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Organization of Chromosomal DNA by SMC Complexes.

Yatskevich S, Rhodes J, Nasmyth K.

Annu Rev Genet. 2019 Oct 2. doi: 10.1146/annurev-genet-112618-043633. [Epub ahead of print]


Scc2 counteracts a Wapl-independent mechanism that releases cohesin from chromosomes during G1.

Srinivasan M, Petela NJ, Scheinost JC, Collier J, Voulgaris M, B Roig M, Beckouët F, Hu B, Nasmyth KA.

Elife. 2019 Jun 21;8. pii: e44736. doi: 10.7554/eLife.44736.


Sister DNA Entrapment between Juxtaposed Smc Heads and Kleisin of the Cohesin Complex.

Chapard C, Jones R, van Oepen T, Scheinost JC, Nasmyth K.

Mol Cell. 2019 Jul 25;75(2):224-237.e5. doi: 10.1016/j.molcel.2019.05.023. Epub 2019 Jun 11.


A folded conformation of MukBEF and cohesin.

Bürmann F, Lee BG, Than T, Sinn L, O'Reilly FJ, Yatskevich S, Rappsilber J, Hu B, Nasmyth K, Löwe J.

Nat Struct Mol Biol. 2019 Mar;26(3):227-236. doi: 10.1038/s41594-019-0196-z. Epub 2019 Mar 4.


Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation.

Cuartero S, Weiss FD, Dharmalingam G, Guo Y, Ing-Simmons E, Masella S, Robles-Rebollo I, Xiao X, Wang YF, Barozzi I, Djeghloul D, Amano MT, Niskanen H, Petretto E, Dowell RD, Tachibana K, Kaikkonen MU, Nasmyth KA, Lenhard B, Natoli G, Fisher AG, Merkenschlager M.

Nat Immunol. 2018 Sep;19(9):932-941. doi: 10.1038/s41590-018-0184-1. Epub 2018 Aug 20.


Scc2 Is a Potent Activator of Cohesin's ATPase that Promotes Loading by Binding Scc1 without Pds5.

Petela NJ, Gligoris TG, Metson J, Lee BG, Voulgaris M, Hu B, Kikuchi S, Chapard C, Chen W, Rajendra E, Srinivisan M, Yu H, Löwe J, Nasmyth KA.

Mol Cell. 2018 Jun 21;70(6):1134-1148.e7. doi: 10.1016/j.molcel.2018.05.022.


The Cohesin Ring Uses Its Hinge to Organize DNA Using Non-topological as well as Topological Mechanisms.

Srinivasan M, Scheinost JC, Petela NJ, Gligoris TG, Wissler M, Ogushi S, Collier JE, Voulgaris M, Kurze A, Chan KL, Hu B, Costanzo V, Nasmyth KA.

Cell. 2018 May 31;173(6):1508-1519.e18. doi: 10.1016/j.cell.2018.04.015. Epub 2018 May 10.


How are DNAs woven into chromosomes?

Nasmyth K.

Science. 2017 Nov 3;358(6363):589-590. doi: 10.1126/science.aap8729. No abstract available.


Cohesin Can Remain Associated with Chromosomes during DNA Replication.

Rhodes JDP, Haarhuis JHI, Grimm JB, Rowland BD, Lavis LD, Nasmyth KA.

Cell Rep. 2017 Sep 19;20(12):2749-2755. doi: 10.1016/j.celrep.2017.08.092.


Scc2/Nipbl hops between chromosomal cohesin rings after loading.

Rhodes J, Mazza D, Nasmyth K, Uphoff S.

Elife. 2017 Sep 15;6. pii: e30000. doi: 10.7554/eLife.30000.


APC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity.

Rattani A, Ballesteros Mejia R, Roberts K, Roig MB, Godwin J, Hopkins M, Eguren M, Sanchez-Pulido L, Okaz E, Ogushi S, Wolna M, Metson J, Pendás AM, Malumbres M, Novák B, Herbert M, Nasmyth K.

Curr Biol. 2017 May 22;27(10):1462-1476.e5. doi: 10.1016/j.cub.2017.04.023. Epub 2017 May 11.


Evolution of condensin and cohesin complexes driven by replacement of Kite by Hawk proteins.

Wells JN, Gligoris TG, Nasmyth KA, Marsh JA.

Curr Biol. 2017 Jan 9;27(1):R17-R18. doi: 10.1016/j.cub.2016.11.050.


Cdk1 Triggers Association of RNA Polymerase to Cell Cycle Promoters Only after Recruitment of the Mediator by SBF.

Cosma MP, Panizza S, Nasmyth K.

Mol Cell. 2016 Aug 4;63(3):539. doi: 10.1016/j.molcel.2016.07.002. Epub 2016 Jul 28. No abstract available.


Ordered Recruitment of Transcription and Chromatin Remodeling Factors to a Cell Cycle- and Developmentally Regulated Promoter.

Cosma MP, Tanaka T, Nasmyth K.

Cell. 2016 Jul 28;166(3):781. doi: 10.1016/j.cell.2016.07.016. No abstract available.


Crystal Structure of the Cohesin Gatekeeper Pds5 and in Complex with Kleisin Scc1.

Lee BG, Roig MB, Jansma M, Petela N, Metson J, Nasmyth K, Löwe J.

Cell Rep. 2016 Mar 8;14(9):2108-2115. doi: 10.1016/j.celrep.2016.02.020. Epub 2016 Feb 25.


Cohesin Releases DNA through Asymmetric ATPase-Driven Ring Opening.

Elbatsh AMO, Haarhuis JHI, Petela N, Chapard C, Fish A, Celie PH, Stadnik M, Ristic D, Wyman C, Medema RH, Nasmyth K, Rowland BD.

Mol Cell. 2016 Feb 18;61(4):575-588. doi: 10.1016/j.molcel.2016.01.025.


Releasing Activity Disengages Cohesin's Smc3/Scc1 Interface in a Process Blocked by Acetylation.

Beckouët F, Srinivasan M, Roig MB, Chan KL, Scheinost JC, Batty P, Hu B, Petela N, Gligoris T, Smith AC, Strmecki L, Rowland BD, Nasmyth K.

Mol Cell. 2016 Feb 18;61(4):563-574. doi: 10.1016/j.molcel.2016.01.026.


Biological chromodynamics: a general method for measuring protein occupancy across the genome by calibrating ChIP-seq.

Hu B, Petela N, Kurze A, Chan KL, Chapard C, Nasmyth K.

Nucleic Acids Res. 2015 Nov 16;43(20):e132. doi: 10.1093/nar/gkv670. Epub 2015 Jun 30.


Condensin confers the longitudinal rigidity of chromosomes.

Houlard M, Godwin J, Metson J, Lee J, Hirano T, Nasmyth K.

Nat Cell Biol. 2015 Jun;17(6):771-81. doi: 10.1038/ncb3167. Epub 2015 May 11.


A meiotic mystery: How sister kinetochores avoid being pulled in opposite directions during the first division.

Nasmyth K.

Bioessays. 2015 Jun;37(6):657-65. doi: 10.1002/bies.201500006. Epub 2015 Apr 15.


Closing the cohesin ring: structure and function of its Smc3-kleisin interface.

Gligoris TG, Scheinost JC, Bürmann F, Petela N, Chan KL, Uluocak P, Beckouët F, Gruber S, Nasmyth K, Löwe J.

Science. 2014 Nov 21;346(6212):963-7. doi: 10.1126/science.1256917.


Centromere-independent accumulation of cohesin at ectopic heterochromatin sites induces chromosome stretching during anaphase.

Oliveira RA, Kotadia S, Tavares A, Mirkovic M, Bowlin K, Eichinger CS, Nasmyth K, Sullivan W.

PLoS Biol. 2014 Oct 7;12(10):e1001962. doi: 10.1371/journal.pbio.1001962. eCollection 2014 Oct.


Structure and function of cohesin's Scc3/SA regulatory subunit.

Roig MB, Löwe J, Chan KL, Beckouët F, Metson J, Nasmyth K.

FEBS Lett. 2014 Oct 16;588(20):3692-702. doi: 10.1016/j.febslet.2014.08.015. Epub 2014 Aug 27.


Dependency of the spindle assembly checkpoint on Cdk1 renders the anaphase transition irreversible.

Rattani A, Vinod PK, Godwin J, Tachibana-Konwalski K, Wolna M, Malumbres M, Novák B, Nasmyth K.

Curr Biol. 2014 Mar 17;24(6):630-7. doi: 10.1016/j.cub.2014.01.033. Epub 2014 Feb 27.


Spindle assembly checkpoint of oocytes depends on a kinetochore structure determined by cohesin in meiosis I.

Tachibana-Konwalski K, Godwin J, Borsos M, Rattani A, Adams DJ, Nasmyth K.

Curr Biol. 2013 Dec 16;23(24):2534-9. doi: 10.1016/j.cub.2013.10.052. Epub 2013 Nov 27.


Sgol2 provides a regulatory platform that coordinates essential cell cycle processes during meiosis I in oocytes.

Rattani A, Wolna M, Ploquin M, Helmhart W, Morrone S, Mayer B, Godwin J, Xu W, Stemmann O, Pendas A, Nasmyth K.

Elife. 2013 Nov 5;2:e01133. doi: 10.7554/eLife.01133.


Cohesin cleavage is insufficient for centriole disengagement in Drosophila.

Oliveira RA, Nasmyth K.

Curr Biol. 2013 Jul 22;23(14):R601-3. doi: 10.1016/j.cub.2013.04.003. No abstract available.


Pds5 promotes and protects cohesin acetylation.

Chan KL, Gligoris T, Upcher W, Kato Y, Shirahige K, Nasmyth K, Beckouët F.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13020-5. doi: 10.1073/pnas.1306900110. Epub 2013 Jul 22.


Disengaging the Smc3/kleisin interface releases cohesin from Drosophila chromosomes during interphase and mitosis.

Eichinger CS, Kurze A, Oliveira RA, Nasmyth K.

EMBO J. 2013 Mar 6;32(5):656-65. doi: 10.1038/emboj.2012.346. Epub 2013 Jan 22.


Cyclin A2 is required for sister chromatid segregation, but not separase control, in mouse oocyte meiosis.

Touati SA, Cladière D, Lister LM, Leontiou I, Chambon JP, Rattani A, Böttger F, Stemmann O, Nasmyth K, Herbert M, Wassmann K.

Cell Rep. 2012 Nov 29;2(5):1077-87. doi: 10.1016/j.celrep.2012.10.002. Epub 2012 Nov 1.


Cohesin's DNA exit gate is distinct from its entrance gate and is regulated by acetylation.

Chan KL, Roig MB, Hu B, Beckouët F, Metson J, Nasmyth K.

Cell. 2012 Aug 31;150(5):961-74. doi: 10.1016/j.cell.2012.07.028. Epub 2012 Aug 14.


The cell cycle.

Hunt T, Nasmyth K, Novák B.

Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27;366(1584):3494-7. doi: 10.1098/rstb.2011.0274. No abstract available.


Cohesin's concatenation of sister DNAs maintains their intertwining.

Farcas AM, Uluocak P, Helmhart W, Nasmyth K.

Mol Cell. 2011 Oct 7;44(1):97-107. doi: 10.1016/j.molcel.2011.07.034.


Cohesin: a catenase with separate entry and exit gates?

Nasmyth K.

Nat Cell Biol. 2011 Oct 3;13(10):1170-7. doi: 10.1038/ncb2349. Review.


A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation.

Seitan VC, Hao B, Tachibana-Konwalski K, Lavagnolli T, Mira-Bontenbal H, Brown KE, Teng G, Carroll T, Terry A, Horan K, Marks H, Adams DJ, Schatz DG, Aragon L, Fisher AG, Krangel MS, Nasmyth K, Merkenschlager M.

Nature. 2011 Aug 10;476(7361):467-71. doi: 10.1038/nature10312.


Splitting the nucleus: what's wrong with the tripartite ring model?

Nasmyth K, Oliveira RA.

Cold Spring Harb Symp Quant Biol. 2010;75:375-88. doi: 10.1101/sqb.2010.75.019. Epub 2011 Jan 5.


The anaphase promoting complex is required for memory function in mice.

Kuczera T, Stilling RM, Hsia HE, Bahari-Javan S, Irniger S, Nasmyth K, Sananbenesi F, Fischer A.

Learn Mem. 2010 Dec 22;18(1):49-57. doi: 10.1101/lm.1998411. Print 2011 Jan.


ATP hydrolysis is required for relocating cohesin from sites occupied by its Scc2/4 loading complex.

Hu B, Itoh T, Mishra A, Katoh Y, Chan KL, Upcher W, Godlee C, Roig MB, Shirahige K, Nasmyth K.

Curr Biol. 2011 Jan 11;21(1):12-24. doi: 10.1016/j.cub.2010.12.004. Epub 2010 Dec 23.


A positively charged channel within the Smc1/Smc3 hinge required for sister chromatid cohesion.

Kurze A, Michie KA, Dixon SE, Mishra A, Itoh T, Khalid S, Strmecki L, Shirahige K, Haering CH, Löwe J, Nasmyth K.

EMBO J. 2011 Jan 19;30(2):364-78. doi: 10.1038/emboj.2010.315. Epub 2010 Dec 7.


Getting through anaphase: splitting the sisters and beyond.

Oliveira RA, Nasmyth K.

Biochem Soc Trans. 2010 Dec;38(6):1639-44. doi: 10.1042/BST0381639. Review.


How far will we see in the future?

Nasmyth K.

Mol Biol Cell. 2010 Nov 15;21(22):3813-4. doi: 10.1091/mbc.E10-04-0359. No abstract available.


Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes.

Tachibana-Konwalski K, Godwin J, van der Weyden L, Champion L, Kudo NR, Adams DJ, Nasmyth K.

Genes Dev. 2010 Nov 15;24(22):2505-16. doi: 10.1101/gad.605910. Epub 2010 Oct 22.


A direct role for cohesin in gene regulation and ecdysone response in Drosophila salivary glands.

Pauli A, van Bemmel JG, Oliveira RA, Itoh T, Shirahige K, van Steensel B, Nasmyth K.

Curr Biol. 2010 Oct 26;20(20):1787-98. doi: 10.1016/j.cub.2010.09.006. Epub 2010 Oct 7.


An Smc3 acetylation cycle is essential for establishment of sister chromatid cohesion.

Beckouët F, Hu B, Roig MB, Sutani T, Komata M, Uluocak P, Katis VL, Shirahige K, Nasmyth K.

Mol Cell. 2010 Sep 10;39(5):689-99. doi: 10.1016/j.molcel.2010.08.008.


ParticleStats: open source software for the analysis of particle motility and cytoskeletal polarity.

Hamilton RS, Parton RM, Oliveira RA, Vendra G, Ball G, Nasmyth K, Davis I.

Nucleic Acids Res. 2010 Jul;38(Web Server issue):W641-6. doi: 10.1093/nar/gkq542. Epub 2010 Jun 11.


Systematic analysis of human protein complexes identifies chromosome segregation proteins.

Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM.

Science. 2010 Apr 30;328(5978):593-9. doi: 10.1126/science.1181348. Epub 2010 Apr 1.


Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis.

Katis VL, Lipp JJ, Imre R, Bogdanova A, Okaz E, Habermann B, Mechtler K, Nasmyth K, Zachariae W.

Dev Cell. 2010 Mar 16;18(3):397-409. doi: 10.1016/j.devcel.2010.01.014.


Both interaction surfaces within cohesin's hinge domain are essential for its stable chromosomal association.

Mishra A, Hu B, Kurze A, Beckouët F, Farcas AM, Dixon SE, Katou Y, Khalid S, Shirahige K, Nasmyth K.

Curr Biol. 2010 Feb 23;20(4):279-89. doi: 10.1016/j.cub.2009.12.059. Epub 2010 Feb 11.


Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei.

Oliveira RA, Hamilton RS, Pauli A, Davis I, Nasmyth K.

Nat Cell Biol. 2010 Feb;12(2):185-92. doi: 10.1038/ncb2018. Epub 2010 Jan 17.


Cohesin: its roles and mechanisms.

Nasmyth K, Haering CH.

Annu Rev Genet. 2009;43:525-58. doi: 10.1146/annurev-genet-102108-134233. Review.


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