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Items: 1 to 50 of 159

1.

Function, Regulation and Biological Roles of PI3Kγ Variants.

Nürnberg B, Beer-Hammer S.

Biomolecules. 2019 Aug 30;9(9). pii: E427. doi: 10.3390/biom9090427. Review.

2.

Correction to: Triggering of eryptosis, the suicidal erythrocyte death, by phenoxodiol.

Fink M, Bhuyan AAM, Nürnberg B, Faggio C, Lang F.

Naunyn Schmiedebergs Arch Pharmacol. 2019 Oct;392(10):1319. doi: 10.1007/s00210-019-01693-4.

PMID:
31332477
3.

Acid sphingomyelinase - a regulator of canonical transient receptor potential channel 6 (TRPC6) activity.

Zeitler S, Ye L, Andreyeva A, Schumacher F, Monti J, Nürnberg B, Nowak G, Kleuser B, Reichel M, Fejtová A, Kornhuber J, Rhein C, Friedland K.

J Neurochem. 2019 Jul 16. doi: 10.1111/jnc.14823. [Epub ahead of print]

PMID:
31310676
4.

Triggering of eryptosis, the suicidal erythrocyte death, by phenoxodiol.

Fink M, Bhuyan AAM, Nürnberg B, Faggio C, Lang F.

Naunyn Schmiedebergs Arch Pharmacol. 2019 Oct;392(10):1311-1318. doi: 10.1007/s00210-019-01681-8. Epub 2019 Jul 6. Erratum in: Naunyn Schmiedebergs Arch Pharmacol. 2019 Jul 23;:.

PMID:
31280326
5.

Garcinol A Novel Inhibitor of Platelet Activation and Apoptosis.

Cao H, Al Mamun Bhuyan A, Umbach AT, Ma K, Borst O, Gawaz M, Zhang S, Nürnberg B, Lang F.

Toxins (Basel). 2019 Jul 1;11(7). pii: E382. doi: 10.3390/toxins11070382.

6.

Renal Fibrosis, Immune Cell Infiltration and Changes of TRPC Channel Expression after Unilateral Ureteral Obstruction in Trpc6-/- Mice.

Kong W, Haschler TN, Nürnberg B, Krämer S, Gollasch M, Markó L.

Cell Physiol Biochem. 2019;52(6):1484-1502. doi: 10.33594/000000103.

7.

Mast cells in hidradenitis suppurativa: a clinicopathological study.

List EK, Pascual JC, Zarchi K, Nürnberg BM, Jemec GBE.

Arch Dermatol Res. 2019 May;311(4):331-335. doi: 10.1007/s00403-019-01910-3. Epub 2019 Mar 15.

PMID:
30877368
8.

A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion.

Heitz SD, Hamelin DJ, Hoffmann RM, Greenberg N, Salloum G, Erami Z, Khalil BD, Shymanets A, Steidle EA, Gong GQ, Nürnberg B, Burke JE, Flanagan JU, Bresnick AR, Backer JM.

J Biol Chem. 2019 Mar 22;294(12):4621-4633. doi: 10.1074/jbc.RA118.006032. Epub 2019 Jan 18.

PMID:
30659094
9.

Anti-inflammatory role of CD11b+Ly6G+ neutrophilic cells in allergic airway inflammation in mice.

Nowroozilarki N, Öz HH, Schroth C, Hector A, Nürnberg B, Hartl D, Kolahian S.

Immunol Lett. 2018 Dec;204:67-74. doi: 10.1016/j.imlet.2018.10.007. Epub 2018 Oct 28.

PMID:
30392943
10.

RXFP1 Receptor Activation by Relaxin-2 Induces Vascular Relaxation in Mice via a Gαi2-Protein/PI3Kß/γ/Nitric Oxide-Coupled Pathway.

Lian X, Beer-Hammer S, König GM, Kostenis E, Nürnberg B, Gollasch M.

Front Physiol. 2018 Sep 4;9:1234. doi: 10.3389/fphys.2018.01234. eCollection 2018.

11.

Heterotrimeric G-protein subunit Gαi2 contributes to agonist-sensitive apoptosis and degranulation in murine platelets.

Cao H, Qadri SM, Lang E, Pelzl L, Umbach AT, Leiss V, Birnbaumer L, Nürnberg B, Pieske B, Voelkl J, Gawaz M, Bissinger R, Lang F.

Physiol Rep. 2018 Sep;6(17):e13841. doi: 10.14814/phy2.13841.

12.

Salmonella Typhimurium effector SseI inhibits chemotaxis and increases host cell survival by deamidation of heterotrimeric Gi proteins.

Brink T, Leiss V, Siegert P, Jehle D, Ebner JK, Schwan C, Shymanets A, Wiese S, Nürnberg B, Hensel M, Aktories K, Orth JHC.

PLoS Pathog. 2018 Aug 13;14(8):e1007248. doi: 10.1371/journal.ppat.1007248. eCollection 2018 Aug.

13.

Gαi Proteins are Indispensable for Hearing.

Beer-Hammer S, Lee SC, Mauriac SA, Leiss V, Groh IAM, Novakovic A, Piekorz RP, Bucher K, Chen C, Ni K, Singer W, Harasztosi C, Schimmang T, Zimmermann U, Pfeffer K, Birnbaumer L, Forge A, Montcouquiol M, Knipper M, Nürnberg B, Rüttiger L.

Cell Physiol Biochem. 2018;47(4):1509-1532. doi: 10.1159/000490867. Epub 2018 Jun 21.

14.

Author Correction: Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome.

Mauriac SA, Hien YE, Bird JE, Carvalho SD, Peyroutou R, Lee SC, Moreau MM, Blanc JM, Gezer A, Medina C, Thoumine O, Beer-Hammer S, Friedman TB, Rüttiger L, Forge A, Nürnberg B, Sans N, Montcouquiol M.

Nat Commun. 2018 May 25;9:16188. doi: 10.1038/ncomms16188.

15.

Correction: mRNA-Mediated Gene Supplementation of Toll-Like Receptors as Treatment Strategy for Asthma In Vivo.

Zeyer F, Mothes B, Will C, Carevic M, Rottenberger J, Nürnberg B, Hartl D, Handgretinger R, Beer-Hammer S, Kormann MSD.

PLoS One. 2018 May 15;13(5):e0197705. doi: 10.1371/journal.pone.0197705. eCollection 2018.

16.

Molecular basis for the sensitivity of TRP channels to polyunsaturated fatty acids.

Riehle M, Tsvetkov D, Gohlke BO, Preissner R, Harteneck C, Gollasch M, Nürnberg B.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Aug;391(8):833-846. doi: 10.1007/s00210-018-1507-3. Epub 2018 May 8.

17.

Rac1-stimulated macropinocytosis enhances Gβγ activation of PI3Kβ.

Erami Z, Khalil BD, Salloum G, Yao Y, LoPiccolo J, Shymanets A, Nürnberg B, Bresnick AR, Backer JM.

Biochem J. 2017 Nov 16;474(23):3903-3914. doi: 10.1042/BCJ20170279.

18.

Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels.

Dembla S, Behrendt M, Mohr F, Goecke C, Sondermann J, Schneider FM, Schmidt M, Stab J, Enzeroth R, Leitner MG, Nuñez-Badinez P, Schwenk J, Nürnberg B, Cohen A, Philipp SE, Greffrath W, Bünemann M, Oliver D, Zakharian E, Schmidt M, Oberwinkler J.

Elife. 2017 Aug 15;6. pii: e26280. doi: 10.7554/eLife.26280.

19.

Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia.

Bucher K, Schmitt F, Mothes B, Blumendeller C, Schäll D, Piekorz R, Hirsch E, Nürnberg B, Beer-Hammer S.

Cell Commun Signal. 2017 Jul 19;15(1):28. doi: 10.1186/s12964-017-0185-y.

20.

Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice.

Grenz A, Bauerle JD, Dalton JH, Ridyard D, Badulak A, Tak E, McNamee EN, Clambey E, Moldovan R, Reyes G, Klawitter J, Ambler K, Magee K, Christians U, Brodsky KS, Ravid K, Choi DS, Wen J, Lukashev D, Blackburn MR, Osswald H, Coe IR, Nürnberg B, Haase VH, Xia Y, Sitkovsky M, Eltzschig HK.

J Clin Invest. 2017 Jun 1;127(6):2438. doi: 10.1172/JCI94890. Epub 2017 Jun 1. No abstract available.

21.

Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome.

Mauriac SA, Hien YE, Bird JE, Carvalho SD, Peyroutou R, Lee SC, Moreau MM, Blanc JM, Geyser A, Medina C, Thoumine O, Beer-Hammer S, Friedman TB, Rüttiger L, Forge A, Nürnberg B, Sans N, Montcouquiol M.

Nat Commun. 2017 Apr 7;8:14907. doi: 10.1038/ncomms14907. Erratum in: Nat Commun. 2018 May 25;9:16188.

22.

Correction: p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation.

Mothes B, Bucher K, Ammon-Treiber S, Schwab M, Piekorz RP, Hirsch E, Nürnberg B, Beer-Hammer S.

PLoS One. 2016 Sep 19;11(9):e0163577. doi: 10.1371/journal.pone.0163577. eCollection 2016.

23.

Better Understanding of Phosphoinositide 3-Kinase (PI3K) Pathways in Vasculature: Towards Precision Therapy Targeting Angiogenesis and Tumor Blood Supply.

Tsvetkov D, Shymanets A, Huang Y, Bucher K, Piekorz R, Hirsch E, Beer-Hammer S, Harteneck C, Gollasch M, Nürnberg B.

Biochemistry (Mosc). 2016 Jul;81(7):691-9. doi: 10.1134/S0006297916070051.

24.

p110γ/δ Double-Deficiency Induces Eosinophilia and IgE Production but Protects from OVA-Induced Airway Inflammation.

Mothes B, Bucher K, Ammon-Treiber S, Schwab M, Piekorz RP, Hirsch E, Nürnberg B, Beer-Hammer S.

PLoS One. 2016 Jul 21;11(7):e0159310. doi: 10.1371/journal.pone.0159310. eCollection 2016. Erratum in: PLoS One. 2016;11(9):e0163577.

25.

Adjunct use of optical coherence tomography increases the detection of recurrent basal cell carcinoma over clinical and dermoscopic examination alone.

Hussain AA, Themstrup L, Nürnberg BM, Jemec G.

Photodiagnosis Photodyn Ther. 2016 Jun;14:178-84. doi: 10.1016/j.pdpdt.2016.04.010. Epub 2016 Apr 22.

PMID:
27109055
26.

mRNA-Mediated Gene Supplementation of Toll-Like Receptors as Treatment Strategy for Asthma In Vivo.

Zeyer F, Mothes B, Will C, Carevic M, Rottenberger J, Nürnberg B, Hartl D, Handgretinger R, Beer-Hammer S, Kormann MS.

PLoS One. 2016 Apr 21;11(4):e0154001. doi: 10.1371/journal.pone.0154001. eCollection 2016. Erratum in: PLoS One. 2018 May 15;13(5):e0197705.

27.

Variation in the Phosphoinositide 3-Kinase Gamma Gene Affects Plasma HDL-Cholesterol without Modification of Metabolic or Inflammatory Markers.

Kächele M, Hennige AM, Machann J, Hieronimus A, Lamprinou A, Machicao F, Schick F, Fritsche A, Stefan N, Nürnberg B, Häring HU, Staiger H.

PLoS One. 2015 Dec 10;10(12):e0144494. doi: 10.1371/journal.pone.0144494. eCollection 2015.

28.

Lack of Gαi2 leads to dilative cardiomyopathy and increased mortality in β1-adrenoceptor overexpressing mice.

Keller K, Maass M, Dizayee S, Leiss V, Annala S, Köth J, Seemann WK, Müller-Ehmsen J, Mohr K, Nürnberg B, Engelhardt S, Herzig S, Birnbaumer L, Matthes J.

Cardiovasc Res. 2015 Dec 1;108(3):348-56. doi: 10.1093/cvr/cvv235. Epub 2015 Oct 13.

29.

p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase.

Barrows D, Schoenfeld SM, Hodakoski C, Silkov A, Honig B, Couvillon A, Shymanets A, Nürnberg B, Asara JM, Parsons R.

J Biol Chem. 2015 Nov 27;290(48):28915-31. doi: 10.1074/jbc.M115.668244. Epub 2015 Oct 5.

30.

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.

Shymanets A, Prajwal, Vadas O, Czupalla C, LoPiccolo J, Brenowitz M, Ghigo A, Hirsch E, Krause E, Wetzker R, Williams RL, Harteneck C, Nürnberg B.

Biochem J. 2015 Jul 1;469(1):59-69. doi: 10.1042/BJ20150099.

31.

Fluorescent Ly6G antibodies determine macrophage phagocytosis of neutrophils and alter the retrieval of neutrophils in mice.

Bucher K, Schmitt F, Autenrieth SE, Dillmann I, Nürnberg B, Schenke-Layland K, Beer-Hammer S.

J Leukoc Biol. 2015 Sep;98(3):365-72. doi: 10.1189/jlb.1AB1014-488RR. Epub 2015 May 27.

PMID:
26019296
32.

In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency.

Mahiny AJ, Dewerth A, Mays LE, Alkhaled M, Mothes B, Malaeksefat E, Loretz B, Rottenberger J, Brosch DM, Reautschnig P, Surapolchai P, Zeyer F, Schams A, Carevic M, Bakele M, Griese M, Schwab M, Nürnberg B, Beer-Hammer S, Handgretinger R, Hartl D, Lehr CM, Kormann MS.

Nat Biotechnol. 2015 Jun;33(6):584-6. doi: 10.1038/nbt.3241. Epub 2015 May 18. No abstract available.

PMID:
25985262
33.

Platelet Gi protein Gαi2 is an essential mediator of thrombo-inflammatory organ damage in mice.

Devanathan V, Hagedorn I, Köhler D, Pexa K, Cherpokova D, Kraft P, Singh M, Rosenberger P, Stoll G, Birnbaumer L, Piekorz RP, Beer-Hammer S, Nieswandt B, Nürnberg B.

Proc Natl Acad Sci U S A. 2015 May 19;112(20):6491-6. doi: 10.1073/pnas.1505887112. Epub 2015 May 5.

34.

Insulin secretion stimulated by L-arginine and its metabolite L-ornithine depends on Gα(i2).

Leiss V, Flockerzie K, Novakovic A, Rath M, Schönsiegel A, Birnbaumer L, Schürmann A, Harteneck C, Nürnberg B.

Am J Physiol Endocrinol Metab. 2014 Nov 1;307(9):E800-12. doi: 10.1152/ajpendo.00337.2014. Epub 2014 Sep 9.

35.

Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1.

Zhang SC, Gremer L, Heise H, Janning P, Shymanets A, Cirstea IC, Krause E, Nürnberg B, Ahmadian MR.

PLoS One. 2014 Jul 11;9(7):e102425. doi: 10.1371/journal.pone.0102425. eCollection 2014.

36.

Development of first lead structures for phosphoinositide 3-kinase-C2γ inhibitors.

Freitag A, Prajwal P, Shymanets A, Harteneck C, Nürnberg B, Schächtele C, Kubbutat M, Totzke F, Laufer SA.

J Med Chem. 2015 Jan 8;58(1):212-21. doi: 10.1021/jm5006034. Epub 2014 Jul 14.

PMID:
24983663
37.

Gαi2- and Gαi3-deficient mice display opposite severity of myocardial ischemia reperfusion injury.

Köhler D, Devanathan V, Bernardo de Oliveira Franz C, Eldh T, Novakovic A, Roth JM, Granja T, Birnbaumer L, Rosenberger P, Beer-Hammer S, Nürnberg B.

PLoS One. 2014 May 23;9(5):e98325. doi: 10.1371/journal.pone.0098325. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0119092.

38.

Recurring axillary, abdominal and genitofemoral nodules and abscesses. Hereditary steatocystoma multiplex.

Kromann CB, Zarchi K, Nürnberg BM, Jemec GB.

Acta Derm Venereol. 2015 Jan;95(1):121-3. doi: 10.2340/00015555-1890. No abstract available.

39.

Gαi2 signaling is required for skeletal muscle growth, regeneration, and satellite cell proliferation and differentiation.

Minetti GC, Feige JN, Bombard F, Heier A, Morvan F, Nürnberg B, Leiss V, Birnbaumer L, Glass DJ, Fornaro M.

Mol Cell Biol. 2014 Feb;34(4):619-30. doi: 10.1128/MCB.00957-13. Epub 2013 Dec 2.

40.

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs).

Vadas O, Dbouk HA, Shymanets A, Perisic O, Burke JE, Abi Saab WF, Khalil BD, Harteneck C, Bresnick AR, Nürnberg B, Backer JM, Williams RL.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18862-7. doi: 10.1073/pnas.1304801110. Epub 2013 Nov 4.

41.

p87 and p101 subunits are distinct regulators determining class IB phosphoinositide 3-kinase (PI3K) specificity.

Shymanets A, Prajwal, Bucher K, Beer-Hammer S, Harteneck C, Nürnberg B.

J Biol Chem. 2013 Oct 25;288(43):31059-68. doi: 10.1074/jbc.M113.508234. Epub 2013 Sep 6.

42.

Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton.

Ezan J, Lasvaux L, Gezer A, Novakovic A, May-Simera H, Belotti E, Lhoumeau AC, Birnbaumer L, Beer-Hammer S, Borg JP, Le Bivic A, Nürnberg B, Sans N, Montcouquiol M.

Nat Cell Biol. 2013 Sep;15(9):1107-15. doi: 10.1038/ncb2819. Epub 2013 Aug 11.

PMID:
23934215
43.

Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase.

Dbouk HA, Khalil BD, Wu H, Shymanets A, Nürnberg B, Backer JM.

PLoS One. 2013 May 29;8(5):e63833. doi: 10.1371/journal.pone.0063833. Print 2013.

44.

Competition for Gβγ dimers mediates a specific cross-talk between stimulatory and inhibitory G protein α subunits of the adenylyl cyclase in cardiomyocytes.

Hippe HJ, Lüdde M, Schnoes K, Novakovic A, Lutz S, Katus HA, Niroomand F, Nürnberg B, Frey N, Wieland T.

Naunyn Schmiedebergs Arch Pharmacol. 2013 Jun;386(6):459-69. doi: 10.1007/s00210-013-0876-x. Epub 2013 Apr 26.

PMID:
23615874
45.

[A primary adenomucinous carcinoma on the upper eyelid].

Akram J, Wooler G, Nürnberg BM, Sjøstrand H.

Ugeskr Laeger. 2013 Mar 25;175(13):890-1. Danish.

PMID:
23582898
46.

A novel knee prosthesis model of implant-related osteomyelitis in rats.

Søe NH, Jensen NV, Nürnberg BM, Jensen AL, Koch J, Poulsen SS, Pier G, Johansen HK.

Acta Orthop. 2013 Feb;84(1):92-7. doi: 10.3109/17453674.2013.773121.

47.

Modified Foxp3 mRNA protects against asthma through an IL-10-dependent mechanism.

Mays LE, Ammon-Treiber S, Mothes B, Alkhaled M, Rottenberger J, Müller-Hermelink ES, Grimm M, Mezger M, Beer-Hammer S, von Stebut E, Rieber N, Nürnberg B, Schwab M, Handgretinger R, Idzko M, Hartl D, Kormann MS.

J Clin Invest. 2013 Mar;123(3):1216-28. doi: 10.1172/JCI65351. Epub 2013 Feb 8.

48.

Transient receptor potential vanilloid 1 (TRPV1), TRPV4, and the kidney.

Kassmann M, Harteneck C, Zhu Z, Nürnberg B, Tepel M, Gollasch M.

Acta Physiol (Oxf). 2013 Mar;207(3):546-64. doi: 10.1111/apha.12051. Epub 2013 Jan 18. Review.

PMID:
23253200
49.

Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins.

Plummer NW, Spicher K, Malphurs J, Akiyama H, Abramowitz J, Nürnberg B, Birnbaumer L.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21366-71. doi: 10.1073/pnas.1219810110. Epub 2012 Dec 11.

50.

Gαi2 is the essential Gαi protein in immune complex-induced lung disease.

Wiege K, Ali SR, Gewecke B, Novakovic A, Konrad FM, Pexa K, Beer-Hammer S, Reutershan J, Piekorz RP, Schmidt RE, Nürnberg B, Gessner JE.

J Immunol. 2013 Jan 1;190(1):324-33. doi: 10.4049/jimmunol.1201398. Epub 2012 Dec 5.

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