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Items: 27

1.

Trefoil Factor Family: Unresolved Questions and Clinical Perspectives.

Braga Emidio N, Hoffmann W, Brierley SM, Muttenthaler M.

Trends Biochem Sci. 2019 May;44(5):387-390. doi: 10.1016/j.tibs.2019.01.004. Epub 2019 Feb 18. Review.

2.

Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides.

Herzig V, de Araujo AD, Greenwood KP, Chin YK, Windley MJ, Chong Y, Muttenthaler M, Mobli M, Audsley N, Nicholson GM, Alewood PF, King GF.

Biomedicines. 2018 Aug 28;6(3). pii: E90. doi: 10.3390/biomedicines6030090.

3.

Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity.

Liutkevičiūtė Z, Gil-Mansilla E, Eder T, Casillas-Pérez B, Di Giglio MG, Muratspahić E, Grebien F, Rattei T, Muttenthaler M, Cremer S, Gruber CW.

FASEB J. 2018 Jun 25:fj201800443. doi: 10.1096/fj.201800443. [Epub ahead of print]

4.

Advancing the Frontiers of Chemical Protein Synthesis-The 7th CPS Meeting, Haifa, Israel.

Conibear AC, Muttenthaler M.

Cell Chem Biol. 2018 Mar 15;25(3):247-254. doi: 10.1016/j.chembiol.2018.03.001.

5.

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development.

Arrowsmith S, Keov P, Muttenthaler M, Gruber CW.

J Vis Exp. 2018 Jan 26;(131). doi: 10.3791/56639.

6.

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species.

Muttenthaler M, Andersson Å, Vetter I, Menon R, Busnelli M, Ragnarsson L, Bergmayr C, Arrowsmith S, Deuis JR, Chiu HS, Palpant NJ, O'Brien M, Smith TJ, Wray S, Neumann ID, Gruber CW, Lewis RJ, Alewood PF.

Sci Signal. 2017 Dec 5;10(508). pii: eaan3398. doi: 10.1126/scisignal.aan3398.

7.

Nanoparticle cellular uptake by dendritic wedge peptides: achieving single peptide facilitated delivery.

Breger JC, Muttenthaler M, Delehanty JB, Thompson DA, Oh E, Susumu K, Deschamps JR, Anderson GP, Field LD, Walper SA, Dawson PE, Medintz IL.

Nanoscale. 2017 Jul 27;9(29):10447-10464. doi: 10.1039/c7nr03362a.

PMID:
28703833
8.

Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide.

Di Giglio MG, Muttenthaler M, Harpsøe K, Liutkeviciute Z, Keov P, Eder T, Rattei T, Arrowsmith S, Wray S, Marek A, Elbert T, Alewood PF, Gloriam DE, Gruber CW.

Sci Rep. 2017 Feb 1;7:41002. doi: 10.1038/srep41002.

9.

Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure.

Busnelli M, Kleinau G, Muttenthaler M, Stoev S, Manning M, Bibic L, Howell LA, McCormick PJ, Di Lascio S, Braida D, Sala M, Rovati GE, Bellini T, Chini B.

J Med Chem. 2016 Aug 11;59(15):7152-66. doi: 10.1021/acs.jmedchem.6b00564. Epub 2016 Jul 28.

PMID:
27420737
10.

Methods, setup and safe handling for anhydrous hydrogen fluoride cleavage in Boc solid-phase peptide synthesis.

Muttenthaler M, Albericio F, Dawson PE.

Nat Protoc. 2015 Jul;10(7):1067-83. doi: 10.1038/nprot.2015.061. Epub 2015 Jun 18.

PMID:
26086408
11.

Lipid bilayer crossing--the gate of symmetry. Water-soluble phenylproline-based blood-brain barrier shuttles.

Arranz-Gibert P, Guixer B, Malakoutikhah M, Muttenthaler M, Guzmán F, Teixidó M, Giralt E.

J Am Chem Soc. 2015 Jun 17;137(23):7357-64. doi: 10.1021/jacs.5b02050. Epub 2015 Jun 2.

PMID:
25992679
12.

Discovery, synthesis, and structure-activity relationships of conotoxins.

Akondi KB, Muttenthaler M, Dutertre S, Kaas Q, Craik DJ, Lewis RJ, Alewood PF.

Chem Rev. 2014 Jun 11;114(11):5815-47. doi: 10.1021/cr400401e. Epub 2014 Apr 10. Review. No abstract available.

PMID:
24720541
13.

Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain.

de Araujo AD, Mobli M, Castro J, Harrington AM, Vetter I, Dekan Z, Muttenthaler M, Wan J, Lewis RJ, King GF, Brierley SM, Alewood PF.

Nat Commun. 2014;5:3165. doi: 10.1038/ncomms4165.

PMID:
24476666
14.

Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design.

Koehbach J, O'Brien M, Muttenthaler M, Miazzo M, Akcan M, Elliott AG, Daly NL, Harvey PJ, Arrowsmith S, Gunasekera S, Smith TJ, Wray S, Göransson U, Dawson PE, Craik DJ, Freissmuth M, Gruber CW.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21183-8. doi: 10.1073/pnas.1311183110. Epub 2013 Nov 18.

15.

Evaluation of diverse peptidyl motifs for cellular delivery of semiconductor quantum dots.

Gemmill KB, Muttenthaler M, Delehanty JB, Stewart MH, Susumu K, Dawson PE, Medintz IL.

Anal Bioanal Chem. 2013 Jul;405(19):6145-54. doi: 10.1007/s00216-013-6982-2. Epub 2013 Jun 4.

PMID:
23732866
16.

Insights into the molecular evolution of oxytocin receptor ligand binding.

Koehbach J, Stockner T, Bergmayr C, Muttenthaler M, Gruber CW.

Biochem Soc Trans. 2013 Feb 1;41(1):197-204. doi: 10.1042/BST20120256. Review.

17.

Exploring bioactive peptides from natural sources for oxytocin and vasopressin drug discovery.

Gruber CW, Koehbach J, Muttenthaler M.

Future Med Chem. 2012 Sep;4(14):1791-8. doi: 10.4155/fmc.12.108. No abstract available.

18.

Discovery of defense- and neuropeptides in social ants by genome-mining.

Gruber CW, Muttenthaler M.

PLoS One. 2012;7(3):e32559. doi: 10.1371/journal.pone.0032559. Epub 2012 Mar 20.

19.

Structure-activity studies on alpha-conotoxins.

Muttenthaler M, Akondi KB, Alewood PF.

Curr Pharm Des. 2011 Dec;17(38):4226-41. Review.

PMID:
22204424
20.

Site-specific pK(a) determination of selenocysteine residues in selenovasopressin by using 77Se NMR spectroscopy.

Mobli M, Morgenstern D, King GF, Alewood PF, Muttenthaler M.

Angew Chem Int Ed Engl. 2011 Dec 9;50(50):11952-5. doi: 10.1002/anie.201104169. Epub 2011 Oct 14. No abstract available.

PMID:
22002840
21.

Modulating oxytocin activity and plasma stability by disulfide bond engineering.

Muttenthaler M, Andersson A, de Araujo AD, Dekan Z, Lewis RJ, Alewood PF.

J Med Chem. 2010 Dec 23;53(24):8585-96. doi: 10.1021/jm100989w. Epub 2010 Nov 30.

PMID:
21117646
22.

Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors.

Gruber CW, Muttenthaler M, Freissmuth M.

Curr Pharm Des. 2010;16(28):3071-88. Review.

23.

p-Nitrobenzyl protection for cysteine and selenocysteine: a more stable alternative to the acetamidomethyl group.

Muttenthaler M, Ramos YG, Feytens D, de Araujo AD, Alewood PF.

Biopolymers. 2010;94(4):423-32. doi: 10.1002/bip.21502.

PMID:
20593464
24.

Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors.

Grishin AA, Wang CI, Muttenthaler M, Alewood PF, Lewis RJ, Adams DJ.

J Biol Chem. 2010 Jul 16;285(29):22254-63. doi: 10.1074/jbc.M110.111880. Epub 2010 May 13.

25.

Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists.

Muttenthaler M, Nevin ST, Grishin AA, Ngo ST, Choy PT, Daly NL, Hu SH, Armishaw CJ, Wang CI, Lewis RJ, Martin JL, Noakes PG, Craik DJ, Adams DJ, Alewood PF.

J Am Chem Soc. 2010 Mar 17;132(10):3514-22. doi: 10.1021/ja910602h.

PMID:
20163143
26.

Selenopeptide chemistry.

Muttenthaler M, Alewood PF.

J Pept Sci. 2008 Dec;14(12):1223-39. doi: 10.1002/psc.1075.

PMID:
18951416
27.

Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides.

Dutertre S, Croker D, Daly NL, Andersson A, Muttenthaler M, Lumsden NG, Craik DJ, Alewood PF, Guillon G, Lewis RJ.

J Biol Chem. 2008 Mar 14;283(11):7100-8. doi: 10.1074/jbc.M706477200. Epub 2008 Jan 2.

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