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Items: 42

1.

A Multicellular Model of Intestinal Crypt Buckling and Fission.

Almet AA, Hughes BD, Landman KA, Näthke IS, Osborne JM.

Bull Math Biol. 2018 Feb;80(2):335-359. doi: 10.1007/s11538-017-0377-z. Epub 2017 Dec 12.

PMID:
29234982
2.

Increased variability in Apc(Min)/+ intestinal tissue can be measured with microultrasound.

Fatehullah A, Sharma S, Newton IP, Langlands AJ, Lay H, Nelson SA, McMahon RK, McIlvenny N, Appleton PL, Cochran S, Näthke IS.

Sci Rep. 2016 Jul 13;6:29570. doi: 10.1038/srep29570.

3.

Paneth Cell-Rich Regions Separated by a Cluster of Lgr5+ Cells Initiate Crypt Fission in the Intestinal Stem Cell Niche.

Langlands AJ, Almet AA, Appleton PL, Newton IP, Osborne JM, Näthke IS.

PLoS Biol. 2016 Jun 27;14(6):e1002491. doi: 10.1371/journal.pbio.1002491. eCollection 2016 Jun.

4.

Promoting microtubule assembly: A hypothesis for the functional significance of the +TIP network.

Gupta KK, Alberico EO, Näthke IS, Goodson HV.

Bioessays. 2014 Sep;36(9):818-26. doi: 10.1002/bies.201400029. Epub 2014 Jun 18.

PMID:
24943963
5.

Computational models reveal a passive mechanism for cell migration in the crypt.

Dunn SJ, Näthke IS, Osborne JM.

PLoS One. 2013 Nov 18;8(11):e80516. doi: 10.1371/journal.pone.0080516. eCollection 2013.

6.

Cell and tissue polarity in the intestinal tract during tumourigenesis: cells still know the right way up, but tissue organization is lost.

Fatehullah A, Appleton PL, Näthke IS.

Philos Trans R Soc Lond B Biol Sci. 2013 Sep 23;368(1629):20130014. doi: 10.1098/rstb.2013.0014. Print 2013.

7.

Interactions and functions of the adenomatous polyposis coli (APC) protein at a glance.

Nelson S, Näthke IS.

J Cell Sci. 2013 Feb 15;126(Pt 4):873-7. doi: 10.1242/jcs.100479. Review. No abstract available.

8.

The adenomatous polyposis coli protein contributes to normal compaction of mitotic chromatin.

Dikovskaya D, Khoudoli G, Newton IP, Chadha GS, Klotz D, Visvanathan A, Lamond A, Swedlow JR, Näthke IS.

PLoS One. 2012;7(6):e38102. doi: 10.1371/journal.pone.0038102. Epub 2012 Jun 13.

9.

A two-dimensional model of the colonic crypt accounting for the role of the basement membrane and pericryptal fibroblast sheath.

Dunn SJ, Appleton PL, Nelson SA, Näthke IS, Gavaghan DJ, Osborne JM.

PLoS Comput Biol. 2012;8(5):e1002515. doi: 10.1371/journal.pcbi.1002515. Epub 2012 May 24.

10.

Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems.

Nelson SA, Li Z, Newton IP, Fraser D, Milne RE, Martin DM, Schiffmann D, Yang X, Dormann D, Weijer CJ, Appleton PL, Näthke IS.

Dis Model Mech. 2012 Nov;5(6):940-7. doi: 10.1242/dmm.008607. Epub 2012 Apr 5.

11.

The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively.

Klotz DM, Nelson SA, Kroboth K, Newton IP, Radulescu S, Ridgway RA, Sansom OJ, Appleton PL, Näthke IS.

J Cell Sci. 2012 Feb 15;125(Pt 4):887-95. doi: 10.1242/jcs.091843. Epub 2012 Mar 7.

12.

Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol.

Radulescu S, Ridgway RA, Appleton P, Kroboth K, Patel S, Woodgett J, Taylor S, Nathke IS, Sansom OJ.

Oncogene. 2010 Dec 9;29(49):6418-27. doi: 10.1038/onc.2010.373. Epub 2010 Aug 23.

13.

Microtubule assembly by the Apc protein is regulated by importin-beta--RanGTP.

Dikovskaya D, Li Z, Newton IP, Davidson I, Hutchins JR, Kalab P, Clarke PR, Näthke IS.

J Cell Sci. 2010 Mar 1;123(Pt 5):736-46. doi: 10.1242/jcs.060806. Epub 2010 Feb 9.

14.

Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.

Quyn AJ, Appleton PL, Carey FA, Steele RJ, Barker N, Clevers H, Ridgway RA, Sansom OJ, Näthke IS.

Cell Stem Cell. 2010 Feb 5;6(2):175-81. doi: 10.1016/j.stem.2009.12.007.

15.

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.

Buchert M, Athineos D, Abud HE, Burke ZD, Faux MC, Samuel MS, Jarnicki AG, Winbanks CE, Newton IP, Meniel VS, Suzuki H, Stacker SA, Näthke IS, Tosh D, Huelsken J, Clarke AR, Heath JK, Sansom OJ, Ernst M.

PLoS Genet. 2010 Jan 15;6(1):e1000816. doi: 10.1371/journal.pgen.1000816.

16.

APC proteins. Preface.

Näthke IS, McCartney BM.

Adv Exp Med Biol. 2009;656:vii-x. No abstract available.

PMID:
19928347
17.

Prognostic and therapeutic implications of Apc mutations in colorectal cancer.

Quyn AJ, Steele RJ, Carey FA, Näthke IS.

Surgeon. 2008 Dec;6(6):350-6. Review.

PMID:
19110823
18.

Novel self-association of the APC molecule affects APC clusters and cell migration.

Li Z, Kroboth K, Newton IP, Näthke IS.

J Cell Sci. 2008 Jun 1;121(11):1916-25. doi: 10.1242/jcs.029470. Epub 2008 May 13.

19.

Cell regulation by the Apc protein Apc as master regulator of epithelia.

McCartney BM, Näthke IS.

Curr Opin Cell Biol. 2008 Apr;20(2):186-93. doi: 10.1016/j.ceb.2008.02.001. Epub 2008 Mar 24. Review.

PMID:
18359618
20.

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis.

Dikovskaya D, Schiffmann D, Newton IP, Oakley A, Kroboth K, Sansom O, Jamieson TJ, Meniel V, Clarke A, Näthke IS.

J Cell Biol. 2007 Jan 15;176(2):183-95. Erratum in: J Cell Biol. 2007 Jan 29;176(3):369.

21.

Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability.

Kroboth K, Newton IP, Kita K, Dikovskaya D, Zumbrunn J, Waterman-Storer CM, Näthke IS.

Mol Biol Cell. 2007 Mar;18(3):910-8. Epub 2006 Dec 27.

22.

Open microscopy environment and findspots: integrating image informatics with quantitative multidimensional image analysis.

Schiffmann DA, Dikovskaya D, Appleton PL, Newton IP, Creager DA, Allan C, Näthke IS, Goldberg IG.

Biotechniques. 2006 Aug;41(2):199-208.

23.

Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1.

Kita K, Wittmann T, Näthke IS, Waterman-Storer CM.

Mol Biol Cell. 2006 May;17(5):2331-45. Epub 2006 Mar 8.

24.

The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions.

Penman GA, Leung L, Näthke IS.

J Cell Sci. 2005 Oct 15;118(Pt 20):4741-50. Epub 2005 Sep 27.

26.
27.

The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium.

Näthke IS.

Annu Rev Cell Dev Biol. 2004;20:337-66. Review.

PMID:
15473844
28.

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.

Sansom OJ, Reed KR, Hayes AJ, Ireland H, Brinkmann H, Newton IP, Batlle E, Simon-Assmann P, Clevers H, Nathke IS, Clarke AR, Winton DJ.

Genes Dev. 2004 Jun 15;18(12):1385-90.

29.

The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts.

Dikovskaya D, Newton IP, Näthke IS.

Mol Biol Cell. 2004 Jun;15(6):2978-91. Epub 2004 Apr 9.

30.
31.

Catch and pull a microtubule: getting a grasp on the cortex.

Allan V, Näthke IS.

Nat Cell Biol. 2001 Oct;3(10):E226-8. No abstract available.

PMID:
11584281
32.

The adenomatous polyposis coli protein: in the limelight out at the edge.

Dikovskaya D, Zumbrunn J, Penman GA, Näthke IS.

Trends Cell Biol. 2001 Sep;11(9):378-84. Review.

PMID:
11514192
33.

A role for the Adenomatous Polyposis Coli protein in chromosome segregation.

Kaplan KB, Burds AA, Swedlow JR, Bekir SS, Sorger PK, Näthke IS.

Nat Cell Biol. 2001 Apr;3(4):429-32.

PMID:
11283619
34.
35.

The adenomatous polyposis coli protein.

Näthke IS.

Mol Pathol. 1999 Aug;52(4):169-73. Review.

36.

Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways.

Barth AI, Näthke IS, Nelson WJ.

Curr Opin Cell Biol. 1997 Oct;9(5):683-90. Review.

PMID:
9330872
37.

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

Näthke IS, Adams CL, Polakis P, Sellin JH, Nelson WJ.

J Cell Biol. 1996 Jul;134(1):165-79.

38.

Beta-catenin: a common target for the regulation of cell adhesion by Wnt-1 and Src signaling pathways.

Hinck L, Näthke IS, Papkoff J, Nelson WJ.

Trends Biochem Sci. 1994 Dec;19(12):538-42. Review.

PMID:
7846766
39.

Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells.

Näthke IS, Hinck L, Swedlow JR, Papkoff J, Nelson WJ.

J Cell Biol. 1994 Jun;125(6):1341-52.

40.

Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly.

Hinck L, Näthke IS, Papkoff J, Nelson WJ.

J Cell Biol. 1994 Jun;125(6):1327-40.

42.

Folding and trimerization of clathrin subunits at the triskelion hub.

Näthke IS, Heuser J, Lupas A, Stock J, Turck CW, Brodsky FM.

Cell. 1992 Mar 6;68(5):899-910.

PMID:
1547490

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