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Items: 1 to 50 of 274

1.
2.

Lipid remodeling in mouse liver and plasma resulting from delta6 fatty acid desaturase inhibition.

Duffin KL, Obukowicz MG, Salsgiver WJ, Welsch DJ, Shieh C, Raz A, Needleman P.

Lipids. 2001 Nov;36(11):1203-8.

PMID:
11795852
3.

Anti-inflammatories for cardiovascular disease.

Masferrer JL, Needleman P.

Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12400-1. Review. No abstract available.

4.
5.

Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice.

Obukowicz M, Welsch D, Salsgiver W, Martin-Berger C, Chinn K, Duffin K, Raz A, Needleman P.

Lipids. 1999;34 Suppl:S149. No abstract available.

PMID:
10419129
6.

COX-2 inhibitors--is there cause for concern?

Seibert K, Lefkowith J, Tripp C, Isakson P, Needleman P.

Nat Med. 1999 Jun;5(6):621-2. No abstract available.

PMID:
10371498
7.

Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice.

Obukowicz MG, Welsch DJ, Salsgiver WJ, Martin-Berger CL, Chinn KS, Duffin KL, Raz A, Needleman P.

J Pharmacol Exp Ther. 1998 Oct;287(1):157-66.

PMID:
9765335
8.

Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent.

Obukowicz MG, Raz A, Pyla PD, Rico JG, Wendling JM, Needleman P.

Biochem Pharmacol. 1998 Apr 1;55(7):1045-58.

PMID:
9605428
9.

Non-steroidal anti-inflammatory drug-induced renal failure: a brief review of the role of cyclo-oxygenase isoforms.

Venturini CM, Isakson P, Needleman P.

Curr Opin Nephrol Hypertens. 1998 Jan;7(1):79-82. Review.

PMID:
9442367
10.

The discovery and function of COX-2.

Needleman P, Isakson PC.

J Rheumatol Suppl. 1997 Jul;49:6-8. Review. No abstract available.

PMID:
9249644
11.

Pharmacological manipulation of cyclo-oxygenase-2 in the inflamed hydronephrotic kidney.

Seibert K, Masferrer JL, Needleman P, Salvemini D.

Br J Pharmacol. 1996 Mar;117(6):1016-20.

12.

Nitric Oxide Activates the Cyclooxygenase Pathway in Inflammation.

Salvemini D, Seibert K, Masferrer JL, Settle SL, Currie MG, Needleman P.

Am J Ther. 1995 Sep;2(9):616-619. No abstract available.

PMID:
11854836
13.

Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors.

Salvemini D, Manning PT, Zweifel BS, Seibert K, Connor J, Currie MG, Needleman P, Masferrer JL.

J Clin Invest. 1995 Jul;96(1):301-8.

14.

Regulation of prostaglandin production by nitric oxide; an in vivo analysis.

Salvemini D, Settle SL, Masferrer JL, Seibert K, Currie MG, Needleman P.

Br J Pharmacol. 1995 Mar;114(6):1171-8.

15.

Discovery of a better aspirin.

Isakson P, Seibert K, Masferrer J, Salvemini D, Lee L, Needleman P.

Adv Prostaglandin Thromboxane Leukot Res. 1995;23:49-54. Review. No abstract available.

PMID:
7732896
16.

Nitric oxide and the cyclooxygenase pathway.

Salvemini D, Seibert K, Masferrer JL, Settle SL, Misko TP, Currie MG, Needleman P.

Adv Prostaglandin Thromboxane Leukot Res. 1995;23:491-3. No abstract available.

PMID:
7537440
17.

In vivo glucocorticoids regulate cyclooxygenase-2 but not cyclooxygenase-1 in peritoneal macrophages.

Masferrer JL, Reddy ST, Zweifel BS, Seibert K, Needleman P, Gilbert RS, Herschman HR.

J Pharmacol Exp Ther. 1994 Sep;270(3):1340-4.

PMID:
7932188
18.

Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation.

Salvemini D, Seibert K, Masferrer JL, Misko TP, Currie MG, Needleman P.

J Clin Invest. 1994 May;93(5):1940-7.

19.

Nitric oxide activates cyclooxygenase enzymes.

Salvemini D, Misko TP, Masferrer JL, Seibert K, Currie MG, Needleman P.

Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7240-4.

20.

Cytokine modulation of immune activation associated suppression of macrophage cyclooxygenase activity in vivo.

Beckerman KP, Schreiber RD, Needleman P.

Prostaglandins Leukot Essent Fatty Acids. 1992 Nov;47(3):231-8.

PMID:
1475281
21.

Processing of atriopeptin prohormone by nonmyocytic atrial cells.

Greenwald JE, Needleman P, Siegel N, Tetens E, Biel B, Ritter D.

Biochem Biophys Res Commun. 1992 Oct 30;188(2):644-54.

PMID:
1445310
22.

Localization, synthetic regulation, and biology of renal atriopeptin-like prohormone.

Ritter D, Chao J, Needleman P, Tetens E, Greenwald JE.

Am J Physiol. 1992 Sep;263(3 Pt 2):F503-9.

PMID:
1357979
23.

Distribution and characterization of cyclooxygenase immunoreactivity in the ovine brain.

Breder CD, Smith WL, Raz A, Masferrer J, Seibert K, Needleman P, Saper CB.

J Comp Neurol. 1992 Aug 15;322(3):409-38.

PMID:
1517485
24.

Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme.

Masferrer JL, Seibert K, Zweifel B, Needleman P.

Proc Natl Acad Sci U S A. 1992 May 1;89(9):3917-21.

25.

Localization of brain and atrial natriuretic peptide in human and porcine heart.

Pucci A, Wharton J, Arbustini E, Grasso M, Diegoli M, Needleman P, ViganĂ² M, Moscoso G, Polak JM.

Int J Cardiol. 1992 Mar;34(3):237-47.

PMID:
1532953
26.

Effect of pharmacological manipulation of endogenous atriopeptin activity on renal function.

Wilkins MR, Needleman P.

Am J Physiol. 1992 Feb;262(2 Pt 2):F161-7. Review.

PMID:
1311520
27.

Atrial amyloid deposits in the failing human heart display both atrial and brain natriuretic peptide-like immunoreactivity.

Pucci A, Wharton J, Arbustini E, Grasso M, Diegoli M, Needleman P, ViganĂ² M, Polak JM.

J Pathol. 1991 Nov;165(3):235-41.

PMID:
1837051
28.

Origin of porcine brain natriuretic peptide-like immunoreactive innervation of the middle cerebral artery in the rat.

Spencer SE, Kibbe MR, Hurley KM, Needleman P, Saper CB.

Neurosci Lett. 1991 Jul 22;128(2):217-20.

PMID:
1834966
29.

Post-translational processing and secretory pathway of human atriopeptin in rat pheochromocytoma cells.

Shiono S, Suganuma N, Bo M, Boime I, Seibert K, Nakao K, Mukoyama M, Imura H, Needleman P.

Biochem Biophys Res Commun. 1991 May 15;176(3):1232-8.

PMID:
1828150
30.

Renal synthesis of atriopeptin-like protein in physiology and pathophysiology.

Greenwald JE, Needleman P, Wilkins MR, Schreiner GF.

Am J Physiol. 1991 Apr;260(4 Pt 2):F602-7.

PMID:
1826411
31.

Autoradiographic discrimination of brain and atrial natriuretic peptide-binding sites in the rat kidney.

Rutherford RA, Wharton J, Needleman P, Polak JM.

J Biol Chem. 1991 Mar 25;266(9):5819-26.

32.

The biochemical and pharmacological manipulation of cellular cyclooxygenase (COX) activity.

Seibert K, Masferrer JL, FU JY, Honda A, Raz A, Needleman P.

Adv Prostaglandin Thromboxane Leukot Res. 1991;21A:45-51. No abstract available.

PMID:
1825580
33.

Synthesis and secretion of an atriopeptin-like protein in rat kidney cell culture.

Ritter D, Needleman P, Greenwald JE.

J Clin Invest. 1991 Jan;87(1):208-12.

34.

Brain natriuretic peptide-like immunoreactive innervation of the cardiovascular and cerebrovascular systems in the rat.

Saper CB, Kibbe MR, Hurley KM, Spencer S, Holmes HR, Leahy KM, Needleman P.

Circ Res. 1990 Dec;67(6):1345-54.

PMID:
1978807
36.

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.

Fu JY, Masferrer JL, Seibert K, Raz A, Needleman P.

J Biol Chem. 1990 Oct 5;265(28):16737-40.

37.

Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice.

Masferrer JL, Zweifel BS, Seibert K, Needleman P.

J Clin Invest. 1990 Oct;86(4):1375-9.

38.

Maximizing the natriuretic effect of endogenous atriopeptin in a rat model of heart failure.

Wilkins MR, Settle SL, Stockmann PT, Needleman P.

Proc Natl Acad Sci U S A. 1990 Aug;87(16):6465-9.

40.

Alternative mechanisms for atriopeptin prohormone processing by isolated perfused rat hearts.

Toki Y, Ito T, Shiono S, Siegel NR, Gierse JK, Wilkins MR, Needleman P.

J Pharmacol Exp Ther. 1990 Jul;254(1):228-35.

PMID:
2142220
42.

Regulation of prostanoids synthesis in human fibroblasts and human blood monocytes by interleukin-1, endotoxin, and glucocorticoids.

Raz A, Wyche A, Fu J, Seibert K, Needleman P.

Adv Prostaglandin Thromboxane Leukot Res. 1990;20:22-7. No abstract available.

PMID:
2144696
43.

Relationship between plasma atriopeptin concentration and function in the conscious primate.

Hoegler C, McIntyre J, Zeballos G, Shapiro J, DeLeonardis M, Needleman P, Hintze T.

J Pharmacol Exp Ther. 1989 Dec;251(3):929-36.

PMID:
2532250
44.

Essential fatty acid deficiency inhibits early but not late leukocyte infiltration in rabbit myocardial infarcts.

Freed MS, Spaethe SM, Lefkowith JB, Saffitz JE, Needleman P.

Prostaglandins. 1989 Jul;38(1):33-44.

PMID:
2546188
45.

Mechanisms underlying atriopeptin-induced increases in hematocrit and vascular permeation in rats.

Williamson JR, Holmberg SW, Chang K, Marvel J, Sutera SP, Needleman P.

Circ Res. 1989 May;64(5):890-9.

PMID:
2523261
47.

Stretch-induced atriopeptin secretion in the isolated rat myocyte and its negative modulation by calcium.

Greenwald JE, Apkon M, Hruska KA, Needleman P.

J Clin Invest. 1989 Mar;83(3):1061-5.

48.
49.

Brain natriuretic peptides: differential localization of a new family of neuropeptides.

Saper CB, Hurley KM, Moga MM, Holmes HR, Adams SA, Leahy KM, Needleman P.

Neurosci Lett. 1989 Jan 2;96(1):29-34.

PMID:
2522605
50.

Differentiation in vivo of the sequential blood cell invasion following ureter obstruction of the rabbit kidney.

Mathias CJ, Welch MJ, Schwartz DB, Spaethe SM, Needleman P.

Int J Rad Appl Instrum B. 1989;16(1):25-32.

PMID:
2714997

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