Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 125

1.

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates.

Cockman ME, Lippl K, Tian YM, Pegg HB, Figg WD Jnr, Abboud MI, Heilig R, Fischer R, Myllyharju J, Schofield CJ, Ratcliffe PJ.

Elife. 2019 Sep 10;8. pii: e46490. doi: 10.7554/eLife.46490.

2.

Role of prolyl hydroxylation in the molecular interactions of collagens.

Rappu P, Salo AM, Myllyharju J, Heino J.

Essays Biochem. 2019 Sep 13;63(3):325-335. doi: 10.1042/EBC20180053. Print 2019 Sep 13. Review.

3.

Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice.

Singh Y, Leinonen H, Fazaludeen F, Jaronen M, Guest D, Buckley N, Byts N, Oksa P, Jalkanen K, Iqbal I, Huuskonen M, Savchenko E, Keksa-Goldsteine V, Chew S, Myllyharju J, Tanila H, Ooi L, Koistinaho J, Kanninen KM, Malm T.

Hum Mol Genet. 2019 Jul 11. pii: ddz165. doi: 10.1093/hmg/ddz165. [Epub ahead of print]

PMID:
31294445
4.

Null mutation in P4h-tm leads to decreased fear and anxiety and increased social behavior in mice.

Leinonen H, Koivisto H, Lipponen HR, Matilainen A, Salo AM, Dimova EY, Hämäläinen E, Stavén S, Miettinen P, Myllyharju J, Koivunen P, Tanila H.

Neuropharmacology. 2019 Jul 15;153:63-72. doi: 10.1016/j.neuropharm.2019.04.023. Epub 2019 Apr 25.

PMID:
31029587
5.

Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease.

Laitakari A, Ollonen T, Kietzmann T, Walkinshaw G, Mennerich D, Izzi V, Haapasaari KM, Myllyharju J, Serpi R, Dimova EY, Koivunen P.

Redox Biol. 2019 Apr;22:101145. doi: 10.1016/j.redox.2019.101145. Epub 2019 Feb 19.

6.

Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II): High affinity peptides have a PxGP sequence motif.

Murthy AV, Sulu R, Koski MK, Tu H, Anantharajan J, Sah-Teli SK, Myllyharju J, Wierenga RK.

Protein Sci. 2018 Sep;27(9):1692-1703. doi: 10.1002/pro.3450.

7.

Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families.

Aviram R, Zaffryar-Eilot S, Hubmacher D, Grunwald H, Mäki JM, Myllyharju J, Apte SS, Hasson P.

Matrix Biol. 2019 Jan;75-76:114-125. doi: 10.1016/j.matbio.2018.05.003. Epub 2018 May 17.

PMID:
29758265
8.

BAMBI is a novel HIF1-dependent modulator of TGFβ-mediated disruption of cell polarity during hypoxia.

Raykhel I, Moafi F, Myllymäki SM, Greciano PG, Matlin KS, Moyano JV, Manninen A, Myllyharju J.

J Cell Sci. 2018 May 23;131(10). pii: jcs210906. doi: 10.1242/jcs.210906.

9.

Proline hydroxylation in collagen supports integrin binding by two distinct mechanisms.

Sipilä KH, Drushinin K, Rappu P, Jokinen J, Salminen TA, Salo AM, Käpylä J, Myllyharju J, Heino J.

J Biol Chem. 2018 May 18;293(20):7645-7658. doi: 10.1074/jbc.RA118.002200. Epub 2018 Apr 3.

10.

Kinetic Analysis of HIF Prolyl Hydroxylases.

Koivunen P, Myllyharju J.

Methods Mol Biol. 2018;1742:15-25. doi: 10.1007/978-1-4939-7665-2_2.

PMID:
29330786
11.

Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways.

Ullah K, Rosendahl AH, Izzi V, Bergmann U, Pihlajaniemi T, Mäki JM, Myllyharju J.

Sci Rep. 2017 Dec 8;7(1):17220. doi: 10.1038/s41598-017-17376-0.

12.

Blocking Surgically Induced Lysyl Oxidase Activity Reduces the Risk of Lung Metastases.

Rachman-Tzemah C, Zaffryar-Eilot S, Grossman M, Ribero D, Timaner M, Mäki JM, Myllyharju J, Bertolini F, Hershkovitz D, Sagi I, Hasson P, Shaked Y.

Cell Rep. 2017 Apr 25;19(4):774-784. doi: 10.1016/j.celrep.2017.04.005.

13.

P4HA1 mutations cause a unique congenital disorder of connective tissue involving tendon, bone, muscle and the eye.

Zou Y, Donkervoort S, Salo AM, Foley AR, Barnes AM, Hu Y, Makareeva E, Leach ME, Mohassel P, Dastgir J, Deardorff MA, Cohn RD, DiNonno WO, Malfait F, Lek M, Leikin S, Marini JC, Myllyharju J, Bönnemann CG.

Hum Mol Genet. 2017 Jun 15;26(12):2207-2217. doi: 10.1093/hmg/ddx110.

14.

Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics.

Ratcliffe P, Koivunen P, Myllyharju J, Ragoussis J, Bovée JV, Batinic-Haberle I, Vinatier C, Trichet V, Robriquet F, Oliver L, Gardie B.

Hypoxia (Auckl). 2017 Mar 15;5:11-20. doi: 10.2147/HP.S127042. eCollection 2017. Review.

15.

Structural basis of homo- and heterotrimerization of collagen I.

Sharma U, Carrique L, Vadon-Le Goff S, Mariano N, Georges RN, Delolme F, Koivunen P, Myllyharju J, Moali C, Aghajari N, Hulmes DJ.

Nat Commun. 2017 Mar 10;8:14671. doi: 10.1038/ncomms14671.

16.

Assembly of the elongated collagen prolyl 4-hydroxylase α2β2 heterotetramer around a central α2 dimer.

Koski MK, Anantharajan J, Kursula P, Dhavala P, Murthy AV, Bergmann U, Myllyharju J, Wierenga RK.

Biochem J. 2017 Feb 20;474(5):751-769. doi: 10.1042/BCJ20161000.

PMID:
28093469
17.

Notch Downregulation and Extramedullary Erythrocytosis in Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2-Deficient Mice.

Myllymäki MNM, Määttä J, Dimova EY, Izzi V, Väisänen T, Myllyharju J, Koivunen P, Serpi R.

Mol Cell Biol. 2017 Jan 4;37(2). pii: e00529-16. doi: 10.1128/MCB.00529-16. Print 2017 Jan 15.

18.

Lack of P4H-TM in mice results in age-related retinal and renal alterations.

Leinonen H, Rossi M, Salo AM, Tiainen P, Hyvärinen J, Pitkänen M, Sormunen R, Miinalainen I, Zhang C, Soininen R, Kivirikko KI, Koskelainen A, Tanila H, Myllyharju J, Koivunen P.

Hum Mol Genet. 2016 Sep 1;25(17):3810-3823. doi: 10.1093/hmg/ddw228. Epub 2016 Jul 27.

PMID:
27466183
19.

CD146(+) cells are essential for kidney vasculature development.

Halt KJ, Pärssinen HE, Junttila SM, Saarela U, Sims-Lucas S, Koivunen P, Myllyharju J, Quaggin S, Skovorodkin IN, Vainio SJ.

Kidney Int. 2016 Aug;90(2):311-324. doi: 10.1016/j.kint.2016.02.021. Epub 2016 Apr 18.

20.

Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis.

Rahtu-Korpela L, Määttä J, Dimova EY, Hörkkö S, Gylling H, Walkinshaw G, Hakkola J, Kivirikko KI, Myllyharju J, Serpi R, Koivunen P.

Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):608-17. doi: 10.1161/ATVBAHA.115.307136. Epub 2016 Feb 4.

PMID:
26848160
21.

Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning.

Pietilä I, Prunskaite-Hyyryläinen R, Kaisto S, Tika E, van Eerde AM, Salo AM, Garma L, Miinalainen I, Feitz WF, Bongers EM, Juffer A, Knoers NV, Renkema KY, Myllyharju J, Vainio SJ.

PLoS One. 2016 Jan 21;11(1):e0147171. doi: 10.1371/journal.pone.0147171. eCollection 2016.

22.

HIF-P4H-2 deficiency protects against skeletal muscle ischemia-reperfusion injury.

Karsikas S, Myllymäki M, Heikkilä M, Sormunen R, Kivirikko KI, Myllyharju J, Serpi R, Koivunen P.

J Mol Med (Berl). 2016 Mar;94(3):301-10. doi: 10.1007/s00109-015-1349-0. Epub 2015 Oct 10.

PMID:
26452676
23.

PHD1 regulates p53-mediated colorectal cancer chemoresistance.

Deschoemaeker S, Di Conza G, Lilla S, Martín-Pérez R, Mennerich D, Boon L, Hendrikx S, Maddocks OD, Marx C, Radhakrishnan P, Prenen H, Schneider M, Myllyharju J, Kietzmann T, Vousden KH, Zanivan S, Mazzone M.

EMBO Mol Med. 2015 Oct;7(10):1350-65. doi: 10.15252/emmm.201505492.

24.

Severe Extracellular Matrix Abnormalities and Chondrodysplasia in Mice Lacking Collagen Prolyl 4-Hydroxylase Isoenzyme II in Combination with a Reduced Amount of Isoenzyme I.

Aro E, Salo AM, Khatri R, Finnilä M, Miinalainen I, Sormunen R, Pakkanen O, Holster T, Soininen R, Prein C, Clausen-Schaumann H, Aszódi A, Tuukkanen J, Kivirikko KI, Schipani E, Myllyharju J.

J Biol Chem. 2015 Jul 3;290(27):16964-78. doi: 10.1074/jbc.M115.662635. Epub 2015 May 22.

25.

Muscle composition is regulated by a Lox-TGFβ feedback loop.

Kutchuk L, Laitala A, Soueid-Bomgarten S, Shentzer P, Rosendahl AH, Eilot S, Grossman M, Sagi I, Sormunen R, Myllyharju J, Mäki JM, Hasson P.

Development. 2015 Mar 1;142(5):983-93. doi: 10.1242/dev.113449.

26.

Extracellular matrix and developing growth plate.

Myllyharju J.

Curr Osteoporos Rep. 2014 Dec;12(4):439-45. doi: 10.1007/s11914-014-0232-1. Review.

PMID:
25212565
27.

Clinical characterization, genetic mapping and whole-genome sequence analysis of a novel autosomal recessive intellectual disability syndrome.

Kaasinen E, Rahikkala E, Koivunen P, Miettinen S, Wamelink MM, Aavikko M, Palin K, Myllyharju J, Moilanen JS, Pajunen L, Karhu A, Aaltonen LA.

Eur J Med Genet. 2014 Oct;57(10):543-51. doi: 10.1016/j.ejmg.2014.07.002. Epub 2014 Jul 29.

PMID:
25078763
28.

HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction.

Rahtu-Korpela L, Karsikas S, Hörkkö S, Blanco Sequeiros R, Lammentausta E, Mäkelä KA, Herzig KH, Walkinshaw G, Kivirikko KI, Myllyharju J, Serpi R, Koivunen P.

Diabetes. 2014 Oct;63(10):3324-33. doi: 10.2337/db14-0472. Epub 2014 May 1.

29.

The structural motifs for substrate binding and dimerization of the α subunit of collagen prolyl 4-hydroxylase.

Anantharajan J, Koski MK, Kursula P, Hieta R, Bergmann U, Myllyharju J, Wierenga RK.

Structure. 2013 Dec 3;21(12):2107-18. doi: 10.1016/j.str.2013.09.005. Epub 2013 Oct 24.

30.

Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection.

Kerkelä R, Karsikas S, Szabo Z, Serpi R, Magga J, Gao E, Alitalo K, Anisimov A, Sormunen R, Pietilä I, Vainio L, Koch WJ, Kivirikko KI, Myllyharju J, Koivunen P.

Mol Cell Biol. 2013 Aug;33(16):3321-9. doi: 10.1128/MCB.00432-13. Epub 2013 Jun 17.

31.

Prolyl 4-hydroxylases, master regulators of the hypoxia response.

Myllyharju J.

Acta Physiol (Oxf). 2013 Jun;208(2):148-65. doi: 10.1111/apha.12096. Epub 2013 Apr 12. Review.

PMID:
23489300
32.

Hypoxia-inducible factor prolyl 4-hydroxylases: common and specific roles.

Myllyharju J, Koivunen P.

Biol Chem. 2013 Apr;394(4):435-48. doi: 10.1515/hsz-2012-0328. Review.

PMID:
23324380
33.

Prolyl 4-hydroxlase activity is essential for development and cuticle formation in the human infective parasitic nematode Brugia malayi.

Winter AD, McCormack G, Myllyharju J, Page AP.

J Biol Chem. 2013 Jan 18;288(3):1750-61. doi: 10.1074/jbc.M112.397604. Epub 2012 Dec 6.

34.

The expression and role of Lysyl oxidase (LOX) in dentinogenesis.

Tjäderhane L, Vered M, Pääkkönen V, Peteri A, Mäki JM, Myllyharju J, Dayan D, Salo T.

Int Endod J. 2013 Jun;46(6):581-9. doi: 10.1111/iej.12031. Epub 2012 Nov 28.

PMID:
23190333
35.

Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis.

Laitala A, Aro E, Walkinshaw G, Mäki JM, Rossi M, Heikkilä M, Savolainen ER, Arend M, Kivirikko KI, Koivunen P, Myllyharju J.

Blood. 2012 Oct 18;120(16):3336-44. doi: 10.1182/blood-2012-07-441824. Epub 2012 Sep 5.

PMID:
22955912
36.

Hypoxia-inducible factor-1 (HIF-1) but not HIF-2 is essential for hypoxic induction of collagen prolyl 4-hydroxylases in primary newborn mouse epiphyseal growth plate chondrocytes.

Aro E, Khatri R, Gerard-O'Riley R, Mangiavini L, Myllyharju J, Schipani E.

J Biol Chem. 2012 Oct 26;287(44):37134-44. doi: 10.1074/jbc.M112.352872. Epub 2012 Aug 28.

37.

High myopia caused by a mutation in LEPREL1, encoding prolyl 3-hydroxylase 2.

Mordechai S, Gradstein L, Pasanen A, Ofir R, El Amour K, Levy J, Belfair N, Lifshitz T, Joshua S, Narkis G, Elbedour K, Myllyharju J, Birk OS.

Am J Hum Genet. 2011 Sep 9;89(3):438-45. doi: 10.1016/j.ajhg.2011.08.003. Epub 2011 Sep 1.

38.

A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases.

Luo X, Liu Y, Kubicek S, Myllyharju J, Tumber A, Ng S, Che KH, Podoll J, Heightman TD, Oppermann U, Schreiber SL, Wang X.

J Am Chem Soc. 2011 Jun 22;133(24):9451-6. doi: 10.1021/ja201597b. Epub 2011 May 31.

39.

The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells.

Sato S, Trackman PC, Mäki JM, Myllyharju J, Kirsch KH, Sonenshein GE.

Mol Cell Biol. 2011 Jul;31(13):2683-95. doi: 10.1128/MCB.01148-10. Epub 2011 May 2.

40.

Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response.

Heikkilä M, Pasanen A, Kivirikko KI, Myllyharju J.

Cell Mol Life Sci. 2011 Dec;68(23):3885-901. doi: 10.1007/s00018-011-0679-5. Epub 2011 Apr 10.

PMID:
21479871
41.

Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1.

Xu H, Raynal N, Stathopoulos S, Myllyharju J, Farndale RW, Leitinger B.

Matrix Biol. 2011 Jan;30(1):16-26. doi: 10.1016/j.matbio.2010.10.004. Epub 2010 Oct 28.

42.

Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function.

Hyvärinen J, Parikka M, Sormunen R, Rämet M, Tryggvason K, Kivirikko KI, Myllyharju J, Koivunen P.

J Biol Chem. 2010 Dec 31;285(53):42023-32. doi: 10.1074/jbc.M110.145904. Epub 2010 Oct 15.

43.

Sandwich ELISA for quantitative detection of human collagen prolyl 4-hydroxylase.

Osmekhina E, Neubauer A, Klinzing K, Myllyharju J, Neubauer P.

Microb Cell Fact. 2010 Jun 17;9:48. doi: 10.1186/1475-2859-9-48.

44.

Characterization of two carnation petal prolyl 4 hydroxylases.

Vlad F, Tiainen P, Owen C, Spano T, Daher FB, Oualid F, Senol NO, Vlad D, Myllyharju J, Kalaitzis P.

Physiol Plant. 2010 Oct;140(2):199-207. doi: 10.1111/j.1399-3054.2010.01390.x.

PMID:
20553416
45.

Hypoxia-inducible factor (HIF)-3alpha is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2.

Pasanen A, Heikkilä M, Rautavuoma K, Hirsilä M, Kivirikko KI, Myllyharju J.

Int J Biochem Cell Biol. 2010 Jul;42(7):1189-200. doi: 10.1016/j.biocel.2010.04.008. Epub 2010 Apr 21.

PMID:
20416395
46.

Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury.

Hyvärinen J, Hassinen IE, Sormunen R, Mäki JM, Kivirikko KI, Koivunen P, Myllyharju J.

J Biol Chem. 2010 Apr 30;285(18):13646-57. doi: 10.1074/jbc.M109.084855. Epub 2010 Feb 25.

47.

Missense mutations that cause Bruck syndrome affect enzymatic activity, folding, and oligomerization of lysyl hydroxylase 2.

Hyry M, Lantto J, Myllyharju J.

J Biol Chem. 2009 Nov 6;284(45):30917-24. doi: 10.1074/jbc.M109.021238. Epub 2009 Sep 17.

48.

HIF prolyl 4-hydroxylases and their potential as drug targets.

Myllyharju J.

Curr Pharm Des. 2009;15(33):3878-85. Review.

PMID:
19671043
49.

Extracellular matrix genes as hypoxia-inducible targets.

Myllyharju J, Schipani E.

Cell Tissue Res. 2010 Jan;339(1):19-29. doi: 10.1007/s00441-009-0841-7. Epub 2009 Aug 7. Review.

50.

The crystal structure of an algal prolyl 4-hydroxylase complexed with a proline-rich peptide reveals a novel buried tripeptide binding motif.

Koski MK, Hieta R, Hirsilä M, Rönkä A, Myllyharju J, Wierenga RK.

J Biol Chem. 2009 Sep 11;284(37):25290-301. doi: 10.1074/jbc.M109.014050. Epub 2009 Jun 24.

Supplemental Content

Loading ...
Support Center