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Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis.
Charidemou E, Tsiarli MA, Theophanous A, Yilmaz V, Pitsouli C, Strati K, Griffin JL, Kirmizis A. Charidemou E, et al. BMC Biol. 2022 Jan 20;20(1):22. doi: 10.1186/s12915-021-01225-8. BMC Biol. 2022. PMID: 35057804 Free PMC article.
Here, we tested this notion by investigating the function of N-alpha-acetyltransferase 40 (NAA40), the enzyme responsible for N-terminal acetylation of histones H2A and H4, which has been previously implicated with metabolic-associated conditions such as age-dependent hepa …
Here, we tested this notion by investigating the function of N-alpha-acetyltransferase 40 (NAA40), the enzyme responsible for N-termi …
Histone N-terminal acetyltransferase NAA40 links one-carbon metabolism to chemoresistance.
Demetriadou C, Raoukka A, Charidemou E, Mylonas C, Michael C, Parekh S, Koufaris C, Skourides P, Papageorgis P, Tessarz P, Kirmizis A. Demetriadou C, et al. Oncogene. 2022 Jan;41(4):571-585. doi: 10.1038/s41388-021-02113-9. Epub 2021 Nov 16. Oncogene. 2022. PMID: 34785778 Free PMC article.
Specifically, NAA40 stimulates transcription of the one-carbon metabolic gene thymidylate synthase (TYMS), whose product is targeted by 5-fluorouracil (5-FU) and accordingly in primary CRC tumours NAA40 expression associates with TYMS levels and poorer 5-FU response …
Specifically, NAA40 stimulates transcription of the one-carbon metabolic gene thymidylate synthase (TYMS), whose product is targeted …
NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression.
Demetriadou C, Pavlou D, Mpekris F, Achilleos C, Stylianopoulos T, Zaravinos A, Papageorgis P, Kirmizis A. Demetriadou C, et al. Cell Death Dis. 2019 Mar 11;10(3):236. doi: 10.1038/s41419-019-1487-3. Cell Death Dis. 2019. PMID: 30858358 Free PMC article.
However, the role of NAA40 in CRC development was not investigated. Here, we show that NAA40 protein and mRNA levels are commonly increased in CRC primary tissues compared to non-malignant specimens. ...Moreover, the absence of NAA40 significantly delays the …
However, the role of NAA40 in CRC development was not investigated. Here, we show that NAA40 protein and mRNA levels are commo …
Identification of NAA40 as a Potential Prognostic Marker for Aggressive Liver Cancer Subtypes.
Koufaris C, Kirmizis A. Koufaris C, et al. Front Oncol. 2021 Jun 2;11:691950. doi: 10.3389/fonc.2021.691950. eCollection 2021. Front Oncol. 2021. PMID: 34150665 Free PMC article.
Accordingly, we observed that high NAA40 expression was associated with worse survival specifically in liver cancer patients with inactivated P53. These findings define NAA40 as a NAT with potentially oncogenic functions in LIHC and uncover its prognostic value for …
Accordingly, we observed that high NAA40 expression was associated with worse survival specifically in liver cancer patients with ina …
N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.
Jonckheere V, Van Damme P. Jonckheere V, et al. Int J Mol Sci. 2021 Apr 1;22(7):3690. doi: 10.3390/ijms22073690. Int J Mol Sci. 2021. PMID: 33916271 Free PMC article.
Interestingly, human Naa40(L) and Naa40(S) displayed differential expression and subcellular localization patterns by exhibiting a principal nuclear and cytoplasmic localization, respectively. Furthermore, Naa40(L) was shown to be N-terminally myristoylated a …
Interestingly, human Naa40(L) and Naa40(S) displayed differential expression and subcellular localization patterns by exhibiti …
Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway.
Pavlou D, Kirmizis A. Pavlou D, et al. Apoptosis. 2016 Mar;21(3):298-311. doi: 10.1007/s10495-015-1207-0. Apoptosis. 2016. PMID: 26666750 Free PMC article.
In the present study, we examine the role of Naa40 in cancer cell survival. We demonstrate that depletion of Naa40 in HCT116 and HT-29 colorectal cancer cells decreases cell survival by enhancing apoptosis, whereas Naa40 reduction in non-cancerous mouse embry …
In the present study, we examine the role of Naa40 in cancer cell survival. We demonstrate that depletion of Naa40 in HCT116 a …
Exploring the role of NAA40 in immune infiltrates and prognostic prediction in hepatocellular carcinoma.
Zhou T, Cao J, Tang Q, Jin J, Liang Y, Feng B. Zhou T, et al. Am J Clin Exp Immunol. 2024 Feb 25;13(1):26-34. eCollection 2024. Am J Clin Exp Immunol. 2024. PMID: 38496356 Free PMC article.
To address this, our study delved into the comprehensive analysis of NAA40 in the context of cancer. Our pan-cancer analysis unveiled elevated NAA40 expression in multiple tumor types, including BLCA, BRCA, CHOL, COAD, ESCA, HNSC, LIHC, LUAD, LUSC, STAD, and THCA. . …
To address this, our study delved into the comprehensive analysis of NAA40 in the context of cancer. Our pan-cancer analysis unveiled …
Cytosolic Genomic DNA functions as a Natural Antisense.
Asada K, Ito K, Yui D, Tagaya H, Yokota T. Asada K, et al. Sci Rep. 2018 Jun 4;8(1):8551. doi: 10.1038/s41598-018-26487-1. Sci Rep. 2018. PMID: 29867148 Free PMC article.
The overexpression of cg721 suppressed the complementary RNA expression using strand selection and knockdown of DNA/RNA hybrid R-loop removing enzyme RNase H and three prime repair exonuclease 1 TREX1 increased the expression levels of cg721 and thus, inhibited the target Naa4 …
The overexpression of cg721 suppressed the complementary RNA expression using strand selection and knockdown of DNA/RNA hybrid R-loop removi …
Effects of Oncohistone Mutations and PTM Crosstalk on the N-Terminal Acetylation Activities of NatD.
Ho YH, Huang R. Ho YH, et al. ACS Chem Biol. 2023 Apr 21;18(4):693-700. doi: 10.1021/acschembio.1c00840. Epub 2022 Jan 19. ACS Chem Biol. 2023. PMID: 35044762
Acetylation at the alpha-N-terminus (Nalpha) is the most abundant modification detected on histone H4 and H2A, which is catalyzed by N-terminal acetyltransferase D (NatD or NAA40). Histone H4 and H2A contain an identical N-terminal SGRGK sequence that is enriched with post …
Acetylation at the alpha-N-terminus (Nalpha) is the most abundant modification detected on histone H4 and H2A, which is catalyzed by N-termi …
16 results