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Items: 1 to 50 of 82

1.

Tetracyclines Modify Translation by Targeting Key Human rRNA Substructures.

Mortison JD, Schenone M, Myers JA, Zhang Z, Chen L, Ciarlo C, Comer E, Natchiar SK, Carr SA, Klaholz BP, Myers AG.

Cell Chem Biol. 2018 Dec 20;25(12):1506-1518.e13. doi: 10.1016/j.chembiol.2018.09.010. Epub 2018 Oct 11.

PMID:
30318461
2.

Large-scale preparation of key building blocks for the manufacture of fully synthetic macrolide antibiotics.

Hogan PC, Chen CL, Mulvihill KM, Lawrence JF, Moorhead E, Rickmeier J, Myers AG.

J Antibiot (Tokyo). 2018 Feb;71(2):318-325. doi: 10.1038/ja.2017.116. Epub 2017 Oct 11.

PMID:
29018266
3.

US immigration order strikes against biotech.

Levin JM, Holtzman SH, Maraganore J, Hastings PJ, Cohen R, Dahiyat B, Adams J, Adams C, Ahrens B, Albers J, Aspinall MG, Audia JE, Babler M, Barrett P, Barry Z, Bermingham N, Bloch S, Blum RI, Bolno PB, Bonney MW, Booth B, Bradbury DM, Brauer SK, Byers B, Cagnoni PJ, Cali BM, Ciechanover I, Clark C, Clayman MD, Cleland JL, Cobb P, Cooper R, Currie MG, Diekman J, Dobmeier EL, Doerfler D, Donley EL, Dunsire D, During M, Eckstein JW, Elenko E, Exter NA, Fleming JJ, Flesher GJ, Formela JF, Forrester R, Francois C, Franklin H, Freeman MW, Furst H, Gage LP, Galakatos N, Gallagher BM, Geraghty JA, Gill S, Goeddel DV, Goldsmith MA, Gowen M, Goyal V, Graney T, Grayzel D, Greene B, Grint P, Gutierrez-Ramos JC, Haney B, Ha-Ngoc T, Harris T, Hasnain F, Hata YS, Hecht P, Henshaw L, Heyman R, Hoppenot H, Horvitz HR, Hughes TE, Hutton WS, Isaacs ST, Jenkins A, Jonker J, Kaplan J, Karsen P, Keiper J, Kim J, Kindler J, King R, King V, Kjellson N, Koenig S, Koenig G, Kolchinsky P, Laikind P, Langer RB, Lee JJ, Leff JS, Leicher BA, Leschly N, Levin A, Levin M, Levine AJ, Levy A, Liu DR, Lodish HF, Lopatin U, Love TW, Macdonald G, Maderis GJ, Mahadevia A, Mahanthappa NK, Martin JF, Martin A, Martucci WE, McArthur JG, McCann CM, McCarthy SA, McDonough CG, Mendlein J, Miller L, Miralles D, Moch KI, More B, Myers AG, Narachi MA, Nashat A, Nelson W, Newell WJ, Olle B, Osborn JE, Owens JC, Pande A, Papadopoulos S, Parker HS, Parmar KM, Patterson MR, Paul SM, Perez R, Perry M, Pfeffer CG, Powell M, Pruzanski M, Purcell DJ, Rakhit A, Ramamoorthi K, Rastetter W, Rawcliffe AA, Reid LE, Renaud RC, Rhodes JP, Rieflin WJ, Robins C, Rocklage SM, Rosenblatt M, Rosin JG, Rutter WJ, Saha S, Samuels C, Sato VL, Scangos G, Scarlett JA, Schenkein D, Schreiber SL, Schwab A, Sekhri P, Shah R, Shenk T, Siegall CB, Simon NJ, Simonian N, Stein J, Su M, Szela MT, Taglietti M, Tandon N, Termeer H, Thornberry NA, Tolar M, Ulevitch R, Vaishnaw AK, VanLent A, Varsavsky M, Vlasuk GP, Vounatsos M, Waksal SG, Warma N, Watts RJ, Werber Y, Westphal C, Wierenga W, Williams DE, Williams LR, Xanthopoulos KG, Zohar D, Zweifach SS.

Nat Biotechnol. 2017 Mar 7;35(3):204-206. doi: 10.1038/nbt.3824. No abstract available.

PMID:
28267733
4.

Diastereoselective Michael-Claisen Cyclizations of γ-Oxa-α,β-unsaturated Ketones en Route to 5-Oxatetracyclines.

Liu F, Wright PM, Myers AG.

Org Lett. 2017 Jan 6;19(1):206-209. doi: 10.1021/acs.orglett.6b03491. Epub 2016 Dec 20.

PMID:
27996275
5.

Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia.

Andresen V, Erikstein BS, Mukherjee H, Sulen A, Popa M, Sørnes S, Reikvam H, Chan KP, Hovland R, McCormack E, Bruserud Ø, Myers AG, Gjertsen BT.

Cell Death Dis. 2016 Dec 1;7(12):e2497. doi: 10.1038/cddis.2016.392.

6.

A platform for the discovery of new macrolide antibiotics.

Seiple IB, Zhang Z, Jakubec P, Langlois-Mercier A, Wright PM, Hog DT, Yabu K, Allu SR, Fukuzaki T, Carlsen PN, Kitamura Y, Zhou X, Condakes ML, Szczypiński FT, Green WD, Myers AG.

Nature. 2016 May 19;533(7603):338-45. doi: 10.1038/nature17967.

7.

Development of a platform for the discovery and practical synthesis of new tetracycline antibiotics.

Liu F, Myers AG.

Curr Opin Chem Biol. 2016 Jun;32:48-57. doi: 10.1016/j.cbpa.2016.03.011. Epub 2016 Apr 1. Review.

PMID:
27043373
8.

Synthesis of D-Desosamine and Analogs by Rapid Assembly of 3-Amino Sugars.

Zhang Z, Fukuzaki T, Myers AG.

Angew Chem Int Ed Engl. 2016 Jan 11;55(2):523-7. doi: 10.1002/anie.201507357. Epub 2015 Nov 27.

PMID:
26612347
9.

Mediator kinase inhibition further activates super-enhancer-associated genes in AML.

Pelish HE, Liau BB, Nitulescu II, Tangpeerachaikul A, Poss ZC, Da Silva DH, Caruso BT, Arefolov A, Fadeyi O, Christie AL, Du K, Banka D, Schneider EV, Jestel A, Zou G, Si C, Ebmeier CC, Bronson RT, Krivtsov AV, Myers AG, Kohl NE, Kung AL, Armstrong SA, Lemieux ME, Taatjes DJ, Shair MD.

Nature. 2015 Oct 8;526(7572):273-276. doi: 10.1038/nature14904. Epub 2015 Sep 28.

10.

Interactions of the natural product (+)-avrainvillamide with nucleophosmin and exportin-1 Mediate the cellular localization of nucleophosmin and its AML-associated mutants.

Mukherjee H, Chan KP, Andresen V, Hanley ML, Gjertsen BT, Myers AG.

ACS Chem Biol. 2015 Mar 20;10(3):855-63. doi: 10.1021/cb500872g. Epub 2015 Jan 5.

11.

Crystalline guanine adducts of natural and synthetic trioxacarcins suggest a common biological mechanism and reveal a basis for the instability of trioxacarcin A.

Pröpper K, Dittrich B, Smaltz DJ, Magauer T, Myers AG.

Bioorg Med Chem Lett. 2014 Sep 15;24(18):4410-4413. doi: 10.1016/j.bmcl.2014.08.016. Epub 2014 Aug 14.

PMID:
25176186
12.

The evolving role of chemical synthesis in antibacterial drug discovery.

Wright PM, Seiple IB, Myers AG.

Angew Chem Int Ed Engl. 2014 Aug 18;53(34):8840-69. doi: 10.1002/anie.201310843. Epub 2014 Jul 2. Review.

13.

Stereocontrolled synthesis of syn-β-Hydroxy-α-amino acids by direct aldolization of pseudoephenamine glycinamide.

Seiple IB, Mercer JA, Sussman RJ, Zhang Z, Myers AG.

Angew Chem Int Ed Engl. 2014 Apr 25;53(18):4642-7. doi: 10.1002/anie.201400928. Epub 2014 Apr 1.

14.

(S)-4-Trimethylsilyl-3-butyn-2-ol as an auxiliary for stereocontrolled synthesis of salinosporamide analogs with modifications at positions C2 and C5.

Blasdel LK, Lee D, Sun B, Myers AG.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6905-10. doi: 10.1016/j.bmcl.2013.09.066. Epub 2013 Sep 30.

15.

A simple, scalable synthetic route to (+)- and (-)-pseudoephenamine.

Mellem KT, Myers AG.

Org Lett. 2013 Nov 1;15(21):5594-7. doi: 10.1021/ol402815d. Epub 2013 Oct 18.

16.

Component-based syntheses of trioxacarcin A, DC-45-A1 and structural analogues.

Magauer T, Smaltz DJ, Myers AG.

Nat Chem. 2013 Oct;5(10):886-93. doi: 10.1038/nchem.1746. Epub 2013 Sep 8.

17.

Synthesis of quaternary α-methyl α-amino acids by asymmetric alkylation of pseudoephenamine alaninamide pivaldimine.

Hugelshofer CL, Mellem KT, Myers AG.

Org Lett. 2013 Jun 21;15(12):3134-7. doi: 10.1021/ol401337p. Epub 2013 Jun 7.

18.

Pseudoephenamine: a practical chiral auxiliary for asymmetric synthesis.

Morales MR, Mellem KT, Myers AG.

Angew Chem Int Ed Engl. 2012 May 7;51(19):4568-71. doi: 10.1002/anie.201200370. Epub 2012 Mar 27. No abstract available.

19.
21.

Short and efficient synthetic route to methyl α-trioxacarcinoside B and anomerically activated derivatives.

Magauer T, Myers AG.

Org Lett. 2011 Oct 21;13(20):5584-7. doi: 10.1021/ol202315m. Epub 2011 Sep 29.

22.

A practical, convergent route to the key precursor to the tetracycline antibiotics.

Kummer DA, Li D, Dion A, Myers AG.

Chem Sci. 2011 Sep;2(9):1710-1718.

23.

A versatile synthesis of substituted isoquinolines.

Si C, Myers AG.

Angew Chem Int Ed Engl. 2011 Oct 24;50(44):10409-13. doi: 10.1002/anie.201104769. Epub 2011 Sep 9. No abstract available.

24.

Scalable synthesis of enantiomerically pure syn-2,3-dihydroxybutyrate by Sharpless asymmetric dihydroxylation of p-phenylbenzyl crotonate.

Smaltz DJ, Myers AG.

J Org Chem. 2011 Oct 21;76(20):8554-9. doi: 10.1021/jo2016746. Epub 2011 Sep 22.

25.

Storable arylpalladium(II) reagents for alkene labeling in aqueous media.

Simmons RL, Yu RT, Myers AG.

J Am Chem Soc. 2011 Oct 12;133(40):15870-3. doi: 10.1021/ja206339s. Epub 2011 Sep 15.

26.

A multiply convergent platform for the synthesis of trioxacarcins.

Švenda J, Hill N, Myers AG.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6709-14. doi: 10.1073/pnas.1015257108. Epub 2011 Jan 18.

27.

Synthesis of cortistatins A, J, K and L.

Flyer AN, Si C, Myers AG.

Nat Chem. 2010 Oct;2(10):886-92. doi: 10.1038/nchem.794. Epub 2010 Aug 1.

29.

A method for the preparation of differentiated trans-1,2-diol derivatives with enantio- and diastereocontrol.

Lim SM, Hill N, Myers AG.

J Am Chem Soc. 2009 Apr 29;131(16):5763-5. doi: 10.1021/ja901283q.

30.

Constitutively active GPR6 is located in the intracellular compartments.

Padmanabhan S, Myers AG, Prasad BM.

FEBS Lett. 2009 Jan 5;583(1):107-12. doi: 10.1016/j.febslet.2008.11.033. Epub 2008 Dec 4.

31.

A robust platform for the synthesis of new tetracycline antibiotics.

Sun C, Wang Q, Brubaker JD, Wright PM, Lerner CD, Noson K, Charest M, Siegel DR, Wang YM, Myers AG.

J Am Chem Soc. 2008 Dec 31;130(52):17913-27. doi: 10.1021/ja806629e.

32.

Stereocontrolled alkylative construction of quaternary carbon centers.

Kummer DA, Chain WJ, Morales MR, Quiroga O, Myers AG.

J Am Chem Soc. 2008 Oct 8;130(40):13231-3. doi: 10.1021/ja806021y. Epub 2008 Sep 13.

33.

The natural product avrainvillamide binds to the oncoprotein nucleophosmin.

Wulff JE, Siegrist R, Myers AG.

J Am Chem Soc. 2007 Nov 21;129(46):14444-51. Epub 2007 Oct 25.

34.

A practical, enantioselective synthetic route to a key precursor to the tetracycline antibiotics.

Brubaker JD, Myers AG.

Org Lett. 2007 Aug 30;9(18):3523-5. Epub 2007 Aug 11.

35.
36.

Kedarcidin chromophore: synthesis of its proposed structure and evidence for a stereochemical revision.

Ren F, Hogan PC, Anderson AJ, Myers AG.

J Am Chem Soc. 2007 May 2;129(17):5381-3. Epub 2007 Apr 7. No abstract available.

37.

Evidence for the rapid conversion of stephacidin B into the electrophilic monomer avrainvillamide in cell culture.

Wulff JE, Herzon SB, Siegrist R, Myers AG.

J Am Chem Soc. 2007 Apr 25;129(16):4898-9. Epub 2007 Mar 31. No abstract available.

38.
39.

Efficient transamidation of primary carboxamides by in situ activation with N,N-dialkylformamide dimethyl acetals.

Dineen TA, Zajac MA, Myers AG.

J Am Chem Soc. 2006 Dec 20;128(50):16406-9.

PMID:
17165798
40.

Enantioselective synthesis of N1999A2.

Ji N, O'Dowd H, Rosen BM, Myers AG.

J Am Chem Soc. 2006 Nov 22;128(46):14825-7.

41.

Evaluation of antitumor properties of novel saframycin analogs in vitro and in vivo.

Spencer JR, Sendzik M, Oeh J, Sabbatini P, Dalrymple SA, Magill C, Kim HM, Zhang P, Squires N, Moss KG, Sukbuntherng J, Graupe D, Eksterowicz J, Young PR, Myers AG, Green MJ.

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4884-8. Epub 2006 Jul 25.

PMID:
16870445
42.

Synthesis of (-)-quinocarcin by directed condensation of alpha-amino aldehydes.

Kwon S, Myers AG.

J Am Chem Soc. 2005 Dec 7;127(48):16796-7.

PMID:
16316220
43.
44.

Biomagnetic detection of injury currents in rabbit ischemic intestine.

Bradshaw LA, Roy OP, O'Mahony GP, Myers AG, McDowell JG, Wikswo JP, Richards WO.

Dig Dis Sci. 2005 Sep;50(9):1561-8.

PMID:
16133952
46.

Synthesis of (-)-tetracycline.

Charest MG, Siegel DR, Myers AG.

J Am Chem Soc. 2005 Jun 15;127(23):8292-3.

PMID:
15941256
47.

A convergent enantioselective route to structurally diverse 6-deoxytetracycline antibiotics.

Charest MG, Lerner CD, Brubaker JD, Siegel DR, Myers AG.

Science. 2005 Apr 15;308(5720):395-8.

48.

Enantioselective synthesis of stephacidin B.

Herzon SB, Myers AG.

J Am Chem Soc. 2005 Apr 20;127(15):5342-4.

PMID:
15826171

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