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Items: 1 to 50 of 145

1.

A Genome-Wide Screen Reveals a Role for the HIR Histone Chaperone Complex in Preventing Mislocalization of Budding Yeast CENP-A.

Ciftci-Yilmaz S, Au WC, Mishra PK, Eisenstatt JR, Chang J, Dawson AR, Zhu I, Rahman M, Bilke S, Costanzo M, Baryshnikova A, Myers CL, Meltzer PS, Landsman D, Baker RE, Boone C, Basrai MA.

Genetics. 2018 Jul 16. pii: genetics.301305.2018. doi: 10.1534/genetics.118.301305. [Epub ahead of print]

2.

In Vitro Pluripotent Stem Cell Differentiation to Hepatocyte Ceases Further Maturation at an Equivalent Stage of E15 in Mouse Embryonic Liver Development.

Raju R, Chau D, Notelaers T, Myers CL, Verfaillie CM, Hu WS.

Stem Cells Dev. 2018 Jul 1;27(13):910-921. doi: 10.1089/scd.2017.0270. Epub 2018 May 31.

PMID:
29851366
3.

Systematic analysis of complex genetic interactions.

Kuzmin E, VanderSluis B, Wang W, Tan G, Deshpande R, Chen Y, Usaj M, Balint A, Mattiazzi Usaj M, van Leeuwen J, Koch EN, Pons C, Dagilis AJ, Pryszlak M, Wang JZY, Hanchard J, Riggi M, Xu K, Heydari H, San Luis BJ, Shuteriqi E, Zhu H, Van Dyk N, Sharifpoor S, Costanzo M, Loewith R, Caudy A, Bolnick D, Brown GW, Andrews BJ, Boone C, Myers CL.

Science. 2018 Apr 20;360(6386). pii: eaao1729. doi: 10.1126/science.aao1729.

PMID:
29674565
4.

Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity.

Kayatekin C, Amasino A, Gaglia G, Flannick J, Bonner JM, Fanning S, Narayan P, Barrasa MI, Pincus D, Landgraf D, Nelson J, Hesse WR, Costanzo M; AMP T2D-GENES Consortium, Myers CL, Boone C, Florez JC, Lindquist S.

Cell. 2018 Mar 22;173(1):62-73.e9. doi: 10.1016/j.cell.2018.02.026. Epub 2018 Mar 8.

PMID:
29526462
5.

Different Modes of Negative Regulation of Plant Immunity by Calmodulin-Related Genes.

Lu Y, Truman W, Liu X, Bethke G, Zhou M, Myers CL, Katagiri F, Glazebrook J.

Plant Physiol. 2018 Apr;176(4):3046-3061. doi: 10.1104/pp.17.01209. Epub 2018 Feb 15.

6.

Chemical genomic guided engineering of gamma-valerolactone tolerant yeast.

Bottoms S, Dickinson Q, McGee M, Hinchman L, Higbee A, Hebert A, Serate J, Xie D, Zhang Y, Coon JJ, Myers CL, Landick R, Piotrowski JS.

Microb Cell Fact. 2018 Jan 12;17(1):5. doi: 10.1186/s12934-017-0848-9.

7.

Development of expression-based biomarkers of Dasatinib response in hematologic malignancies.

Akre MK, Mitra A, Wang W, Myers CL, Van Ness B.

Blood Cancer J. 2017 Dec 15;7(12):652. doi: 10.1038/s41408-017-0013-z. No abstract available.

8.

MOSAIC: a chemical-genetic interaction data repository and web resource for exploring chemical modes of action.

Nelson J, Simpkins SW, Safizadeh H, Li SC, Piotrowski JS, Hirano H, Yashiroda Y, Osada H, Yoshida M, Boone C, Myers CL.

Bioinformatics. 2018 Apr 1;34(7):1251-1252. doi: 10.1093/bioinformatics/btx732.

PMID:
29206899
9.

Errata: Functional annotation of chemical libraries across diverse biological processes.

Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, DeRango-Adem E, van Leeuwen J, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL, Boone C.

Nat Chem Biol. 2017 Nov 21;13(12):1286. doi: 10.1038/nchembio1217-1286a.

PMID:
29161247
10.

Errata: Functional annotation of chemical libraries across diverse biological processes.

Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, DeRango-Adem E, van Leeuwen J, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL, Boone C.

Nat Chem Biol. 2017 Nov 21;13(12):1286. doi: 10.1038/nchembio1217-1286b.

PMID:
29161244
11.

Coculture of Marine Invertebrate-Associated Bacteria and Interdisciplinary Technologies Enable Biosynthesis and Discovery of a New Antibiotic, Keyicin.

Adnani N, Chevrette MG, Adibhatla SN, Zhang F, Yu Q, Braun DR, Nelson J, Simpkins SW, McDonald BR, Myers CL, Piotrowski JS, Thompson CJ, Currie CR, Li L, Rajski SR, Bugni TS.

ACS Chem Biol. 2017 Dec 15;12(12):3093-3102. doi: 10.1021/acschembio.7b00688. Epub 2017 Nov 22.

PMID:
29121465
12.

Up For A Challenge (U4C): Stimulating innovation in breast cancer genetic epidemiology.

Mechanic LE, Lindström S, Daily KM, Sieberts SK, Amos CI, Chen HS, Cox NJ, Dathe M, Feuer EJ, Guertin MJ, Hoffman J, Liu Y, Moore JH, Myers CL, Ritchie MD, Schildkraut J, Schumacher F, Witte JS, Wang W, Williams SM; U4C Challenge Participants; U4C Challenge Data Contributors, Gillanders EM.

PLoS Genet. 2017 Sep 28;13(9):e1006945. doi: 10.1371/journal.pgen.1006945. eCollection 2017 Sep. No abstract available.

13.

Pathway-based discovery of genetic interactions in breast cancer.

Wang W, Xu ZZ, Costanzo M, Boone C, Lange CA, Myers CL.

PLoS Genet. 2017 Sep 28;13(9):e1006973. doi: 10.1371/journal.pgen.1006973. eCollection 2017 Sep.

14.

Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping.

Rizzolo K, Huen J, Kumar A, Phanse S, Vlasblom J, Kakihara Y, Zeineddine HA, Minic Z, Snider J, Wang W, Pons C, Seraphim TV, Boczek EE, Alberti S, Costanzo M, Myers CL, Stagljar I, Boone C, Babu M, Houry WA.

Cell Rep. 2017 Sep 12;20(11):2735-2748. doi: 10.1016/j.celrep.2017.08.074.

15.

Functional annotation of chemical libraries across diverse biological processes.

Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, DeRango-Adem E, van Leeuwen J, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL, Boone C.

Nat Chem Biol. 2017 Sep;13(9):982-993. doi: 10.1038/nchembio.2436. Epub 2017 Jul 24. Erratum in: Nat Chem Biol. 2017 Nov 21;13(12 ):1286. Nat Chem Biol. 2017 Nov 21;13(12 ):1286.

PMID:
28759014
16.

Chemical Genomics, Structure Elucidation, and in Vivo Studies of the Marine-Derived Anticlostridial Ecteinamycin.

Wyche TP, Alvarenga RFR, Piotrowski JS, Duster MN, Warrack SR, Cornilescu G, De Wolfe TJ, Hou Y, Braun DR, Ellis GA, Simpkins SW, Nelson J, Myers CL, Steele J, Mori H, Safdar N, Markley JL, Rajski SR, Bugni TS.

ACS Chem Biol. 2017 Sep 15;12(9):2287-2295. doi: 10.1021/acschembio.7b00388. Epub 2017 Jul 26.

17.

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.

Hart T, Tong AHY, Chan K, Van Leeuwen J, Seetharaman A, Aregger M, Chandrashekhar M, Hustedt N, Seth S, Noonan A, Habsid A, Sizova O, Nedyalkova L, Climie R, Tworzyanski L, Lawson K, Sartori MA, Alibeh S, Tieu D, Masud S, Mero P, Weiss A, Brown KR, Usaj M, Billmann M, Rahman M, Constanzo M, Myers CL, Andrews BJ, Boone C, Durocher D, Moffat J.

G3 (Bethesda). 2017 Aug 7;7(8):2719-2727. doi: 10.1534/g3.117.041277.

18.

Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite.

Morales EH, Pinto CA, Luraschi R, Muñoz-Villagrán CM, Cornejo FA, Simpkins SW, Nelson J, Arenas FA, Piotrowski JS, Myers CL, Mori H, Vásquez CC.

Nat Commun. 2017 May 11;8:15320. doi: 10.1038/ncomms15320.

19.

The highly buffered Arabidopsis immune signaling network conceals the functions of its components.

Hillmer RA, Tsuda K, Rallapalli G, Asai S, Truman W, Papke MD, Sakakibara H, Jones JDG, Myers CL, Katagiri F.

PLoS Genet. 2017 May 4;13(5):e1006639. doi: 10.1371/journal.pgen.1006639. eCollection 2017 May.

20.

A New Natural Product Analog of Blasticidin S Reveals Cellular Uptake Facilitated by the NorA Multidrug Transporter.

Davison JR, Lohith KM, Wang X, Bobyk K, Mandadapu SR, Lee SL, Cencic R, Nelson J, Simpkins S, Frank KM, Pelletier J, Myers CL, Piotrowski J, Smith HE, Bewley CA.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e02635-16. doi: 10.1128/AAC.02635-16. Print 2017 Jun.

21.

TheCellMap.org: A Web-Accessible Database for Visualizing and Mining the Global Yeast Genetic Interaction Network.

Usaj M, Tan Y, Wang W, VanderSluis B, Zou A, Myers CL, Costanzo M, Andrews B, Boone C.

G3 (Bethesda). 2017 May 5;7(5):1539-1549. doi: 10.1534/g3.117.040220.

22.

Co-expression network analysis of duplicate genes in maize (Zea mays L.) reveals no subgenome bias.

Li L, Briskine R, Schaefer R, Schnable PS, Myers CL, Flagel LE, Springer NM, Muehlbauer GJ.

BMC Genomics. 2016 Nov 4;17(1):875.

23.

Exploring genetic suppression interactions on a global scale.

van Leeuwen J, Pons C, Mellor JC, Yamaguchi TN, Friesen H, Koschwanez J, Ušaj MM, Pechlaner M, Takar M, Ušaj M, VanderSluis B, Andrusiak K, Bansal P, Baryshnikova A, Boone CE, Cao J, Cote A, Gebbia M, Horecka G, Horecka I, Kuzmin E, Legro N, Liang W, van Lieshout N, McNee M, San Luis BJ, Shaeri F, Shuteriqi E, Sun S, Yang L, Youn JY, Yuen M, Costanzo M, Gingras AC, Aloy P, Oostenbrink C, Murray A, Graham TR, Myers CL, Andrews BJ, Roth FP, Boone C.

Science. 2016 Nov 4;354(6312). pii: aag0839.

24.

Identification of Two Phosphate Starvation-induced Wall Teichoic Acid Hydrolases Provides First Insights into the Degradative Pathway of a Key Bacterial Cell Wall Component.

Myers CL, Li FK, Koo BM, El-Halfawy OM, French S, Gross CA, Strynadka NC, Brown ED.

J Biol Chem. 2016 Dec 9;291(50):26066-26082. Epub 2016 Oct 25.

25.

A gene-centered C. elegans protein-DNA interaction network provides a framework for functional predictions.

Fuxman Bass JI, Pons C, Kozlowski L, Reece-Hoyes JS, Shrestha S, Holdorf AD, Mori A, Myers CL, Walhout AJ.

Mol Syst Biol. 2016 Oct 24;12(10):884. doi: 10.15252/msb.20167131.

26.

A cell-based approach to characterize antimicrobial compounds through kinetic dose response.

MacNair CR, Stokes JM, French S, Myers CL, Iyer KR, Brown ED.

Bioorg Med Chem. 2016 Dec 15;24(24):6315-6319. doi: 10.1016/j.bmc.2016.09.053. Epub 2016 Sep 22.

PMID:
27713016
27.

A global genetic interaction network maps a wiring diagram of cellular function.

Costanzo M, VanderSluis B, Koch EN, Baryshnikova A, Pons C, Tan G, Wang W, Usaj M, Hanchard J, Lee SD, Pelechano V, Styles EB, Billmann M, van Leeuwen J, van Dyk N, Lin ZY, Kuzmin E, Nelson J, Piotrowski JS, Srikumar T, Bahr S, Chen Y, Deshpande R, Kurat CF, Li SC, Li Z, Usaj MM, Okada H, Pascoe N, San Luis BJ, Sharifpoor S, Shuteriqi E, Simpkins SW, Snider J, Suresh HG, Tan Y, Zhu H, Malod-Dognin N, Janjic V, Przulj N, Troyanskaya OG, Stagljar I, Xia T, Ohya Y, Gingras AC, Raught B, Boutros M, Steinmetz LM, Moore CL, Rosebrock AP, Caudy AA, Myers CL, Andrews B, Boone C.

Science. 2016 Sep 23;353(6306). pii: aaf1420.

28.

Exploring Quantitative Yeast Phenomics with Single-Cell Analysis of DNA Damage Foci.

Styles EB, Founk KJ, Zamparo LA, Sing TL, Altintas D, Ribeyre C, Ribaud V, Rougemont J, Mayhew D, Costanzo M, Usaj M, Verster AJ, Koch EN, Novarina D, Graf M, Luke B, Muzi-Falconi M, Myers CL, Mitra RD, Shore D, Brown GW, Zhang Z, Boone C, Andrews BJ.

Cell Syst. 2016 Sep 28;3(3):264-277.e10. doi: 10.1016/j.cels.2016.08.008. Epub 2016 Sep 8.

29.

Unraveling gene function in agricultural species using gene co-expression networks.

Schaefer RJ, Michno JM, Myers CL.

Biochim Biophys Acta. 2017 Jan;1860(1):53-63. doi: 10.1016/j.bbagrm.2016.07.016. Epub 2016 Jul 30. Review.

PMID:
27485388
30.

Fine-Mapping of 18q21.1 Locus Identifies Single Nucleotide Polymorphisms Associated with Nonsyndromic Cleft Lip with or without Cleft Palate.

Mitra AK, Stessman HA, Schaefer RJ, Wang W, Myers CL, Van Ness BG, Beiraghi S.

Front Genet. 2016 May 23;7:88. doi: 10.3389/fgene.2016.00088. eCollection 2016.

31.

Mechanism of imidazolium ionic liquids toxicity in Saccharomyces cerevisiae and rational engineering of a tolerant, xylose-fermenting strain.

Dickinson Q, Bottoms S, Hinchman L, McIlwain S, Li S, Myers CL, Boone C, Coon JJ, Hebert A, Sato TK, Landick R, Piotrowski JS.

Microb Cell Fact. 2016 Jan 20;15:17. doi: 10.1186/s12934-016-0417-7.

32.

Controlling microbial contamination during hydrolysis of AFEX-pretreated corn stover and switchgrass: effects on hydrolysate composition, microbial response and fermentation.

Serate J, Xie D, Pohlmann E, Donald C Jr, Shabani M, Hinchman L, Higbee A, Mcgee M, La Reau A, Klinger GE, Li S, Myers CL, Boone C, Bates DM, Cavalier D, Eilert D, Oates LG, Sanford G, Sato TK, Dale B, Landick R, Piotrowski J, Ong RG, Zhang Y.

Biotechnol Biofuels. 2015 Nov 14;8:180. doi: 10.1186/s13068-015-0356-2. eCollection 2015.

33.

Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing.

Becker JR, Pons C, Nguyen HD, Costanzo M, Boone C, Myers CL, Bielinsky AK.

PLoS Genet. 2015 Nov 6;11(11):e1005659. doi: 10.1371/journal.pgen.1005659. eCollection 2015 Nov.

34.

Functional roles in S-adenosyl-L-methionine binding and catalysis for active site residues of the thiostrepton resistance methyltransferase.

Myers CL, Kuiper EG, Grant PC, Hernandez J, Conn GL, Honek JF.

FEBS Lett. 2015 Oct 24;589(21):3263-70. doi: 10.1016/j.febslet.2015.09.028. Epub 2015 Oct 9.

35.

Transcription Factor Activity Mapping of a Tissue-Specific in vivo Gene Regulatory Network.

MacNeil LT, Pons C, Arda HE, Giese GE, Myers CL, Walhout AJ.

Cell Syst. 2015 Aug 26;1(2):152-162.

36.

Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase.

Farha MA, Czarny TL, Myers CL, Worrall LJ, French S, Conrady DG, Wang Y, Oldfield E, Strynadka NC, Brown ED.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11048-53. doi: 10.1073/pnas.1511751112. Epub 2015 Aug 17.

37.

Characterization of Wall Teichoic Acid Degradation by the Bacteriophage ϕ29 Appendage Protein GP12 Using Synthetic Substrate Analogs.

Myers CL, Ireland RG, Garrett TA, Brown ED.

J Biol Chem. 2015 Jul 31;290(31):19133-45. doi: 10.1074/jbc.M115.662866. Epub 2015 Jun 17.

38.

Prospective functional outcomes in sequential population based cohorts of stage III/ IV oropharyngeal carcinoma patients treated with 3D conformal vs. intensity modulated radiotherapy.

Kerr P, Myers CL, Butler J, Alessa M, Lambert P, Cooke AL.

J Otolaryngol Head Neck Surg. 2015 May 13;44:17. doi: 10.1186/s40463-015-0068-4.

39.

Plant-derived antifungal agent poacic acid targets β-1,3-glucan.

Piotrowski JS, Okada H, Lu F, Li SC, Hinchman L, Ranjan A, Smith DL, Higbee AJ, Ulbrich A, Coon JJ, Deshpande R, Bukhman YV, McIlwain S, Ong IM, Myers CL, Boone C, Landick R, Ralph J, Kabbage M, Ohya Y.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1490-7. doi: 10.1073/pnas.1410400112. Epub 2015 Mar 9.

40.

Chemical genomic profiling via barcode sequencing to predict compound mode of action.

Piotrowski JS, Simpkins SW, Li SC, Deshpande R, McIlwain SJ, Ong IM, Myers CL, Boone C, Andersen RJ.

Methods Mol Biol. 2015;1263:299-318. doi: 10.1007/978-1-4939-2269-7_23.

41.

YMAP: a pipeline for visualization of copy number variation and loss of heterozygosity in eukaryotic pathogens.

Abbey DA, Funt J, Lurie-Weinberger MN, Thompson DA, Regev A, Myers CL, Berman J.

Genome Med. 2014 Nov 20;6(11):100. doi: 10.1186/s13073-014-0100-8. eCollection 2014.

42.

Unraveling the biology of a fungal meningitis pathogen using chemical genetics.

Brown JCS, Nelson J, VanderSluis B, Deshpande R, Butts A, Kagan S, Polacheck I, Krysan DJ, Myers CL, Madhani HD.

Cell. 2014 Nov 20;159(5):1168-1187. doi: 10.1016/j.cell.2014.10.044.

43.

Synthetic genetic array analysis for global mapping of genetic networks in yeast.

Kuzmin E, Sharifpoor S, Baryshnikova A, Costanzo M, Myers CL, Andrews BJ, Boone C.

Methods Mol Biol. 2014;1205:143-68. doi: 10.1007/978-1-4939-1363-3_10.

PMID:
25213244
44.

Forazoline A: marine-derived polyketide with antifungal in vivo efficacy.

Wyche TP, Piotrowski JS, Hou Y, Braun D, Deshpande R, McIlwain S, Ong IM, Myers CL, Guzei IA, Westler WM, Andes DR, Bugni TS.

Angew Chem Int Ed Engl. 2014 Oct 20;53(43):11583-6. doi: 10.1002/anie.201405990. Epub 2014 Sep 4.

45.

High-throughput drug screening identifies compounds and molecular strategies for targeting proteasome inhibitor-resistant multiple myeloma.

Stessman HA, Lulla A, Xia T, Mitra A, Harding T, Mansoor A, Myers CL, Van Ness BG, Dolloff NG.

Leukemia. 2014 Nov;28(11):2263-7. doi: 10.1038/leu.2014.214. Epub 2014 Jul 9. No abstract available.

PMID:
25005244
46.

Linking genetics to structural biology: complex heterozygosity screening with actin alanine scan alleles identifies functionally related surfaces on yeast actin.

DiPrima S, Haarer B, Viggiano S, Pons C, Myers CL, Amberg DC.

G3 (Bethesda). 2014 Jun 17;4(8):1491-501. doi: 10.1534/g3.114.012054.

47.

Discovering functional modules across diverse maize transcriptomes using COB, the Co-expression Browser.

Schaefer RJ, Briskine R, Springer NM, Myers CL.

PLoS One. 2014 Jun 12;9(6):e99193. doi: 10.1371/journal.pone.0099193. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0120222.

48.

Broad metabolic sensitivity profiling of a prototrophic yeast deletion collection.

VanderSluis B, Hess DC, Pesyna C, Krumholz EW, Syed T, Szappanos B, Nislow C, Papp B, Troyanskaya OG, Myers CL, Caudy AA.

Genome Biol. 2014 Apr 10;15(4):R64. doi: 10.1186/gb-2014-15-4-r64.

49.

Molecular interactions between thiostrepton and the TipAS protein from Streptomyces lividans.

Myers CL, Harris J, Yeung JC, Honek JF.

Chembiochem. 2014 Mar 21;15(5):681-7. doi: 10.1002/cbic.201300724. Epub 2014 Feb 24.

PMID:
24616128
50.

Mechanisms underlying robustness and tunability in a plant immune signaling network.

Kim Y, Tsuda K, Igarashi D, Hillmer RA, Sakakibara H, Myers CL, Katagiri F.

Cell Host Microbe. 2014 Jan 15;15(1):84-94. doi: 10.1016/j.chom.2013.12.002.

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