Aso S, Padrones S, Navarro V, González-Barboteo J, Borràs JM, Cardenal F, Nadal E.

Br J Cancer. 2018 Mar 6;118(5):639-647. doi: 10.1038/bjc.2017.455. Epub 2018 Jan 30.

PMID:
29381689
13.

Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts.

Duch A, Canal B, Barroso SI, García-Rubio M, Seisenbacher G, Aguilera A, de Nadal E, Posas F.

Nat Commun. 2018 Jan 25;9(1):379. doi: 10.1038/s41467-017-02756-x.

14.

Activation of the Hog1 MAPK by the Ssk2/Ssk22 MAP3Ks, in the absence of the osmosensors, is not sufficient to trigger osmostress adaptation in Saccharomyces cerevisiae.

Vázquez-Ibarra A, Subirana L, Ongay-Larios L, Kawasaki L, Rojas-Ortega E, Rodríguez-González M, de Nadal E, Posas F, Coria R.

FEBS J. 2018 Mar;285(6):1079-1096. doi: 10.1111/febs.14385. Epub 2018 Jan 30.

PMID:
29341399
15.

Randomized, Double-Blind Phase Ib/III Study of Erlotinib With Ramucirumab or Placebo in Previously Untreated EGFR-Mutant Metastatic Non-Small-Cell Lung Cancer (RELAY): Phase Ib Results.

Reck M, Garon EB, Paz-Ares L, Ponce S, Jaime JC, Juan O, Nadal E, Kiura K, Widau RC, He S, Dalal R, Lee P, Nakagawa K.

Clin Lung Cancer. 2018 May;19(3):213-220.e4. doi: 10.1016/j.cllc.2017.11.003. Epub 2017 Nov 21.

16.

Conductive vancomycin-loaded mesoporous silica polypyrrole-based scaffolds for bone regeneration.

Zanjanizadeh Ezazi N, Shahbazi MA, Shatalin YV, Nadal E, Mäkilä E, Salonen J, Kemell M, Correia A, Hirvonen J, Santos HA.

Int J Pharm. 2018 Jan 30;536(1):241-250. doi: 10.1016/j.ijpharm.2017.11.065. Epub 2017 Nov 28.

PMID:
29195917
17.

Regulation of transcription elongation in response to osmostress.

Silva A, Cavero S, Begley V, Solé C, Böttcher R, Chávez S, Posas F, de Nadal E.

PLoS Genet. 2017 Nov 20;13(11):e1007090. doi: 10.1371/journal.pgen.1007090. eCollection 2017 Nov.

18.

Genetic screening and molecular characterization of MET alterations in non-small cell lung cancer.

Saigi M, McLeer-Florin A, Pros E, Nadal E, Brambilla E, Sanchez-Cespedes M.

Clin Transl Oncol. 2018 Jul;20(7):881-888. doi: 10.1007/s12094-017-1799-7. Epub 2017 Nov 14.

PMID:
29139039
19.

The Hog1p kinase regulates Aft1p transcription factor to control iron accumulation.

Martins TS, Pereira C, Canadell D, Vilaça R, Teixeira V, Moradas-Ferreira P, de Nadal E, Posas F, Costa V.

Biochim Biophys Acta. 2018 Jan;1863(1):61-70. doi: 10.1016/j.bbalip.2017.10.001. Epub 2017 Oct 12.

PMID:
29032057
20.

Downregulation of miR-99a/let-7c/miR-125b miRNA cluster predicts clinical outcome in patients with unresected malignant pleural mesothelioma.

Truini A, Coco S, Nadal E, Genova C, Mora M, Dal Bello MG, Vanni I, Alama A, Rijavec E, Biello F, Barletta G, Merlo DF, Valentino A, Ferro P, Ravetti GL, Stigliani S, Vigani A, Fedeli F, Beer DG, Roncella S, Grossi F.

Oncotarget. 2017 Aug 2;8(40):68627-68640. doi: 10.18632/oncotarget.19800. eCollection 2017 Sep 15.

21.

Dual MET and ERBB inhibition overcomes intratumor plasticity in osimertinib-resistant-advanced non-small-cell lung cancer (NSCLC).

Martinez-Marti A, Felip E, Matito J, Mereu E, Navarro A, Cedrés S, Pardo N, Martinez de Castro A, Remon J, Miquel JM, Guillaumet-Adkins A, Nadal E, Rodriguez-Esteban G, Arqués O, Fasani R, Nuciforo P, Heyn H, Villanueva A, Palmer HG, Vivancos A.

Ann Oncol. 2017 Oct 1;28(10):2451-2457. doi: 10.1093/annonc/mdx396.

PMID:
28961841
22.

A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer.

Gasa L, Sanchez-Botet A, Quandt E, Hernández-Ortega S, Jiménez J, Carrasco-García MA, Simonetti S, Kron SJ, Ribeiro MP, Nadal E, Villanueva A, Clotet J.

Sci Rep. 2017 Aug 31;7(1):10228. doi: 10.1038/s41598-017-10770-8.

23.

Interaction Dynamics Determine Signaling and Output Pathway Responses.

Stojanovski K, Ferrar T, Benisty H, Uschner F, Delgado J, Jimenez J, Solé C, de Nadal E, Klipp E, Posas F, Serrano L, Kiel C.

Cell Rep. 2017 Apr 4;19(1):136-149. doi: 10.1016/j.celrep.2017.03.029.

24.

Genomic Profiling of Patient-Derived Xenografts for Lung Cancer Identifies B2M Inactivation Impairing Immunorecognition.

Pereira C, Gimenez-Xavier P, Pros E, Pajares MJ, Moro M, Gomez A, Navarro A, Condom E, Moran S, Gomez-Lopez G, Graña O, Rubio-Camarillo M, Martinez-Martí A, Yokota J, Carretero J, Galbis JM, Nadal E, Pisano D, Sozzi G, Felip E, Montuenga LM, Roz L, Villanueva A, Sanchez-Cespedes M.

Clin Cancer Res. 2017 Jun 15;23(12):3203-3213. doi: 10.1158/1078-0432.CCR-16-1946. Epub 2017 Mar 16.

25.

Role of the Sln1-phosphorelay pathway in the response to hyperosmotic stress in the yeast Kluyveromyces lactis.

Rodríguez-González M, Kawasaki L, Velázquez-Zavala N, Domínguez-Martín E, Trejo-Medecigo A, Martagón N, Espinoza-Simón E, Vázquez-Ibarra A, Ongay-Larios L, Georgellis D, de Nadal E, Posas F, Coria R.

Mol Microbiol. 2017 Jun;104(5):822-836. doi: 10.1111/mmi.13664. Epub 2017 Mar 28.

PMID:
28295748
26.

An RB insensitive to CDK regulation.

Joaquin M, de Nadal E, Posas F.

Mol Cell Oncol. 2016 Dec 14;4(1):e1268242. doi: 10.1080/23723556.2016.1268242. eCollection 2017.

27.

Identification of ALK, ROS1, and RET Fusions by a Multiplexed mRNA-Based Assay in Formalin-Fixed, Paraffin-Embedded Samples from Advanced Non-Small-Cell Lung Cancer Patients.

Reguart N, Teixidó C, Giménez-Capitán A, Paré L, Galván P, Viteri S, Rodríguez S, Peg V, Aldeguer E, Viñolas N, Remon J, Karachaliou N, Conde E, Lopez-Rios F, Nadal E, Merkelbach-Bruse S, Büttner R, Rosell R, Molina-Vila MA, Prat A.

Clin Chem. 2017 Mar;63(3):751-760. doi: 10.1373/clinchem.2016.265314. Epub 2017 Jan 10.

28.

Management of biliary anastomotic strictures after liver transplantation (BASALT study): A nationwide Italian survey.

Cantù P, Parzanese I, Balassone V, Di Sario A, Soggiu F, Lombardi G, Barbaro F, Pisani A, Baldan A, Cariani G, Boarino V, Fasoli A, Bertani H, Forti E, Bulajic M, Ghinolfi D, Nadal E, Cerofolini A, Barresi L, Catalano G, Stroppa I, Traini S, Mazzaferro V, Cipolletta L, Tringali A, Costamagna G, Ravelli P, Bazzoli F, Merighi A, Parodi MC, Conigliaro R, Mutignani M, Zilli M, Filipponi F, Fantin A, Rodella L, Tarantino I, Traina M, Salizzoni M, Rosa R, Malinverno F, Invernizzi F, Manini MA, Donato MF, Colombo M, Conte D, Rossi G, Penagini R.

Liver Transpl. 2017 Feb;23(2):257-261. doi: 10.1002/lt.24701. No abstract available.

29.

Treatment Rationale and Study Design for the RELAY Study: A Multicenter, Randomized, Double-Blind Study of Erlotinib With Ramucirumab or Placebo in Patients With Epidermal Growth Factor Receptor Mutation-Positive Metastatic Non-Small-Cell Lung Cancer.

Garon EB, Reck M, Paz-Ares L, Ponce S, Jaime JC, Juan O, Nadal E, Lee P, Dalal R, Liu J, He S, Treat J, Nakagawa K.

Clin Lung Cancer. 2017 Jan;18(1):96-99. doi: 10.1016/j.cllc.2016.05.023. Epub 2016 Jun 8.

PMID:
27894601
30.

KRAS-driven lung adenocarcinoma: combined DDR1/Notch inhibition as an effective therapy.

Ambrogio C, Nadal E, Villanueva A, Gómez-López G, Cash TP, Barbacid M, Santamaría D.

ESMO Open. 2016 Sep 6;1(5):e000076. eCollection 2016. Review.

31.

Evolution of protein phosphorylation across 18 fungal species.

Studer RA, Rodriguez-Mias RA, Haas KM, Hsu JI, Viéitez C, Solé C, Swaney DL, Stanford LB, Liachko I, Böttcher R, Dunham MJ, de Nadal E, Posas F, Beltrao P, Villén J.

Science. 2016 Oct 14;354(6309):229-232.

PMID:
27738172
32.

The N-Terminal Phosphorylation of RB by p38 Bypasses Its Inactivation by CDKs and Prevents Proliferation in Cancer Cells.

Gubern A, Joaquin M, Marquès M, Maseres P, Garcia-Garcia J, Amat R, González-Nuñez D, Oliva B, Real FX, de Nadal E, Posas F.

Mol Cell. 2016 Oct 6;64(1):25-36. doi: 10.1016/j.molcel.2016.08.015. Epub 2016 Sep 15.

33.

A Synthetic Multicellular Memory Device.

Urrios A, Macia J, Manzoni R, Conde N, Bonforti A, de Nadal E, Posas F, Solé R.

ACS Synth Biol. 2016 Aug 19;5(8):862-73. doi: 10.1021/acssynbio.5b00252. Epub 2016 Aug 8.

PMID:
27439436
34.

Genomic similarity between gastroesophageal junction and esophageal Barrett's adenocarcinomas.

Ferrer-Torres D, Nancarrow DJ, Kuick R, Thomas DG, Nadal E, Lin J, Chang AC, Reddy RM, Orringer MB, Taylor JM, Wang TD, Beer DG.

Oncotarget. 2016 Aug 23;7(34):54867-54882. doi: 10.18632/oncotarget.10253.

35.

Pancreatic melanoma metastasis diagnosed by endoscopic ultrasound-guided SharkCore biopsy.

Nadal E, Burra P, Mescoli C, Albertoni L, Sperti C, Sturniolo GC, Fantin A.

Endoscopy. 2016;48 Suppl 1:E208-9. doi: 10.1055/s-0042-109050. Epub 2016 Jun 16. No abstract available.

PMID:
27310890
36.

Synthetic biology: insights into biological computation.

Manzoni R, Urrios A, Velazquez-Garcia S, de Nadal E, Posas F.

Integr Biol (Camb). 2016 Apr 18;8(4):518-32. doi: 10.1039/c5ib00274e. Epub 2016 Apr 13. Review.

PMID:
27074335
37.

Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma.

Ambrogio C, Gómez-López G, Falcone M, Vidal A, Nadal E, Crosetto N, Blasco RB, Fernández-Marcos PJ, Sánchez-Céspedes M, Ren X, Wang Z, Ding K, Hidalgo M, Serrano M, Villanueva A, Santamaría D, Barbacid M.

Nat Med. 2016 Mar;22(3):270-7. doi: 10.1038/nm.4041. Epub 2016 Feb 8.

PMID:
26855149
38.

A Novel Epigenetic Signature for Early Diagnosis in Lung Cancer.

Diaz-Lagares A, Mendez-Gonzalez J, Hervas D, Saigi M, Pajares MJ, Garcia D, Crujerias AB, Pio R, Montuenga LM, Zulueta J, Nadal E, Rosell A, Esteller M, Sandoval J.

Clin Cancer Res. 2016 Jul 1;22(13):3361-71. doi: 10.1158/1078-0432.CCR-15-2346. Epub 2016 Feb 3.

39.

Implementation of Complex Biological Logic Circuits Using Spatially Distributed Multicellular Consortia.

Macia J, Manzoni R, Conde N, Urrios A, de Nadal E, Solé R, Posas F.

PLoS Comput Biol. 2016 Feb 1;12(2):e1004685. doi: 10.1371/journal.pcbi.1004685. eCollection 2016 Feb.

40.

Liver transplantation for viral hepatitis in 2015.

Ferrarese A, Zanetto A, Gambato M, Bortoluzzi I, Nadal E, Germani G, Senzolo M, Burra P, Russo FP.

World J Gastroenterol. 2016 Jan 28;22(4):1570-81. doi: 10.3748/wjg.v22.i4.1570. Review.

41.

SEOM clinical guidelines for the treatment of non-small cell lung cancer (NSCLC) 2015.

García-Campelo R, Bernabé R, Cobo M, Corral J, Coves J, Dómine M, Nadal E, Rodriguez-Abreu D, Viñolas N, Massuti B.

Clin Transl Oncol. 2015 Dec;17(12):1020-9. doi: 10.1007/s12094-015-1455-z. Epub 2015 Dec 21.

42.

A Novel Serum 4-microRNA Signature for Lung Cancer Detection.

Nadal E, Truini A, Nakata A, Lin J, Reddy RM, Chang AC, Ramnath N, Gotoh N, Beer DG, Chen G.

Sci Rep. 2015 Jul 23;5:12464. doi: 10.1038/srep12464.

43.

The role of Dickkopf-3 overexpression in esophageal adenocarcinoma.

Wang Z, Lin L, Thomas DG, Nadal E, Chang AC, Beer DG, Lin J.

J Thorac Cardiovasc Surg. 2015 Aug;150(2):377-385.e2. doi: 10.1016/j.jtcvs.2015.05.006. Epub 2015 May 8.

44.

Osmostress-induced gene expression--a model to understand how stress-activated protein kinases (SAPKs) regulate transcription.

de Nadal E, Posas F.

FEBS J. 2015 Sep;282(17):3275-85. doi: 10.1111/febs.13323. Epub 2015 Jun 10. Review.

45.

Long lasting control of viral rebound with a new drug ABX464 targeting Rev - mediated viral RNA biogenesis.

Campos N, Myburgh R, Garcel A, Vautrin A, Lapasset L, Nadal ES, Mahuteau-Betzer F, Najman R, Fornarelli P, Tantale K, Basyuk E, Séveno M, Venables JP, Pau B, Bertrand E, Wainberg MA, Speck RF, Scherrer D, Tazi J.

Retrovirology. 2015 Apr 9;12:30. doi: 10.1186/s12977-015-0159-3.

46.

H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes.

Nadal-Ribelles M, Mas G, Millán-Zambrano G, Solé C, Ammerer G, Chávez S, Posas F, de Nadal E.

Nucleic Acids Res. 2015 May 26;43(10):4937-49. doi: 10.1093/nar/gkv220. Epub 2015 Mar 26.

47.

Elevated levels of the complement activation product C4d in bronchial fluids for the diagnosis of lung cancer.

Ajona D, Razquin C, Pastor MD, Pajares MJ, Garcia J, Cardenal F, Fleischhacker M, Lozano MD, Zulueta JJ, Schmidt B, Nadal E, Paz-Ares L, Montuenga LM, Pio R.

PLoS One. 2015 Mar 23;10(3):e0119878. doi: 10.1371/journal.pone.0119878. eCollection 2015.

48.

Hog1 targets Whi5 and Msa1 transcription factors to downregulate cyclin expression upon stress.

González-Novo A, Jiménez J, Clotet J, Nadal-Ribelles M, Cavero S, de Nadal E, Posas F.

Mol Cell Biol. 2015 May;35(9):1606-18. doi: 10.1128/MCB.01279-14. Epub 2015 Mar 2.

49.

KRAS-G12C mutation is associated with poor outcome in surgically resected lung adenocarcinoma.

Nadal E, Beer DG, Ramnath N.

J Thorac Oncol. 2015 Feb;10(2):e9-10. doi: 10.1097/JTO.0000000000000438. No abstract available.

50.

Intrinsic cancer subtypes--next steps into personalized medicine.

Santos C, Sanz-Pamplona R, Nadal E, Grasselli J, Pernas S, Dienstmann R, Moreno V, Tabernero J, Salazar R.

Cell Oncol (Dordr). 2015 Feb;38(1):3-16. doi: 10.1007/s13402-014-0203-7. Epub 2015 Jan 14. Review.

PMID:
25586691

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