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Items: 22

1.

Identification of DHODH as a therapeutic target in small cell lung cancer.

Li L, Ng SR, Colón CI, Drapkin BJ, Hsu PP, Li Z, Nabel CS, Lewis CA, Romero R, Mercer KL, Bhutkar A, Phat S, Myers DT, Muzumdar MD, Westcott PMK, Beytagh MC, Farago AF, Vander Heiden MG, Dyson NJ, Jacks T.

Sci Transl Med. 2019 Nov 6;11(517). pii: eaaw7852. doi: 10.1126/scitranslmed.aaw7852.

PMID:
31694929
2.

Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease.

Fajgenbaum DC, Langan RA, Japp AS, Partridge HL, Pierson SK, Singh A, Arenas DJ, Ruth JR, Nabel CS, Stone K, Okumura M, Schwarer A, Jose FF, Hamerschlak N, Wertheim GB, Jordan MB, Cohen AD, Krymskaya V, Rubenstein A, Betts MR, Kambayashi T, van Rhee F, Uldrick TS.

J Clin Invest. 2019 Aug 13;130:4451-4463. doi: 10.1172/JCI126091.

3.

Virome capture sequencing does not identify active viral infection in unicentric and idiopathic multicentric Castleman disease.

Nabel CS, Sameroff S, Shilling D, Alapat D, Ruth JR, Kawano M, Sato Y, Stone K, Spetalen S, Valdivieso F, Feldman MD, Chadburn A, Fosså A, van Rhee F, Lipkin WI, Fajgenbaum DC.

PLoS One. 2019 Jun 26;14(6):e0218660. doi: 10.1371/journal.pone.0218660. eCollection 2019.

4.

Anti-PD-1 Immunotherapy-Induced Flare of a Known Underlying Relapsing Vasculitis Mimicking Recurrent Cancer.

Nabel CS, Severgnini M, Hung YP, Cunningham-Bussel A, Gjini E, Kleinsteuber K, Seymour LJ, Holland MK, Cunningham R, Felt KD, Vivero M, Rodig SJ, Massarotti EM, Rahma OE, Harshman LC.

Oncologist. 2019 Aug;24(8):1013-1021. doi: 10.1634/theoncologist.2018-0633. Epub 2019 May 14.

PMID:
31088979
5.

Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase.

Schutsky EK, DeNizio JE, Hu P, Liu MY, Nabel CS, Fabyanic EB, Hwang Y, Bushman FD, Wu H, Kohli RM.

Nat Biotechnol. 2018 Oct 8. doi: 10.1038/nbt.4204. [Epub ahead of print]

6.

Plasma proteomics identifies a 'chemokine storm' in idiopathic multicentric Castleman disease.

Pierson SK, Stonestrom AJ, Shilling D, Ruth J, Nabel CS, Singh A, Ren Y, Stone K, Li H, van Rhee F, Fajgenbaum DC.

Am J Hematol. 2018 Jul;93(7):902-912. doi: 10.1002/ajh.25123. Epub 2018 May 16.

7.

Canakinumab and Lung Cancer: Intriguing, but Is It Real?

Chabner BA, Nabel CS.

Oncologist. 2018 Jun;23(6):637-638. doi: 10.1634/theoncologist.2018-0116. Epub 2018 Apr 17. No abstract available.

8.

APOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA.

Schutsky EK, Nabel CS, Davis AKF, DeNizio JE, Kohli RM.

Nucleic Acids Res. 2017 Jul 27;45(13):7655-7665. doi: 10.1093/nar/gkx345.

9.

DNA Methyltransferases Demonstrate Reduced Activity against Arabinosylcytosine: Implications for Epigenetic Instability in Acute Myeloid Leukemia.

Nabel CS, DeNizio JE, Carroll M, Kohli RM.

Biochemistry. 2017 Apr 25;56(16):2166-2169. doi: 10.1021/acs.biochem.7b00208. Epub 2017 Apr 12.

10.

International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease.

Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, Simpson D, Liu AY, Menke D, Chandrakasan S, Lechowicz MJ, Wong RS, Pierson S, Paessler M, Rossi JF, Ide M, Ruth J, Croglio M, Suarez A, Krymskaya V, Chadburn A, Colleoni G, Nasta S, Jayanthan R, Nabel CS, Casper C, Dispenzieri A, Fosså A, Kelleher D, Kurzrock R, Voorhees P, Dogan A, Yoshizaki K, van Rhee F, Oksenhendler E, Jaffe ES, Elenitoba-Johnson KS, Lim MS.

Blood. 2017 Mar 23;129(12):1646-1657. doi: 10.1182/blood-2016-10-746933. Epub 2017 Jan 13.

11.

Idiopathic multicentric Castleman's disease: a systematic literature review.

Liu AY, Nabel CS, Finkelman BS, Ruth JR, Kurzrock R, van Rhee F, Krymskaya VP, Kelleher D, Rubenstein AH, Fajgenbaum DC.

Lancet Haematol. 2016 Apr;3(4):e163-75. doi: 10.1016/S2352-3026(16)00006-5. Epub 2016 Mar 17. Review.

PMID:
27063975
12.

Clinicopathologic analysis of TAFRO syndrome demonstrates a distinct subtype of HHV-8-negative multicentric Castleman disease.

Iwaki N, Fajgenbaum DC, Nabel CS, Gion Y, Kondo E, Kawano M, Masunari T, Yoshida I, Moro H, Nikkuni K, Takai K, Matsue K, Kurosawa M, Hagihara M, Saito A, Okamoto M, Yokota K, Hiraiwa S, Nakamura N, Nakao S, Yoshino T, Sato Y.

Am J Hematol. 2016 Feb;91(2):220-6. doi: 10.1002/ajh.24242.

13.

Tet2 Catalyzes Stepwise 5-Methylcytosine Oxidation by an Iterative and de novo Mechanism.

Crawford DJ, Liu MY, Nabel CS, Cao XJ, Garcia BA, Kohli RM.

J Am Chem Soc. 2016 Jan 27;138(3):730-3. doi: 10.1021/jacs.5b10554. Epub 2016 Jan 13.

14.

HHV-8-negative, idiopathic multicentric Castleman disease: novel insights into biology, pathogenesis, and therapy.

Fajgenbaum DC, van Rhee F, Nabel CS.

Blood. 2014 May 8;123(19):2924-33. doi: 10.1182/blood-2013-12-545087. Epub 2014 Mar 12. Review.

PMID:
24622327
15.

Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.

Sun Z, Feng D, Fang B, Mullican SE, You SH, Lim HW, Everett LJ, Nabel CS, Li Y, Selvakumaran V, Won KJ, Lazar MA.

Mol Cell. 2013 Dec 26;52(6):769-82. doi: 10.1016/j.molcel.2013.10.022. Epub 2013 Nov 21.

16.

Molecular targeting of mutagenic AID and APOBEC deaminases.

Nabel CS, Schutsky EK, Kohli RM.

Cell Cycle. 2014;13(2):171-2. doi: 10.4161/cc.27036. Epub 2013 Nov 15. No abstract available.

17.

Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase.

Nabel CS, Lee JW, Wang LC, Kohli RM.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14225-30. doi: 10.1073/pnas.1306345110. Epub 2013 Aug 13.

18.

AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation.

Nabel CS, Jia H, Ye Y, Shen L, Goldschmidt HL, Stivers JT, Zhang Y, Kohli RM.

Nat Chem Biol. 2012 Sep;8(9):751-8. doi: 10.1038/nchembio.1042. Epub 2012 Jul 8.

19.

A tool kit for quantifying eukaryotic rRNA gene sequences from human microbiome samples.

Dollive S, Peterfreund GL, Sherrill-Mix S, Bittinger K, Sinha R, Hoffmann C, Nabel CS, Hill DA, Artis D, Bachman MA, Custers-Allen R, Grunberg S, Wu GD, Lewis JD, Bushman FD.

Genome Biol. 2012 Jul 3;13(7):R60. doi: 10.1186/gb-2012-13-7-r60.

20.

The curious chemical biology of cytosine: deamination, methylation, and oxidation as modulators of genomic potential.

Nabel CS, Manning SA, Kohli RM.

ACS Chem Biol. 2012 Jan 20;7(1):20-30. doi: 10.1021/cb2002895. Epub 2011 Oct 31. Review.

21.

Molecular biology. Demystifying DNA demethylation.

Nabel CS, Kohli RM.

Science. 2011 Sep 2;333(6047):1229-30. doi: 10.1126/science.1211917. No abstract available.

PMID:
21885763
22.

Ebolavirus proteins suppress the effects of small interfering RNA by direct interaction with the mammalian RNA interference pathway.

Fabozzi G, Nabel CS, Dolan MA, Sullivan NJ.

J Virol. 2011 Mar;85(6):2512-23. doi: 10.1128/JVI.01160-10. Epub 2011 Jan 12.

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