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Items: 1 to 50 of 55

1.

Sequencing Orbitides by Acid-Mediated Ring Cleavage Followed by Tandem Mass Spectrometry.

Fisher MF, Mylne JS.

J Proteome Res. 2019 Nov 1;18(11):4065-4071. doi: 10.1021/acs.jproteome.9b00516. Epub 2019 Oct 9.

PMID:
31566373
2.

An Orbitide from Ratibida columnifera Seed Containing 16 Amino Acid Residues.

Fisher MF, Payne CD, Rosengren KJ, Mylne JS.

J Nat Prod. 2019 Aug 23;82(8):2152-2158. doi: 10.1021/acs.jnatprod.9b00111. Epub 2019 Aug 8.

PMID:
31392883
3.

Total Synthesis of the Antimalarial Ascidian Natural Product Albopunctatone.

Pullella GA, Wdowiak AP, Sykes ML, Lucantoni L, Sukhoverkov KV, Zulfiqar B, Sobolev AN, West NP, Mylne JS, Avery VM, Piggott MJ.

Org Lett. 2019 Jul 19;21(14):5519-5523. doi: 10.1021/acs.orglett.9b01838. Epub 2019 Jul 9.

PMID:
31287326
4.

An interstitial peptide is readily processed from within seed proteins.

Pouvreau B, Fenske R, Ivanova A, Murcha MW, Mylne JS.

Plant Sci. 2019 Aug;285:175-183. doi: 10.1016/j.plantsci.2019.05.001. Epub 2019 May 11.

PMID:
31203882
5.

An Ancient Peptide Family Buried within Vicilin Precursors.

Zhang J, Payne CD, Pouvreau B, Schaefer H, Fisher MF, Taylor NL, Berkowitz O, Whelan J, Rosengren KJ, Mylne JS.

ACS Chem Biol. 2019 May 17;14(5):979-993. doi: 10.1021/acschembio.9b00167. Epub 2019 Apr 25.

PMID:
30973714
6.

The macrocyclizing protease butelase 1 remains autocatalytic and reveals the structural basis for ligase activity.

James AM, Haywood J, Leroux J, Ignasiak K, Elliott AG, Schmidberger JW, Fisher MF, Nonis SG, Fenske R, Bond CS, Mylne JS.

Plant J. 2019 Jun;98(6):988-999. doi: 10.1111/tpj.14293. Epub 2019 Mar 28.

PMID:
30790358
7.

A family of small, cyclic peptides buried in preproalbumin since the Eocene epoch.

Fisher MF, Zhang J, Taylor NL, Howard MJ, Berkowitz O, Debowski AW, Behsaz B, Whelan J, Pevzner PA, Mylne JS.

Plant Direct. 2018 Feb;2(2). pii: e00042. doi: 10.1002/pld3.42. Epub 2018 Feb 28.

8.

Targeting plant DIHYDROFOLATE REDUCTASE with antifolates and mechanisms for genetic resistance.

Corral MG, Haywood J, Stehl LH, Stubbs KA, Murcha MW, Mylne JS.

Plant J. 2018 Jun 7. doi: 10.1111/tpj.13983. [Epub ahead of print]

9.

Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action.

Wallace MD, Waraich NF, Debowski AW, Corral MG, Maxwell A, Mylne JS, Stubbs KA.

Chem Commun (Camb). 2018 Feb 15;54(15):1869-1872. doi: 10.1039/c7cc09518j.

PMID:
29388638
10.

Structural basis of ribosomal peptide macrocyclization in plants.

Haywood J, Schmidberger JW, James AM, Nonis SG, Sukhoverkov KV, Elias M, Bond CS, Mylne JS.

Elife. 2018 Jan 31;7. pii: e32955. doi: 10.7554/eLife.32955.

11.

Buried treasure: biosynthesis, structures and applications of cyclic peptides hidden in seed storage albumins.

Franke B, Mylne JS, Rosengren KJ.

Nat Prod Rep. 2018 Feb 21;35(2):137-146. doi: 10.1039/c7np00066a. Review.

PMID:
29379937
12.

A herbicide structure-activity analysis of the antimalarial lead compound MMV007978 against Arabidopsis thaliana.

Corral MG, Leroux J, Tresch S, Newton T, Stubbs KA, Mylne JS.

Pest Manag Sci. 2018 Jul;74(7):1558-1563. doi: 10.1002/ps.4872. Epub 2018 Mar 5.

PMID:
29377434
13.

Exploiting the Evolutionary Relationship between Malarial Parasites and Plants To Develop New Herbicides.

Corral MG, Leroux J, Tresch S, Newton T, Stubbs KA, Mylne JS.

Angew Chem Int Ed Engl. 2017 Aug 7;56(33):9881-9885. doi: 10.1002/anie.201705400. Epub 2017 Jul 12.

PMID:
28654179
14.

Two proteins for the price of one: Structural studies of the dual-destiny protein preproalbumin with sunflower trypsin inhibitor-1.

Franke B, James AM, Mobli M, Colgrave ML, Mylne JS, Rosengren KJ.

J Biol Chem. 2017 Jul 28;292(30):12398-12411. doi: 10.1074/jbc.M117.776955. Epub 2017 May 23.

15.

Herbicidal properties of antimalarial drugs.

Corral MG, Leroux J, Stubbs KA, Mylne JS.

Sci Rep. 2017 Mar 31;7:45871. doi: 10.1038/srep45871.

16.

Stepwise Evolution of a Buried Inhibitor Peptide over 45 My.

Jayasena AS, Fisher MF, Panero JL, Secco D, Bernath-Levin K, Berkowitz O, Taylor NL, Schilling EE, Whelan J, Mylne JS.

Mol Biol Evol. 2017 Jun 1;34(6):1505-1516. doi: 10.1093/molbev/msx104.

PMID:
28333296
17.

Macrocyclization by asparaginyl endopeptidases.

James AM, Haywood J, Mylne JS.

New Phytol. 2018 May;218(3):923-928. doi: 10.1111/nph.14511. Epub 2017 Mar 21. Review.

18.

Evidence for Ancient Origins of Bowman-Birk Inhibitors from Selaginella moellendorffii.

James AM, Jayasena AS, Zhang J, Berkowitz O, Secco D, Knott GJ, Whelan J, Bond CS, Mylne JS.

Plant Cell. 2017 Mar;29(3):461-473. doi: 10.1105/tpc.16.00831. Epub 2017 Mar 14.

19.

Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR.

Grage SL, Sani MA, Cheneval O, Henriques ST, Schalck C, Heinzmann R, Mylne JS, Mykhailiuk PK, Afonin S, Komarov IV, Separovic F, Craik DJ, Ulrich AS.

Biophys J. 2017 Feb 28;112(4):630-642. doi: 10.1016/j.bpj.2016.12.040.

20.

Natural structural diversity within a conserved cyclic peptide scaffold.

Elliott AG, Franke B, Armstrong DA, Craik DJ, Mylne JS, Rosengren KJ.

Amino Acids. 2017 Jan;49(1):103-116. doi: 10.1007/s00726-016-2333-x. Epub 2016 Oct 1.

PMID:
27695949
21.

Diverse cyclic seed peptides in the Mexican zinnia (Zinnia haageana).

Franke B, Jayasena AS, Fisher MF, Swedberg JE, Taylor NL, Mylne JS, Rosengren KJ.

Biopolymers. 2016 Nov;106(6):806-817. doi: 10.1002/bip.22901.

PMID:
27352920
22.

Mature forms of the major seed storage albumins in sunflower: A mass spectrometric approach.

Franke B, Colgrave ML, Mylne JS, Rosengren KJ.

J Proteomics. 2016 Sep 16;147:177-186. doi: 10.1016/j.jprot.2016.05.004. Epub 2016 May 10.

PMID:
27185550
23.

A tripartite approach identifies the major sunflower seed albumins.

Jayasena AS, Franke B, Rosengren J, Mylne JS.

Theor Appl Genet. 2016 Mar;129(3):613-29. doi: 10.1007/s00122-015-2653-3. Epub 2016 Jan 14.

24.

DNA Gyrase Is the Target for the Quinolone Drug Ciprofloxacin in Arabidopsis thaliana.

Evans-Roberts KM, Mitchenall LA, Wall MK, Leroux J, Mylne JS, Maxwell A.

J Biol Chem. 2016 Feb 12;291(7):3136-44. doi: 10.1074/jbc.M115.689554. Epub 2015 Dec 9.

25.

Peptide macrocyclization by a bifunctional endoprotease.

Bernath-Levin K, Nelson C, Elliott AG, Jayasena AS, Millar AH, Craik DJ, Mylne JS.

Chem Biol. 2015 May 21;22(5):571-82. doi: 10.1016/j.chembiol.2015.04.010. Epub 2015 May 7.

26.

An interactive database to explore herbicide physicochemical properties.

Gandy MN, Corral MG, Mylne JS, Stubbs KA.

Org Biomol Chem. 2015 May 28;13(20):5586-90. doi: 10.1039/c5ob00469a. Epub 2015 Apr 21. Review.

PMID:
25895669
27.

The evolution of Momordica cyclic peptides.

Mahatmanto T, Mylne JS, Poth AG, Swedberg JE, Kaas Q, Schaefer H, Craik DJ.

Mol Biol Evol. 2015 Feb;32(2):392-405. doi: 10.1093/molbev/msu307. Epub 2014 Nov 6.

PMID:
25376175
28.

Next generation sequencing and de novo transcriptomics to study gene evolution.

Jayasena AS, Secco D, Bernath-Levin K, Berkowitz O, Whelan J, Mylne JS.

Plant Methods. 2014 Oct 20;10(1):34. doi: 10.1186/1746-4811-10-34. eCollection 2014.

29.

Evolutionary origins of a bioactive peptide buried within Preproalbumin.

Elliott AG, Delay C, Liu H, Phua Z, Rosengren KJ, Benfield AH, Panero JL, Colgrave ML, Jayasena AS, Dunse KM, Anderson MA, Schilling EE, Ortiz-Barrientos D, Craik DJ, Mylne JS.

Plant Cell. 2014 Mar;26(3):981-95. doi: 10.1105/tpc.114.123620. Epub 2014 Mar 28.

30.

A comparative study of extraction methods reveals preferred solvents for cystine knot peptide isolation from Momordica cochinchinensis seeds.

Mahatmanto T, Poth AG, Mylne JS, Craik DJ.

Fitoterapia. 2014 Jun;95:22-33. doi: 10.1016/j.fitote.2014.02.016. Epub 2014 Mar 5.

PMID:
24613804
31.

Physical clustering of FLC alleles during Polycomb-mediated epigenetic silencing in vernalization.

Rosa S, De Lucia F, Mylne JS, Zhu D, Ohmido N, Pendle A, Kato N, Shaw P, Dean C.

Genes Dev. 2013 Sep 1;27(17):1845-50. doi: 10.1101/gad.221713.113.

32.

The Arabidopsis B3 domain protein VERNALIZATION1 (VRN1) is involved in processes essential for development, with structural and mutational studies revealing its DNA-binding surface.

King GJ, Chanson AH, McCallum EJ, Ohme-Takagi M, Byriel K, Hill JM, Martin JL, Mylne JS.

J Biol Chem. 2013 Feb 1;288(5):3198-207. doi: 10.1074/jbc.M112.438572. Epub 2012 Dec 19.

33.

Cyclotide isolation and characterization.

Craik DJ, Henriques ST, Mylne JS, Wang CK.

Methods Enzymol. 2012;516:37-62. doi: 10.1016/B978-0-12-394291-3.00024-1.

PMID:
23034223
34.

Cyclic peptides arising by evolutionary parallelism via asparaginyl-endopeptidase-mediated biosynthesis.

Mylne JS, Chan LY, Chanson AH, Daly NL, Schaefer H, Bailey TL, Nguyencong P, Cascales L, Craik DJ.

Plant Cell. 2012 Jul;24(7):2765-78. doi: 10.1105/tpc.112.099085. Epub 2012 Jul 20.

35.

Cyclotides associate with leaf vasculature and are the products of a novel precursor in petunia (Solanaceae).

Poth AG, Mylne JS, Grassl J, Lyons RE, Millar AH, Colgrave ML, Craik DJ.

J Biol Chem. 2012 Aug 3;287(32):27033-46. doi: 10.1074/jbc.M112.370841. Epub 2012 Jun 14.

36.

Cyclotides as a basis for drug design.

Craik DJ, Swedberg JE, Mylne JS, Cemazar M.

Expert Opin Drug Discov. 2012 Mar;7(3):179-94. doi: 10.1517/17460441.2012.661554. Epub 2012 Feb 21. Review.

PMID:
22468950
37.

Plant chemical biology: Florigen takes two to tango.

Mylne JS, Wigge PA.

Nat Chem Biol. 2011 Sep 19;7(10):665-6. doi: 10.1038/nchembio.666. No abstract available.

PMID:
21931316
38.

Cycloquest: identification of cyclopeptides via database search of their mass spectra against genome databases.

Mohimani H, Liu WT, Mylne JS, Poth AG, Colgrave ML, Tran D, Selsted ME, Dorrestein PC, Pevzner PA.

J Proteome Res. 2011 Oct 7;10(10):4505-12. doi: 10.1021/pr200323a. Epub 2011 Sep 7. Erratum in: J Proteome Res. 2011 Dec 2;10(12):5575.

39.

NMR assignment and secondary structure of the C-terminal DNA binding domain of Arabidopsis thaliana VERNALIZATION1.

Mylne JS, Mas C, Hill JM.

Biomol NMR Assign. 2012 Apr;6(1):5-8. doi: 10.1007/s12104-011-9313-6. Epub 2011 May 8.

PMID:
21553305
40.

Albumins and their processing machinery are hijacked for cyclic peptides in sunflower.

Mylne JS, Colgrave ML, Daly NL, Chanson AH, Elliott AG, McCallum EJ, Jones A, Craik DJ.

Nat Chem Biol. 2011 May;7(5):257-9. doi: 10.1038/nchembio.542. Epub 2011 Mar 20.

PMID:
21423169
41.

Protocol: A simple phenol-based method for 96-well extraction of high quality RNA from Arabidopsis.

Box MS, Coustham V, Dean C, Mylne JS.

Plant Methods. 2011 Mar 13;7:7. doi: 10.1186/1746-4811-7-7.

42.

Cyclotides are a component of the innate defense of Oldenlandia affinis.

Mylne JS, Wang CK, van der Weerden NL, Craik DJ.

Biopolymers. 2010;94(5):635-46. doi: 10.1002/bip.21419.

PMID:
20564018
43.

Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinis.

Qin Q, McCallum EJ, Kaas Q, Suda J, Saska I, Craik DJ, Mylne JS.

BMC Genomics. 2010 Feb 16;11:111. doi: 10.1186/1471-2164-11-111.

44.

Cyclotides: macrocyclic peptides with applications in drug design and agriculture.

Craik DJ, Mylne JS, Daly NL.

Cell Mol Life Sci. 2010 Jan;67(1):9-16. doi: 10.1007/s00018-009-0159-3. Epub 2009 Oct 1. Review.

PMID:
19795188
45.

Circular proteins from Melicytus (Violaceae) refine the conserved protein and gene architecture of cyclotides.

Trabi M, Mylne JS, Sando L, Craik DJ.

Org Biomol Chem. 2009 Jun 7;7(11):2378-88. doi: 10.1039/b823020j. Epub 2009 Apr 6.

PMID:
19462049
46.

Expression, purification and preliminary X-ray diffraction studies of VERNALIZATION1(208-341) from Arabidopsis thaliana.

King G, Hill JM, Martin JL, Mylne JS.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Mar 1;65(Pt 3):291-4. doi: 10.1107/S1744309109004217. Epub 2009 Feb 26.

47.

15N cyclotides by whole plant labeling.

Mylne JS, Craik DJ.

Biopolymers. 2008;90(4):575-80. doi: 10.1002/bip.21012.

PMID:
18464271
48.

ARABIDOPSIS TRITHORAX1 dynamically regulates FLOWERING LOCUS C activation via histone 3 lysine 4 trimethylation.

Pien S, Fleury D, Mylne JS, Crevillen P, Inzé D, Avramova Z, Dean C, Grossniklaus U.

Plant Cell. 2008 Mar;20(3):580-8. doi: 10.1105/tpc.108.058172. Epub 2008 Mar 28.

49.

The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity.

Herrmann A, Burman R, Mylne JS, Karlsson G, Gullbo J, Craik DJ, Clark RJ, Göransson U.

Phytochemistry. 2008 Feb;69(4):939-52. doi: 10.1016/j.phytochem.2007.10.023. Epub 2008 Jan 14.

PMID:
18191970
50.

The PHD finger protein VRN5 functions in the epigenetic silencing of Arabidopsis FLC.

Greb T, Mylne JS, Crevillen P, Geraldo N, An H, Gendall AR, Dean C.

Curr Biol. 2007 Jan 9;17(1):73-8. Epub 2006 Dec 14.

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