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Five-Year Impact of Different Multi-Year Mass Drug Administration Strategies on Childhood Schistosoma mansoni-Associated Morbidity: A Combined Analysis from the Schistosomiasis Consortium for Operational Research and Evaluation Cohort Studies in the Lake Victoria Regions of Kenya and Tanzania.

Shen Y, Wiegand RE, Olsen A, King CH, Kittur N, Binder S, Zhang F, Whalen CC, Secor WE, Montgomery SP, Mwinzi PNM, Magnussen P, Kinung'hi S, Campbell CH, Colley DG.

Am J Trop Med Hyg. 2019 Dec;101(6):1336-1344. doi: 10.4269/ajtmh.19-0273.


Persistent Hotspots in Schistosomiasis Consortium for Operational Research and Evaluation Studies for Gaining and Sustaining Control of Schistosomiasis after Four Years of Mass Drug Administration of Praziquantel.

Kittur N, King CH, Campbell CH, Kinung'hi S, Mwinzi PNM, Karanja DMS, N'Goran EK, Phillips AE, Gazzinelli-Guimaraes PH, Olsen A, Magnussen P, Secor WE, Montgomery SP, Utzinger J, Walker JW, Binder S, Colley DG.

Am J Trop Med Hyg. 2019 Sep;101(3):617-627. doi: 10.4269/ajtmh.19-0193.


Aberrant plasma MMP and TIMP dynamics in Schistosoma - Immune reconstitution inflammatory syndrome (IRIS).

Goovaerts O, Mwinzi PNM, Muok EMO, Ceulemans A, Colebunders R, Kestens L.

PLoS Negl Trop Dis. 2018 Aug 8;12(8):e0006710. doi: 10.1371/journal.pntd.0006710. eCollection 2018 Aug.


Relative Contribution of Schistosomiasis and Malaria to Anemia in Western Kenya.

Valice EM, Wiegand RE, Mwinzi PNM, Karanja DMS, Williamson JM, Ochola E, Samuels A, Verani JR, Leon JS, Secor WE, Montgomery SP.

Am J Trop Med Hyg. 2018 Sep;99(3):713-715. doi: 10.4269/ajtmh.18-0069. Epub 2018 Jul 5.


Schistosoma mansoni Mass Drug Administration Regimens and Their Effect on Morbidity among Schoolchildren over a 5-Year Period-Kenya, 2010-2015.

Sircar AD, Mwinzi PNM, Onkanga IO, Wiegand RE, Montgomery SP, Secor WE.

Am J Trop Med Hyg. 2018 Aug;99(2):362-369. doi: 10.4269/ajtmh.18-0067. Epub 2018 Jun 7.


Diet and hygiene practices influence morbidity in schoolchildren living in Schistosomiasis endemic areas along Lake Victoria in Kenya and Tanzania-A cross-sectional study.

Mohamed I, Kinung'hi S, Mwinzi PNM, Onkanga IO, Andiego K, Muchiri G, Odiere MR, Vennervald BJ, Olsen A.

PLoS Negl Trop Dis. 2018 Mar 28;12(3):e0006373. doi: 10.1371/journal.pntd.0006373. eCollection 2018 Mar.


Cluster randomized trial comparing school-based mass drug administration schedules in areas of western Kenya with moderate initial prevalence of Schistosoma mansoni infections.

Karanja DMS, Awino EK, Wiegand RE, Okoth E, Abudho BO, Mwinzi PNM, Montgomery SP, Secor WE.

PLoS Negl Trop Dis. 2017 Oct 23;11(10):e0006033. doi: 10.1371/journal.pntd.0006033. eCollection 2017 Oct.


A Persistent Hotspot of Schistosoma mansoni Infection in a Five-Year Randomized Trial of Praziquantel Preventative Chemotherapy Strategies.

Wiegand RE, Mwinzi PNM, Montgomery SP, Chan YL, Andiego K, Omedo M, Muchiri G, Ogutu MO, Rawago F, Odiere MR, Karanja DMS, Secor WE.

J Infect Dis. 2017 Dec 12;216(11):1425-1433. doi: 10.1093/infdis/jix496. Erratum in: J Infect Dis. 2018 May 15;217(10):1672.


Protocol and baseline data for a multi-year cohort study of the effects of different mass drug treatment approaches on functional morbidities from schistosomiasis in four African countries.

Shen Y, King CH, Binder S, Zhang F, Whalen CC, Evan Secor W, Montgomery SP, Mwinzi PNM, Olsen A, Magnussen P, Kinung'hi S, Phillips AE, Nalá R, Ferro J, Aurelio HO, Fleming F, Garba A, Hamidou A, Fenwick A, Campbell CH Jr, Colley DG.

BMC Infect Dis. 2017 Sep 29;17(1):652. doi: 10.1186/s12879-017-2738-5.


Change in children's school behavior after mass administration of praziquantel for Schistosoma mansoni infection in endemic areas of western Kenya: A pilot study using the Behavioral Assessment System for Children (BASC-2).

Musuva R, Shen Y, Wei X, Binder S, Ivy JA, Secor WE, Montgomery SP, King CH, Mwinzi PNM.

PLoS One. 2017 Jul 26;12(7):e0181975. doi: 10.1371/journal.pone.0181975. eCollection 2017.


Evaluation of medicine retail outlets for sale of typhoid fever vaccine among adults in two urban and rural settings in western Kenya: a proof-of-concept study.

Ho J, Odhiambo G, Meng'anyi LW, Musuva RM, Mule JM, Alaly ZS, Odiere MR, Mwinzi PN, Ganley-Leal L.

BMC Health Serv Res. 2016 Sep 29;16(1):527.


Gaining and sustaining schistosomiasis control: study protocol and baseline data prior to different treatment strategies in five African countries.

Ezeamama AE, He CL, Shen Y, Yin XP, Binder SC, Campbell CH Jr, Rathbun S, Whalen CC, N'Goran EK, Utzinger J, Olsen A, Magnussen P, Kinung'hi S, Fenwick A, Phillips A, Ferro J, Karanja DM, Mwinzi PN, Montgomery S, Secor WE, Hamidou A, Garba A, King CH, Colley DG.

BMC Infect Dis. 2016 May 26;16:229. doi: 10.1186/s12879-016-1575-2.


Impact of two rounds of praziquantel mass drug administration on Schistosoma mansoni infection prevalence and intensity: a comparison between community wide treatment and school based treatment in western Kenya.

Onkanga IO, Mwinzi PN, Muchiri G, Andiego K, Omedo M, Karanja DM, Wiegand RE, Secor WE, Montgomery SP.

Int J Parasitol. 2016 Jun;46(7):439-45. doi: 10.1016/j.ijpara.2016.01.006. Epub 2016 Mar 2.


A cross-sectional study on schistosomiasis and soil-transmitted helminths in Mbita district, western Kenya using different copromicroscopic techniques.

Ng'etich AI, Rawago FO, Jura WG, Mwinzi PN, Won KY, Odiere MR.

Parasit Vectors. 2016 Feb 16;9:87. doi: 10.1186/s13071-016-1368-x.


Predictive Value of School-Aged Children's Schistosomiasis Prevalence and Egg Intensity for Other Age Groups in Western Kenya.

Mwinzi PN, Muchiri G, Wiegand RE, Omedo M, Abudho B, Karanja DM, Montgomery SP, Secor WE.

Am J Trop Med Hyg. 2015 Dec;93(6):1311-7. doi: 10.4269/ajtmh.15-0467. Epub 2015 Sep 28.


Effect of Repeated Anthelminthic Treatment on Malaria in School Children in Kenya: A Randomized, Open-Label, Equivalence Trial.

Kepha S, Nuwaha F, Nikolay B, Gichuki P, Mwandawiro CS, Mwinzi PN, Odiere MR, Edwards T, Allen E, Brooker SJ.

J Infect Dis. 2016 Jan 15;213(2):266-75. doi: 10.1093/infdis/jiv382. Epub 2015 Jul 13.


Improved sensitivity of the urine CAA lateral-flow assay for diagnosing active Schistosoma infections by using larger sample volumes.

Corstjens PL, Nyakundi RK, de Dood CJ, Kariuki TM, Ochola EA, Karanja DM, Mwinzi PN, van Dam GJ.

Parasit Vectors. 2015 Apr 22;8:241. doi: 10.1186/s13071-015-0857-7.


Cost analysis of tests for the detection of Schistosoma mansoni infection in children in western Kenya.

Worrell CM, Bartoces M, Karanja DM, Ochola EA, Matete DO, Mwinzi PN, Montgomery SP, Secor WE.

Am J Trop Med Hyg. 2015 Jun;92(6):1233-9. doi: 10.4269/ajtmh.14-0644. Epub 2015 Apr 13.


Evaluation of point-of-contact circulating cathodic antigen assays for the detection of Schistosoma mansoni infection in low-, moderate-, and high-prevalence schools in western Kenya.

Foo KT, Blackstock AJ, Ochola EA, Matete DO, Mwinzi PN, Montgomery SP, Karanja DM, Secor WE.

Am J Trop Med Hyg. 2015 Jun;92(6):1227-32. doi: 10.4269/ajtmh.14-0643. Epub 2015 Apr 13.


Additional Evaluation of the Point-of-Contact Circulating Cathodic Antigen Assay for Schistosoma mansoni Infection.

Mwinzi PN, Kittur N, Ochola E, Cooper PJ, Campbell CH Jr, King CH, Colley DG.

Front Public Health. 2015 Mar 19;3:48. doi: 10.3389/fpubh.2015.00048. eCollection 2015.


Low levels of awareness despite high prevalence of schistosomiasis among communities in Nyalenda informal settlement, Kisumu city, western Kenya.

Odhiambo GO, Musuva RM, Atuncha VO, Mutete ET, Odiere MR, Onyango RO, Alaii JA, Mwinzi PN.

PLoS Negl Trop Dis. 2014 Apr 3;8(4):e2784. doi: 10.1371/journal.pntd.0002784. eCollection 2014 Apr.


Schistosoma haematobium hotspots in south Nyanza, western Kenya: prevalence, distribution and co-endemicity with Schistosoma mansoni and soil-transmitted helminths.

Sang HC, Muchiri G, Ombok M, Odiere MR, Mwinzi PN.

Parasit Vectors. 2014 Mar 25;7:125. doi: 10.1186/1756-3305-7-125.


Community knowledge, attitudes and practices on schistosomiasis in western Kenya--the SCORE Project.

Musuva RM, Awiti A, Omedo M, Ogutu M, Secor WE, Montgomery SP, Alaii J, Mwinzi PN.

Am J Trop Med Hyg. 2014 Apr;90(4):646-52. doi: 10.4269/ajtmh.13-0488. Epub 2014 Feb 17.


Assessment of quality of life as a tool for measuring morbidity due to Schistosoma mansoni infection and the impact of treatment.

Won KY, Abudho B, Blackstock AJ, Montgomery SP, Kennedy ED, Person B, Mwinzi PN, Ochola EA, Foo KT, Hightower AW, Karanja DM, Secor WE.

Am J Trop Med Hyg. 2014 Feb;90(2):322-8. doi: 10.4269/ajtmh.13-0361. Epub 2013 Dec 9.


Association between CD4+ T-lymphocyte counts and fecal excretion of Schistosoma mansoni eggs in patients coinfected with S. mansoni and human immunodeficiency virus before and after initiation of antiretroviral therapy.

Muok EM, Simiyu EW, Ochola EA, Ng'ang'a ZW, Secor WE, Karanja DM, Mwinzi PN.

Am J Trop Med Hyg. 2013 Jul;89(1):42-5. doi: 10.4269/ajtmh.13-0045. Epub 2013 May 13.


High prevalence of schistosomiasis in Mbita and its adjacent islands of Lake Victoria, western Kenya.

Odiere MR, Rawago FO, Ombok M, Secor WE, Karanja DM, Mwinzi PN, Lammie PJ, Won K.

Parasit Vectors. 2012 Dec 3;5:278. doi: 10.1186/1756-3305-5-278.


Faecal contamination of public water sources in informal settlements of Kisumu City, western Kenya.

Opisa S, Odiere MR, Jura WG, Karanja DM, Mwinzi PN.

Water Sci Technol. 2012;66(12):2674-81. doi: 10.2166/wst.2012.503.


Community health workers' experiences and perspectives on mass drug administration for schistosomiasis control in western Kenya: the SCORE Project.

Omedo MO, Matey EJ, Awiti A, Ogutu M, Alaii J, Karanja DM, Montgomery SP, Secor WE, Mwinzi PN.

Am J Trop Med Hyg. 2012 Dec;87(6):1065-72. doi: 10.4269/ajtmh.2012.12-0435. Epub 2012 Oct 22.


Schistosoma mansoni morbidity among school-aged children: a SCORE project in Kenya.

Samuels AM, Matey E, Mwinzi PN, Wiegand RE, Muchiri G, Ireri E, Hyde M, Montgomery SP, Karanja DM, Secor WE.

Am J Trop Med Hyg. 2012 Nov;87(5):874-82. doi: 10.4269/ajtmh.2012.12-0397. Epub 2012 Sep 17.


Integrated community-directed intervention for schistosomiasis and soil transmitted helminths in western Kenya - a pilot study.

Mwinzi PN, Montgomery SP, Owaga CO, Mwanje M, Muok EM, Ayisi JG, Laserson KF, Muchiri EM, Secor WE, Karanja DM.

Parasit Vectors. 2012 Aug 31;5:182.


Malacological survey and geographical distribution of vector snails for schistosomiasis within informal settlements of Kisumu City, western Kenya.

Opisa S, Odiere MR, Jura WG, Karanja DM, Mwinzi PN.

Parasit Vectors. 2011 Dec 7;4:226. doi: 10.1186/1756-3305-4-226.


Preclinical prophylactic efficacy testing of Sm-p80-based vaccine in a nonhuman primate model of Schistosoma mansoni infection and immunoglobulin G and E responses to Sm-p80 in human serum samples from an area where schistosomiasis is endemic.

Ahmad G, Zhang W, Torben W, Ahrorov A, Damian RT, Wolf RF, White GL, Carey DW, Mwinzi PN, Ganley-Leal L, Kennedy RC, Siddiqui AA.

J Infect Dis. 2011 Nov;204(9):1437-49. doi: 10.1093/infdis/jir545. Epub 2011 Sep 15.


Geographical distribution of schistosomiasis and soil-transmitted helminths among school children in informal settlements in Kisumu City, Western Kenya.

Odiere MR, Opisa S, Odhiambo G, Jura WG, Ayisi JM, Karanja DM, Mwinzi PN.

Parasitology. 2011 Oct;138(12):1569-77. doi: 10.1017/S003118201100059X. Epub 2011 Jun 17.


Schistosomiasis among young children in Usoma, Kenya.

Verani JR, Abudho B, Montgomery SP, Mwinzi PN, Shane HL, Butler SE, Karanja DM, Secor WE.

Am J Trop Med Hyg. 2011 May;84(5):787-91. doi: 10.4269/ajtmh.2011.10-0685.


Identification of cytokeratin 18 as a biomarker of mouse and human hepatosplenic schistosomiasis.

Manivannan B, Rawson P, Jordan TW, Karanja DM, Mwinzi PN, Secor WE, La Flamme AC.

Infect Immun. 2011 May;79(5):2051-8. doi: 10.1128/IAI.01214-10. Epub 2011 Feb 28.


Evaluation of urine CCA assays for detection of Schistosoma mansoni infection in Western Kenya.

Shane HL, Verani JR, Abudho B, Montgomery SP, Blackstock AJ, Mwinzi PN, Butler SE, Karanja DM, Secor WE.

PLoS Negl Trop Dis. 2011 Jan 25;5(1):e951. doi: 10.1371/journal.pntd.0000951.


CD23-bound IgE augments and dominates recall responses through human naive B cells.

Griffith QK, Liang Y, Onguru DO, Mwinzi PN, Ganley-Leal LM.

J Immunol. 2011 Jan 15;186(2):1060-7. doi: 10.4049/jimmunol.1002709. Epub 2010 Dec 15.


Efficacy of artesunate with sulfalene plus pyrimethamine versus praziquantel for treatment of Schistosoma mansoni in Kenyan children: an open-label randomised controlled trial.

Obonyo CO, Muok EM, Mwinzi PN.

Lancet Infect Dis. 2010 Sep;10(9):603-11. doi: 10.1016/S1473-3099(10)70161-4. Epub 2010 Aug 10.


Increases in levels of schistosome-specific immunoglobulin E and CD23(+) B cells in a cohort of Kenyan children undergoing repeated treatment and reinfection with Schistosoma mansoni.

Black CL, Muok EM, Mwinzi PN, Carter JM, Karanja DM, Secor WE, Colley DG.

J Infect Dis. 2010 Aug 15;202(3):399-405. doi: 10.1086/653828.


Influence of exposure history on the immunology and development of resistance to human Schistosomiasis mansoni.

Black CL, Mwinzi PN, Muok EM, Abudho B, Fitzsimmons CM, Dunne DW, Karanja DM, Secor WE, Colley DG.

PLoS Negl Trop Dis. 2010 Mar 23;4(3):e637. doi: 10.1371/journal.pntd.0000637.


Short report: Childhood coinfections with Plasmodium falciparum and Schistosoma mansoni result in lower percentages of activated T cells and T regulatory memory cells than schistosomiasis only.

Muok EM, Mwinzi PN, Black CL, Carter JM, Ng'ang'a ZW, Gicheru MM, Secor WE, Karanja DM, Colley DG.

Am J Trop Med Hyg. 2009 Mar;80(3):475-8. Erratum in: Am J Trop Med Hyg. 2009 Aug;81(2):370. Am J Trop Med Hyg. 2009 May;80(5):877. Mouk, Erick M O [corrected to Muok, Erick M O].


Impact of intense, longitudinal retreatment with praziquantel on cure rates of schistosomiasis mansoni in a cohort of occupationally exposed adults in western Kenya.

Black CL, Steinauer ML, Mwinzi PN, Evan Secor W, Karanja DM, Colley DG.

Trop Med Int Health. 2009 Apr;14(4):450-7. doi: 10.1111/j.1365-3156.2009.02234.x. Epub 2009 Feb 14.


Association of the gene polymorphisms IFN-gamma +874, IL-13 -1055 and IL-4 -590 with patterns of reinfection with Schistosoma mansoni.

Gatlin MR, Black CL, Mwinzi PN, Secor WE, Karanja DM, Colley DG.

PLoS Negl Trop Dis. 2009;3(2):e375. doi: 10.1371/journal.pntd.0000375. Epub 2009 Feb 3.


Public-health crisis after the election violence in Kenya.

Obonyo CO, Omondi DS, Mwinzi PN.

Lancet. 2008 Apr 19;371(9621):1319-21. doi: 10.1016/S0140-6736(08)60575-9. No abstract available.


T regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment.

Watanabe K, Mwinzi PN, Black CL, Muok EM, Karanja DM, Secor WE, Colley DG.

Am J Trop Med Hyg. 2007 Oct;77(4):676-82.


Higher percentages of circulating mast cell precursors correlate with susceptibility to reinfection with Schistosoma mansoni.

Ganley-Leal LM, Mwinzi PN, Cetre-Sossah CB, Andove J, Hightower AW, Karanja DM, Colley DG, Secor WE.

Am J Trop Med Hyg. 2006 Dec;75(6):1053-7.


Correlation between eosinophils and protection against reinfection with Schistosoma mansoni and the effect of human immunodeficiency virus type 1 coinfection in humans.

Ganley-Leal LM, Mwinzi PN, Cetre-Sossah CB, Andove J, Hightower AW, Karanja DM, Colley DG, Secor WE.

Infect Immun. 2006 Apr;74(4):2169-76.

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