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Items: 15

1.

Lymphocyte DNA methylation mediates genetic risk at shared immune mediated disease loci.

Clark AD, Nair N, Anderson AE, Thalayasingam N, Naamane N, Skelton AJ, Diboll J, Barton A, Eyre S, Isaacs JD, Pratt AG, Reynard LN.

J Allergy Clin Immunol. 2020 Jan 13. pii: S0091-6749(20)30032-4. doi: 10.1016/j.jaci.2019.12.910. [Epub ahead of print]

2.

IL-6 Mediated Transcriptional Programming of Naïve CD4+ T Cells in Early Rheumatoid Arthritis Drives Dysregulated Effector Function.

Ridgley LA, Anderson AE, Maney NJ, Naamane N, Skelton AJ, Lawson CA, Emery P, Isaacs JD, Carmody RJ, Pratt AG.

Front Immunol. 2019 Jul 3;10:1535. doi: 10.3389/fimmu.2019.01535. eCollection 2019.

3.

Between a ROC and a hard place: Teaching prevalence plots to understand real world biomarker performance in the clinic.

Lendrem BC, Lendrem DW, Pratt AG, Naamane N, McMeekin P, Ng WF, Allen AJ, Power M, Isaacs JD.

Pharm Stat. 2019 Nov;18(6):632-635. doi: 10.1002/pst.1963. Epub 2019 Jun 23.

PMID:
31231892
4.

JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway.

Cunha DA, Gurzov EN, Naamane N, Ortis F, Cardozo AK, Bugliani M, Marchetti P, Eizirik DL, Cnop M.

Cell Death Differ. 2014 Aug;21(8):1313-24. doi: 10.1038/cdd.2014.53. Epub 2014 May 2.

5.

Unraveling the effects of 1,25OH2D3 on global gene expression in pancreatic islets.

Wolden-Kirk H, Overbergh L, Gysemans C, Brusgaard K, Naamane N, Van Lommel L, Schuit F, Eizirik DL, Christesen H, Mathieu C.

J Steroid Biochem Mol Biol. 2013 Jul;136:68-79. doi: 10.1016/j.jsbmb.2012.10.017. Epub 2012 Nov 5.

PMID:
23137852
6.

Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis.

Cunha DA, Igoillo-Esteve M, Gurzov EN, Germano CM, Naamane N, Marhfour I, Fukaya M, Vanderwinden JM, Gysemans C, Mathieu C, Marselli L, Marchetti P, Harding HP, Ron D, Eizirik DL, Cnop M.

Diabetes. 2012 Nov;61(11):2763-75. doi: 10.2337/db12-0123. Epub 2012 Jul 6.

7.

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients.

Volkmar M, Dedeurwaerder S, Cunha DA, Ndlovu MN, Defrance M, Deplus R, Calonne E, Volkmar U, Igoillo-Esteve M, Naamane N, Del Guerra S, Masini M, Bugliani M, Marchetti P, Cnop M, Eizirik DL, Fuks F.

EMBO J. 2012 Mar 21;31(6):1405-26. doi: 10.1038/emboj.2011.503. Epub 2012 Jan 31.

8.

Pancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammation.

Gurzov EN, Barthson J, Marhfour I, Ortis F, Naamane N, Igoillo-Esteve M, Gysemans C, Mathieu C, Kitajima S, Marchetti P, Ørntoft TF, Bakiri L, Wagner EF, Eizirik DL.

Oncogene. 2012 Mar 29;31(13):1723-32. doi: 10.1038/onc.2011.353. Epub 2011 Aug 15.

PMID:
21841823
9.

STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation.

Moore F, Naamane N, Colli ML, Bouckenooghe T, Ortis F, Gurzov EN, Igoillo-Esteve M, Mathieu C, Bontempi G, Thykjaer T, Ørntoft TF, Eizirik DL.

J Biol Chem. 2011 Jan 14;286(2):929-41. doi: 10.1074/jbc.M110.162131. Epub 2010 Oct 27.

10.

EuroDia: a beta-cell gene expression resource.

Liechti R, Csárdi G, Bergmann S, Schütz F, Sengstag T, Boj SF, Servitja JM, Ferrer J, Van Lommel L, Schuit F, Klinger S, Thorens B, Naamane N, Eizirik DL, Marselli L, Bugliani M, Marchetti P, Lucas S, Holm C, Jongeneel CV, Xenarios I.

Database (Oxford). 2010 Oct 12;2010:baq024. doi: 10.1093/database/baq024.

11.

Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells.

Ortis F, Naamane N, Flamez D, Ladrière L, Moore F, Cunha DA, Colli ML, Thykjaer T, Thorsen K, Orntoft TF, Eizirik DL.

Diabetes. 2010 Feb;59(2):358-74. doi: 10.2337/db09-1159. Epub 2009 Nov 23.

12.

Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells.

Ortis F, Pirot P, Naamane N, Kreins AY, Rasschaert J, Moore F, Théâtre E, Verhaeghe C, Magnusson NE, Chariot A, Orntoft TF, Eizirik DL.

Diabetologia. 2008 Jul;51(7):1213-25. doi: 10.1007/s00125-008-0999-7. Epub 2008 May 8.

13.

Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs.

Pirot P, Naamane N, Libert F, Magnusson NE, Ørntoft TF, Cardozo AK, Eizirik DL.

Diabetologia. 2007 May;50(5):1006-14. Epub 2007 Mar 1.

PMID:
17333111
14.

In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells.

Naamane N, van Helden J, Eizirik DL.

BMC Bioinformatics. 2007 Feb 15;8:55.

15.

New approaches for in silico identification of cytokine-modified beta cell gene networks.

Kutlu B, Naamane N, Berthou L, Eizirik DL.

Ann N Y Acad Sci. 2004 Dec;1037:41-58. Review.

PMID:
15699492

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