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Comparative genomic analysis identifies X-factor (haemin)-independent Haemophilus haemolyticus: a formal re-classification of 'Haemophilus intermedius'.

Harris TM, Price EP, Sarovich DS, Nørskov-Lauritsen N, Beissbarth J, Chang AB, Smith-Vaughan HC.

Microb Genom. 2019 Dec 20. doi: 10.1099/mgen.0.000303. [Epub ahead of print]


Whole Genome Sequencing of Aggregatibacter actinomycetemcomitans Cultured from Blood Stream Infections Reveals Three Major Phylogenetic Groups Including a Novel Lineage Expressing Serotype a Membrane O Polysaccharide.

Nedergaard S, Kobel CM, Nielsen MB, Møller RT, Jensen AB, Nørskov-Lauritsen N.

Pathogens. 2019 Nov 22;8(4). pii: E256. doi: 10.3390/pathogens8040256.


Aggregatibacter Actinomycetemcomitans: Clinical Significance of a Pathobiont Subjected to Ample Changes in Classification and Nomenclature.

Nørskov-Lauritsen N, Claesson R, Birkeholm Jensen A, Åberg CH, Haubek D.

Pathogens. 2019 Nov 18;8(4). pii: E243. doi: 10.3390/pathogens8040243. Review.


Differential Cell Lysis Among Periodontal Strains of JP2 and Non-JP2 Genotype of Aggregatibacter actinomycetemcomitans Serotype B Is Not Reflected in Dissimilar Expression and Production of Leukotoxin.

Jensen AB, Lund M, Nørskov-Lauritsen N, Johansson A, Claesson R, Reinholdt J, Haubek D.

Pathogens. 2019 Oct 30;8(4). pii: E211. doi: 10.3390/pathogens8040211.


Comprehensive antimicrobial susceptibility testing of a large collection of clinical strains of Aggregatibacter actinomycetemcomitans does not identify resistance to amoxicillin.

Jensen AB, Haubek D, Claesson R, Johansson A, Nørskov-Lauritsen N.

J Clin Periodontol. 2019 Aug;46(8):846-854. doi: 10.1111/jcpe.13148. Epub 2019 Jun 25.


The use of genomic DNA sequences as type material for valid publication of bacterial species names will have severe implications for clinical microbiology and related disciplines.

Bisgaard M, Christensen H, Clermont D, Dijkshoorn L, Janda JM, Moore ERB, Nemec A, Nørskov-Lauritsen N, Overmann J, Reubsaet FAG.

Diagn Microbiol Infect Dis. 2019 Sep;95(1):102-103. doi: 10.1016/j.diagmicrobio.2019.03.007. Epub 2019 Mar 22. No abstract available.


Motility, Biofilm Formation and Antimicrobial Efflux of Sessile and Planktonic Cells of Achromobacter xylosoxidans.

Nielsen SM, Penstoft LN, Nørskov-Lauritsen N.

Pathogens. 2019 Jan 27;8(1). pii: E14. doi: 10.3390/pathogens8010014.


A new DNA sensor system for specific and quantitative detection of mycobacteria.

Franch O, Han X, Marcussen LB, Givskov A, Andersen MB, Godbole AA, Harmsen C, Nørskov-Lauritsen N, Thomsen J, Pedersen FS, Wang Y, Shi D, Wejse C, Pødenphant L, Nagaraja V, Bertl J, Stougaard M, Ho YP, Hede MS, Labouriau R, Knudsen BR.

Nanoscale. 2019 Jan 3;11(2):587-597. doi: 10.1039/c8nr07850e.


Multispacer sequence typing of Coxiella burnetii DNA from removed prosthetic heart valve material discloses first human case of infective endocarditis caused by MST_18.

Nielsen SY, Nørskov-Lauritsen N.

Int J Infect Dis. 2019 Feb;79:139-141. doi: 10.1016/j.ijid.2018.11.015. Epub 2018 Nov 26.


Whole-Genome Sequencing of Aggregatibacter Species Isolated from Human Clinical Specimens and Description of Aggregatibacter kilianii sp. nov.

Murra M, Lützen L, Barut A, Zbinden R, Lund M, Villesen P, Nørskov-Lauritsen N.

J Clin Microbiol. 2018 Jun 25;56(7). pii: e00053-18. doi: 10.1128/JCM.00053-18. Print 2018 Jul.


Incidence of HACEK bacteraemia in Denmark: A 6-year population-based study.

Lützen L, Olesen B, Voldstedlund M, Christensen JJ, Moser C, Knudsen JD, Fuursted K, Hartmeyer GN, Chen M, Søndergaard TS, Rosenvinge FS, Dzajic E, Schønheyder HC, Nørskov-Lauritsen N.

Int J Infect Dis. 2018 Mar;68:83-87. doi: 10.1016/j.ijid.2018.01.025. Epub 2018 Feb 1.


Colistin resistance in Pseudomonas aeruginosa and Achromobacter spp. cultured from Danish cystic fibrosis patients is not related to plasmid-mediated expression of mcr-1.

Pedersen MG, Olesen HV, Jensen-Fangel S, Nørskov-Lauritsen N, Wang M.

J Cyst Fibros. 2018 Mar;17(2):e22-e23. doi: 10.1016/j.jcf.2017.12.001. Epub 2017 Dec 15. No abstract available.


The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria.

Christiansen SH, Murphy RA, Juul-Madsen K, Fredborg M, Hvam ML, Axelgaard E, Skovdal SM, Meyer RL, Sørensen UBS, Möller A, Nyengaard JR, Nørskov-Lauritsen N, Wang M, Gadjeva M, Howard KA, Davies JC, Petersen E, Vorup-Jensen T.

Sci Rep. 2017 Nov 15;7(1):15653. doi: 10.1038/s41598-017-15969-3.


The effect of pneumococcal conjugate vaccines on incidence and microbiology associated with complicated acute otitis media.

Laursen BB, Danstrup CS, Hoffmann S, Nørskov-Lauritsen N, Christensen ALB, Ovesen T.

Int J Pediatr Otorhinolaryngol. 2017 Oct;101:249-253. doi: 10.1016/j.ijporl.2017.07.002. Epub 2017 Jul 4.


Differences in Gene Expression Profiles between Early and Late Isolates in Monospecies Achromobacter Biofilm.

Nielsen SM, Meyer RL, Nørskov-Lauritsen N.

Pathogens. 2017 May 19;6(2). pii: E20. doi: 10.3390/pathogens6020020.


Prevalence and species distribution of Achromobacter sp. cultured from cystic fibrosis patients attending the Aarhus centre in Denmark.

Gade SS, Nørskov-Lauritsen N, Ridderberg W.

J Med Microbiol. 2017 May;66(5):686-689. doi: 10.1099/jmm.0.000499. Epub 2017 May 8. No abstract available.


Achromobacter Species Isolated from Cystic Fibrosis Patients Reveal Distinctly Different Biofilm Morphotypes.

Nielsen SM, Nørskov-Lauritsen N, Bjarnsholt T, Meyer RL.

Microorganisms. 2016 Sep 14;4(3). pii: E33. doi: 10.3390/microorganisms4030033.


Comparison of identification and antimicrobial resistance pattern of Staphylococcus aureus isolated from Amassoma, Bayelsa state, Nigeria.

Ayeni FA, Gbarabon T, Andersen C, Norskov-Lauritsen N.

Afr Health Sci. 2015 Dec;15(4):1282-8. doi: 10.4314/ahs.v15i4.30.


Contribution of PBP3 Substitutions and TEM-1, TEM-15, and ROB-1 Beta-Lactamases to Cefotaxime Resistance in Haemophilus influenzae and Haemophilus parainfluenzae.

Søndergaard A, Nørskov-Lauritsen N.

Microb Drug Resist. 2016 Jun;22(4):247-52. doi: 10.1089/mdr.2015.0189. Epub 2015 Dec 18.


TEM-1-encoding small plasmids impose dissimilar fitness costs on Haemophilus influenzae and Haemophilus parainfluenzae.

Søndergaard A, Lund M, Nørskov-Lauritsen N.

Microbiology. 2015 Dec;161(12):2310-5. doi: 10.1099/mic.0.000183. Epub 2015 Sep 17.


Genetic Adaptation of Achromobacter sp. during Persistence in the Lungs of Cystic Fibrosis Patients.

Ridderberg W, Nielsen SM, Nørskov-Lauritsen N.

PLoS One. 2015 Aug 27;10(8):e0136790. doi: 10.1371/journal.pone.0136790. eCollection 2015.


Unconventional N-Linked Glycosylation Promotes Trimeric Autotransporter Function in Kingella kingae and Aggregatibacter aphrophilus.

Rempe KA, Spruce LA, Porsch EA, Seeholzer SH, Nørskov-Lauritsen N, St Geme JW 3rd.

mBio. 2015 Aug 25;6(4). pii: e01206-15. doi: 10.1128/mBio.01206-15.


Lack of evidence of increased risk of bacterial transmission during cystic fibrosis educational programmes.

Ridderberg W, Andersen C, Væth M, Bregnballe V, Nørskov-Lauritsen N, Schiøtz PO.

J Cyst Fibros. 2016 Jan;15(1):109-15. doi: 10.1016/j.jcf.2015.04.007. Epub 2015 May 21.


Interspecies transfer of the penicillin-binding protein 3-encoding gene ftsI between Haemophilus influenzae and Haemophilus haemolyticus can confer reduced susceptibility to β-lactam antimicrobial agents.

Søndergaard A, Witherden EA, Nørskov-Lauritsen N, Tristram SG.

Antimicrob Agents Chemother. 2015 Jul;59(7):4339-42. doi: 10.1128/AAC.04854-14. Epub 2015 Apr 27.


The capsule biosynthesis locus of Haemophilus influenzae shows conspicuous similarity to the corresponding locus in Haemophilus sputorum and may have been recruited from this species by horizontal gene transfer.

Nielsen SM, de Gier C, Dimopoulou C, Gupta V, Hansen LH, Nørskov-Lauritsen N.

Microbiology. 2015 Jun;161(6):1182-8. doi: 10.1099/mic.0.000081. Epub 2015 Mar 20.


Intrapatient diversity of Achromobacter spp. involved in chronic colonization of Cystic Fibrosis airways.

Dupont C, Michon AL, Jumas-Bilak E, Nørskov-Lauritsen N, Chiron R, Marchandin H.

Infect Genet Evol. 2015 Jun;32:214-23. doi: 10.1016/j.meegid.2015.03.012. Epub 2015 Mar 16.


Increased prevalence and altered species composition of filamentous fungi in respiratory specimens from cystic fibrosis patients.

Nielsen SM, Kristensen L, Søndergaard A, Handberg KJ, Stenderup J, Nørskov-Lauritsen N.

APMIS. 2014 Oct;122(10):1007-12. doi: 10.1111/apm.12253. Epub 2014 Apr 3.


Classification, identification, and clinical significance of Haemophilus and Aggregatibacter species with host specificity for humans.

Nørskov-Lauritsen N.

Clin Microbiol Rev. 2014 Apr;27(2):214-40. doi: 10.1128/CMR.00103-13. Review.


Intravenous antibiotics given for 2 weeks do not eradicate persistent Staphylococcus aureus clones in cystic fibrosis patients.

Andersen C, Kahl BC, Olesen HV, Jensen-Fangel S, Nørskov-Lauritsen N.

Clin Microbiol Infect. 2014 May;20(5):O285-91. doi: 10.1111/1469-0691.12406. Epub 2013 Nov 4.


Bacteria of the genus Dyella can chronically colonise the airways of patients with cystic fibrosis and elicit a pronounced antibody response.

Duus LM, Høiby N, Wang M, Schiøtz O, Nørskov-Lauritsen N.

Int J Med Microbiol. 2013 Jul;303(5):267-9. doi: 10.1016/j.ijmm.2013.04.005. Epub 2013 May 7.


Early treatment with inhaled antibiotics postpones next occurrence of Achromobacter in cystic fibrosis.

Wang M, Ridderberg W, Hansen CR, Høiby N, Jensen-Fangel S, Olesen HV, Skov M, Lemming LE, Pressler T, Johansen HK, Nørskov-Lauritsen N.

J Cyst Fibros. 2013 Dec;12(6):638-43. doi: 10.1016/j.jcf.2013.04.013. Epub 2013 May 31.


Low occurrence of 'non-haemolytic Haemophilus haemolyticus' misidentified as Haemophilus influenzae in cystic fibrosis respiratory specimens, and frequent recurrence of persistent H. influenzae clones despite antimicrobial treatment.

Fenger MG, Ridderberg W, Olesen HV, Nørskov-Lauritsen N.

Int J Med Microbiol. 2012 Dec;302(7-8):315-9. doi: 10.1016/j.ijmm.2012.10.001. Epub 2012 Nov 20.


Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to β-lactams in Haemophilus influenzae.

Søndergaard A, San Millan A, Santos-Lopez A, Nielsen SM, Gonzalez-Zorn B, Nørskov-Lauritsen N.

Antimicrob Agents Chemother. 2012 Sep;56(9):4958-60. doi: 10.1128/AAC.00408-12. Epub 2012 Jun 25.


Multilocus sequence analysis of isolates of Achromobacter from patients with cystic fibrosis reveals infecting species other than Achromobacter xylosoxidans.

Ridderberg W, Wang M, Nørskov-Lauritsen N.

J Clin Microbiol. 2012 Aug;50(8):2688-94. doi: 10.1128/JCM.00728-12. Epub 2012 Jun 6.


Identification of haemolytic Haemophilus species isolated from human clinical specimens and description of Haemophilus sputorum sp. nov.

Nørskov-Lauritsen N, Bruun B, Andersen C, Kilian M.

Int J Med Microbiol. 2012 Mar;302(2):78-83. doi: 10.1016/j.ijmm.2012.01.001. Epub 2012 Feb 13.


Multilocus sequence phylogenetic analysis of Avibacterium.

Bisgaard M, Nørskov-Lauritsen N, de Wit SJ, Hess C, Christensen H.

Microbiology. 2012 Apr;158(Pt 4):993-1004. doi: 10.1099/mic.0.054429-0. Epub 2012 Jan 12.


Marked increase in incidence of Achromobacter xylosoxidans infections caused by sporadic acquisition from the environment.

Ridderberg W, Bendstrup KE, Olesen HV, Jensen-Fangel S, Nørskov-Lauritsen N.

J Cyst Fibros. 2011 Dec;10(6):466-9. doi: 10.1016/j.jcf.2011.07.004. Epub 2011 Aug 10.


Evaluation of disk diffusion methods to detect low-level β-lactamase-negative ampicillin-resistant Haemophilus influenzae.

Nørskov-Lauritsen N, Ridderberg W, Erikstrup LT, Fuursted K.

APMIS. 2011 Jun;119(6):385-92. doi: 10.1111/j.1600-0463.2011.02745.x. Epub 2011 Apr 29.


Increased level of intragenomic 16S rRNA gene heterogeneity in commensal strains closely related to Haemophilus influenzae.

Nørskov-Lauritsen N.

Microbiology. 2011 Apr;157(Pt 4):1050-5. doi: 10.1099/mic.0.047233-0. Epub 2011 Feb 10.


Unusual distribution of Burkholderia cepacia complex species in Danish cystic fibrosis clinics may stem from restricted transmission between patients.

Nørskov-Lauritsen N, Johansen HK, Fenger MG, Nielsen XC, Pressler T, Olesen HV, Høiby N.

J Clin Microbiol. 2010 Aug;48(8):2981-3. doi: 10.1128/JCM.00383-10. Epub 2010 Jun 2.


Haemophilus influenzae may be untypable by the multilocus sequence typing scheme due to a complete deletion of the fucose operon.

Ridderberg W, Fenger MG, Nørskov-Lauritsen N.

J Med Microbiol. 2010 Jun;59(Pt 6):740-2. doi: 10.1099/jmm.0.018424-0. Epub 2010 Feb 25. No abstract available.


Detection of cryptic genospecies misidentified as Haemophilus influenzae in routine clinical samples by assessment of marker genes fucK, hap, and sodC.

Nørskov-Lauritsen N.

J Clin Microbiol. 2009 Aug;47(8):2590-2. doi: 10.1128/JCM.00013-09. Epub 2009 Jun 17.


Antimicrobial susceptibility of tigecycline and comparators against bacterial isolates collected as part of the TEST study in Europe (2004-2007).

Nørskov-Lauritsen N, Marchandin H, Dowzicky MJ.

Int J Antimicrob Agents. 2009 Aug;34(2):121-30. doi: 10.1016/j.ijantimicag.2009.02.003. Epub 2009 Apr 1.


Delineation of the species Haemophilus influenzae by phenotype, multilocus sequence phylogeny, and detection of marker genes.

Nørskov-Lauritsen N, Overballe MD, Kilian M.

J Bacteriol. 2009 Feb;191(3):822-31. doi: 10.1128/JB.00782-08. Epub 2008 Dec 5.


Multilocus sequence phylogenetic study of the genus Haemophilus with description of Haemophilus pittmaniae sp. nov.

Nørskov-Lauritsen N, Bruun B, Kilian M.

Int J Syst Evol Microbiol. 2005 Jan;55(Pt 1):449-56.


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