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Items: 15


Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism.

Fox NG, Yu X, Feng X, Bailey HJ, Martelli A, Nabhan JF, Strain-Damerell C, Bulawa C, Yue WW, Han S.

Nat Commun. 2019 May 17;10(1):2210. doi: 10.1038/s41467-019-09989-y.


4'-Phosphopantetheine and long acyl chain-dependent interactions are integral to human mitochondrial acyl carrier protein function.

Majmudar JD, Feng X, Fox NG, Nabhan JF, Towle T, Ma T, Gooch R, Bulawa C, Yue WW, Martelli A.

Medchemcomm. 2019 Jan 8;10(2):209-220. doi: 10.1039/c8md00489g. eCollection 2019 Feb 1.


Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity.

Fox NG, Martelli A, Nabhan JF, Janz J, Borkowska O, Bulawa C, Yue WW.

Biochimie. 2018 Sep;152:211-218. doi: 10.1016/j.biochi.2018.07.012. Epub 2018 Jul 20.


Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).

Gopalsamy A, Narayanan A, Liu S, Parikh MD, Kyne RE Jr, Fadeyi O, Tones MA, Cherry JJ, Nabhan JF, LaRosa G, Petersen DN, Menard C, Foley TL, Noell S, Ren Y, Loria PM, Maglich-Goodwin J, Rong H, Jones LH.

J Med Chem. 2017 Apr 13;60(7):3094-3108. doi: 10.1021/acs.jmedchem.7b00124. Epub 2017 Mar 16.


Intrathecal delivery of frataxin mRNA encapsulated in lipid nanoparticles to dorsal root ganglia as a potential therapeutic for Friedreich's ataxia.

Nabhan JF, Wood KM, Rao VP, Morin J, Bhamidipaty S, LaBranche TP, Gooch RL, Bozal F, Bulawa CE, Guild BC.

Sci Rep. 2016 Feb 17;6:20019. doi: 10.1038/srep20019.


Perturbation of cellular proteostasis networks identifies pathways that modulate precursor and intermediate but not mature levels of frataxin.

Nabhan JF, Gooch RL, Piatnitski Chekler EL, Pierce B, Bulawa CE.

Sci Rep. 2015 Dec 16;5:18251. doi: 10.1038/srep18251.


Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein.

Nabhan JF, Hu R, Oh RS, Cohen SN, Lu Q.

Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4146-51. doi: 10.1073/pnas.1200448109. Epub 2012 Feb 6.


A novel EST-derived RNAi screen reveals a critical role for farnesyl diphosphate synthase in β2-adrenergic receptor internalization and down-regulation.

Jiang X, Pan H, Nabhan JF, Krishnan R, Koziol-White C, Panettieri RA, Lu Q.

FASEB J. 2012 May;26(5):1995-2007. doi: 10.1096/fj.11-193870. Epub 2012 Jan 25.


Mechanical responsiveness of the endothelial cell of Schlemm's canal: scope, variability and its potential role in controlling aqueous humour outflow.

Zhou EH, Krishnan R, Stamer WD, Perkumas KM, Rajendran K, Nabhan JF, Lu Q, Fredberg JJ, Johnson M.

J R Soc Interface. 2012 Jun 7;9(71):1144-55. doi: 10.1098/rsif.2011.0733. Epub 2011 Dec 14.


Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi.

Moreno Y, Nabhan JF, Solomon J, Mackenzie CD, Geary TG.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20120-5. doi: 10.1073/pnas.1011983107. Epub 2010 Nov 1.


Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor.

Nabhan JF, Pan H, Lu Q.

EMBO Rep. 2010 Aug;11(8):605-11. doi: 10.1038/embor.2010.80. Epub 2010 Jun 18.


The 26S proteasome in Schistosoma mansoni: bioinformatics analysis, developmental expression, and RNA interference (RNAi) studies.

Nabhan JF, El-Shehabi F, Patocka N, Ribeiro P.

Exp Parasitol. 2007 Nov;117(3):337-47. Epub 2007 Aug 16.


A Schistosoma mansoni Pad1 homologue stabilizes c-Jun.

Nabhan JF, Hamdan FF, Ribeiro P.

Mol Biochem Parasitol. 2002 Apr 30;121(1):163-72.


A Schistosoma mansoni Pad1 homologue stabilizes c-Jun.

Nabhan JF, Hamdan FF, Ribeiro P.

Mol Biochem Parasitol. 2001 Sep 3;116(2):209-18. Corrected and republished in: Mol Biochem Parasitol. 2002 Apr 30;121(1):163-72.


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