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Novel 3D analysis using optical tissue clearing documents the evolution of murine rapidly progressive glomerulonephritis.

Puelles VG, Fleck D, Ortz L, Papadouri S, Strieder T, Böhner AMC, van der Wolde JW, Vogt M, Saritas T, Kuppe C, Fuss A, Menzel S, Klinkhammer BM, Müller-Newen G, Heymann F, Decker L, Braun F, Kretz O, Huber TB, Susaki EA, Ueda HR, Boor P, Floege J, Kramann R, Kurts C, Bertram JF, Spehr M, Nikolic-Paterson DJ, Moeller MJ.

Kidney Int. 2019 Mar 15. pii: S0085-2538(19)30318-7. doi: 10.1016/j.kint.2019.02.034. [Epub ahead of print]


Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis.

Han Y, Tian L, Ma F, Tesch G, Vesey DA, Gobe GC, Lohman RJ, Morais C, Suen JY, Fairlie DP, Nikolic-Paterson DJ.

Clin Exp Pharmacol Physiol. 2019 May;46(5):456-464. doi: 10.1111/1440-1681.13077. Epub 2019 Mar 25.


Macrophages: versatile players in renal inflammation and fibrosis.

Tang PM, Nikolic-Paterson DJ, Lan HY.

Nat Rev Nephrol. 2019 Mar;15(3):144-158. doi: 10.1038/s41581-019-0110-2. Epub 2019 Jan 28. Review.


ASK1 contributes to fibrosis and dysfunction in models of kidney disease.

Liles JT, Corkey BK, Notte GT, Budas GR, Lansdon EB, Hinojosa-Kirschenbaum F, Badal SS, Lee M, Schultz BE, Wise S, Pendem S, Graupe M, Castonguay L, Koch KA, Wong MH, Papalia GA, French DM, Sullivan T, Huntzicker EG, Ma FY, Nikolic-Paterson DJ, Altuhaifi T, Yang H, Fogo AB, Breckenridge DG.

J Clin Invest. 2018 Oct 1;128(10):4485-4500. doi: 10.1172/JCI99768. Epub 2018 Jul 19.


ASK1 inhibitor treatment suppresses p38/JNK signalling with reduced kidney inflammation and fibrosis in rat crescentic glomerulonephritis.

Amos LA, Ma FY, Tesch GH, Liles JT, Breckenridge DG, Nikolic-Paterson DJ, Han Y.

J Cell Mol Med. 2018 Sep;22(9):4522-4533. doi: 10.1111/jcmm.13705. Epub 2018 Jul 11.


An inhibitor of spleen tyrosine kinase suppresses experimental crescentic glomerulonephritis.

Han Y, Ma FY, Di Paolo J, Nikolic-Paterson DJ.

Int J Immunopathol Pharmacol. 2018 Jan-Dec;32:2058738418783404. doi: 10.1177/2058738418783404.


Editorial: Advances in Mechanisms of Renal Fibrosis.

Lan HY, Nikolic-Paterson DJ.

Front Physiol. 2018 Mar 23;9:284. doi: 10.3389/fphys.2018.00284. eCollection 2018. No abstract available.


Proximal tubular epithelial cells preferentially endocytose covalently-modified albumin compared to native albumin.

Ly ND, Tesch GH, Nikolic-Paterson DJ, Poronnik P.

Nephrology (Carlton). 2019 Jan;24(1):121-126. doi: 10.1111/nep.13211.


Cyclophilin D promotes tubular cell damage and the development of interstitial fibrosis in the obstructed kidney.

Hou W, Leong KG, Ozols E, Tesch GH, Nikolic-Paterson DJ, Ma FY.

Clin Exp Pharmacol Physiol. 2018 Mar;45(3):250-260. doi: 10.1111/1440-1681.12881. Epub 2017 Dec 12.


Reduced tubular degradation of glomerular filtered plasma albumin is a common feature in acute and chronic kidney disease.

Han Y, Ly NDK, Tesch GH, Poronnik P, Nikolic-Paterson DJ.

Clin Exp Pharmacol Physiol. 2018 Mar;45(3):241-249. doi: 10.1111/1440-1681.12878. Epub 2017 Nov 28.


The JNK Signaling Pathway in Renal Fibrosis.

Grynberg K, Ma FY, Nikolic-Paterson DJ.

Front Physiol. 2017 Oct 24;8:829. doi: 10.3389/fphys.2017.00829. eCollection 2017. Review.


A Model of Acute Antibody-Mediated Renal Allograft Rejection in the Sensitized Rata.

Chandran SR, Mulley WR, Kanellis J, Nikolic-Paterson DJ, Ma FY.

Exp Clin Transplant. 2018 Jun;16(3):294-300. doi: 10.6002/ect.2016.0316. Epub 2017 Jul 31.


Long-term graft survival in patients with chronic antibody-mediated rejection with persistent peritubular capillaritis treated with intravenous immunoglobulin and rituximab.

Mulley WR, Huang LL, Ramessur Chandran S, Longano A, Amos LAR, Polkinghorne KR, Nikolic-Paterson DJ, Kanellis J.

Clin Transplant. 2017 Sep;31(9). doi: 10.1111/ctr.13037. Epub 2017 Jul 13.


Inhibition of Spleen Tyrosine Kinase Reduces Renal Allograft Injury in a Rat Model of Acute Antibody-Mediated Rejection in Sensitized Recipients.

Ramessur Chandran S, Han Y, Tesch GH, Di Paolo J, Mulley WR, Kanellis J, Ma FY, Nikolic-Paterson DJ.

Transplantation. 2017 Aug;101(8):e240-e248. doi: 10.1097/TP.0000000000001826.


Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury.

Wang YY, Jiang H, Pan J, Huang XR, Wang YC, Huang HF, To KF, Nikolic-Paterson DJ, Lan HY, Chen JH.

J Am Soc Nephrol. 2017 Jul;28(7):2053-2067. doi: 10.1681/ASN.2016050573. Epub 2017 Feb 16.


Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis.

Meng XM, Wang S, Huang XR, Yang C, Xiao J, Zhang Y, To KF, Nikolic-Paterson DJ, Lan HY.

Cell Death Dis. 2016 Dec 1;7(12):e2495. doi: 10.1038/cddis.2016.402.


Matrix metalloproteinase-12 deficiency attenuates experimental crescentic anti-glomerular basement membrane glomerulonephritis.

Abraham AP, Ma FY, Mulley WR, Nikolic-Paterson DJ, Tesch GH.

Nephrology (Carlton). 2018 Feb;23(2):183-189. doi: 10.1111/nep.12964.


Spleen Tyrosine Kinase Signaling Promotes Myeloid Cell Recruitment and Kidney Damage after Renal Ischemia/Reperfusion Injury.

Ryan J, Kanellis J, Blease K, Ma FY, Nikolic-Paterson DJ.

Am J Pathol. 2016 Aug;186(8):2032-2042. doi: 10.1016/j.ajpath.2016.04.007. Epub 2016 Jun 17.


ASK1: a new therapeutic target for kidney disease.

Tesch GH, Ma FY, Nikolic-Paterson DJ.

Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F373-81. doi: 10.1152/ajprenal.00208.2016. Epub 2016 May 25. Review.


TGF-β: the master regulator of fibrosis.

Meng XM, Nikolic-Paterson DJ, Lan HY.

Nat Rev Nephrol. 2016 Jun;12(6):325-38. doi: 10.1038/nrneph.2016.48. Epub 2016 Apr 25. Review.


Validation of a Three-Dimensional Method for Counting and Sizing Podocytes in Whole Glomeruli.

Puelles VG, van der Wolde JW, Schulze KE, Short KM, Wong MN, Bensley JG, Cullen-McEwen LA, Caruana G, Hokke SN, Li J, Firth SD, Harper IS, Nikolic-Paterson DJ, Bertram JF.

J Am Soc Nephrol. 2016 Oct;27(10):3093-3104. Epub 2016 Mar 14.


Targeting c-fms kinase attenuates chronic aristolochic acid nephropathy in mice.

Dai XY, Huang XR, Zhou L, Zhang L, Fu P, Manthey C, Nikolic-Paterson DJ, Lan HY.

Oncotarget. 2016 Mar 8;7(10):10841-56. doi: 10.18632/oncotarget.7460.


A role for spleen tyrosine kinase in renal fibrosis in the mouse obstructed kidney.

Ma FY, Blease K, Nikolic-Paterson DJ.

Life Sci. 2016 Feb 1;146:192-200. doi: 10.1016/j.lfs.2016.01.023. Epub 2016 Jan 15.


Suppression of Rapidly Progressive Mouse Glomerulonephritis with the Non-Steroidal Mineralocorticoid Receptor Antagonist BR-4628.

Ma FY, Han Y, Nikolic-Paterson DJ, Kolkhof P, Tesch GH.

PLoS One. 2015 Dec 23;10(12):e0145666. doi: 10.1371/journal.pone.0145666. eCollection 2015.


TGF-β/Smad3 signalling regulates the transition of bone marrow-derived macrophages into myofibroblasts during tissue fibrosis.

Wang S, Meng XM, Ng YY, Ma FY, Zhou S, Zhang Y, Yang C, Huang XR, Xiao J, Wang YY, Ka SM, Tang YJ, Chung AC, To KF, Nikolic-Paterson DJ, Lan HY.

Oncotarget. 2016 Feb 23;7(8):8809-22. doi: 10.18632/oncotarget.6604.


Methods in renal research: kidney transplantation in the rat.

Tillou X, Howden BO, Kanellis J, Nikolic-Paterson DJ, Ma FY.

Nephrology (Carlton). 2016 Jun;21(6):451-6. doi: 10.1111/nep.12697. Review.


Cathepsin S-Dependent Protease-Activated Receptor-2 Activation: A New Mechanism of Endothelial Dysfunction.

Nikolic-Paterson DJ.

J Am Soc Nephrol. 2016 Jun;27(6):1577-9. doi: 10.1681/ASN.2015101162. Epub 2015 Nov 20. No abstract available.


Macrophages promote renal fibrosis through direct and indirect mechanisms.

Nikolic-Paterson DJ, Wang S, Lan HY.

Kidney Int Suppl (2011). 2014 Nov;4(1):34-38. Review.


Myeloid cell-mediated renal injury in rapidly progressive glomerulonephritis depends upon spleen tyrosine kinase.

Ryan J, Ma FY, Han Y, Ozols E, Kanellis J, Tesch GH, Nikolic-Paterson DJ.

J Pathol. 2016 Jan;238(1):10-20. doi: 10.1002/path.4598. Epub 2015 Sep 22.


The Smad3/Smad4/CDK9 complex promotes renal fibrosis in mice with unilateral ureteral obstruction.

Qu X, Jiang M, Sun YB, Jiang X, Fu P, Ren Y, Wang D, Dai L, Caruana G, Bertram JF, Nikolic-Paterson DJ, Li J.

Kidney Int. 2015 Dec;88(6):1323-1335. doi: 10.1038/ki.2015.235. Epub 2015 Jul 29.


Renal physiology: The proximal tubule and albuminuria—at last a starring role.

Poronnik P, Nikolic-Paterson DJ.

Nat Rev Nephrol. 2015 Oct;11(10):573-5. doi: 10.1038/nrneph.2015.127. Epub 2015 Jul 28. No abstract available.


ASK1 Inhibitor Halts Progression of Diabetic Nephropathy in Nos3-Deficient Mice.

Tesch GH, Ma FY, Han Y, Liles JT, Breckenridge DG, Nikolic-Paterson DJ.

Diabetes. 2015 Nov;64(11):3903-13. doi: 10.2337/db15-0384. Epub 2015 Jul 15.


Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance.

Sun YB, Qu X, Howard V, Dai L, Jiang X, Ren Y, Fu P, Puelles VG, Nikolic-Paterson DJ, Caruana G, Bertram JF, Sleeman MW, Li J.

Kidney Int. 2015 Aug;88(2):286-98. doi: 10.1038/ki.2015.121. Epub 2015 May 6.


Chloride channel ClC-5 binds to aspartyl aminopeptidase to regulate renal albumin endocytosis.

Lee A, Slattery C, Nikolic-Paterson DJ, Hryciw DH, Wilk S, Wilk E, Zhang Y, Valova VA, Robinson PJ, Kelly DJ, Poronnik P.

Am J Physiol Renal Physiol. 2015 Apr 1;308(7):F784-92. doi: 10.1152/ajprenal.00322.2014. Epub 2015 Jan 13.


Spleen tyrosine kinase contributes to acute renal allograft rejection in the rat.

Ramessur Chandran S, Tesch GH, Han Y, Woodman N, Mulley WR, Kanellis J, Blease K, Ma FY, Nikolic-Paterson DJ.

Int J Exp Pathol. 2015 Feb;96(1):54-62. doi: 10.1111/iep.12110. Epub 2014 Dec 22.


Alternatively activated macrophages in the pathogenesis of chronic kidney allograft injury.

Ikezumi Y, Suzuki T, Yamada T, Hasegawa H, Kaneko U, Hara M, Yanagihara T, Nikolic-Paterson DJ, Saitoh A.

Pediatr Nephrol. 2015 Jun;30(6):1007-17. doi: 10.1007/s00467-014-3023-0. Epub 2014 Dec 9.


ASK1/p38 signaling in renal tubular epithelial cells promotes renal fibrosis in the mouse obstructed kidney.

Ma FY, Tesch GH, Nikolic-Paterson DJ.

Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1263-73. doi: 10.1152/ajprenal.00211.2014. Epub 2014 Oct 8.


Induction monotherapy with sirolimus has selected beneficial effects on glomerular and tubulointersititial injury in nephrotoxic serum nephritis.

Succar L, Lai-Kwon J, Nikolic-Paterson DJ, Rangan GK.

Int J Nephrol Renovasc Dis. 2014 Jul 18;7:303-13. doi: 10.2147/IJNRD.S64202. eCollection 2014.


Inflammatory processes in renal fibrosis.

Meng XM, Nikolic-Paterson DJ, Lan HY.

Nat Rev Nephrol. 2014 Sep;10(9):493-503. doi: 10.1038/nrneph.2014.114. Epub 2014 Jul 1. Review.


Myeloid mineralocorticoid receptor activation contributes to progressive kidney disease.

Huang LL, Nikolic-Paterson DJ, Han Y, Ozols E, Ma FY, Young MJ, Tesch GH.

J Am Soc Nephrol. 2014 Oct;25(10):2231-40. doi: 10.1681/ASN.2012111094. Epub 2014 Apr 3.


Regulation of renal fibrosis by Smad3 Thr388 phosphorylation.

Qu X, Li X, Zheng Y, Ren Y, Puelles VG, Caruana G, Nikolic-Paterson DJ, Li J.

Am J Pathol. 2014 Apr;184(4):944-952. doi: 10.1016/j.ajpath.2013.12.003. Epub 2014 Jan 30.


Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney.

Sun YB, Qu X, Li X, Nikolic-Paterson DJ, Li J.

PLoS One. 2013 Dec 31;8(12):e84063. doi: 10.1371/journal.pone.0084063. eCollection 2013.


Macrophages contribute to cellular but not humoral mechanisms of acute rejection in rat renal allografts.

Ma FY, Woodman N, Mulley WR, Kanellis J, Nikolic-Paterson DJ.

Transplantation. 2013 Dec 15;96(11):949-57. doi: 10.1097/TP.0b013e3182a4befa.


The role of macrophage migration inhibitory factor in autoimmune liver disease.

Assis DN, Leng L, Du X, Zhang CK, Grieb G, Merk M, Garcia AB, McCrann C, Chapiro J, Meinhardt A, Mizue Y, Nikolic-Paterson DJ, Bernhagen J, Kaplan MM, Zhao H, Boyer JL, Bucala R.

Hepatology. 2014 Feb;59(2):580-91. doi: 10.1002/hep.26664. Epub 2013 Dec 20.


Resolvin D1 protects podocytes in adriamycin-induced nephropathy through modulation of 14-3-3β acetylation.

Zhang X, Qu X, Sun YB, Caruana G, Bertram JF, Nikolic-Paterson DJ, Li J.

PLoS One. 2013 Jun 28;8(6):e67471. doi: 10.1371/journal.pone.0067471. Print 2013.


Role of macrophages in the fibrotic phase of rat crescentic glomerulonephritis.

Han Y, Ma FY, Tesch GH, Manthey CL, Nikolic-Paterson DJ.

Am J Physiol Renal Physiol. 2013 Apr 15;304(8):F1043-53. doi: 10.1152/ajprenal.00389.2012. Epub 2013 Feb 13.


Aldosterone induces kidney fibroblast proliferation via activation of growth factor receptors and PI3K/MAPK signalling.

Huang LL, Nikolic-Paterson DJ, Ma FY, Tesch GH.

Nephron Exp Nephrol. 2012;120(4):e115-22. doi: 10.1159/000339500. Epub 2012 Jul 18.


Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction.

Summers SA, Gan PY, Dewage L, Ma FT, Ooi JD, O'Sullivan KM, Nikolic-Paterson DJ, Kitching AR, Holdsworth SR.

Kidney Int. 2012 Sep;82(6):676-85. doi: 10.1038/ki.2012.211. Epub 2012 Jun 6.


Resolvins E1 and D1 inhibit interstitial fibrosis in the obstructed kidney via inhibition of local fibroblast proliferation.

Qu X, Zhang X, Yao J, Song J, Nikolic-Paterson DJ, Li J.

J Pathol. 2012 Dec;228(4):506-19. doi: 10.1002/path.4050. Epub 2012 Nov 6.


Macrophage infiltration and renal damage are independent of matrix metalloproteinase 12 in the obstructed kidney.

Abraham AP, Ma FY, Mulley WR, Ozols E, Nikolic-Paterson DJ.

Nephrology (Carlton). 2012 May;17(4):322-9. doi: 10.1111/j.1440-1797.2012.01567.x.


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