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Viral Appropriation: Laying Claim to Host Nuclear Transport Machinery.

Tessier TM, Dodge MJ, Prusinkiewicz MA, Mymryk JS.

Cells. 2019 Jun 8;8(6). pii: E559. doi: 10.3390/cells8060559. Review.


Metabolic Reprogramming of the Host Cell by Human Adenovirus Infection.

Prusinkiewicz MA, Mymryk JS.

Viruses. 2019 Feb 8;11(2). pii: E141. doi: 10.3390/v11020141. Review.


Mutational analysis of head and neck squamous cell carcinoma stratified by smoking status.

Ghasemi F, Prokopec SD, MacNeil D, Mundi N, Gameiro SF, Howlett C, Stecho W, Plantinga P, Pinto N, Ruicci KM, Khan MI, Yoo J, Fung K, Sahovaler A, Palma DA, Winquist E, Mymryk JS, Barrett JW, Boutros PC, Nichols AC.

JCI Insight. 2019 Jan 10;4(1). pii: 123443. doi: 10.1172/jci.insight.123443. [Epub ahead of print]


The Transcriptional Repressor BS69 is a Conserved Target of the E1A Proteins from Several Human Adenovirus Species.

Zhang A, Tessier TM, Galpin KJC, King CR, Gameiro SF, Anderson WW, Yousef AF, Qin WT, Li SSC, Mymryk JS.

Viruses. 2018 Nov 22;10(12). pii: E662. doi: 10.3390/v10120662.


A controlled trial of HNSCC patient-derived xenografts reveals broad efficacy of PI3Kα inhibition in controlling tumor growth.

Ruicci KM, Meens J, Sun RX, Rizzo G, Pinto N, Yoo J, Fung K, MacNeil D, Mymryk JS, Barrett JW, Boutros PC, Ailles L, Nichols AC.

Int J Cancer. 2018 Nov 23. doi: 10.1002/ijc.32009. [Epub ahead of print]


Lestaurtinib is a potent inhibitor of anaplastic thyroid cancer cell line models.

Pinto N, Prokopec SD, Vizeacoumar F, Searle K, Lowerison M, Ruicci KM, Yoo J, Fung K, MacNeil D, Lacefield JC, Leong HS, Mymryk JS, Barrett JW, Datti A, Boutros PC, Nichols AC.

PLoS One. 2018 Nov 12;13(11):e0207152. doi: 10.1371/journal.pone.0207152. eCollection 2018.


Treatment-naïve HPV+ head and neck cancers display a T-cell-inflamed phenotype distinct from their HPV- counterparts that has implications for immunotherapy.

Gameiro SF, Ghasemi F, Barrett JW, Koropatnick J, Nichols AC, Mymryk JS, Maleki Vareki S.

Oncoimmunology. 2018 Jul 30;7(10):e1498439. doi: 10.1080/2162402X.2018.1498439. eCollection 2018.


ERK-TSC2 signalling in constitutively-active HRAS mutant HNSCC cells promotes resistance to PI3K inhibition.

Ruicci KM, Pinto N, Khan MI, Yoo J, Fung K, MacNeil D, Mymryk JS, Barrett JW, Nichols AC.

Oral Oncol. 2018 Sep;84:95-103. doi: 10.1016/j.oraloncology.2018.07.010. Epub 2018 Jul 27.


Inhibition of androgen receptor transactivation function by adenovirus type 12 E1A undermines prostate cancer cell survival.

Li D, Tian G, Wang J, Zhao LY, Co O, Underill ZC, Mymryk JS, Claessens F, Dehm SM, Daaka Y, Liao D.

Prostate. 2018 Nov;78(15):1140-1156. doi: 10.1002/pros.23689. Epub 2018 Jul 15.


High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines.

Ghasemi F, Black M, Sun RX, Vizeacoumar F, Pinto N, Ruicci KM, Yoo J, Fung K, MacNeil D, Palma DA, Winquist E, Mymryk JS, Ailles LA, Datti A, Barrett JW, Boutros PC, Nichols AC.

Oncotarget. 2018 May 25;9(40):26064-26071. doi: 10.18632/oncotarget.25436. eCollection 2018 May 25.


Hacking the Cell: Network Intrusion and Exploitation by Adenovirus E1A.

King CR, Zhang A, Tessier TM, Gameiro SF, Mymryk JS.

MBio. 2018 May 1;9(3). pii: e00390-18. doi: 10.1128/mBio.00390-18. Review.


Mimicry of Cellular A Kinase-Anchoring Proteins Is a Conserved and Critical Function of E1A across Various Human Adenovirus Species.

King CR, Gameiro SF, Tessier TM, Zhang A, Mymryk JS.

J Virol. 2018 Mar 28;92(8). pii: e01902-17. doi: 10.1128/JVI.01902-17. Print 2018 Apr 15.


Human papillomavirus dysregulates the cellular apparatus controlling the methylation status of H3K27 in different human cancers to consistently alter gene expression regardless of tissue of origin.

Gameiro SF, Kolendowski B, Zhang A, Barrett JW, Nichols AC, Torchia J, Mymryk JS.

Oncotarget. 2017 Aug 3;8(42):72564-72576. doi: 10.18632/oncotarget.19885. eCollection 2017 Sep 22.


Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer.

Ghasemi F, Black M, Vizeacoumar F, Pinto N, Ruicci KM, Le CCSH, Lowerison MR, Leong HS, Yoo J, Fung K, MacNeil D, Palma DA, Winquist E, Mymryk JS, Boutros PC, Datti A, Barrett JW, Nichols AC.

Oncotarget. 2017 Apr 20;8(42):71512-71519. doi: 10.18632/oncotarget.17292. eCollection 2017 Sep 22.


Analysis of Class I Major Histocompatibility Complex Gene Transcription in Human Tumors Caused by Human Papillomavirus Infection.

Gameiro SF, Zhang A, Ghasemi F, Barrett JW, Nichols AC, Mymryk JS.

Viruses. 2017 Sep 10;9(9). pii: E252. doi: 10.3390/v9090252.


Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas.

Papillon-Cavanagh S, Lu C, Gayden T, Mikael LG, Bechet D, Karamboulas C, Ailles L, Karamchandani J, Marchione DM, Garcia BA, Weinreb I, Goldstein D, Lewis PW, Dancu OM, Dhaliwal S, Stecho W, Howlett CJ, Mymryk JS, Barrett JW, Nichols AC, Allis CD, Majewski J, Jabado N.

Nat Genet. 2017 Feb;49(2):180-185. doi: 10.1038/ng.3757. Epub 2017 Jan 9.


Activation of Langerhans-Type Dendritic Cells Alters Human Cytomegalovirus Infection and Reactivation in a Stimulus-Dependent Manner.

Coronel R, Jesus DM, Dalle Ore L, Mymryk JS, Hertel L.

Front Microbiol. 2016 Sep 14;7:1445. doi: 10.3389/fmicb.2016.01445. eCollection 2016.


Color Me Infected: Painting Cellular Chromatin with a Viral Histone Mimic.

King CR, Tessier TM, Mymryk JS.

Trends Microbiol. 2016 Oct;24(10):774-776. doi: 10.1016/j.tim.2016.08.005. Epub 2016 Sep 1.


The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2.

Glenewinkel F, Cohen MJ, King CR, Kaspar S, Bamberg-Lemper S, Mymryk JS, Becker W.

Sci Rep. 2016 Jun 16;6:28241. doi: 10.1038/srep28241.


Functional and Structural Mimicry of Cellular Protein Kinase A Anchoring Proteins by a Viral Oncoprotein.

King CR, Cohen MJ, Fonseca GJ, Dirk BS, Dikeakos JD, Mymryk JS.

PLoS Pathog. 2016 May 3;12(5):e1005621. doi: 10.1371/journal.ppat.1005621. eCollection 2016 May.


The Persistent Mystery of Adenovirus Persistence.

King CR, Zhang A, Mymryk JS.

Trends Microbiol. 2016 May;24(5):323-324. doi: 10.1016/j.tim.2016.02.007. Epub 2016 Feb 22. No abstract available.


Genomically driven precision medicine to improve outcomes in anaplastic thyroid cancer.

Pinto N, Black M, Patel K, Yoo J, Mymryk JS, Barrett JW, Nichols AC.

J Oncol. 2014;2014:936285. doi: 10.1155/2014/936285. Epub 2014 Sep 7. Review.


Adenovirus E1A targets the DREF nuclear factor to regulate virus gene expression, DNA replication, and growth.

Radko S, Koleva M, James KM, Jung R, Mymryk JS, Pelka P.

J Virol. 2014 Nov;88(22):13469-81. doi: 10.1128/JVI.02538-14. Epub 2014 Sep 10.


Functional analysis of the C-terminal region of human adenovirus E1A reveals a misidentified nuclear localization signal.

Cohen MJ, King CR, Dikeakos JD, Mymryk JS.

Virology. 2014 Nov;468-470:238-243. doi: 10.1016/j.virol.2014.08.014. Epub 2014 Sep 6.


The control of anaplastic thyroid carcinoma cell lines by oncolytic poxviruses.

Mundi N, Um S, Yoo J, Rizzo G, Black M, Pinto N, Palma DA, Fung K, MacNeil D, Mymryk JS, Barrett JW, Nichols AC.

Virus Res. 2014 Sep 22;190:53-9. doi: 10.1016/j.virusres.2014.07.009. Epub 2014 Jul 16.


Variable expression of the forgotten oncogene E5 in HPV-positive oropharyngeal cancer.

Um SH, Mundi N, Yoo J, Palma DA, Fung K, MacNeil D, Wehrli B, Mymryk JS, Barrett JW, Nichols AC.

J Clin Virol. 2014 Sep;61(1):94-100. doi: 10.1016/j.jcv.2014.06.019. Epub 2014 Jun 30.


Identification and characterization of multiple conserved nuclear localization signals within adenovirus E1A.

Marshall KS, Cohen MJ, Fonseca GJ, Todorovic B, King CR, Yousef AF, Zhang Z, Mymryk JS.

Virology. 2014 Apr;454-455:206-14. doi: 10.1016/j.virol.2014.02.020. Epub 2014 Mar 13.


Defining the genomic landscape of head and neck cancers through next-generation sequencing.

Rizzo G, Black M, Mymryk JS, Barrett JW, Nichols AC.

Oral Dis. 2015 Jan;21(1):e11-24. doi: 10.1111/odi.12246. Epub 2014 Apr 30. Review.


Adenovirus E1A recruits the human Paf1 complex to enhance transcriptional elongation.

Fonseca GJ, Cohen MJ, Mymryk JS.

J Virol. 2014 May;88(10):5630-7. doi: 10.1128/JVI.03518-13. Epub 2014 Mar 5.


The human papillomavirus E7 proteins associate with p190RhoGAP and alter its function.

Todorovic B, Nichols AC, Chitilian JM, Myers MP, Shepherd TG, Parsons SJ, Barrett JW, Banks L, Mymryk JS.

J Virol. 2014 Apr;88(7):3653-63. doi: 10.1128/JVI.03263-13. Epub 2014 Jan 8.


The adenovirus 55 residue E1A protein is a transcriptional activator and binds the unliganded thyroid hormone receptor.

Arulsundaram VD, Webb P, Yousef AF, Pelka P, Fonseca GJ, Baxter JD, Walfish PG, Mymryk JS.

J Gen Virol. 2014 Jan;95(Pt 1):142-52. doi: 10.1099/vir.0.056838-0. Epub 2013 Oct 17.


Vaccinia virus outperforms a panel of other poxviruses as a potent oncolytic agent for the control of head and neck squamous cell carcinoma cell lines.

Nichols AC, Yoo J, Um S, Mundi N, Palma DA, Fung K, Macneil SD, Koropatnick J, Mymryk JS, Barrett JW.

Intervirology. 2014;57(1):17-22. doi: 10.1159/000353854. Epub 2013 Aug 13.


The epidemic of human papillomavirus and oropharyngeal cancer in a Canadian population.

Nichols AC, Palma DA, Dhaliwal SS, Tan S, Theuer J, Chow W, Rajakumar C, Um S, Mundi N, Berk S, Zhou R, Basmaji J, Rizzo G, Franklin JH, Fung K, Kwan K, Wehrli B, Salvadori MI, Winquist E, Ernst S, Kuruvilla S, Read N, Venkatesan V, Todorovic B, Hammond JA, Koropatnick J, Mymryk JS, Yoo J, Barrett JW.

Curr Oncol. 2013 Aug;20(4):212-9. doi: 10.3747/co.20.1375.


Dissection of the C-terminal region of E1A redefines the roles of CtBP and other cellular targets in oncogenic transformation.

Cohen MJ, Yousef AF, Massimi P, Fonseca GJ, Todorovic B, Pelka P, Turnell AS, Banks L, Mymryk JS.

J Virol. 2013 Sep;87(18):10348-55. doi: 10.1128/JVI.00786-13. Epub 2013 Jul 17.


High frequency of activating PIK3CA mutations in human papillomavirus-positive oropharyngeal cancer.

Nichols AC, Palma DA, Chow W, Tan S, Rajakumar C, Rizzo G, Fung K, Kwan K, Wehrli B, Winquist E, Koropatnick J, Mymryk JS, Yoo J, Barrett JW.

JAMA Otolaryngol Head Neck Surg. 2013 Jun;139(6):617-22. doi: 10.1001/jamaoto.2013.3210.


Viral retasking of hBre1/RNF20 to recruit hPaf1 for transcriptional activation.

Fonseca GJ, Cohen MJ, Nichols AC, Barrett JW, Mymryk JS.

PLoS Pathog. 2013;9(6):e1003411. doi: 10.1371/journal.ppat.1003411. Epub 2013 Jun 13.


Does HPV type affect outcome in oropharyngeal cancer?

Nichols AC, Dhaliwal SS, Palma DA, Basmaji J, Chapeskie C, Dowthwaite S, Franklin JH, Fung K, Kwan K, Wehrli B, Howlett C, Siddiqui I, Salvadori MI, Winquist E, Ernst S, Kuruvilla S, Read N, Venkatesan V, Todorovic B, Hammond JA, Koropatnick J, Mymryk JS, Yoo J, Barrett JW.

J Otolaryngol Head Neck Surg. 2013 Feb 1;42:9. doi: 10.1186/1916-0216-42-9.


A case report and genetic characterization of a massive acinic cell carcinoma of the parotid with delayed distant metastases.

Nichols AC, Chan-Seng-Yue M, Yoo J, Agrawal SK, Starmans MH, Waggott D, Harding NJ, Dowthwaite SA, Palma DA, Fung K, Wehrli B, Macneil SD, Lambin P, Winquist E, Koropatnick J, Mymryk JS, Boutros PC, Barrett JW.

Case Rep Oncol Med. 2013;2013:270362. doi: 10.1155/2013/270362. Epub 2013 Apr 3.


A Pilot Study Comparing HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas by Whole Exome Sequencing.

Nichols AC, Chan-Seng-Yue M, Yoo J, Xu W, Dhaliwal S, Basmaji J, Szeto CC, Dowthwaite S, Todorovic B, Starmans MH, Lambin P, Palma DA, Fung K, Franklin JH, Wehrli B, Kwan K, Koropatnick J, Mymryk JS, Boutros P, Barrett JW.

ISRN Oncol. 2012;2012:809370. doi: 10.5402/2012/809370. Epub 2012 Dec 12.


Conserved region 3 of human papillomavirus 16 E7 contributes to deregulation of the retinoblastoma tumor suppressor.

Todorovic B, Hung K, Massimi P, Avvakumov N, Dick FA, Shaw GS, Banks L, Mymryk JS.

J Virol. 2012 Dec;86(24):13313-23. doi: 10.1128/JVI.01637-12. Epub 2012 Sep 26.


Frequent mutations in TP53 and CDKN2A found by next-generation sequencing of head and neck cancer cell lines.

Nichols AC, Yoo J, Palma DA, Fung K, Franklin JH, Koropatnick J, Mymryk JS, Batada NN, Barrett JW.

Arch Otolaryngol Head Neck Surg. 2012 Aug;138(8):732-9. doi: 10.1001/archoto.2012.1558.


Adenovirus evasion of interferon-mediated innate immunity by direct antagonism of a cellular histone posttranslational modification.

Fonseca GJ, Thillainadesan G, Yousef AF, Ablack JN, Mossman KL, Torchia J, Mymryk JS.

Cell Host Microbe. 2012 Jun 14;11(6):597-606. doi: 10.1016/j.chom.2012.05.005.


Cellular GCN5 is a novel regulator of human adenovirus E1A-conserved region 3 transactivation.

Ablack JN, Cohen M, Thillainadesan G, Fonseca GJ, Pelka P, Torchia J, Mymryk JS.

J Virol. 2012 Aug;86(15):8198-209. doi: 10.1128/JVI.00289-12. Epub 2012 May 23.


Ki-67 expression predicts radiotherapy failure in early glottic cancer.

Nichols AC, Whelan F, Basmaji J, Dhaliwal S, Dowthwaite S, Chapeskie C, Read N, Palma DA, Fung K, Venkatesan V, Hammond JA, Franklin JH, Siddiqui I, Wehrli B, Kwan K, Koropatnick J, Mymryk JS, Barrett JW, Yoo J.

J Otolaryngol Head Neck Surg. 2012 Apr;41(2):124-30.


TGF-β-dependent active demethylation and expression of the p15ink4b tumor suppressor are impaired by the ZNF217/CoREST complex.

Thillainadesan G, Chitilian JM, Isovic M, Ablack JN, Mymryk JS, Tini M, Torchia J.

Mol Cell. 2012 Jun 8;46(5):636-49. doi: 10.1016/j.molcel.2012.03.027. Epub 2012 May 3.


Characterization of the 55-residue protein encoded by the 9S E1A mRNA of species C adenovirus.

Miller MS, Pelka P, Fonseca GJ, Cohen MJ, Kelly JN, Barr SD, Grand RJ, Turnell AS, Whyte P, Mymryk JS.

J Virol. 2012 Apr;86(8):4222-33. doi: 10.1128/JVI.06399-11. Epub 2012 Feb 1.


The C-terminal region of E1A: a molecular tool for cellular cartography.

Yousef AF, Fonseca GJ, Cohen MJ, Mymryk JS.

Biochem Cell Biol. 2012 Apr;90(2):153-63. doi: 10.1139/o11-080. Epub 2012 Jan 31. Review.


Detection of circulating tumor cells in advanced head and neck cancer using the CellSearch system.

Nichols AC, Lowes LE, Szeto CC, Basmaji J, Dhaliwal S, Chapeskie C, Todorovic B, Read N, Venkatesan V, Hammond A, Palma DA, Winquist E, Ernst S, Fung K, Franklin JH, Yoo J, Koropatnick J, Mymryk JS, Barrett JW, Allan AL.

Head Neck. 2012 Oct;34(10):1440-4. doi: 10.1002/hed.21941. Epub 2011 Nov 11.


Adenovirus E1A interacts directly with, and regulates the level of expression of, the immunoproteasome component MECL1.

Berhane S, Aresté C, Ablack JN, Ryan GB, Blackbourn DJ, Mymryk JS, Turnell AS, Steele JC, Grand RJ.

Virology. 2011 Dec 20;421(2):149-58. doi: 10.1016/j.virol.2011.09.025. Epub 2011 Oct 21.


An unhealthy relationship: viral manipulation of the nuclear receptor superfamily.

Miller MS, Mymryk JS.

Future Microbiol. 2011 Sep;6(9):999-1019. doi: 10.2217/fmb.11.80. Review.


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