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Items: 1 to 50 of 149

1.

MerCASBA: an updated and refined database of caspase substrates.

Fridman A, Pak I, Butts BD, Hoek M, Nicholson DW, Mehmet H.

Apoptosis. 2013 Mar;18(3):369-71. doi: 10.1007/s10495-012-0789-z. No abstract available.

PMID:
23334582
2.

Lung eQTLs to help reveal the molecular underpinnings of asthma.

Hao K, Bossé Y, Nickle DC, Paré PD, Postma DS, Laviolette M, Sandford A, Hackett TL, Daley D, Hogg JC, Elliott WM, Couture C, Lamontagne M, Brandsma CA, van den Berge M, Koppelman G, Reicin AS, Nicholson DW, Malkov V, Derry JM, Suver C, Tsou JA, Kulkarni A, Zhang C, Vessey R, Opiteck GJ, Curtis SP, Timens W, Sin DD.

PLoS Genet. 2012;8(11):e1003029. doi: 10.1371/journal.pgen.1003029. Epub 2012 Nov 29. Erratum in: PLoS Genet. 2012 Dec;8(12). doi: 10.1371/annotation/80d53ac6-4f5d-4c34-b92b-3fec00d514ac.

3.

Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment.

Gallant M, Aspiotis R, Day S, Dias R, Dubé D, Dubé L, Friesen RW, Girard M, Guay D, Hamel P, Huang Z, Lacombe P, Laliberté S, Lévesque JF, Liu S, Macdonald D, Mancini J, Nicholson DW, Styhler A, Townson K, Waters K, Young RN, Girard Y.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6387-93. doi: 10.1016/j.bmcl.2010.09.087. Epub 2010 Sep 21.

PMID:
20933411
4.

The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors.

Aspiotis R, Deschênes D, Dubé D, Girard Y, Huang Z, Laliberté F, Liu S, Papp R, Nicholson DW, Young RN.

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5502-5. doi: 10.1016/j.bmcl.2010.07.076. Epub 2010 Jul 21.

PMID:
20709547
5.

Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors.

Lacombe P, Chauret N, Claveau D, Day S, Deschênes D, Dubé D, Gallant M, Girard Y, Huang Z, Laliberté F, Lévesque JF, Liu S, Macdonald D, Mancini JA, Masson P, Nicholson DW, Nicoll-Griffith DA, Salem M, Styhler A, Young RN.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):5266-9. doi: 10.1016/j.bmcl.2009.03.105. Epub 2009 Mar 26.

PMID:
19640717
6.

Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection.

Yeretssian G, Doiron K, Shao W, Leavitt BR, Hayden MR, Nicholson DW, Saleh M.

Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9016-20. doi: 10.1073/pnas.0813362106. Epub 2009 May 15.

7.

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G.

Cell Death Differ. 2009 Aug;16(8):1093-107. doi: 10.1038/cdd.2009.44. Epub 2009 Apr 17. Review.

8.

Neuroscience: Good and bad cell death.

Nicholson DW.

Nature. 2009 Feb 19;457(7232):970-1. doi: 10.1038/457970a. No abstract available.

PMID:
19225511
9.

Huntingtin interacting protein 1 can regulate neurogenesis in Drosophila.

Moores JN, Roy S, Nicholson DW, Staveley BE.

Eur J Neurosci. 2008 Aug;28(3):599-609. doi: 10.1111/j.1460-9568.2008.06359.x.

PMID:
18702731
10.

Confinement of caspase-12 proteolytic activity to autoprocessing.

Roy S, Sharom JR, Houde C, Loisel TP, Vaillancourt JP, Shao W, Saleh M, Nicholson DW.

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4133-8. doi: 10.1073/pnas.0706658105. Epub 2008 Mar 10. Erratum in: Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4852. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):2047.

11.

L-454,560, a potent and selective PDE4 inhibitor with in vivo efficacy in animal models of asthma and cognition.

Huang Z, Dias R, Jones T, Liu S, Styhler A, Claveau D, Otu F, Ng K, Laliberte F, Zhang L, Goetghebeur P, Abraham WM, Macdonald D, Dubé D, Gallant M, Lacombe P, Girard Y, Young RN, Turner MJ, Nicholson DW, Mancini JA.

Biochem Pharmacol. 2007 Jun 15;73(12):1971-81. Epub 2007 Mar 16.

PMID:
17428447
12.

Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.

Isabel E, Aspiotis R, Black WC, Colucci J, Fortin R, Giroux A, Grimm EL, Han Y, Mellon C, Nicholson DW, Rasper DM, Renaud J, Roy S, Tam J, Tawa P, Vaillancourt JP, Xanthoudakis S, Zamboni RJ.

Bioorg Med Chem Lett. 2007 Mar 15;17(6):1671-4. Epub 2007 Jan 11.

PMID:
17251019
13.

Apoptosis and caspases regulate death and inflammation in sepsis.

Hotchkiss RS, Nicholson DW.

Nat Rev Immunol. 2006 Nov;6(11):813-22. Epub 2006 Oct 13. Review.

PMID:
17039247
14.

Hippi is essential for node cilia assembly and Sonic hedgehog signaling.

Houde C, Dickinson RJ, Houtzager VM, Cullum R, Montpetit R, Metzler M, Simpson EM, Roy S, Hayden MR, Hoodless PA, Nicholson DW.

Dev Biol. 2006 Dec 15;300(2):523-33. Epub 2006 Sep 9.

15.
16.

Peripheral phosphodiesterase 4 inhibition produced by 4-[2-(3,4-Bis-difluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]-3-methylpyridine-1-oxide (L-826,141) prevents experimental autoimmune encephalomyelitis.

Moore CS, Earl N, Frenette R, Styhler A, Mancini JA, Nicholson DW, Hebb AL, Owens T, Robertson GS.

J Pharmacol Exp Ther. 2006 Oct;319(1):63-72. Epub 2006 Jun 29.

PMID:
16809479
17.

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.

Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, Warby SC, Doty CN, Roy S, Wellington CL, Leavitt BR, Raymond LA, Nicholson DW, Hayden MR.

Cell. 2006 Jun 16;125(6):1179-91.

18.

Caspase-3 cleaved spectrin colocalizes with neurofilament-immunoreactive neurons in Alzheimer's disease.

Ayala-Grosso C, Tam J, Roy S, Xanthoudakis S, Da Costa D, Nicholson DW, Robertson GS.

Neuroscience. 2006 Aug 25;141(2):863-74. Epub 2006 Jun 5.

PMID:
16750894
19.

Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice.

Saleh M, Mathison JC, Wolinski MK, Bensinger SJ, Fitzgerald P, Droin N, Ulevitch RJ, Green DR, Nicholson DW.

Nature. 2006 Apr 20;440(7087):1064-8. Erratum in: Nature. 2014 Apr 10;508(7495):274.

PMID:
16625199
20.

Correlating the fractional inhibition of caspase-3 in NT2 cells with apoptotic markers using an active-caspase-3 enzyme-linked immunosorbent assay.

Tawa P, Giroux A, Grimm E, Han Y, Nicholson DW, Xanthoudakis S.

Anal Biochem. 2006 Mar 1;350(1):32-40. Epub 2005 Dec 21.

PMID:
16430849
21.

Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.

Mellon C, Aspiotis R, Black CW, Bayly CI, Grimm EL, Giroux A, Han Y, Isabel E, McKay DJ, Nicholson DW, Rasper DM, Roy S, Tam J, Thornberry NA, Vaillancourt JP, Xanthoudakis S, Zamboni R.

Bioorg Med Chem Lett. 2005 Sep 1;15(17):3886-90.

PMID:
16023344
22.

Axonal dynactin p150Glued transports caspase-8 to drive retrograde olfactory receptor neuron apoptosis.

Carson C, Saleh M, Fung FW, Nicholson DW, Roskams AJ.

J Neurosci. 2005 Jun 29;25(26):6092-104.

23.

Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.

Han Y, Giroux A, Colucci J, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt J, Rasper DM, Tam J, Tawa P, Nicholson DW, Zamboni RJ.

Bioorg Med Chem Lett. 2005 Feb 15;15(4):1173-80.

PMID:
15686936
24.

Caspase-7 expanded function and intrinsic expression level underlies strain-specific brain phenotype of caspase-3-null mice.

Houde C, Banks KG, Coulombe N, Rasper D, Grimm E, Roy S, Simpson EM, Nicholson DW.

J Neurosci. 2004 Nov 3;24(44):9977-84.

25.

Differential regulation of caspase-3 by pharmacological and developmental stimuli as demonstrated using humanised caspase-3 mice.

Kerr LE, Birse-Archbold JL, Simon A, Logan N, Scott F, Carlson G, Nicholson DW, Kelly JS, Sharkey J.

Apoptosis. 2004 Nov;9(6):739-47.

PMID:
15505416
26.

Effects of fimbria-fornix transection on calpain and choline acetyl transferase activities in the septohippocampal pathway.

Ayala-Grosso C, Tam J, Xanthoudakis S, Bureau Y, Roy S, Nicholson DW, Robertson GS.

Neuroscience. 2004;126(4):927-40.

PMID:
15207327
27.

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.

Saleh M, Vaillancourt JP, Graham RK, Huyck M, Srinivasula SM, Alnemri ES, Steinberg MH, Nolan V, Baldwin CT, Hotchkiss RS, Buchman TG, Zehnbauer BA, Hayden MR, Farrer LA, Roy S, Nicholson DW.

Nature. 2004 May 6;429(6987):75-9.

28.

Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.

Becker JW, Rotonda J, Soisson SM, Aspiotis R, Bayly C, Francoeur S, Gallant M, Garcia-Calvo M, Giroux A, Grimm E, Han Y, McKay D, Nicholson DW, Peterson E, Renaud J, Roy S, Thornberry N, Zamboni R.

J Med Chem. 2004 May 6;47(10):2466-74.

PMID:
15115390
29.
30.

A caspase active site probe reveals high fractional inhibition needed to block DNA fragmentation.

Méthot N, Vaillancourt JP, Huang J, Colucci J, Han Y, Ménard S, Zamboni R, Toulmond S, Nicholson DW, Roy S.

J Biol Chem. 2004 Jul 2;279(27):27905-14. Epub 2004 Apr 5.

31.

Solid phase synthesis of selective caspase-3 peptide inhibitors.

Grimm EL, Roy B, Aspiotis R, Bayly CI, Nicholson DW, Rasper DM, Renaud J, Roy S, Tam J, Tawa P, Vaillancourt JP, Xanthoudakis S, Zamboni RJ.

Bioorg Med Chem. 2004 Mar 1;12(5):845-51.

PMID:
14980595
32.

Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease.

Toulmond S, Tang K, Bureau Y, Ashdown H, Degen S, O'Donnell R, Tam J, Han Y, Colucci J, Giroux A, Zhu Y, Boucher M, Pikounis B, Xanthoudakis S, Roy S, Rigby M, Zamboni R, Robertson GS, Ng GY, Nicholson DW, Flückiger JP.

Br J Pharmacol. 2004 Feb;141(4):689-97. Epub 2004 Jan 26.

33.

Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.

Han Y, Giroux A, Grimm EL, Aspiotis R, Francoeur S, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt JP, Rasper DM, Tam J, Tawa P, Thornberry NA, Paterson EP, Garcia-Calvo M, Becker JW, Rotonda J, Nicholson DW, Zamboni RJ.

Bioorg Med Chem Lett. 2004 Feb 9;14(3):805-8.

PMID:
14741294
34.

Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics.

Méthot N, Huang J, Coulombe N, Vaillancourt JP, Rasper D, Tam J, Han Y, Colucci J, Zamboni R, Xanthoudakis S, Toulmond S, Nicholson DW, Roy S.

J Exp Med. 2004 Jan 19;199(2):199-207. Epub 2004 Jan 12.

35.

Catalytic activity of caspase-3 is required for its degradation: stabilization of the active complex by synthetic inhibitors.

Tawa P, Hell K, Giroux A, Grimm E, Han Y, Nicholson DW, Xanthoudakis S.

Cell Death Differ. 2004 Apr;11(4):439-47.

36.

Substrate cleavage by caspases generates protein fragments with Smac/Diablo-like activities.

Hell K, Saleh M, Crescenzo GD, O'Connor-McCourt MD, Nicholson DW.

Cell Death Differ. 2003 Nov;10(11):1234-9.

37.

Nicotinyl aspartyl ketones as inhibitors of caspase-3.

Isabel E, Black WC, Bayly CI, Grimm EL, Janes MK, McKay DJ, Nicholson DW, Rasper DM, Renaud J, Roy S, Tam J, Thornberry NA, Vaillancourt JP, Xanthoudakis S, Zamboni R.

Bioorg Med Chem Lett. 2003 Jul 7;13(13):2137-40.

PMID:
12798321
38.

The cell adhesion molecule CEACAM1-L is a substrate of caspase-3-mediated cleavage in apoptotic mouse intestinal cells.

Houde C, Roy S, Leung N, Nicholson DW, Beauchemin N.

J Biol Chem. 2003 May 9;278(19):16929-35. Epub 2003 Mar 11.

39.

Apoptosis. Life and death decisions.

Nicholson DW, Thornberry NA.

Science. 2003 Jan 10;299(5604):214-5. No abstract available.

PMID:
12522239
40.

Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2.

Sawyer N, Cauchon E, Chateauneuf A, Cruz RP, Nicholson DW, Metters KM, O'Neill GP, Gervais FG.

Br J Pharmacol. 2002 Dec;137(8):1163-72.

41.

NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa B.

Cogswell PC, Kashatus DF, Keifer JA, Guttridge DC, Reuther JY, Bristow C, Roy S, Nicholson DW, Baldwin AS Jr.

J Biol Chem. 2003 Jan 31;278(5):2963-8. Epub 2002 Nov 13.

42.

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome.

Marsden VS, O'Connor L, O'Reilly LA, Silke J, Metcalf D, Ekert PG, Huang DC, Cecconi F, Kuida K, Tomaselli KJ, Roy S, Nicholson DW, Vaux DL, Bouillet P, Adams JM, Strasser A.

Nature. 2002 Oct 10;419(6907):634-7. Epub 2002 Sep 25.

PMID:
12374983
43.

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR.

J Neurosci. 2002 Sep 15;22(18):7862-72.

44.

The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex.

Micheau O, Thome M, Schneider P, Holler N, Tschopp J, Nicholson DW, Briand C, Grütter MG.

J Biol Chem. 2002 Nov 22;277(47):45162-71. Epub 2002 Sep 4.

45.

Cleavage of plasma membrane calcium pumps by caspases: a link between apoptosis and necrosis.

Schwab BL, Guerini D, Didszun C, Bano D, Ferrando-May E, Fava E, Tam J, Xu D, Xanthoudakis S, Nicholson DW, Carafoli E, Nicotera P.

Cell Death Differ. 2002 Aug;9(8):818-31.

46.

Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury.

Han BH, Xu D, Choi J, Han Y, Xanthoudakis S, Roy S, Tam J, Vaillancourt J, Colucci J, Siman R, Giroux A, Robertson GS, Zamboni R, Nicholson DW, Holtzman DM.

J Biol Chem. 2002 Aug 16;277(33):30128-36. Epub 2002 Jun 10.

47.

Caspase inhibitors attenuate 1-methyl-4-phenylpyridinium toxicity in primary cultures of mesencephalic dopaminergic neurons.

Bilsland J, Roy S, Xanthoudakis S, Nicholson DW, Han Y, Grimm E, Hefti F, Harper SJ.

J Neurosci. 2002 Apr 1;22(7):2637-49.

48.

Effects of finasteride on apoptosis and regulation of the human hair cycle.

Sawaya ME, Blume-Peytavi U, Mullins DL, Nusbaum BP, Whiting D, Nicholson DW, Lotocki G, Keane RW.

J Cutan Med Surg. 2002 Jan-Feb;6(1):1-9. Epub 2002 Jan 9.

PMID:
11896416
49.

The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7.

Maier JK, Lahoua Z, Gendron NH, Fetni R, Johnston A, Davoodi J, Rasper D, Roy S, Slack RS, Nicholson DW, MacKenzie AE.

J Neurosci. 2002 Mar 15;22(6):2035-43.

50.

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.

Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW.

Nat Cell Biol. 2002 Feb;4(2):95-105.

PMID:
11788820

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