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Items: 16

1.

Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking.

Feltes M, Moores S, Gale SE, Krishnan K, Mydock-McGrane L, Covey DF, Ory DS, Schaffer JE.

J Lipid Res. 2019 Mar;60(3):707-716. doi: 10.1194/jlr.D091470. Epub 2019 Jan 7.

PMID:
30617147
2.

Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel.

Budelier MM, Cheng WWL, Chen ZW, Bracamontes JR, Sugasawa Y, Krishnan K, Mydock-McGrane L, Covey DF, Evers AS.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Feb;1864(2):128-136. doi: 10.1016/j.bbalip.2018.11.005. Epub 2018 Nov 22.

PMID:
30471426
3.

Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection.

Kalas V, Hibbing ME, Maddirala AR, Chugani R, Pinkner JS, Mydock-McGrane LK, Conover MS, Janetka JW, Hultgren SJ.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2819-E2828. doi: 10.1073/pnas.1720140115. Epub 2018 Mar 5.

4.

Rational design strategies for FimH antagonists: new drugs on the horizon for urinary tract infection and Crohn's disease.

Mydock-McGrane LK, Hannan TJ, Janetka JW.

Expert Opin Drug Discov. 2017 Jul;12(7):711-731. doi: 10.1080/17460441.2017.1331216. Epub 2017 Jun 2. Review.

5.

Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1.

Budelier MM, Cheng WWL, Bergdoll L, Chen ZW, Janetka JW, Abramson J, Krishnan K, Mydock-McGrane L, Covey DF, Whitelegge JP, Evers AS.

J Biol Chem. 2017 Jun 2;292(22):9294-9304. doi: 10.1074/jbc.M116.773069. Epub 2017 Apr 10.

6.

Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.

Castellano BM, Thelen AM, Moldavski O, Feltes M, van der Welle RE, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey DF, Nomura DK, Ory DS, Zoncu R.

Science. 2017 Mar 24;355(6331):1306-1311. doi: 10.1126/science.aag1417.

7.

Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections.

Mydock-McGrane L, Cusumano Z, Han Z, Binkley J, Kostakioti M, Hannan T, Pinkner JS, Klein R, Kalas V, Crowley J, Rath NP, Hultgren SJ, Janetka JW.

J Med Chem. 2016 Oct 27;59(20):9390-9408. Epub 2016 Oct 14.

8.

Structural basis of Smoothened regulation by its extracellular domains.

Byrne EFX, Sircar R, Miller PS, Hedger G, Luchetti G, Nachtergaele S, Tully MD, Mydock-McGrane L, Covey DF, Rambo RP, Sansom MSP, Newstead S, Rohatgi R, Siebold C.

Nature. 2016 Jul 28;535(7613):517-522. doi: 10.1038/nature18934. Epub 2016 Jul 20.

9.

Development of a bile acid-based newborn screen for Niemann-Pick disease type C.

Jiang X, Sidhu R, Mydock-McGrane L, Hsu FF, Covey DF, Scherrer DE, Earley B, Gale SE, Farhat NY, Porter FD, Dietzen DJ, Orsini JJ, Berry-Kravis E, Zhang X, Reunert J, Marquardt T, Runz H, Giugliani R, Schaffer JE, Ory DS.

Sci Transl Med. 2016 May 4;8(337):337ra63. doi: 10.1126/scitranslmed.aaf2326.

10.

Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI.

Jarvis C, Han Z, Kalas V, Klein R, Pinkner JS, Ford B, Binkley J, Cusumano CK, Cusumano Z, Mydock-McGrane L, Hultgren SJ, Janetka JW.

ChemMedChem. 2016 Feb 17;11(4):367-73. doi: 10.1002/cmdc.201600006. Epub 2016 Jan 26.

11.

Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.

Mydock-McGrane LK, Cusumano ZT, Janetka JW.

Expert Opin Ther Pat. 2016;26(2):175-97. doi: 10.1517/13543776.2016.1131266. Epub 2016 Jan 22. Review.

PMID:
26651364
12.

Correction to Synthesis of a Smoothened Cholesterol: 18,19-Di-nor-cholesterol.

Mydock-McGrane L, Rath NP, Covey DF.

J Org Chem. 2015 Jun 5;80(11):6000. doi: 10.1021/acs.joc.5b01073. Epub 2015 May 19. No abstract available.

13.

Eliminating the roughness in cholesterol's β-face: does it matter?

Krause MR, Wang M, Mydock-McGrane L, Covey DF, Tejada E, Almeida PF, Regen SL.

Langmuir. 2014 Oct 21;30(41):12114-8. doi: 10.1021/la503075e. Epub 2014 Oct 10.

14.

Synthesis of a smoothened cholesterol: 18,19-di-nor-cholesterol.

Mydock-McGrane L, Rath NP, Covey DF.

J Org Chem. 2014 Jun 20;79(12):5636-43. doi: 10.1021/jo500813n. Epub 2014 May 29. Erratum in: J Org Chem. 2015 Jun 5;80(11):6000.

15.

Side-chain oxysterols modulate cholesterol accessibility through membrane remodeling.

Bielska AA, Olsen BN, Gale SE, Mydock-McGrane L, Krishnan K, Baker NA, Schlesinger PH, Covey DF, Ory DS.

Biochemistry. 2014 May 13;53(18):3042-51. doi: 10.1021/bi5000096. Epub 2014 May 1.

16.

Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi.

Peyrot SM, Nachtergaele S, Luchetti G, Mydock-McGrane LK, Fujiwara H, Scherrer D, Jallouk A, Schlesinger PH, Ory DS, Covey DF, Rohatgi R.

J Biol Chem. 2014 Apr 18;289(16):11095-110. doi: 10.1074/jbc.M113.540351. Epub 2014 Mar 4.

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