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Items: 1 to 50 of 217

1.

[11C]PIB PET Is Associated with the Brain Biopsy Amyloid-β Load in Subjects Examined for Normal Pressure Hydrocephalus.

Rinne JO, Suotunen T, Rummukainen J, Herukka SK, Nerg O, Koivisto AM, Rauramaa T, Någren K, Hiltunen M, Alafuzoff I, Rinne J, Jääskeläinen JE, Soininen H, Leinonen V.

J Alzheimers Dis. 2019;67(4):1343-1351. doi: 10.3233/JAD-180645.

PMID:
30689567
2.

Brain Cholinergic Function and Response to Rivastigmine in Patients With Chronic Sequels of Traumatic Brain Injury: A PET Study.

Östberg A, Virta J, Rinne JO, Oikonen V, Luoto P, Någren K, Arponen E, Tenovuo O.

J Head Trauma Rehabil. 2018 Jan/Feb;33(1):25-32. doi: 10.1097/HTR.0000000000000279.

PMID:
28060207
3.

Highly Effective Auger-Electron Therapy in an Orthotopic Glioblastoma Xenograft Model using Convection-Enhanced Delivery.

Thisgaard H, Halle B, Aaberg-Jessen C, Olsen BB, Therkelsen AS, Dam JH, Langkjær N, Munthe S, Någren K, Høilund-Carlsen PF, Kristensen BW.

Theranostics. 2016 Sep 29;6(12):2278-2291. eCollection 2016.

4.

Verbal memory and 5-HT1A receptors in healthy volunteers--A PET study with [carbonyl-(11)C]WAY-100635.

Penttilä J, Hirvonen J, Tuominen L, Lumme V, Ilonen T, Någren K, Hietala J.

Eur Neuropsychopharmacol. 2016 Mar;26(3):570-7. doi: 10.1016/j.euroneuro.2015.12.028. Epub 2015 Dec 21.

PMID:
26775837
5.

[¹¹C]NS9531, [¹¹C]NS9762 and [¹¹C]NS6417, specific SERT tracers: pre-clinical evaluation in pigs and optimization of synthesis conditions using [¹¹C]methyl triflate.

Dam JH, Bender D, Peters D, Någren K.

Nucl Med Biol. 2016 Jan;43(1):42-51. doi: 10.1016/j.nucmedbio.2015.10.004. Epub 2015 Oct 21.

PMID:
26702786
6.

Author reply to: "Depressive symptomatology, serotonergic activity, and neuroticism: A methodological recommendation".

Hirvonen J, Tuominen L, Hietala J, Någren K.

Psychiatry Res. 2015 Dec 30;234(3):391. doi: 10.1016/j.pscychresns.2015.10.015. Epub 2015 Oct 28. No abstract available.

PMID:
26603911
7.

Long-Term Interrelationship between Brain Metabolism and Amyloid Deposition in Mild Cognitive Impairment.

Kemppainen N, Joutsa J, Johansson J, Scheinin NM, Någren K, Rokka J, Parkkola R, Rinne JO.

J Alzheimers Dis. 2015;48(1):123-33. doi: 10.3233/JAD-150190.

PMID:
26401934
8.

Neuroticism and serotonin 5-HT1A receptors in healthy subjects.

Hirvonen J, Tuominen L, Någren K, Hietala J.

Psychiatry Res. 2015 Oct 30;234(1):1-6. doi: 10.1016/j.pscychresns.2015.04.007. Epub 2015 May 2.

PMID:
26337006
9.

Intravenous ethanol increases dopamine release in the ventral striatum in humans: PET study using bolus-plus-infusion administration of [(11)C]raclopride.

Aalto S, Ingman K, Alakurtti K, Kaasinen V, Virkkala J, Någren K, Rinne JO, Scheinin H.

J Cereb Blood Flow Metab. 2015 Mar;35(3):424-31. doi: 10.1038/jcbfm.2014.209. Epub 2014 Dec 10.

10.

A PET Tracer for Brain α2C Adrenoceptors, (11)C-ORM-13070: Radiosynthesis and Preclinical Evaluation in Rats and Knockout Mice.

Arponen E, Helin S, Marjamäki P, Grönroos T, Holm P, Löyttyniemi E, Någren K, Scheinin M, Haaparanta-Solin M, Sallinen J, Solin O.

J Nucl Med. 2014 Jul;55(7):1171-7. doi: 10.2967/jnumed.113.135574. Epub 2014 May 5.

11.

Cortical ¹¹C-PIB uptake is associated with age, APOE genotype, and gender in "healthy aging".

Scheinin NM, Wikman K, Jula A, Perola M, Vahlberg T, Rokka J, Någren K, Viitanen M, Rinne JO.

J Alzheimers Dis. 2014;41(1):193-202. doi: 10.3233/JAD-132783.

PMID:
24603945
12.

Five-year follow-up of 11C-PIB uptake in Alzheimer's disease and MCI.

Kemppainen NM, Scheinin NM, Koivunen J, Johansson J, Toivonen JT, Någren K, Rokka J, Karrasch M, Parkkola R, Rinne JO.

Eur J Nucl Med Mol Imaging. 2014 Feb;41(2):283-9. doi: 10.1007/s00259-013-2562-0. Epub 2013 Sep 27.

PMID:
24072346
13.

[11C]PIB, [18F]FDG and MR imaging in patients with mild cognitive impairment.

Brück A, Virta JR, Koivunen J, Koikkalainen J, Scheinin NM, Helenius H, Någren K, Helin S, Parkkola R, Viitanen M, Rinne JO.

Eur J Nucl Med Mol Imaging. 2013 Oct;40(10):1567-72. doi: 10.1007/s00259-013-2478-8. Epub 2013 Jun 26.

PMID:
23801168
14.

Rostrocaudal gradients of dopamine D2/3 receptor binding in striatal subregions measured with [(11)C]raclopride and high-resolution positron emission tomography.

Alakurtti K, Johansson JJ, Tuokkola T, Någren K, Rinne JO.

Neuroimage. 2013 Nov 15;82:252-9. doi: 10.1016/j.neuroimage.2013.05.091. Epub 2013 May 28.

PMID:
23727314
15.

Characterization of hepatic tumors using [11C]metomidate through positron emission tomography: comparison with [11C]acetate.

Roivainen A, Naum A, Nuutinen H, Leino R, Nurmi H, Någren K, Parkkola R, Virtanen J, Kallajoki M, Kujari H, Ovaska J, Roberts P, Seppänen M.

EJNMMI Res. 2013 Feb 27;3(1):13. doi: 10.1186/2191-219X-3-13.

16.

A European multicentre PET study of fibrillar amyloid in Alzheimer's disease.

Nordberg A, Carter SF, Rinne J, Drzezga A, Brooks DJ, Vandenberghe R, Perani D, Forsberg A, Långström B, Scheinin N, Karrasch M, Någren K, Grimmer T, Miederer I, Edison P, Okello A, Van Laere K, Nelissen N, Vandenbulcke M, Garibotto V, Almkvist O, Kalbe E, Hinz R, Herholz K.

Eur J Nucl Med Mol Imaging. 2013 Jan;40(1):104-14. doi: 10.1007/s00259-012-2237-2. Epub 2012 Sep 8.

17.

Cognitive decline and amyloid accumulation in patients with mild cognitive impairment.

Koivunen J, Karrasch M, Scheinin NM, Aalto S, Vahlberg T, Någren K, Helin S, Viitanen M, Rinne JO.

Dement Geriatr Cogn Disord. 2012;34(1):31-7. doi: 10.1159/000341580. Epub 2012 Aug 3.

PMID:
22868352
18.

Temperament, character and serotonin activity in the human brain: a positron emission tomography study based on a general population cohort.

Tuominen L, Salo J, Hirvonen J, Någren K, Laine P, Melartin T, Isometsä E, Viikari J, Cloninger CR, Raitakari O, Hietala J, Keltikangas-Järvinen L.

Psychol Med. 2013 Apr;43(4):881-94. doi: 10.1017/S003329171200164X. Epub 2012 Jul 31.

PMID:
22850434
19.

Striatal μ-opioid receptor availability predicts cold pressor pain threshold in healthy human subjects.

Hagelberg N, Aalto S, Tuominen L, Pesonen U, Någren K, Hietala J, Scheinin H, Pertovaara A, Martikainen IK.

Neurosci Lett. 2012 Jul 11;521(1):11-4. doi: 10.1016/j.neulet.2012.05.042. Epub 2012 May 20.

PMID:
22622175
20.

Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parents.

Mosconi L, Rinne JO, Tsui WH, Murray J, Li Y, Glodzik L, McHugh P, Williams S, Cummings M, Pirraglia E, Goldsmith SJ, Vallabhajosula S, Scheinin N, Viljanen T, Någren K, de Leon MJ.

Neurobiol Aging. 2013 Jan;34(1):22-34. doi: 10.1016/j.neurobiolaging.2012.03.002. Epub 2012 Apr 11.

21.

Temperament trait Harm Avoidance associates with μ-opioid receptor availability in frontal cortex: a PET study using [(11)C]carfentanil.

Tuominen L, Salo J, Hirvonen J, Någren K, Laine P, Melartin T, Isometsä E, Viikari J, Raitakari O, Keltikangas-Järvinen L, Hietala J.

Neuroimage. 2012 Jul 2;61(3):670-6. doi: 10.1016/j.neuroimage.2012.03.063. Epub 2012 Mar 29.

PMID:
22484309
22.

Trimetazidine reduces endogenous free fatty acid oxidation and improves myocardial efficiency in obese humans.

Bucci M, Borra R, Någren K, Pärkkä JP, Del Ry S, Maggio R, Tuunanen H, Viljanen T, Cabiati M, Rigazio S, Taittonen M, Pagotto U, Parkkola R, Opie LH, Nuutila P, Knuuti J, Iozzo P.

Cardiovasc Ther. 2012 Dec;30(6):333-41. doi: 10.1111/j.1755-5922.2011.00275.x. Epub 2011 Jul 31.

PMID:
21884010
23.

Human obesity is characterized by defective fat storage and enhanced muscle fatty acid oxidation, and trimetazidine gradually counteracts these abnormalities.

Bucci M, Borra R, Någren K, Maggio R, Tuunanen H, Oikonen V, Del Ry S, Viljanen T, Taittonen M, Rigazio S, Giannessi D, Parkkola R, Knuuti J, Nuutila P, Iozzo P.

Am J Physiol Endocrinol Metab. 2011 Jul;301(1):E105-12. doi: 10.1152/ajpendo.00680.2010. Epub 2011 Apr 19.

24.

Cholinergic dysfunction after traumatic brain injury: preliminary findings from a PET study.

Östberg A, Virta J, Rinne JO, Oikonen V, Luoto P, Någren K, Arponen E, Tenovuo O.

Neurology. 2011 Mar 22;76(12):1046-50. doi: 10.1212/WNL.0b013e318211c1c4.

PMID:
21422456
25.

Amyloid PET imaging in patients with mild cognitive impairment: a 2-year follow-up study.

Koivunen J, Scheinin N, Virta JR, Aalto S, Vahlberg T, Någren K, Helin S, Parkkola R, Viitanen M, Rinne JO.

Neurology. 2011 Mar 22;76(12):1085-90. doi: 10.1212/WNL.0b013e318212015e. Epub 2011 Feb 16.

PMID:
21325653
26.

Gender differences in brain serotonin transporter availability in panic disorder.

Maron E, Tõru I, Hirvonen J, Tuominen L, Lumme V, Vasar V, Shlik J, Nutt DJ, Helin S, Någren K, Tiihonen J, Hietala J.

J Psychopharmacol. 2011 Jul;25(7):952-9. doi: 10.1177/0269881110389207. Epub 2010 Dec 8.

PMID:
21148024
27.

Radiosynthesis and evaluation of 11C-CIMBI-5 as a 5-HT2A receptor agonist radioligand for PET.

Ettrup A, Palner M, Gillings N, Santini MA, Hansen M, Kornum BR, Rasmussen LK, Någren K, Madsen J, Begtrup M, Knudsen GM.

J Nucl Med. 2010 Nov;51(11):1763-70. doi: 10.2967/jnumed.109.074021. Epub 2010 Oct 18.

28.

Development of an automated modular system for the synthesis of [11C]acetate.

Felicini C, Någren K, Berton A, Pascali G, Salvadori PA.

Nucl Med Commun. 2010 Dec;31(12):1033-9. doi: 10.1097/MNM.0b013e328340421a.

PMID:
20881892
29.

[(11)C]PIB-, [(18)F]FDG-PET and MRI imaging in patients with Parkinson's disease with and without dementia.

Jokinen P, Scheinin N, Aalto S, Någren K, Savisto N, Parkkola R, Rokka J, Haaparanta M, Röyttä M, Rinne JO.

Parkinsonism Relat Disord. 2010 Dec;16(10):666-70. doi: 10.1016/j.parkreldis.2010.08.021. Epub 2010 Sep 25.

PMID:
20870446
30.

Effects of antidepressant drug treatment and psychotherapy on striatal and thalamic dopamine D2/3 receptors in major depressive disorder studied with [11C]raclopride PET.

Hirvonen J, Hietala J, Kajander J, Markkula J, Rasi-Hakala H, Salminen JK, Någren K, Aalto S, Karlsson H.

J Psychopharmacol. 2011 Oct;25(10):1329-36. doi: 10.1177/0269881110376691. Epub 2010 Sep 9.

PMID:
20829308
31.

Assessment of islet specificity of dihydrotetrabenazine radiotracer binding in rat pancreas and human pancreas.

Fagerholm V, Mikkola KK, Ishizu T, Arponen E, Kauhanen S, Någren K, Solin O, Nuutila P, Haaparanta M.

J Nucl Med. 2010 Sep;51(9):1439-46. doi: 10.2967/jnumed.109.074492. Epub 2010 Aug 18.

32.

Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals.

Iozzo P, Bucci M, Roivainen A, Någren K, Järvisalo MJ, Kiss J, Guiducci L, Fielding B, Naum AG, Borra R, Virtanen K, Savunen T, Salvadori PA, Ferrannini E, Knuuti J, Nuutila P.

Gastroenterology. 2010 Sep;139(3):846-56, 856.e1-6. doi: 10.1053/j.gastro.2010.05.039. Epub 2010 May 25.

PMID:
20685204
33.

Increased brain fatty acid uptake in metabolic syndrome.

Karmi A, Iozzo P, Viljanen A, Hirvonen J, Fielding BA, Virtanen K, Oikonen V, Kemppainen J, Viljanen T, Guiducci L, Haaparanta-Solin M, Någren K, Solin O, Nuutila P.

Diabetes. 2010 Sep;59(9):2171-7. doi: 10.2337/db09-0138. Epub 2010 Jun 21.

34.

Reproducibility of striatal and thalamic dopamine D2 receptor binding using [11C]raclopride with high-resolution positron emission tomography.

Alakurtti K, Aalto S, Johansson JJ, Någren K, Tuokkola T, Oikonen V, Laine M, Rinne JO.

J Cereb Blood Flow Metab. 2011 Jan;31(1):155-65. doi: 10.1038/jcbfm.2010.64. Epub 2010 May 5.

35.

Uptake of 11C-choline in mouse atherosclerotic plaques.

Laitinen IE, Luoto P, Någren K, Marjamäki PM, Silvola JM, Hellberg S, Laine VJ, Ylä-Herttuala S, Knuuti J, Roivainen A.

J Nucl Med. 2010 May;51(5):798-802. doi: 10.2967/jnumed.109.071704. Epub 2010 Apr 15.

36.

Increased fibrillar amyloid-{beta} burden in normal individuals with a family history of late-onset Alzheimer's.

Mosconi L, Rinne JO, Tsui WH, Berti V, Li Y, Wang H, Murray J, Scheinin N, Någren K, Williams S, Glodzik L, De Santi S, Vallabhajosula S, de Leon MJ.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5949-54. doi: 10.1073/pnas.0914141107. Epub 2010 Mar 15.

37.

Cortical dopamine D2/D3 receptors and verbal memory in man.

Lumme V, Hirvonen MM, Ilonen T, Hirvonen J, Någren K, Hietala J.

Neuroimage. 2010 Jun;51(2):918-22. doi: 10.1016/j.neuroimage.2010.02.039. Epub 2010 Feb 24.

PMID:
20188195
38.

Positron emission tomography in at risk patients and in the progression of mild cognitive impairment to Alzheimer's disease.

Rinne JO, Någren K.

J Alzheimers Dis. 2010;19(1):291-300. doi: 10.3233/JAD-2010-1224. Review.

PMID:
20061645
39.

Radiopharmaceuticals for positron emission tomography investigations of Alzheimer's disease.

Någren K, Halldin C, Rinne JO.

Eur J Nucl Med Mol Imaging. 2010 Aug;37(8):1575-93. doi: 10.1007/s00259-009-1301-z. Epub 2009 Dec 22. Review.

PMID:
20033156
40.

Human dosimetry of carbon-11 labeled N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide extrapolated from whole-body distribution kinetics and radiometabolism in rats.

Luoto P, Laitinen I, Suilamo S, Någren K, Roivainen A.

Mol Imaging Biol. 2010 Aug;12(4):435-42. doi: 10.1007/s11307-009-0293-1. Epub 2009 Nov 26.

PMID:
19941083
41.

Research letter: Psychotherapy increases brain serotonin 5-HT1A receptors in patients with major depressive disorder.

Karlsson H, Hirvonen J, Kajander J, Markkula J, Rasi-Hakala H, Salminen JK, Någren K, Aalto S, Hietala J.

Psychol Med. 2010 Mar;40(3):523-8. doi: 10.1017/S0033291709991607. Epub 2009 Nov 11. No abstract available.

PMID:
19903365
42.

Human biodistribution and radiation dosimetry of 11C-(R)-PK11195, the prototypic PET ligand to image inflammation.

Hirvonen J, Roivainen A, Virta J, Helin S, Någren K, Rinne JO.

Eur J Nucl Med Mol Imaging. 2010 Mar;37(3):606-12. doi: 10.1007/s00259-009-1298-3. Epub 2009 Oct 28.

PMID:
19862517
43.

The effects of lorazepam on extrastriatal dopamine D(2/3)-receptors-A double-blind randomized placebo-controlled PET study.

Vilkman H, Kajander J, Aalto S, Vahlberg T, Någren K, Allonen T, Syvälahti E, Hietala J.

Psychiatry Res. 2009 Nov 30;174(2):130-7. doi: 10.1016/j.pscychresns.2009.04.006.

PMID:
19846281
44.

EANM procedure guidelines for PET brain imaging using [18F]FDG, version 2.

Varrone A, Asenbaum S, Vander Borght T, Booij J, Nobili F, Någren K, Darcourt J, Kapucu OL, Tatsch K, Bartenstein P, Van Laere K; European Association of Nuclear Medicine Neuroimaging Committee.

Eur J Nucl Med Mol Imaging. 2009 Dec;36(12):2103-10. doi: 10.1007/s00259-009-1264-0.

PMID:
19838705
45.

EANM procedure guidelines for brain neurotransmission SPECT/PET using dopamine D2 receptor ligands, version 2.

Van Laere K, Varrone A, Booij J, Vander Borght T, Nobili F, Kapucu OL, Walker Z, Någren K, Tatsch K, Darcourt J.

Eur J Nucl Med Mol Imaging. 2010 Feb;37(2):434-42. doi: 10.1007/s00259-009-1265-z.

PMID:
19838704
46.

EANM procedure guideline for brain perfusion SPECT using 99mTc-labelled radiopharmaceuticals, version 2.

Kapucu OL, Nobili F, Varrone A, Booij J, Vander Borght T, Någren K, Darcourt J, Tatsch K, Van Laere KJ.

Eur J Nucl Med Mol Imaging. 2009 Dec;36(12):2093-102. doi: 10.1007/s00259-009-1266-y.

PMID:
19838703
47.

EANM procedure guidelines for brain neurotransmission SPECT using (123)I-labelled dopamine transporter ligands, version 2.

Darcourt J, Booij J, Tatsch K, Varrone A, Vander Borght T, Kapucu OL, Någren K, Nobili F, Walker Z, Van Laere K.

Eur J Nucl Med Mol Imaging. 2010 Feb;37(2):443-50. doi: 10.1007/s00259-009-1267-x.

PMID:
19838702
48.

COMT Val158Met genotype does not alter cortical or striatal dopamine D2 receptor availability in vivo.

Hirvonen MM, Någren K, Rinne JO, Pesonen U, Vahlberg T, Hagelberg N, Hietala J.

Mol Imaging Biol. 2010 Apr;12(2):192-7. doi: 10.1007/s11307-009-0257-5. Epub 2009 Oct 1.

PMID:
19795175
49.

Follow-up of [11C]PIB uptake and brain volume in patients with Alzheimer disease and controls.

Scheinin NM, Aalto S, Koikkalainen J, Lötjönen J, Karrasch M, Kemppainen N, Viitanen M, Någren K, Helin S, Scheinin M, Rinne JO.

Neurology. 2009 Oct 13;73(15):1186-92. doi: 10.1212/WNL.0b013e3181bacf1b. Epub 2009 Sep 2.

PMID:
19726751
50.

Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study.

Okello A, Koivunen J, Edison P, Archer HA, Turkheimer FE, Någren K, Bullock R, Walker Z, Kennedy A, Fox NC, Rossor MN, Rinne JO, Brooks DJ.

Neurology. 2009 Sep 8;73(10):754-60. doi: 10.1212/WNL.0b013e3181b23564. Epub 2009 Jul 8.

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