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Items: 1 to 50 of 207

1.

Structural diversity in the Mycobacteria DUF3349 superfamily.

Buchko GW, Abendroth J, Robinson JI, Phan IQ, Myler PJ, Edwards TE.

Protein Sci. 2019 Oct 28. doi: 10.1002/pro.3758. [Epub ahead of print]

PMID:
31658388
2.

Dynamic colocalization of 2 simultaneously active VSG expression sites within a single expression-site body in Trypanosoma brucei.

Budzak J, Kerry LE, Aristodemou A, Hall BS, Witmer K, Kushwaha M, Davies C, Povelones ML, McDonald JR, Sur A, Myler PJ, Rudenko G.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16561-16570. doi: 10.1073/pnas.1905552116. Epub 2019 Jul 29.

3.

Dramatic changes in gene expression in different forms of Crithidia fasciculata reveal potential mechanisms for insect-specific adhesion in kinetoplastid parasites.

Filosa JN, Berry CT, Ruthel G, Beverley SM, Warren WC, Tomlinson C, Myler PJ, Dudkin EA, Povelones ML, Povelones M.

PLoS Negl Trop Dis. 2019 Jul 29;13(7):e0007570. doi: 10.1371/journal.pntd.0007570. eCollection 2019 Jul.

4.

Structural characterization of β-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites.

Patterson EI, Nanson JD, Abendroth J, Bryan C, Sankaran B, Myler PJ, Forwood JK.

Proteins. 2019 Jun 25. doi: 10.1002/prot.25765. [Epub ahead of print]

PMID:
31237717
5.

Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors.

Schlott AC, Mayclin S, Reers AR, Coburn-Flynn O, Bell AS, Green J, Knuepfer E, Charter D, Bonnert R, Campo B, Burrows J, Lyons-Abbott S, Staker BL, Chung CW, Myler PJ, Fidock DA, Tate EW, Holder AA.

Cell Chem Biol. 2019 Jul 18;26(7):991-1000.e7. doi: 10.1016/j.chembiol.2019.03.015. Epub 2019 May 9.

6.

Functional genomics in sand fly-derived Leishmania promastigotes.

Alcolea PJ, Alonso A, Molina R, Jiménez M, Myler PJ, Larraga V.

PLoS Negl Trop Dis. 2019 May 9;13(5):e0007288. doi: 10.1371/journal.pntd.0007288. eCollection 2019 May. Review.

7.

Quantitative RNA Analysis Using RNA-Seq.

Myler PJ, McDonald JA, Alcolea PJ, Sur A.

Methods Mol Biol. 2019;1971:95-108. doi: 10.1007/978-1-4939-9210-2_4.

PMID:
30980299
8.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Baragaña B, Forte B, Choi R, Nakazawa Hewitt S, Bueren-Calabuig JA, Pisco JP, Peet C, Dranow DM, Robinson DA, Jansen C, Norcross NR, Vinayak S, Anderson M, Brooks CF, Cooper CA, Damerow S, Delves M, Dowers K, Duffy J, Edwards TE, Hallyburton I, Horst BG, Hulverson MA, Ferguson L, Jiménez-Díaz MB, Jumani RS, Lorimer DD, Love MS, Maher S, Matthews H, McNamara CW, Miller P, O'Neill S, Ojo KK, Osuna-Cabello M, Pinto E, Post J, Riley J, Rottmann M, Sanz LM, Scullion P, Sharma A, Shepherd SM, Shishikura Y, Simeons FRC, Stebbins EE, Stojanovski L, Straschil U, Tamaki FK, Tamjar J, Torrie LS, Vantaux A, Witkowski B, Wittlin S, Yogavel M, Zuccotto F, Angulo-Barturen I, Sinden R, Baum J, Gamo FJ, Mäser P, Kyle DE, Winzeler EA, Myler PJ, Wyatt PG, Floyd D, Matthews D, Sharma A, Striepen B, Huston CD, Gray DW, Fairlamb AH, Pisliakov AV, Walpole C, Read KD, Van Voorhis WC, Gilbert IH.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7015-7020. doi: 10.1073/pnas.1814685116. Epub 2019 Mar 20.

9.

Comparative transcriptomics in Leishmania braziliensis: disclosing differential gene expression of coding and putative noncoding RNAs across developmental stages.

Ruy PC, Monteiro-Teles NM, Miserani Magalhães RD, Freitas-Castro F, Dias L, Aquino Defina TP, Rosas De Vasconcelos EJ, Myler PJ, Kaysel Cruz A.

RNA Biol. 2019 May;16(5):639-660. doi: 10.1080/15476286.2019.1574161. Epub 2019 Feb 22.

PMID:
30689499
10.

Ab initio structure solution of a proteolytic fragment using ARCIMBOLDO.

Abendroth J, Sankaran B, Myler PJ, Lorimer DD, Edwards TE.

Acta Crystallogr F Struct Biol Commun. 2018 Sep 1;74(Pt 9):530-535. doi: 10.1107/S2053230X18010063. Epub 2018 Aug 29.

11.

Cytosolic expression, solution structures, and molecular dynamics simulation of genetically encodable disulfide-rich de novo designed peptides.

Buchko GW, Pulavarti SVSRK, Ovchinnikov V, Shaw EA, Rettie SA, Myler PJ, Karplus M, Szyperski T, Baker D, Bahl CD.

Protein Sci. 2018 Sep;27(9):1611-1623. doi: 10.1002/pro.3453.

12.

Structure and analysis of nucleoside diphosphate kinase from Borrelia burgdorferi prepared in a transition-state complex with ADP and vanadate moieties.

Dumais M, Davies DR, Lin T, Staker BL, Myler PJ, Van Voorhis WC.

Acta Crystallogr F Struct Biol Commun. 2018 Jun 1;74(Pt 6):373-384. doi: 10.1107/S2053230X18007392. Epub 2018 May 31.

13.

Crystal structure of chorismate mutase from Burkholderia thailandensis.

Asojo OA, Dranow DM, Serbzhinskiy D, Subramanian S, Staker B, Edwards TE, Myler PJ.

Acta Crystallogr F Struct Biol Commun. 2018 May 1;74(Pt 5):294-299. doi: 10.1107/S2053230X1800506X. Epub 2018 Apr 16.

14.

Crystal structure of chorismate mutase from Burkholderia phymatum.

Asojo OA, Subramanian S, Abendroth J, Exley I, Lorimer DD, Edwards TE, Myler PJ.

Acta Crystallogr F Struct Biol Commun. 2018 Apr 1;74(Pt 4):187-192. doi: 10.1107/S2053230X18002868. Epub 2018 Mar 22.

15.

RNA-seq analysis reveals differences in transcript abundance between cultured and sand fly-derived Leishmania infantum promastigotes.

Alcolea PJ, Alonso A, Baugh L, Paisie C, Ramasamy G, Sekar A, Sur A, Jiménez M, Molina R, Larraga V, Myler PJ.

Parasitol Int. 2018 Aug;67(4):476-480. doi: 10.1016/j.parint.2018.03.008. Epub 2018 Mar 30.

PMID:
29609036
16.

The identification of inhibitory compounds of Rickettsia prowazekii methionine aminopeptidase for antibacterial applications.

Helgren TR, Seven ES, Chen C, Edwards TE, Staker BL, Abendroth J, Myler PJ, Horn JR, Hagen TJ.

Bioorg Med Chem Lett. 2018 May 1;28(8):1376-1380. doi: 10.1016/j.bmcl.2018.03.002. Epub 2018 Mar 15.

17.

Solution NMR structures of oxidized and reduced Ehrlichia chaffeensis thioredoxin: NMR-invisible structure owing to backbone dynamics.

Buchko GW, Hewitt SN, Van Voorhis WC, Myler PJ.

Acta Crystallogr F Struct Biol Commun. 2018 Jan 1;74(Pt 1):46-56. doi: 10.1107/S2053230X1701799X. Epub 2018 Jan 1.

18.

Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein.

Abendroth J, Frando A, Phan IQ, Staker BL, Myler PJ, Edwards TE, Grundner C.

Protein Sci. 2018 Feb;27(2):568-572. doi: 10.1002/pro.3343. Epub 2017 Dec 5.

19.

Disclosing 3' UTR cis-elements and putative partners involved in gene expression regulation in Leishmania spp.

Terrão MC, Rosas de Vasconcelos EJ, Defina TA, Myler PJ, Cruz AK.

PLoS One. 2017 Aug 31;12(8):e0183401. doi: 10.1371/journal.pone.0183401. eCollection 2017.

20.

Structural and Biophysical Characterization of the Mycobacterium tuberculosis Protein Rv0577, a Protein Associated with Neutral Red Staining of Virulent Tuberculosis Strains and Homologue of the Streptomyces coelicolor Protein KbpA.

Buchko GW, Echols N, Flynn EM, Ng HL, Stephenson S, Kim HB, Myler PJ, Terwilliger TC, Alber T, Kim CY.

Biochemistry. 2017 Aug 1;56(30):4015-4027. doi: 10.1021/acs.biochem.7b00511. Epub 2017 Jul 25.

PMID:
28692281
21.

Multiplexed Spliced-Leader Sequencing: A high-throughput, selective method for RNA-seq in Trypanosomatids.

Cuypers B, Domagalska MA, Meysman P, Muylder G, Vanaerschot M, Imamura H, Dumetz F, Verdonckt TW, Myler PJ, Ramasamy G, Laukens K, Dujardin JC.

Sci Rep. 2017 Jun 16;7(1):3725. doi: 10.1038/s41598-017-03987-0.

22.

Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms.

Moen SO, Edwards TE, Dranow DM, Clifton MC, Sankaran B, Van Voorhis WC, Sharma A, Manoil C, Staker BL, Myler PJ, Lorimer DD.

Sci Rep. 2017 Mar 16;7(1):223. doi: 10.1038/s41598-017-00367-6.

23.

Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors.

Haft DH, Pierce PG, Mayclin SJ, Sullivan A, Gardberg AS, Abendroth J, Begley DW, Phan IQ, Staker BL, Myler PJ, Marathias VM, Lorimer DD, Edwards TE.

Sci Rep. 2017 Jan 25;7:41074. doi: 10.1038/srep41074.

24.

Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.

Helgren TR, Chen C, Wangtrakuldee P, Edwards TE, Staker BL, Abendroth J, Sankaran B, Housley NA, Myler PJ, Audia JP, Horn JR, Hagen TJ.

Bioorg Med Chem. 2017 Feb 1;25(3):813-824. doi: 10.1016/j.bmc.2016.11.013. Epub 2016 Nov 10.

25.

Backbone chemical shift assignments and secondary structure analysis of the U1 protein from the Bas-Congo virus.

Buchko GW, Clifton MC, Wallace EG, Atkins KA, Myler PJ.

Biomol NMR Assign. 2017 Apr;11(1):51-56. doi: 10.1007/s12104-016-9719-2. Epub 2016 Dec 15.

PMID:
27981424
26.

The crystal structure of dihydrodipicolinate reductase from the human-pathogenic bacterium Bartonella henselae strain Houston-1 at 2.3 Å resolution.

Cala AR, Nadeau MT, Abendroth J, Staker BL, Reers AR, Weatherhead AW, Dobson RC, Myler PJ, Hudson AO.

Acta Crystallogr F Struct Biol Commun. 2016 Dec 1;72(Pt 12):885-891. Epub 2016 Nov 25.

27.

Membrane skeletal association and post-translational allosteric regulation of Toxoplasma gondii GAPDH1.

Dubey R, Staker BL, Foe IT, Bogyo M, Myler PJ, Ngô HM, Gubbels MJ.

Mol Microbiol. 2017 Feb;103(4):618-634. doi: 10.1111/mmi.13577. Epub 2016 Dec 23.

28.

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.

Hewitt SN, Dranow DM, Horst BG, Abendroth JA, Forte B, Hallyburton I, Jansen C, Baragaña B, Choi R, Rivas KL, Hulverson MA, Dumais M, Edwards TE, Lorimer DD, Fairlamb AH, Gray DW, Read KD, Lehane AM, Kirk K, Myler PJ, Wernimont A, Walpole C, Stacy R, Barrett LK, Gilbert IH, Van Voorhis WC.

ACS Infect Dis. 2017 Jan 13;3(1):34-44. doi: 10.1021/acsinfecdis.6b00078. Epub 2016 Nov 16.

29.

The Rickettsia type IV secretion system: unrealized complexity mired by gene family expansion.

Gillespie JJ, Phan IQ, Driscoll TP, Guillotte ML, Lehman SS, Rennoll-Bankert KE, Subramanian S, Beier-Sexton M, Myler PJ, Rahman MS, Azad AF.

Pathog Dis. 2016 Aug;74(6). pii: ftw058. doi: 10.1093/femspd/ftw058. Epub 2016 Jun 14.

30.

Integrative analysis of the Trypanosoma brucei gene expression cascade predicts differential regulation of mRNA processing and unusual control of ribosomal protein expression.

Antwi EB, Haanstra JR, Ramasamy G, Jensen B, Droll D, Rojas F, Minia I, Terrao M, Mercé C, Matthews K, Myler PJ, Parsons M, Clayton C.

BMC Genomics. 2016 Apr 26;17:306. doi: 10.1186/s12864-016-2624-3.

31.

Illuminating Parasite Protein Production by Ribosome Profiling.

Parsons M, Myler PJ.

Trends Parasitol. 2016 Jun;32(6):446-457. doi: 10.1016/j.pt.2016.03.005. Epub 2016 Apr 6. Review.

32.

An Arginine Deprivation Response Pathway Is Induced in Leishmania during Macrophage Invasion.

Goldman-Pinkovich A, Balno C, Strasser R, Zeituni-Molad M, Bendelak K, Rentsch D, Ephros M, Wiese M, Jardim A, Myler PJ, Zilberstein D.

PLoS Pathog. 2016 Apr 4;12(4):e1005494. doi: 10.1371/journal.ppat.1005494. eCollection 2016 Apr.

33.

Cloning, expression, purification, crystallization and X-ray diffraction analysis of dihydrodipicolinate synthase from the human pathogenic bacterium Bartonella henselae strain Houston-1 at 2.1 Å resolution.

Naqvi KF, Staker BL, Dobson RC, Serbzhinskiy D, Sankaran B, Myler PJ, Hudson AO.

Acta Crystallogr F Struct Biol Commun. 2016 Jan;72(Pt 1):2-9. doi: 10.1107/S2053230X15023213. Epub 2016 Jan 1.

34.

Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems.

Gillespie JJ, Phan IQ, Scheib H, Subramanian S, Edwards TE, Lehman SS, Piitulainen H, Rahman MS, Rennoll-Bankert KE, Staker BL, Taira S, Stacy R, Myler PJ, Azad AF, Pulliainen AT.

MBio. 2015 Dec 8;6(6):e01867-15. doi: 10.1128/mBio.01867-15.

35.

Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents.

Goshu GM, Ghose D, Bain JM, Pierce PG, Begley DW, Hewitt SN, Udell HS, Myler PJ, Meganathan R, Hagen TJ.

Bioorg Med Chem Lett. 2015 Dec 15;25(24):5699-704. doi: 10.1016/j.bmcl.2015.10.096.

36.

Size does matter: 18 amino acids at the N-terminal tip of an amino acid transporter in Leishmania determine substrate specificity.

Schlisselberg D, Mazarib E, Inbar E, Rentsch D, Myler PJ, Zilberstein D.

Sci Rep. 2015 Nov 9;5:16289. doi: 10.1038/srep16289.

37.

Recent contributions of structure-based drug design to the development of antibacterial compounds.

Staker BL, Buchko GW, Myler PJ.

Curr Opin Microbiol. 2015 Oct;27:133-8. doi: 10.1016/j.mib.2015.09.003. Review.

38.

Advancing Trypanosoma brucei genome annotation through ribosome profiling and spliced leader mapping.

Parsons M, Ramasamy G, Vasconcelos EJ, Jensen BC, Myler PJ.

Mol Biochem Parasitol. 2015 Aug;202(2):1-10. doi: 10.1016/j.molbiopara.2015.09.002. Epub 2015 Sep 21.

39.

Structural Genomics Support for Infectious Disease Drug Design.

Stacy R, Anderson WF, Myler PJ.

ACS Infect Dis. 2015 Mar 13;1(3):127-129. Epub 2015 Jan 20. No abstract available.

40.

Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures.

Phan IQ, Davies DR, Moretti NS, Shanmugam D, Cestari I, Anupama A, Fairman JW, Edwards TE, Stuart K, Schenkman S, Myler PJ.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):615-21. doi: 10.1107/S2053230X15004185. Epub 2015 May 7.

41.

High-resolution Crystal Structure of Dimeric VP40 From Sudan ebolavirus.

Clifton MC, Bruhn JF, Atkins K, Webb TL, Baydo RO, Raymond A, Lorimer DD, Edwards TE, Myler PJ, Saphire EO.

J Infect Dis. 2015 Oct 1;212 Suppl 2:S167-71. doi: 10.1093/infdis/jiv090. Epub 2015 May 9.

42.

Backbone chemical shift assignments for the sensor domain of the Burkholderia pseudomallei histidine kinase RisS: "missing" resonances at the dimer interface.

Buchko GW, Edwards TE, Hewitt SN, Phan IQ, Van Voorhis WC, Miller SI, Myler PJ.

Biomol NMR Assign. 2015 Oct;9(2):381-5. doi: 10.1007/s12104-015-9614-2. Epub 2015 May 9.

43.

Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP.

Moen SO, Fairman JW, Barnes SR, Sullivan A, Nakazawa-Hewitt S, Van Voorhis WC, Staker BL, Lorimer DD, Myler PJ, Edwards TE.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):609-14. doi: 10.1107/S2053230X15006883. Epub 2015 Apr 21.

44.

Structure of an ADP-ribosylation factor, ARF1, from Entamoeba histolytica bound to Mg(2+)-GDP.

Serbzhinskiy DA, Clifton MC, Sankaran B, Staker BL, Edwards TE, Myler PJ.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):594-9. doi: 10.1107/S2053230X15004677. Epub 2015 Apr 21.

45.

Structures of a histidine triad family protein from Entamoeba histolytica bound to sulfate, AMP and GMP.

Lorimer DD, Choi R, Abramov A, Nakazawa Hewitt S, Gardberg AS, Van Voorhis WC, Staker BL, Myler PJ, Edwards TE.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):572-6. doi: 10.1107/S2053230X1500237X. Epub 2015 Apr 21.

46.

Structure of uridine diphosphate N-acetylglucosamine pyrophosphorylase from Entamoeba histolytica.

Edwards TE, Gardberg AS, Phan IQ, Zhang Y, Staker BL, Myler PJ, Lorimer DD.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):560-5. doi: 10.1107/S2053230X1500179X. Epub 2015 Apr 21.

47.

Structure of a CutA1 divalent-cation tolerance protein from Cryptosporidium parvum, the protozoal parasite responsible for cryptosporidiosis.

Buchko GW, Abendroth J, Clifton MC, Robinson H, Zhang Y, Hewitt SN, Staker BL, Edwards TE, Van Voorhis WC, Myler PJ.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):522-30. doi: 10.1107/S2053230X14028210. Epub 2015 Apr 18.

48.

Solution-state NMR structure of the putative morphogene protein BolA (PFE0790c) from Plasmodium falciparum.

Buchko GW, Yee A, Semesi A, Myler PJ, Arrowsmith CH, Hui R.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):514-21. doi: 10.1107/S2053230X1402799X. Epub 2015 Apr 18.

49.

Crystal structures of Mycobacterial MeaB and MMAA-like GTPases.

Edwards TE, Baugh L, Bullen J, Baydo RO, Witte P, Thompkins K, Phan IQ, Abendroth J, Clifton MC, Sankaran B, Van Voorhis WC, Myler PJ, Staker BL, Grundner C, Lorimer DD.

J Struct Funct Genomics. 2015 Jun;16(2):91-9. doi: 10.1007/s10969-015-9197-2. Epub 2015 Apr 2.

50.

Small RNAs derived from tRNAs and rRNAs are highly enriched in exosomes from both old and new world Leishmania providing evidence for conserved exosomal RNA Packaging.

Lambertz U, Oviedo Ovando ME, Vasconcelos EJ, Unrau PJ, Myler PJ, Reiner NE.

BMC Genomics. 2015 Mar 5;16:151. doi: 10.1186/s12864-015-1260-7.

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