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Items: 17

1.

HDAC6 Inhibition Synergizes with Anti-PD-L1 Therapy in ARID1A-Inactivated Ovarian Cancer.

Fukumoto T, Fatkhutdinov N, Zundell JA, Tcyganov EN, Nacarelli T, Karakashev S, Wu S, Liu Q, Gabrilovich DI, Zhang R.

Cancer Res. 2019 Nov 1;79(21):5482-5489. doi: 10.1158/0008-5472.CAN-19-1302. Epub 2019 Jul 16.

PMID:
31311810
2.

NAD+ metabolism controls inflammation during senescence.

Nacarelli T, Zhang R.

Mol Cell Oncol. 2019 Apr 29;6(4):1605819. doi: 10.1080/23723556.2019.1605819. eCollection 2019.

PMID:
31211232
3.

N6-Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance.

Fukumoto T, Zhu H, Nacarelli T, Karakashev S, Fatkhutdinov N, Wu S, Liu P, Kossenkov AV, Showe LC, Jean S, Zhang L, Zhang R.

Cancer Res. 2019 Jun 1;79(11):2812-2820. doi: 10.1158/0008-5472.CAN-18-3592. Epub 2019 Apr 9.

PMID:
30967398
4.

NAD+ metabolism governs the proinflammatory senescence-associated secretome.

Nacarelli T, Lau L, Fukumoto T, Zundell J, Fatkhutdinov N, Wu S, Aird KM, Iwasaki O, Kossenkov AV, Schultz D, Noma KI, Baur JA, Schug Z, Tang HY, Speicher DW, David G, Zhang R.

Nat Cell Biol. 2019 Mar;21(3):397-407. doi: 10.1038/s41556-019-0287-4. Epub 2019 Feb 18.

5.

Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts.

Nacarelli T, Azar A, Altinok O, Orynbayeva Z, Sell C.

Geroscience. 2018 Jun 21. doi: 10.1007/s11357-018-0030-2. [Epub ahead of print]

6.

Correlations between age, functional status, and the senescence-associated proteins HMGB2 and p16INK4a.

Lawrence I, Bene M, Nacarelli T, Azar A, Cohen JZ, Torres C, Johannes G, Sell C.

Geroscience. 2018 Apr;40(2):193-199. doi: 10.1007/s11357-018-0015-1. Epub 2018 Apr 12.

7.

Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer.

Fukumoto T, Park PH, Wu S, Fatkhutdinov N, Karakashev S, Nacarelli T, Kossenkov AV, Speicher DW, Jean S, Zhang L, Wang TL, Shih IM, Conejo-Garcia JR, Bitler BG, Zhang R.

Cell Rep. 2018 Mar 27;22(13):3393-3400. doi: 10.1016/j.celrep.2018.03.019.

8.

Induction of a Senescence-Like Phenotype in Cultured Human Fetal Microglia During HIV-1 Infection.

Chen NC, Partridge AT, Tuzer F, Cohen J, Nacarelli T, Navas-Martín S, Sell C, Torres C, Martín-García J.

J Gerontol A Biol Sci Med Sci. 2018 Aug 10;73(9):1187-1196. doi: 10.1093/gerona/gly022.

9.

Epigenetic Basis of Cellular Senescence and Its Implications in Aging.

Nacarelli T, Liu P, Zhang R.

Genes (Basel). 2017 Nov 24;8(12). pii: E343. doi: 10.3390/genes8120343. Review.

10.

Targeting metabolism in cellular senescence, a role for intervention.

Nacarelli T, Sell C.

Mol Cell Endocrinol. 2017 Nov 5;455:83-92. doi: 10.1016/j.mce.2016.08.049. Epub 2016 Aug 31. Review.

PMID:
27591812
11.

Mitochondrial stress induces cellular senescence in an mTORC1-dependent manner.

Nacarelli T, Azar A, Sell C.

Free Radic Biol Med. 2016 Jun;95:133-54. doi: 10.1016/j.freeradbiomed.2016.03.008. Epub 2016 Mar 23.

PMID:
27016071
12.

Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?

Nacarelli T, Azar A, Sell C.

Exp Gerontol. 2015 Aug;68:66-70. doi: 10.1016/j.exger.2014.11.004. Epub 2014 Nov 6. Review.

13.

Inhibition of mTOR Prevents ROS Production Initiated by Ethidium Bromide-Induced Mitochondrial DNA Depletion.

Nacarelli T, Azar A, Sell C.

Front Endocrinol (Lausanne). 2014 Jul 24;5:122. doi: 10.3389/fendo.2014.00122. eCollection 2014.

14.

Detecting senescence: methods and approaches.

Crowe EP, Nacarelli T, Bitto A, Lerner C, Sell C, Torres C.

Methods Mol Biol. 2014;1170:425-45. doi: 10.1007/978-1-4939-0888-2_23.

PMID:
24906328
15.

P62/SQSTM1 at the interface of aging, autophagy, and disease.

Bitto A, Lerner CA, Nacarelli T, Crowe E, Torres C, Sell C.

Age (Dordr). 2014 Jun;36(3):9626. doi: 10.1007/s11357-014-9626-3. Epub 2014 Feb 21. Review.

16.

Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts.

Lerner C, Bitto A, Pulliam D, Nacarelli T, Konigsberg M, Van Remmen H, Torres C, Sell C.

Aging Cell. 2013 Dec;12(6):966-77. doi: 10.1111/acel.12122. Epub 2013 Jul 30.

17.

Pathogen-associated molecular pattern-induced mitochondrial membrane depolarization in the earthworm Eisenia hortensis.

Nacarelli T, Fuller-Espie SL.

J Invertebr Pathol. 2011 Nov;108(3):174-9. doi: 10.1016/j.jip.2011.08.008. Epub 2011 Aug 31.

PMID:
21907209

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