Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 24

1.

A role for endothelial nitric oxide synthase in intestinal stem cell proliferation and mesenchymal colorectal cancer.

Peñarando J, López-Sánchez LM, Mena R, Guil-Luna S, Conde F, Hernández V, Toledano M, Gudiño V, Raponi M, Billard C, Villar C, Díaz C, Gómez-Barbadillo J, De la Haba-Rodríguez J, Myant K, Aranda E, Rodríguez-Ariza A.

BMC Biol. 2018 Jan 10;16(1):3. doi: 10.1186/s12915-017-0472-5.

2.

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.

Myant KB, Cammareri P, Hodder MC, Wills J, Von Kriegsheim A, Győrffy B, Rashid M, Polo S, Maspero E, Vaughan L, Gurung B, Barry E, Malliri A, Camargo F, Adams DJ, Iavarone A, Lasorella A, Sansom OJ.

EMBO Mol Med. 2017 Feb;9(2):181-197. doi: 10.15252/emmm.201606684.

3.

Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation.

Myant K, Qiao X, Halonen T, Come C, Laine A, Janghorban M, Partanen JI, Cassidy J, Ogg EL, Cammareri P, Laiterä T, Okkeri J, Klefström J, Sears RC, Sansom OJ, Westermarck J.

Cell Rep. 2015 Aug 11;12(6):1019-31. doi: 10.1016/j.celrep.2015.07.003. Epub 2015 Jul 30.

4.

mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.

Faller WJ, Jackson TJ, Knight JR, Ridgway RA, Jamieson T, Karim SA, Jones C, Radulescu S, Huels DJ, Myant KB, Dudek KM, Casey HA, Scopelliti A, Cordero JB, Vidal M, Pende M, Ryazanov AG, Sonenberg N, Meyuhas O, Hall MN, Bushell M, Willis AE, Sansom OJ.

Nature. 2015 Jan 22;517(7535):497-500. doi: 10.1038/nature13896. Epub 2014 Nov 5.

5.

Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.

Peter S, Bultinck J, Myant K, Jaenicke LA, Walz S, Müller J, Gmachl M, Treu M, Boehmelt G, Ade CP, Schmitz W, Wiegering A, Otto C, Popov N, Sansom O, Kraut N, Eilers M.

EMBO Mol Med. 2014 Dec;6(12):1525-41. doi: 10.15252/emmm.201403927.

6.

The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues.

Johnsson AE, Dai Y, Nobis M, Baker MJ, McGhee EJ, Walker S, Schwarz JP, Kadir S, Morton JP, Myant KB, Huels DJ, Segonds-Pichon A, Sansom OJ, Anderson KI, Timpson P, Welch HCE.

Cell Rep. 2014 Mar 27;6(6):1153-1164. doi: 10.1016/j.celrep.2014.02.024. Epub 2014 Mar 13.

7.

Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo.

Phesse TJ, Myant KB, Cole AM, Ridgway RA, Pearson H, Muncan V, van den Brink GR, Vousden KH, Sears R, Vassilev LT, Clarke AR, Sansom OJ.

Cell Death Differ. 2014 Jun;21(6):956-66. doi: 10.1038/cdd.2014.15. Epub 2014 Feb 28.

8.

Rac1 drives intestinal stem cell proliferation and regeneration.

Myant KB, Scopelliti A, Haque S, Vidal M, Sansom OJ, Cordero JB.

Cell Cycle. 2013 Sep 15;12(18):2973-7. doi: 10.4161/cc.26031. Epub 2013 Aug 12.

9.

ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.

Myant KB, Cammareri P, McGhee EJ, Ridgway RA, Huels DJ, Cordero JB, Schwitalla S, Kalna G, Ogg EL, Athineos D, Timpson P, Vidal M, Murray GI, Greten FR, Anderson KI, Sansom OJ.

Cell Stem Cell. 2013 Jun 6;12(6):761-73. doi: 10.1016/j.stem.2013.04.006. Epub 2013 May 9.

10.

Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut.

Cordero JB, Stefanatos RK, Myant K, Vidal M, Sansom OJ.

Development. 2012 Dec;139(24):4524-35. doi: 10.1242/dev.078261.

11.

The SNF2 family ATPase LSH promotes phosphorylation of H2AX and efficient repair of DNA double-strand breaks in mammalian cells.

Burrage J, Termanis A, Geissner A, Myant K, Gordon K, Stancheva I.

J Cell Sci. 2012 Nov 15;125(Pt 22):5524-34. doi: 10.1242/jcs.111252. Epub 2012 Sep 3.

12.

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.

Muñoz J, Stange DE, Schepers AG, van de Wetering M, Koo BK, Itzkovitz S, Volckmann R, Kung KS, Koster J, Radulescu S, Myant K, Versteeg R, Sansom OJ, van Es JH, Barker N, van Oudenaarden A, Mohammed S, Heck AJ, Clevers H.

EMBO J. 2012 Jun 12;31(14):3079-91. doi: 10.1038/emboj.2012.166.

13.

Wnt/Myc interactions in intestinal cancer: partners in crime.

Myant K, Sansom OJ.

Exp Cell Res. 2011 Nov 15;317(19):2725-31. doi: 10.1016/j.yexcr.2011.08.001. Epub 2011 Aug 7. Review.

PMID:
21851818
14.

More, more, more: downregulation of a MK5-FoxO3a-mir34b/c pathway further increases c-Myc levels in colorectal cancer.

Myant K, Sansom OJ.

Mol Cell. 2011 Feb 18;41(4):369-70. doi: 10.1016/j.molcel.2011.01.028.

15.

Efficient Wnt mediated intestinal hyperproliferation requires the cyclin D2-CDK4/6 complex.

Myant K, Sansom O.

Cell Div. 2011 Feb 2;6(1):3. doi: 10.1186/1747-1028-6-3.

16.

A FAK-PI-3K-mTOR axis is required for Wnt-Myc driven intestinal regeneration and tumorigenesis.

Morton JP, Myant KB, Sansom OJ.

Cell Cycle. 2011 Jan 15;10(2):173-5. Epub 2011 Jan 15. No abstract available.

PMID:
21228625
17.

LSH and G9a/GLP complex are required for developmentally programmed DNA methylation.

Myant K, Termanis A, Sundaram AY, Boe T, Li C, Merusi C, Burrage J, de Las Heras JI, Stancheva I.

Genome Res. 2011 Jan;21(1):83-94. doi: 10.1101/gr.108498.110. Epub 2010 Dec 13.

18.

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss.

Cole AM, Myant K, Reed KR, Ridgway RA, Athineos D, Van den Brink GR, Muncan V, Clevers H, Clarke AR, Sicinski P, Sansom OJ.

Cancer Res. 2010 Oct 15;70(20):8149-58. doi: 10.1158/0008-5472.CAN-10-0315. Epub 2010 Aug 24. Erratum in: Cancer Res. 2013 Jan 1;73(1):469.

19.

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

Ashton GH, Morton JP, Myant K, Phesse TJ, Ridgway RA, Marsh V, Wilkins JA, Athineos D, Muncan V, Kemp R, Neufeld K, Clevers H, Brunton V, Winton DJ, Wang X, Sears RC, Clarke AR, Frame MC, Sansom OJ.

Dev Cell. 2010 Aug 17;19(2):259-69. doi: 10.1016/j.devcel.2010.07.015.

20.

Targeting of de novo DNA methylation throughout the Oct-4 gene regulatory region in differentiating embryonic stem cells.

Athanasiadou R, de Sousa D, Myant K, Merusi C, Stancheva I, Bird A.

PLoS One. 2010 Apr 1;5(4):e9937. doi: 10.1371/journal.pone.0009937.

21.

Tiam1-Rac signaling counteracts Eg5 during bipolar spindle assembly to facilitate chromosome congression.

Woodcock SA, Rushton HJ, Castañeda-Saucedo E, Myant K, White GR, Blyth K, Sansom OJ, Malliri A.

Curr Biol. 2010 Apr 13;20(7):669-75. doi: 10.1016/j.cub.2010.02.033. Epub 2010 Mar 25.

22.

LSH cooperates with DNA methyltransferases to repress transcription.

Myant K, Stancheva I.

Mol Cell Biol. 2008 Jan;28(1):215-26. Epub 2007 Oct 29.

23.
24.

Supplemental Content

Support Center