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Items: 1 to 50 of 160

1.

Biodistribution of adeno-associated virus type 2 with mutations in the capsid that contribute to heparan sulfate proteoglycan binding.

Gorbatyuk OS, Warrington KH Jr, Gorbatyuk MS, Zolotukhin I, Lewin AS, Muzyczka N.

Virus Res. 2019 Sep 29;274:197771. doi: 10.1016/j.virusres.2019.197771. [Epub ahead of print]

2.

The Lipase Activity of Phospholipase D2 is Responsible for Nigral Neurodegeneration in a Rat Model of Parkinson's Disease.

Mendez-Gomez HR, Singh J, Meyers C, Chen W, Gorbatyuk OS, Muzyczka N.

Neuroscience. 2018 May 1;377:174-183. doi: 10.1016/j.neuroscience.2018.02.047. Epub 2018 Mar 9.

3.

AAV: An Overview of Unanswered Questions.

Berns KI, Muzyczka N.

Hum Gene Ther. 2017 Apr;28(4):308-313. doi: 10.1089/hum.2017.048. Review.

4.

Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging.

Drouin LM, Lins B, Janssen M, Bennett A, Chipman P, McKenna R, Chen W, Muzyczka N, Cardone G, Baker TS, Agbandje-McKenna M.

J Virol. 2016 Sep 12;90(19):8542-51. doi: 10.1128/JVI.00575-16. Print 2016 Oct 1.

5.

Mutants at the 2-Fold Interface of Adeno-associated Virus Type 2 (AAV2) Structural Proteins Suggest a Role in Viral Transcription for AAV Capsids.

Aydemir F, Salganik M, Resztak J, Singh J, Bennett A, Agbandje-McKenna M, Muzyczka N.

J Virol. 2016 Jul 27;90(16):7196-7204. doi: 10.1128/JVI.00493-16. Print 2016 Aug 15.

6.

The Adeno-Associated Virus Genome Packaging Puzzle.

Ling C, Wang Y, Lu Y, Wang L, Jayandharan GR, Aslanidi GV, Li B, Cheng B, Ma W, Lentz T, Ling C, Xiao X, Samulski RJ, Muzyczka N, Srivastava A.

J Mol Genet Med. 2015 Aug;9(3). pii: 175. Epub 2015 Jul 15. No abstract available.

7.

Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma?

Berns KI, Byrne BJ, Flotte TR, Gao G, Hauswirth WW, Herzog RW, Muzyczka N, VandenDriessche T, Xiao X, Zolotukhin S, Srivastava A.

Hum Gene Ther. 2015 Dec;26(12):779-81. doi: 10.1089/hum.2015.29014.kib. No abstract available.

8.

Transcytosis in the blood-cerebrospinal fluid barrier of the mouse brain with an engineered receptor/ligand system.

Méndez-Gómez HR, Galera-Prat A, Meyers C, Chen W, Singh J, Carrión-Vázquez M, Muzyczka N.

Mol Ther Methods Clin Dev. 2015 Oct 7;2:15037. doi: 10.1038/mtm.2015.37. eCollection 2015.

9.

AAV's Golden Jubilee.

Muzyczka N, Berns KI.

Mol Ther. 2015 May;23(5):807-808. doi: 10.1038/mt.2015.55. No abstract available.

10.

Adeno-associated virus serotype 1 (AAV1)- and AAV5-antibody complex structures reveal evolutionary commonalities in parvovirus antigenic reactivity.

Tseng YS, Gurda BL, Chipman P, McKenna R, Afione S, Chiorini JA, Muzyczka N, Olson NH, Baker TS, Kleinschmidt J, Agbandje-McKenna M.

J Virol. 2015 Feb;89(3):1794-808. doi: 10.1128/JVI.02710-14. Epub 2014 Nov 19.

11.

AAV-Mediated Gene Therapy for Research and Therapeutic Purposes.

Samulski RJ, Muzyczka N.

Annu Rev Virol. 2014 Nov;1(1):427-51. doi: 10.1146/annurev-virology-031413-085355.

PMID:
26958729
12.

Enhanced transgene expression from recombinant single-stranded D-sequence-substituted adeno-associated virus vectors in human cell lines in vitro and in murine hepatocytes in vivo.

Ling C, Wang Y, Lu Y, Wang L, Jayandharan GR, Aslanidi GV, Li B, Cheng B, Ma W, Lentz T, Ling C, Xiao X, Samulski RJ, Muzyczka N, Srivastava A.

J Virol. 2015 Jan 15;89(2):952-61. doi: 10.1128/JVI.02581-14. Epub 2014 Oct 29.

13.

Overcoming the cystic fibrosis sputum barrier to leading adeno-associated virus gene therapy vectors.

Schuster BS, Kim AJ, Kays JC, Kanzawa MM, Guggino WB, Boyle MP, Rowe SM, Muzyczka N, Suk JS, Hanes J.

Mol Ther. 2014 Aug;22(8):1484-1493. doi: 10.1038/mt.2014.89. Epub 2014 May 29.

14.

OneBac: platform for scalable and high-titer production of adeno-associated virus serotype 1-12 vectors for gene therapy.

Mietzsch M, Grasse S, Zurawski C, Weger S, Bennett A, Agbandje-McKenna M, Muzyczka N, Zolotukhin S, Heilbronn R.

Hum Gene Ther. 2014 Mar;25(3):212-22. doi: 10.1089/hum.2013.184. Epub 2014 Jan 23.

15.

Adeno-associated virus capsid proteins may play a role in transcription and second-strand synthesis of recombinant genomes.

Salganik M, Aydemir F, Nam HJ, McKenna R, Agbandje-McKenna M, Muzyczka N.

J Virol. 2014 Jan;88(2):1071-9. doi: 10.1128/JVI.02093-13. Epub 2013 Nov 6.

16.

Molecular cloning, overexpression, and an efficient one-step purification of α5β1 integrin.

Tartaglia LJ, Bennett A, Plattner AS, Muzyczka N, Ling C, Srivastava A, Agbandje-McKenna M.

Protein Expr Purif. 2013 Nov;92(1):21-8. doi: 10.1016/j.pep.2013.08.013. Epub 2013 Aug 29.

17.

Structural insights into adeno-associated virus serotype 5.

Govindasamy L, DiMattia MA, Gurda BL, Halder S, McKenna R, Chiorini JA, Muzyczka N, Zolotukhin S, Agbandje-McKenna M.

J Virol. 2013 Oct;87(20):11187-99. doi: 10.1128/JVI.00867-13. Epub 2013 Aug 7.

18.

Capsid antibodies to different adeno-associated virus serotypes bind common regions.

Gurda BL, DiMattia MA, Miller EB, Bennett A, McKenna R, Weichert WS, Nelson CD, Chen WJ, Muzyczka N, Olson NH, Sinkovits RS, Chiorini JA, Zolotutkhin S, Kozyreva OG, Samulski RJ, Baker TS, Parrish CR, Agbandje-McKenna M.

J Virol. 2013 Aug;87(16):9111-24. doi: 10.1128/JVI.00622-13. Epub 2013 Jun 12.

19.

Construction, expression, and purification of recombinant αVβ5 integrin.

Tartaglia LJ, Bennett A, Woodhouse AG, Aydemir F, Muzyczka N, Agbandje-McKenna M.

Protein Expr Purif. 2013 Jun;89(2):225-31. doi: 10.1016/j.pep.2013.04.002. Epub 2013 Apr 12.

20.

Structure and dynamics of adeno-associated virus serotype 1 VP1-unique N-terminal domain and its role in capsid trafficking.

Venkatakrishnan B, Yarbrough J, Domsic J, Bennett A, Bothner B, Kozyreva OG, Samulski RJ, Muzyczka N, McKenna R, Agbandje-McKenna M.

J Virol. 2013 May;87(9):4974-84. doi: 10.1128/JVI.02524-12. Epub 2013 Feb 20.

21.

Evidence for pH-dependent protease activity in the adeno-associated virus capsid.

Salganik M, Venkatakrishnan B, Bennett A, Lins B, Yarbrough J, Muzyczka N, Agbandje-McKenna M, McKenna R.

J Virol. 2012 Nov;86(21):11877-85. doi: 10.1128/JVI.01717-12. Epub 2012 Aug 22.

22.

Structural insight into the unique properties of adeno-associated virus serotype 9.

DiMattia MA, Nam HJ, Van Vliet K, Mitchell M, Bennett A, Gurda BL, McKenna R, Olson NH, Sinkovits RS, Potter M, Byrne BJ, Aslanidi G, Zolotukhin S, Muzyczka N, Baker TS, Agbandje-McKenna M.

J Virol. 2012 Jun;86(12):6947-58. doi: 10.1128/JVI.07232-11. Epub 2012 Apr 11.

23.

Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of Parkinson disease.

Gorbatyuk MS, Shabashvili A, Chen W, Meyers C, Sullivan LF, Salganik M, Lin JH, Lewin AS, Muzyczka N, Gorbatyuk OS.

Mol Ther. 2012 Jul;20(7):1327-37. doi: 10.1038/mt.2012.28. Epub 2012 Mar 20.

24.

Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of rats: Impact on cognitive function, synaptic plasticity and pathology.

Wu K, Li S, Bodhinathan K, Meyers C, Chen W, Campbell-Thompson M, McIntyre L, Foster TC, Muzyczka N, Kumar A.

Neurobiol Learn Mem. 2012 Jan;97(1):69-80. doi: 10.1016/j.nlm.2011.09.006. Epub 2011 Sep 25.

25.

Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking.

Nam HJ, Gurda BL, McKenna R, Potter M, Byrne B, Salganik M, Muzyczka N, Agbandje-McKenna M.

J Virol. 2011 Nov;85(22):11791-9. doi: 10.1128/JVI.05305-11. Epub 2011 Sep 7.

26.

The effect of DNA-dependent protein kinase on adeno-associated virus replication.

Choi YK, Nash K, Byrne BJ, Muzyczka N, Song S.

PLoS One. 2010 Dec 20;5(12):e15073. doi: 10.1371/journal.pone.0015073.

27.

Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation.

Rex CS, Gavin CF, Rubio MD, Kramar EA, Chen LY, Jia Y, Huganir RL, Muzyczka N, Gall CM, Miller CA, Lynch G, Rumbaugh G.

Neuron. 2010 Aug 26;67(4):603-17. doi: 10.1016/j.neuron.2010.07.016.

28.

An animal model of PDH deficiency using AAV8-siRNA vector-mediated knockdown of pyruvate dehydrogenase E1α.

Ojano-Dirain C, Glushakova LG, Zhong L, Zolotukhin S, Muzyczka N, Srivastava A, Stacpoole PW.

Mol Genet Metab. 2010 Oct-Nov;101(2-3):183-91. doi: 10.1016/j.ymgme.2010.07.008. Epub 2010 Jul 15.

29.

α-Synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegeneration.

Gorbatyuk OS, Li S, Nguyen FN, Manfredsson FP, Kondrikova G, Sullivan LF, Meyers C, Chen W, Mandel RJ, Muzyczka N.

Mol Ther. 2010 Oct;18(10):1758-68. doi: 10.1038/mt.2010.137. Epub 2010 Jul 27.

30.

Efficacy of recombinant adeno-associated viral vectors serotypes 1, 2, and 5 for the transduction of pancreatic and colon carcinoma cells.

Teschendorf C, Emons B, Muzyczka N, Graeven U, Schmiegel W.

Anticancer Res. 2010 Jun;30(6):1931-5.

PMID:
20651336
31.

In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degeneration.

Gorbatyuk OS, Li S, Nash K, Gorbatyuk M, Lewin AS, Sullivan LF, Mandel RJ, Chen W, Meyers C, Manfredsson FP, Muzyczka N.

Mol Ther. 2010 Aug;18(8):1450-7. doi: 10.1038/mt.2010.115. Epub 2010 Jun 15.

32.

Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78.

Gorbatyuk MS, Knox T, LaVail MM, Gorbatyuk OS, Noorwez SM, Hauswirth WW, Lin JH, Muzyczka N, Lewin AS.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5961-6. doi: 10.1073/pnas.0911991107. Epub 2010 Mar 15.

33.

Tight Long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector.

Manfredsson FP, Burger C, Rising AC, Zuobi-Hasona K, Sullivan LF, Lewin AS, Huang J, Piercefield E, Muzyczka N, Mandel RJ.

Mol Ther. 2009 Nov;17(11):1857-67. doi: 10.1038/mt.2009.196. Epub 2009 Aug 25.

34.

Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 9.

Mitchell M, Nam HJ, Carter A, McCall A, Rence C, Bennett A, Gurda B, McKenna R, Porter M, Sakai Y, Byrne BJ, Muzyczka N, Aslanidi G, Zolotukhin S, Agbandje-McKenna M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jul 1;65(Pt 7):715-8. doi: 10.1107/S1744309109021460. Epub 2009 Jun 27.

35.

Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity.

Manfredsson FP, Tumer N, Erdos B, Landa T, Broxson CS, Sullivan LF, Rising AC, Foust KD, Zhang Y, Muzyczka N, Gorbatyuk OS, Scarpace PJ, Mandel RJ.

Mol Ther. 2009 Jun;17(6):980-91. doi: 10.1038/mt.2009.45. Epub 2009 Mar 10.

36.

Striatal readministration of rAAV vectors reveals an immune response against AAV2 capsids that can be circumvented.

Peden CS, Manfredsson FP, Reimsnider SK, Poirier AE, Burger C, Muzyczka N, Mandel RJ.

Mol Ther. 2009 Mar;17(3):524-37. doi: 10.1038/mt.2008.284. Epub 2009 Jan 13.

37.

Heparin binding induces conformational changes in Adeno-associated virus serotype 2.

Levy HC, Bowman VD, Govindasamy L, McKenna R, Nash K, Warrington K, Chen W, Muzyczka N, Yan X, Baker TS, Agbandje-McKenna M.

J Struct Biol. 2009 Mar;165(3):146-56. doi: 10.1016/j.jsb.2008.12.002. Epub 2008 Dec 13.

38.

Identification of cellular proteins that interact with the adeno-associated virus rep protein.

Nash K, Chen W, Salganik M, Muzyczka N.

J Virol. 2009 Jan;83(1):454-69. doi: 10.1128/JVI.01939-08. Epub 2008 Oct 29.

39.

Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression.

Zhong L, Li B, Jayandharan G, Mah CS, Govindasamy L, Agbandje-McKenna M, Herzog RW, Weigel-Van Aken KA, Hobbs JA, Zolotukhin S, Muzyczka N, Srivastava A.

Virology. 2008 Nov 25;381(2):194-202. doi: 10.1016/j.virol.2008.08.027. Epub 2008 Oct 2.

40.

Adeno-associated Viral (AAV) Serotype 5 Vector Mediated Gene Delivery of Endothelin-converting Enzyme Reduces Aβ Deposits in APP + PS1 Transgenic Mice.

Carty NC, Nash K, Lee D, Mercer M, Gottschall PE, Meyers C, Muzyczka N, Gordon MN, Morgan D.

Mol Ther. 2008 Sep;16(9):1580-1586. doi: 10.1038/mt.2008.148. Epub 2016 Dec 8.

PMID:
28189012
41.

Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Abeta deposits in APP + PS1 transgenic mice.

Carty NC, Nash K, Lee D, Mercer M, Gottschall PE, Meyers C, Muzyczka N, Gordon MN, Morgan D.

Mol Ther. 2008 Sep;16(9):1580-6. doi: 10.1038/mt.2008.148. Epub 2008 Jul 29.

42.

Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses.

Zhong L, Li B, Mah CS, Govindasamy L, Agbandje-McKenna M, Cooper M, Herzog RW, Zolotukhin I, Warrington KH Jr, Weigel-Van Aken KA, Hobbs JA, Zolotukhin S, Muzyczka N, Srivastava A.

Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7827-32. doi: 10.1073/pnas.0802866105. Epub 2008 May 29. Erratum in: Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):11032.

43.

Genome-wide analysis of aging and learning-related genes in the hippocampal dentate gyrus.

Burger C, Lopez MC, Baker HV, Mandel RJ, Muzyczka N.

Neurobiol Learn Mem. 2008 May;89(4):379-96. doi: 10.1016/j.nlm.2007.11.006. Epub 2008 Jan 29.

44.

The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease.

Gorbatyuk OS, Li S, Sullivan LF, Chen W, Kondrikova G, Manfredsson FP, Mandel RJ, Muzyczka N.

Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):763-8. doi: 10.1073/pnas.0711053105. Epub 2008 Jan 4.

45.

Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 7.

Quesada O, Gurda B, Govindasamy L, McKenna R, Kohlbrenner E, Aslanidi G, Zolotukhin S, Muzyczka N, Agbandje-McKenna M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt 12):1073-6. Epub 2007 Nov 30.

46.
47.

Structure of adeno-associated virus serotype 8, a gene therapy vector.

Nam HJ, Lane MD, Padron E, Gurda B, McKenna R, Kohlbrenner E, Aslanidi G, Byrne B, Muzyczka N, Zolotukhin S, Agbandje-McKenna M.

J Virol. 2007 Nov;81(22):12260-71. Epub 2007 Aug 29.

48.

rAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson's disease.

Manfredsson FP, Burger C, Sullivan LF, Muzyczka N, Lewin AS, Mandel RJ.

Exp Neurol. 2007 Oct;207(2):289-301. Epub 2007 Jul 10.

PMID:
17678648
49.

Time course of transgene expression after intrastriatal pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 transduction in the rat.

Reimsnider S, Manfredsson FP, Muzyczka N, Mandel RJ.

Mol Ther. 2007 Aug;15(8):1504-11. Epub 2007 Jun 12.

50.

Purification of host cell enzymes involved in adeno-associated virus DNA replication.

Nash K, Chen W, McDonald WF, Zhou X, Muzyczka N.

J Virol. 2007 Jun;81(11):5777-87. Epub 2007 Mar 14.

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