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Longitudinal DNA methylation changes at MET may alter HGF/c-MET signalling in adolescents at risk for depression.

Ciuculete DM, Voisin S, Kular L, Welihinda N, Jonsson J, Jagodic M, Mwinyi J, Schiöth HB.

Epigenetics. 2019 Dec 19:1-18. doi: 10.1080/15592294.2019.1700628. [Epub ahead of print]


Major depression subtypes are differentially associated with migraine subtype, prevalence and severity.

Pisanu C, Lundin E, Preisig M, Gholam-Rezaee M, Castelao E, Pistis G, Merikangas KR, Glaus J, Squassina A, Del Zompo M, Schiöth HB, Mwinyi J.

Cephalalgia. 2019 Oct 24:333102419884935. doi: 10.1177/0333102419884935. [Epub ahead of print]


A pharmacogenetic risk score for the evaluation of major depression severity under treatment with antidepressants.

Kanders SH, Pisanu C, Bandstein M, Jonsson J, Castelao E, Pistis G, Gholam-Rezaee M, Eap CB, Preisig M, Schiöth HB, Mwinyi J.

Drug Dev Res. 2020 Feb;81(1):102-113. doi: 10.1002/ddr.21609. Epub 2019 Oct 16.


Hypermethylation-associated downregulation of microRNA-4456 in hypersexual disorder with putative influence on oxytocin signalling: A DNA methylation analysis of miRNA genes.

Boström AE, Chatzittofis A, Ciuculete DM, Flanagan JN, Krattinger R, Bandstein M, Mwinyi J, Kullak-Ublick GA, Öberg KG, Arver S, Schiöth HB, Jokinen J.

Epigenetics. 2020 Jan - Feb;15(1-2):145-160. doi: 10.1080/15592294.2019.1656157. Epub 2019 Sep 22.


Plasma levels of leptin and adiponectin and depressive symptoms in young adults.

Syk M, Ellström S, Mwinyi J, Schiöth HB, Ekselius L, Ramklint M, Cunningham JL.

Psychiatry Res. 2019 Feb;272:1-7. doi: 10.1016/j.psychres.2018.11.075. Epub 2018 Dec 3.


Plasma stearoyl-CoA desaturase activity indices and bile acid concentrations after a low-fat meal: association with a genetic variant in the FTO gene.

Skuladottir GV, Oskarsdottir H, Pisanu C, Sjödin M, Lindberg J, Mwinyi J, Schiöth HB.

Diabetes Metab Syndr Obes. 2018 Oct 9;11:611-618. doi: 10.2147/DMSO.S175730. eCollection 2018.


Changes in methylation within the STK32B promoter are associated with an increased risk for generalized anxiety disorder in adolescents.

Ciuculete DM, Boström AE, Tuunainen AK, Sohrabi F, Kular L, Jagodic M, Voisin S, Mwinyi J, Schiöth HB.

J Psychiatr Res. 2018 Jul;102:44-51. doi: 10.1016/j.jpsychires.2018.03.008. Epub 2018 Mar 26.


Response to Smit et al.

Ciuculete DM, Schiöth HB, Mwinyi J.

Clin Genet. 2017 Nov;92(5):566. doi: 10.1111/cge.13042. No abstract available. Erratum in: Clin Genet. 2018 Apr;93(4):939. Title corrected.


A genetic variant in the catechol-O-methyl transferase (COMT) gene is related to age-dependent differences in the therapeutic effect of calcium-channel blockers.

Xu J, Boström AE, Saeed M, Dubey RK, Waeber G, Vollenweider P, Marques-Vidal P, Mwinyi J, Schiöth HB.

Medicine (Baltimore). 2017 Jul;96(30):e7029. doi: 10.1097/MD.0000000000007029.


A genetic risk score is differentially associated with migraine with and without aura.

Pisanu C, Preisig M, Castelao E, Glaus J, Pistis G, Squassina A, Del Zompo M, Merikangas KR, Waeber G, Vollenweider P, Mwinyi J, Schiöth HB.

Hum Genet. 2017 Aug;136(8):999-1008. doi: 10.1007/s00439-017-1816-5. Epub 2017 Jun 27.


A MIR4646 associated methylation locus is hypomethylated in adolescent depression.

Boström AE, Ciuculete DM, Attwood M, Krattinger R, Nikontovic L, Titova OE, Kullak-Ublick GA, Mwinyi J, Schiöth HB.

J Affect Disord. 2017 Oct 1;220:117-128. doi: 10.1016/j.jad.2017.05.017. Epub 2017 May 17.


Correction: Plasma 1-deoxysphingolipids are early predictors of incident type 2 diabetes mellitus.

Mwinyi J, Boström A, Fehrer I, Othman A, Waeber G, Marti-Soler H, Vollenweider P, Marques-Vidal P, Schiöth HB, von Eckardstein A, Hornemann T.

PLoS One. 2017 Jun 5;12(6):e0179313. doi: 10.1371/journal.pone.0179313. eCollection 2017.


Plasma 1-deoxysphingolipids are early predictors of incident type 2 diabetes mellitus.

Mwinyi J, Boström A, Fehrer I, Othman A, Waeber G, Marti-Soler H, Vollenweider P, Marques-Vidal P, Schiöth HB, von Eckardstein A, Hornemann T.

PLoS One. 2017 May 4;12(5):e0175776. doi: 10.1371/journal.pone.0175776. eCollection 2017. Erratum in: PLoS One. 2017 Jun 5;12 (6):e0179313.


Anxiety Disorders are Associated with Low Socioeconomic Status in Women but Not in Men.

Mwinyi J, Pisanu C, Castelao E, Stringhini S, Preisig M, Schiöth HB.

Womens Health Issues. 2017 May - Jun;27(3):302-307. doi: 10.1016/j.whi.2017.01.001. Epub 2017 Feb 15.


A methylome-wide mQTL analysis reveals associations of methylation sites with GAD1 and HDAC3 SNPs and a general psychiatric risk score.

Ciuculete DM, Boström AE, Voisin S, Philipps H, Titova OE, Bandstein M, Nikontovic L, Williams MJ, Mwinyi J, Schiöth HB.

Transl Psychiatry. 2017 Jan 17;7(1):e1002. doi: 10.1038/tp.2016.275.


NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition.

Mwinyi J, Boström AE, Pisanu C, Murphy SK, Erhart W, Schafmayer C, Hampe J, Moylan C, Schiöth HB.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Mar;1862(3):314-323. doi: 10.1016/j.bbalip.2016.12.005. Epub 2016 Dec 18.


A genetic risk score is significantly associated with statin therapy response in the elderly population.

Ciuculete DM, Bandstein M, Benedict C, Waeber G, Vollenweider P, Lind L, Schiöth HB, Mwinyi J.

Clin Genet. 2017 Mar;91(3):379-385. doi: 10.1111/cge.12890. Epub 2016 Dec 12.


One-night sleep deprivation induces changes in the DNA methylation and serum activity indices of stearoyl-CoA desaturase in young healthy men.

Skuladottir GV, Nilsson EK, Mwinyi J, Schiöth HB.

Lipids Health Dis. 2016 Aug 26;15(1):137. doi: 10.1186/s12944-016-0309-1.


Epigenomics of Total Acute Sleep Deprivation in Relation to Genome-Wide DNA Methylation Profiles and RNA Expression.

Nilsson EK, Boström AE, Mwinyi J, Schiöth HB.

OMICS. 2016 Jun;20(6):334-42. doi: 10.1089/omi.2016.0041.


A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease.

Schiöth HB, Boström A, Murphy SK, Erhart W, Hampe J, Moylan C, Mwinyi J.

BMC Genomics. 2016 Jun 14;17:462. doi: 10.1186/s12864-016-2814-z.


A genetic variant in proximity to the gene LYPLAL1 is associated with lower hunger feelings and increased weight loss following Roux-en-Y gastric bypass surgery.

Bandstein M, Mwinyi J, Ernst B, Thurnheer M, Schultes B, Schiöth HB.

Scand J Gastroenterol. 2016 Sep;51(9):1050-5. doi: 10.3109/00365521.2016.1166519. Epub 2016 May 16.


Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes.

Krattinger R, Boström A, Lee SML, Thasler WE, Schiöth HB, Kullak-Ublick GA, Mwinyi J.

Life Sci. 2016 Jul 1;156:47-56. doi: 10.1016/j.lfs.2016.04.037. Epub 2016 May 10.


High leptin levels are associated with migraine with aura.

Pisanu C, Preisig M, Castelao E, Glaus J, Cunningham JL, Del Zompo M, Merikangas KR, Schiöth HB, Mwinyi J.

Cephalalgia. 2017 Apr;37(5):435-441. doi: 10.1177/0333102416648650. Epub 2016 May 10.


Longitudinal genome-wide methylation study of Roux-en-Y gastric bypass patients reveals novel CpG sites associated with essential hypertension.

Boström AE, Mwinyi J, Voisin S, Wu W, Schultes B, Zhang K, Schiöth HB.

BMC Med Genomics. 2016 Apr 22;9:20. doi: 10.1186/s12920-016-0180-y.


microRNA-192 suppresses the expression of the farnesoid X receptor.

Krattinger R, Boström A, Schiöth HB, Thasler WE, Mwinyi J, Kullak-Ublick GA.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1044-51. doi: 10.1152/ajpgi.00297.2015. Epub 2016 Apr 14.


A Genetic Risk Score Is Associated with Weight Loss Following Roux-en Y Gastric Bypass Surgery.

Bandstein M, Voisin S, Nilsson EK, Schultes B, Ernst B, Thurnheer M, Benedict C, Mwinyi J, Schiöth HB.

Obes Surg. 2016 Sep;26(9):2183-2189. doi: 10.1007/s11695-016-2072-9.


Roux-en Y gastric bypass surgery induces genome-wide promoter-specific changes in DNA methylation in whole blood of obese patients.

Nilsson EK, Ernst B, Voisin S, Almén MS, Benedict C, Mwinyi J, Fredriksson R, Schultes B, Schiöth HB.

PLoS One. 2015 Feb 24;10(2):e0115186. doi: 10.1371/journal.pone.0115186. eCollection 2015.


Risk factors for repetitive ileocolic resection in patients with Crohn's disease: results of an observational cohort study.

Manser CN, Frei P, Grandinetti T, Biedermann L, Mwinyi J, Vavricka SR, Schoepfer A, Fried M, Rogler G; Investigators of the Swiss IBD Cohort Study.

Inflamm Bowel Dis. 2014 Sep;20(9):1548-54. doi: 10.1097/MIB.0000000000000123.


The effectiveness and safety of rescue treatments in 108 patients with steroid-refractory ulcerative colitis with sequential rescue therapies in a subgroup of patients.

Protic M, Seibold F, Schoepfer A, Radojicic Z, Juillerat P, Bojic D, Mwinyi J, Mottet C, Jojic N, Beglinger C, Vavricka S, Rogler G, Frei P.

J Crohns Colitis. 2014 Nov;8(11):1427-37. doi: 10.1016/j.crohns.2014.05.004. Epub 2014 Jun 5.


The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes.

Schaffner CA, Mwinyi J, Gai Z, Thasler WE, Eloranta JJ, Kullak-Ublick GA.

Liver Int. 2015 Apr;35(4):1152-61. doi: 10.1111/liv.12558. Epub 2014 Apr 29.


Impact of variable CYP genotypes on breast cancer relapse in patients undergoing adjuvant tamoxifen therapy.

Mwinyi J, Vokinger K, Jetter A, Breitenstein U, Hiller C, Kullak-Ublick GA, Trojan A.

Cancer Chemother Pharmacol. 2014 Jun;73(6):1181-8. doi: 10.1007/s00280-014-2453-5. Epub 2014 Mar 29.


Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG.

Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23. Review.


Smoking cessation induces profound changes in the composition of the intestinal microbiota in humans.

Biedermann L, Zeitz J, Mwinyi J, Sutter-Minder E, Rehman A, Ott SJ, Steurer-Stey C, Frei A, Frei P, Scharl M, Loessner MJ, Vavricka SR, Fried M, Schreiber S, Schuppler M, Rogler G.

PLoS One. 2013;8(3):e59260. doi: 10.1371/journal.pone.0059260. Epub 2013 Mar 14.


Association of genetic variation in the NR1H4 gene, encoding the nuclear bile acid receptor FXR, with inflammatory bowel disease.

Attinkara R, Mwinyi J, Truninger K, Regula J, Gaj P, Rogler G, Kullak-Ublick GA, Eloranta JJ; Swiss IBD Cohort Study Group.

BMC Res Notes. 2012 Aug 28;5:461. doi: 10.1186/1756-0500-5-461.


Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis - an open pilot study.

Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, Vavricka SR, Fried M, Weber A, Humpf HU, Peschke S, Jetter A, Krammer G, Rogler G.

J Crohns Colitis. 2013 May;7(4):271-9. doi: 10.1016/j.crohns.2012.07.010. Epub 2012 Aug 9.


The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course.

Mwinyi J, Grete-Wenger C, Eloranta JJ, Kullak-Ublick GA.

PPAR Res. 2012;2012:349469. doi: 10.1155/2012/349469. Epub 2012 Feb 14.


Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy.

Scharl M, Mwinyi J, Fischbeck A, Leucht K, Eloranta JJ, Arikkat J, Pesch T, Kellermeier S, Mair A, Kullak-Ublick GA, Truninger K, Noreen F, Regula J, Gaj P, Pittet V, Mueller C, Hofmann C, Fried M, McCole DF, Rogler G.

Inflamm Bowel Dis. 2012 May;18(5):900-12. doi: 10.1002/ibd.21913. Epub 2011 Oct 21.


Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease.

Eloranta JJ, Wenger C, Mwinyi J, Hiller C, Gubler C, Vavricka SR, Fried M, Kullak-Ublick GA; Swiss IBD Cohort Study Group.

Pharmacogenet Genomics. 2011 Sep;21(9):559-64. doi: 10.1097/FPC.0b013e328348f70c.


The ligands of estrogen receptor α regulate cytochrome P4502C9 (CYP2C9) expression.

Mwinyi J, Cavaco I, Yurdakok B, Mkrtchian S, Ingelman-Sundberg M.

J Pharmacol Exp Ther. 2011 Jul;338(1):302-9. doi: 10.1124/jpet.110.175075. Epub 2011 Apr 14.


The human organic anion transporter genes OAT5 and OAT7 are transactivated by hepatocyte nuclear factor-1α (HNF-1α).

Klein K, Jüngst C, Mwinyi J, Stieger B, Krempler F, Patsch W, Eloranta JJ, Kullak-Ublick GA.

Mol Pharmacol. 2010 Dec;78(6):1079-87. doi: 10.1124/mol.110.065201. Epub 2010 Sep 9.


Glucocorticoid receptor gene haplotype structure and steroid therapy outcome in IBD patients.

Mwinyi J, Wenger C, Eloranta JJ, Kullak-Ublick GA.

World J Gastroenterol. 2010 Aug 21;16(31):3888-96.


Regulation of CYP2C19 expression by estrogen receptor α: implications for estrogen-dependent inhibition of drug metabolism.

Mwinyi J, Cavaco I, Pedersen RS, Persson A, Burkhardt S, Mkrtchian S, Ingelman-Sundberg M.

Mol Pharmacol. 2010 Nov;78(5):886-94. doi: 10.1124/mol.110.065540. Epub 2010 Jul 30.


The transcription factor GATA-4 regulates cytochrome P4502C19 gene expression.

Mwinyi J, Hofmann Y, Pedersen RS, Nekvindová J, Cavaco I, Mkrtchian S, Ingelman-Sundberg M.

Life Sci. 2010 May 8;86(19-20):699-706. doi: 10.1016/j.lfs.2010.02.021. Epub 2010 Mar 4.


New insights into the regulation of CYP2C9 gene expression: the role of the transcription factor GATA-4.

Mwinyi J, Nekvindová J, Cavaco I, Hofmann Y, Pedersen RS, Landman E, Mkrtchian S, Ingelman-Sundberg M.

Drug Metab Dispos. 2010 Mar;38(3):415-21. doi: 10.1124/dmd.109.029405. Epub 2009 Dec 7.


Regulation of human CYP2C18 and CYP2C19 in transgenic mice: influence of castration, testosterone, and growth hormone.

Löfgren S, Baldwin RM, Carlerös M, Terelius Y, Fransson-Steen R, Mwinyi J, Waxman DJ, Ingelman-Sundberg M.

Drug Metab Dispos. 2009 Jul;37(7):1505-12. doi: 10.1124/dmd.109.026963. Epub 2009 Apr 1.


Kinetics of omeprazole and escitalopram in relation to the CYP2C19*17 allele in healthy subjects.

Ohlsson Rosenborg S, Mwinyi J, Andersson M, Baldwin RM, Pedersen RS, Sim SC, Bertilsson L, Ingelman-Sundberg M, Eliasson E.

Eur J Clin Pharmacol. 2008 Dec;64(12):1175-9. doi: 10.1007/s00228-008-0529-z. Epub 2008 Jul 25.


Increased omeprazole metabolism in carriers of the CYP2C19*17 allele; a pharmacokinetic study in healthy volunteers.

Baldwin RM, Ohlsson S, Pedersen RS, Mwinyi J, Ingelman-Sundberg M, Eliasson E, Bertilsson L.

Br J Clin Pharmacol. 2008 May;65(5):767-74. doi: 10.1111/j.1365-2125.2008.03104.x. Epub 2008 Feb 20.


Comparison of SLCO1B1 sequence variability among German, Turkish, and African populations.

Mwinyi J, Köpke K, Schaefer M, Roots I, Gerloff T.

Eur J Clin Pharmacol. 2008 Mar;64(3):257-66. doi: 10.1007/s00228-007-0409-y. Epub 2008 Jan 6.


Influence of the SLCO1B1*1b and *5 haplotypes on pravastatin's cholesterol lowering capabilities and basal sterol serum levels.

Gerloff T, Schaefer M, Mwinyi J, Johne A, Sudhop T, Lütjohann D, Roots I, von Bergmann K.

Naunyn Schmiedebergs Arch Pharmacol. 2006 Apr;373(1):45-50. Epub 2006 Mar 28.


Quantification of pravastatin in human plasma and urine after solid phase extraction using high performance liquid chromatography with ultraviolet detection.

Bauer S, Mwinyi J, Stoeckle A, Gerloff T, Roots I.

J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Apr 25;818(2):257-62.


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