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Items: 38

1.

Discovery of Novel Potential Reversible Peptidyl Arginine Deiminase Inhibitor.

Aliko A, Kamińska M, Falkowski K, Bielecka E, Benedyk-Machaczka M, Malicki S, Kozieł J, Wong A, Bryzek D, Kantyka T, Mydel P.

Int J Mol Sci. 2019 May 2;20(9). pii: E2174. doi: 10.3390/ijms20092174.

2.

Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.

Dominy SS, Lynch C, Ermini F, Benedyk M, Marczyk A, Konradi A, Nguyen M, Haditsch U, Raha D, Griffin C, Holsinger LJ, Arastu-Kapur S, Kaba S, Lee A, Ryder MI, Potempa B, Mydel P, Hellvard A, Adamowicz K, Hasturk H, Walker GD, Reynolds EC, Faull RLM, Curtis MA, Dragunow M, Potempa J.

Sci Adv. 2019 Jan 23;5(1):eaau3333. doi: 10.1126/sciadv.aau3333. eCollection 2019 Jan.

3.

Development of a novel, high-affinity ssDNA trypsin inhibitor.

Malicki S, Ksiazek M, Majewski P, Pecak A, Mydel P, Grudnik P, Dubin G.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):638-643. doi: 10.1080/14756366.2019.1569648.

4.

Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity.

Svensson MN, Doody KM, Schmiedel BJ, Bhattacharyya S, Panwar B, Wiede F, Yang S, Santelli E, Wu DJ, Sacchetti C, Gujar R, Seumois G, Kiosses WB, Aubry I, Kim G, Mydel P, Sakaguchi S, Kronenberg M, Tiganis T, Tremblay ML, Ay F, Vijayanand P, Bottini N.

J Clin Invest. 2019 Mar 1;129(3):1193-1210. doi: 10.1172/JCI123267. Epub 2019 Feb 11.

5.

Effects of statins on multispecies oral biofilm identify simvastatin as a drug candidate targeting Porphyromonas gingivalis.

Kamińska M, Aliko A, Hellvard A, Bielecka E, Binder V, Marczyk A, Potempa J, Delaleu N, Kantyka T, Mydel P.

J Periodontol. 2018 Dec 2. doi: 10.1002/JPER.18-0179. [Epub ahead of print]

PMID:
30506795
6.

Impact of Porphyromonas gingivalis Peptidylarginine Deiminase on Bacterial Biofilm Formation, Epithelial Cell Invasion, and Epithelial Cell Transcriptional Landscape.

Aliko A, Kamińska M, Bergum B, Gawron K, Benedyk M, Lamont RJ, Malicki S, Delaleu N, Potempa J, Mydel P.

Sci Rep. 2018 Sep 20;8(1):14144. doi: 10.1038/s41598-018-32603-y.

7.

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70.

Zhao M, Svensson MND, Venken K, Chawla A, Liang S, Engel I, Mydel P, Day J, Elewaut D, Bottini N, Kronenberg M.

Nat Commun. 2018 Jul 6;9(1):2627. doi: 10.1038/s41467-018-05095-7.

8.

A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA.

Wong A, Bryzek D, Dobosz E, Scavenius C, Svoboda P, Rapala-Kozik M, Lesner A, Frydrych I, Enghild J, Mydel P, Pohl J, Thompson PR, Potempa J, Koziel J.

J Immunol. 2018 Apr 1;200(7):2327-2340. doi: 10.4049/jimmunol.1701391. Epub 2018 Feb 23.

9.

The case for periodontitis in the pathogenesis of rheumatoid arthritis.

Potempa J, Mydel P, Koziel J.

Nat Rev Rheumatol. 2017 Oct;13(10):606-620. doi: 10.1038/nrrheum.2017.132. Epub 2017 Aug 24. Review.

PMID:
28835673
10.

Impact of fibrinogen carbamylation on fibrin clot formation and stability.

Binder V, Bergum B, Jaisson S, Gillery P, Scavenius C, Spriet E, Nyhaug AK, Roberts HM, Chapple ILC, Hellvard A, Delaleu N, Mydel P.

Thromb Haemost. 2017 May 3;117(5):899-910. doi: 10.1160/TH16-09-0704. Epub 2017 Apr 6.

11.

Effects by periodontitis on pristane-induced arthritis in rats.

Eriksson K, Lönnblom E, Tour G, Kats A, Mydel P, Georgsson P, Hultgren C, Kharlamova N, Norin U, Jönsson J, Lundmark A, Hellvard A, Lundberg K, Jansson L, Holmdahl R, Yucel-Lindberg T.

J Transl Med. 2016 Nov 3;14(1):311.

12.

Bone loss and aggravated autoimmune arthritis in HLA-DRβ1-bearing humanized mice following oral challenge with Porphyromonas gingivalis.

Sandal I, Karydis A, Luo J, Prislovsky A, Whittington KB, Rosloniec EF, Dong C, Novack DV, Mydel P, Zheng SG, Radic MZ, Brand DD.

Arthritis Res Ther. 2016 Oct 26;18(1):249.

13.

Microbiological and bioinformatics analysis of primary Sjogren's syndrome patients with normal salivation.

Siddiqui H, Chen T, Aliko A, Mydel PM, Jonsson R, Olsen I.

J Oral Microbiol. 2016 Oct 20;8:31119. doi: 10.3402/jom.v8.31119. eCollection 2016.

14.

Serum calprotectin is a biomarker of carotid atherosclerosis in patients with primary Sjögren's syndrome.

Balarini GM, Zandonade E, Tanure L, Ferreira GA, Sardenberg WM, Serrano ÉV, Dias CC, Navarro TP, Nordal HH, Mydel PM, Brun JG, Brokstad KA, Gerdts E, Jonsson R, Valim V.

Clin Exp Rheumatol. 2016 Nov-Dec;34(6):1006-1012. Epub 2016 Sep 8.

PMID:
27749218
15.

Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis.

Hellvard A, Zeitlmann L, Heiser U, Kehlen A, Niestroj A, Demuth HU, Koziel J, Delaleu N, Jan Potempa, Mydel P.

Sci Rep. 2016 Aug 11;6:31441. doi: 10.1038/srep31441.

16.

Sjögren's syndrome patients with ectopic germinal centers present with a distinct salivary proteome.

Delaleu N, Mydel P, Brun JG, Jonsson MV, Alimonti A, Jonsson R.

Rheumatology (Oxford). 2016 Jun;55(6):1127-37. doi: 10.1093/rheumatology/kew013. Epub 2016 Feb 26.

PMID:
26921905
17.

Carbamylated LL-37 as a modulator of the immune response.

Koro C, Hellvard A, Delaleu N, Binder V, Scavenius C, Bergum B, Główczyk I, Roberts HM, Chapple IL, Grant MM, Rapala-Kozik M, Klaga K, Enghild JJ, Potempa J, Mydel P.

Innate Immun. 2016 Apr;22(3):218-29. doi: 10.1177/1753425916631404. Epub 2016 Feb 15.

18.

Atherosclerosis in Sjögren's syndrome: evidence, possible mechanisms and knowledge gaps.

Valim V, Gerdts E, Jonsson R, Ferreira GA, Brokstad KA, Brun JG, Midtbø H, Mydel PM.

Clin Exp Rheumatol. 2016 Jan-Feb;34(1):133-42. Epub 2016 Jan 20. Review.

PMID:
26812164
19.

Transcriptional, post-transcriptional and chromatin-associated regulation of pri-miRNAs, pre-miRNAs and moRNAs.

Nepal C, Coolen M, Hadzhiev Y, Cussigh D, Mydel P, Steen VM, Carninci P, Andersen JB, Bally-Cuif L, Müller F, Lenhard B.

Nucleic Acids Res. 2016 Apr 20;44(7):3070-81. doi: 10.1093/nar/gkv1354. Epub 2015 Dec 15.

20.

Gingipains: Critical Factors in the Development of Aspiration Pneumonia Caused by Porphyromonas gingivalis.

Benedyk M, Mydel PM, Delaleu N, Płaza K, Gawron K, Milewska A, Maresz K, Koziel J, Pyrc K, Potempa J.

J Innate Immun. 2016;8(2):185-98. doi: 10.1159/000441724. Epub 2015 Nov 28.

21.

Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.

Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N.

Arthritis Rheumatol. 2016 Feb;68(2):359-69. doi: 10.1002/art.39442.

22.

Antibodies against carbamylated proteins are present in primary Sjögren's syndrome and are associated with disease severity.

Bergum B, Koro C, Delaleu N, Solheim M, Hellvard A, Binder V, Jonsson R, Valim V, Hammenfors DS, Jonsson MV, Mydel P.

Ann Rheum Dis. 2016 Aug;75(8):1494-500. doi: 10.1136/annrheumdis-2015-207751. Epub 2015 Sep 8.

23.

Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase.

Goulas T, Mizgalska D, Garcia-Ferrer I, Kantyka T, Guevara T, Szmigielski B, Sroka A, Millán C, Usón I, Veillard F, Potempa B, Mydel P, Solà M, Potempa J, Gomis-Rüth FX.

Sci Rep. 2015 Jul 1;5:11969. doi: 10.1038/srep11969.

24.

High fidelity between saliva proteomics and the biologic state of salivary glands defines biomarker signatures for primary Sjögren's syndrome.

Delaleu N, Mydel P, Kwee I, Brun JG, Jonsson MV, Jonsson R.

Arthritis Rheumatol. 2015 Apr;67(4):1084-95. doi: 10.1002/art.39015.

25.

Carbamylation of immunoglobulin abrogates activation of the classical complement pathway.

Koro C, Bielecka E, Dahl-Knudsen A, Enghild JJ, Scavenius C, Brun JG, Binder V, Hellvard A, Bergum B, Jonsson R, Potempa J, Blom AM, Mydel P.

Eur J Immunol. 2014 Nov;44(11):3403-12. doi: 10.1002/eji.201444869. Epub 2014 Oct 20.

26.

The link between periodontal disease and rheumatoid arthritis: an updated review.

Koziel J, Mydel P, Potempa J.

Curr Rheumatol Rep. 2014 Mar;16(3):408. doi: 10.1007/s11926-014-0408-9. Review.

27.

The 2013 Nobel Prize in Physiology or Medicine.

Hellvard A, Mydel P.

Scand J Immunol. 2013 Dec;78(6):485. doi: 10.1111/sji.12124. No abstract available.

28.

Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD).

Maresz KJ, Hellvard A, Sroka A, Adamowicz K, Bielecka E, Koziel J, Gawron K, Mizgalska D, Marcinska KA, Benedyk M, Pyrc K, Quirke AM, Jonsson R, Alzabin S, Venables PJ, Nguyen KA, Mydel P, Potempa J.

PLoS Pathog. 2013 Sep;9(9):e1003627. doi: 10.1371/journal.ppat.1003627. Epub 2013 Sep 12.

29.

The role of Mcl-1 in S. aureus-induced cytoprotection of infected macrophages.

Koziel J, Kmiecik K, Chmiest D, Maresz K, Mizgalska D, Maciag-Gudowska A, Mydel P, Potempa J.

Mediators Inflamm. 2013;2013:427021. doi: 10.1155/2013/427021. Epub 2013 Jan 28.

30.

Glutaminyl cyclases as novel targets for the treatment of septic arthritis.

Hellvard A, Maresz K, Schilling S, Graubner S, Heiser U, Jonsson R, Cynis H, Demuth HU, Potempa J, Mydel P.

J Infect Dis. 2013 Mar 1;207(5):768-77. doi: 10.1093/infdis/jis729. Epub 2012 Nov 29.

31.

The N-methyl-d-aspartic acid receptor antagonist memantine ameliorates and delays the development of arthritis by enhancing regulatory T cells.

Lindblad SS, Mydel P, Hellvard A, Jonsson IM, Bokarewa MI.

Neurosignals. 2012;20(2):61-71. doi: 10.1159/000329551. Epub 2011 Dec 1.

32.

Carbamylation-dependent activation of T cells: a novel mechanism in the pathogenesis of autoimmune arthritis.

Mydel P, Wang Z, Brisslert M, Hellvard A, Dahlberg LE, Hazen SL, Bokarewa M.

J Immunol. 2010 Jun 15;184(12):6882-90. doi: 10.4049/jimmunol.1000075. Epub 2010 May 19.

33.

Smoking and nicotine exposure delay development of collagen-induced arthritis in mice.

Lindblad SS, Mydel P, Jonsson IM, Senior RM, Tarkowski A, Bokarewa M.

Arthritis Res Ther. 2009;11(3):R88. doi: 10.1186/ar2728. Epub 2009 Jun 11.

34.

Neutrophil elastase cleaves laminin-332 (laminin-5) generating peptides that are chemotactic for neutrophils.

Mydel P, Shipley JM, Adair-Kirk TL, Kelley DG, Broekelmann TJ, Mecham RP, Senior RM.

J Biol Chem. 2008 Apr 11;283(15):9513-22. doi: 10.1074/jbc.M706239200. Epub 2008 Jan 4.

35.

In vivo sortase A and clumping factor A mRNA expression during Staphylococcus aureus infection.

Josefsson E, Kubica M, Mydel P, Potempa J, Tarkowski A.

Microb Pathog. 2008 Feb;44(2):103-10. Epub 2007 Aug 21.

PMID:
17890045
36.

Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NF-kappa B.

Bylund J, MacDonald KL, Brown KL, Mydel P, Collins LV, Hancock RE, Speert DP.

Eur J Immunol. 2007 Apr;37(4):1087-96.

37.

Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection.

Mydel P, Takahashi Y, Yumoto H, Sztukowska M, Kubica M, Gibson FC 3rd, Kurtz DM Jr, Travis J, Collins LV, Nguyen KA, Genco CA, Potempa J.

PLoS Pathog. 2006 Jul;2(7):e76.

38.

Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases.

Sieprawska-Lupa M, Mydel P, Krawczyk K, Wójcik K, Puklo M, Lupa B, Suder P, Silberring J, Reed M, Pohl J, Shafer W, McAleese F, Foster T, Travis J, Potempa J.

Antimicrob Agents Chemother. 2004 Dec;48(12):4673-9.

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