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Items: 1 to 50 of 137

1.

Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes.

Piao L, Fang YH, Hamanaka RB, Mutlu GM, Dezfulian C, Archer SL, Sharp WW.

Crit Care Med. 2020 Feb;48(2):e133-e140. doi: 10.1097/CCM.0000000000004095.

2.

FGFR2 is Required for AEC2 Homeostasis and Survival Following Bleomycin-Induced Lung Injury.

Dorry SJ, Ansbro BO, Ornitz DM, Mutlu GM, Guzy RD.

Am J Respir Cell Mol Biol. 2019 Dec 20. doi: 10.1165/rcmb.2019-0079OC. [Epub ahead of print]

PMID:
31860803
3.

Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation.

Woods PS, Kimmig LM, Meliton AY, Sun KA, Tian Y, O'Leary EM, Gökalp GA, Hamanaka RB, Mutlu GM.

Am J Respir Cell Mol Biol. 2020 Feb;62(2):243-255. doi: 10.1165/rcmb.2019-0244OC.

PMID:
31469581
4.

Anti-fibrotic effects of tannic acid through regulation of a sustained TGF-beta receptor signaling.

Reed EB, Ard S, La J, Park CY, Culligan L, Fredberg JJ, Smolyaninova LV, Orlov SN, Chen B, Guzy R, Mutlu GM, Dulin NO.

Respir Res. 2019 Jul 29;20(1):168. doi: 10.1186/s12931-019-1141-8.

5.

Air Pollution, Asthma, and Sleep Apnea: New Epidemiological Links?

Mutlu GM, Peker Y.

Ann Am Thorac Soc. 2019 Mar;16(3):307-308. doi: 10.1513/AnnalsATS.201812-924ED. No abstract available.

PMID:
31339334
6.

Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.

Hamanaka RB, O'Leary EM, Witt LJ, Tian Y, Gökalp GA, Meliton AY, Dulin NO, Mutlu GM.

Am J Respir Cell Mol Biol. 2019 Nov;61(5):597-606. doi: 10.1165/rcmb.2019-0008OC.

PMID:
30973753
7.

Update in Chronic Obstructive Pulmonary Disease 2018.

Labaki WW, Kimmig LM, Mutlu GM, Han MK, Bhatt SP.

Am J Respir Crit Care Med. 2019 Jun 15;199(12):1462-1470. doi: 10.1164/rccm.201902-0374UP. No abstract available.

PMID:
30958976
8.

Sustained Smad2 Phosphorylation Is Required for Myofibroblast Transformation in Response to TGF-β.

Ard S, Reed EB, Smolyaninova LV, Orlov SN, Mutlu GM, Guzy RD, Dulin NO.

Am J Respir Cell Mol Biol. 2019 Mar;60(3):367-369. doi: 10.1165/rcmb.2018-0252LE. No abstract available.

PMID:
30821500
9.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2019 Feb 5;29(2):503. doi: 10.1016/j.cmet.2018.12.001. No abstract available.

10.

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.

Reyfman PA, Walter JM, Joshi N, Anekalla KR, McQuattie-Pimentel AC, Chiu S, Fernandez R, Akbarpour M, Chen CI, Ren Z, Verma R, Abdala-Valencia H, Nam K, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Watanabe S, Williams KJN, Flozak AS, Nicholson TT, Morgan VK, Winter DR, Hinchcliff M, Hrusch CL, Guzy RD, Bonham CA, Sperling AI, Bag R, Hamanaka RB, Mutlu GM, Yeldandi AV, Marshall SA, Shilatifard A, Amaral LAN, Perlman H, Sznajder JI, Argento AC, Gillespie CT, Dematte J, Jain M, Singer BD, Ridge KM, Lam AP, Bharat A, Bhorade SM, Gottardi CJ, Budinger GRS, Misharin AV.

Am J Respir Crit Care Med. 2019 Jun 15;199(12):1517-1536. doi: 10.1164/rccm.201712-2410OC.

11.

Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1.

Radigan KA, Nicholson TT, Welch LC, Chi M, Amarelle L, Angulo M, Shigemura M, Shigemura A, Runyan CE, Morales-Nebreda L, Perlman H, Ceco E, Lecuona E, Dada LA, Misharin AV, Mutlu GM, Sznajder JI, Budinger GRS.

J Immunol. 2019 Jan 15;202(2):484-493. doi: 10.4049/jimmunol.1701433. Epub 2018 Dec 7.

12.

Particulate Matter Air Pollution: Effects on the Cardiovascular System.

Hamanaka RB, Mutlu GM.

Front Endocrinol (Lausanne). 2018 Nov 16;9:680. doi: 10.3389/fendo.2018.00680. eCollection 2018. Review.

13.

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.

Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS.

Cell Metab. 2019 Feb 5;29(2):335-347.e5. doi: 10.1016/j.cmet.2018.09.019. Epub 2018 Oct 11. Erratum in: Cell Metab. 2019 Feb 5;29(2):503.

14.

Alveolar Epithelial Cells Burn Fat to Survive Acute Lung Injury.

Hamanaka RB, Mutlu GM.

Am J Respir Cell Mol Biol. 2019 Feb;60(2):135-136. doi: 10.1165/rcmb.2018-0300ED. No abstract available.

15.

P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-β1, -β2, and -β3 Translation.

Duan FF, Barron G, Meliton A, Mutlu GM, Dulin NO, Schuger L.

Am J Respir Cell Mol Biol. 2019 Feb;60(2):221-231. doi: 10.1165/rcmb.2018-0028OC.

16.

Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome.

Mutlu EA, Comba IY, Cho T, Engen PA, Yazıcı C, Soberanes S, Hamanaka RB, Niğdelioğlu R, Meliton AY, Ghio AJ, Budinger GRS, Mutlu GM.

Environ Pollut. 2018 Sep;240:817-830. doi: 10.1016/j.envpol.2018.04.130. Epub 2018 May 18.

17.

Role of Cellular Metabolism in Pulmonary Diseases.

Wu D, Woods PS, Duong HT, Mutlu GM.

Am J Respir Cell Mol Biol. 2018 Jul;59(1):127-129. doi: 10.1165/rcmb.2018-0103RO. No abstract available.

18.

Letter by Mutlu and Budinger Regarding Article, "Particulate Matter Exposure and Stress Hormone Levels: A Randomized, Double-Blind, Crossover Trial of Air Purification".

Mutlu GM, Budinger GRS.

Circulation. 2018 Mar 13;137(11):1203-1204. doi: 10.1161/CIRCULATIONAHA.117.031206. No abstract available.

19.

The NIEHS TaRGET II Consortium and environmental epigenomics.

Wang T, Pehrsson EC, Purushotham D, Li D, Zhuo X, Zhang B, Lawson HA, Province MA, Krapp C, Lan Y, Coarfa C, Katz TA, Tang WY, Wang Z, Biswal S, Rajagopalan S, Colacino JA, Tsai ZT, Sartor MA, Neier K, Dolinoy DC, Pinto J, Hamanaka RB, Mutlu GM, Patisaul HB, Aylor DL, Crawford GE, Wiltshire T, Chadwick LH, Duncan CG, Garton AE, McAllister KA; TaRGET II Consortium, Bartolomei MS, Walker CL, Tyson FL.

Nat Biotechnol. 2018 Mar 6;36(3):225-227. doi: 10.1038/nbt.4099. No abstract available.

20.

Letter by Wu et al Regarding Article, "Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites".

Wu D, Hamanaka RB, Fang Y, Mutlu GM.

Arterioscler Thromb Vasc Biol. 2017 Dec;37(12):e197-e198. doi: 10.1161/ATVBAHA.117.310335. No abstract available.

21.

Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.

Hamanaka RB, Nigdelioglu R, Meliton AY, Tian Y, Witt LJ, O'Leary E, Sun KA, Woods PS, Wu D, Ansbro B, Ard S, Rohde JM, Dulin NO, Guzy RD, Mutlu GM.

Am J Respir Cell Mol Biol. 2018 May;58(5):585-593. doi: 10.1165/rcmb.2017-0186OC.

22.

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.

Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H.

J Exp Med. 2017 Aug 7;214(8):2387-2404. doi: 10.1084/jem.20162152. Epub 2017 Jul 10.

23.

HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium.

Wu D, Huang RT, Hamanaka RB, Krause M, Oh MJ, Kuo CH, Nigdelioglu R, Meliton AY, Witt L, Dai G, Civelek M, Prabhakar NR, Fang Y, Mutlu GM.

Elife. 2017 May 30;6. pii: e25217. doi: 10.7554/eLife.25217.

24.

PFKFB3, a Direct Target of p63, Is Required for Proliferation and Inhibits Differentiation in Epidermal Keratinocytes.

Hamanaka RB, Mutlu GM.

J Invest Dermatol. 2017 Jun;137(6):1267-1276. doi: 10.1016/j.jid.2016.12.020. Epub 2017 Jan 17.

25.

Downregulation of TGF-β Receptor-2 Expression and Signaling through Inhibition of Na/K-ATPase.

La J, Reed E, Chan L, Smolyaninova LV, Akomova OA, Mutlu GM, Orlov SN, Dulin NO.

PLoS One. 2016 Dec 22;11(12):e0168363. doi: 10.1371/journal.pone.0168363. eCollection 2016.

26.

Experimental Lung Injury Reduces Krüppel-like Factor 2 to Increase Endothelial Permeability via Regulation of RAPGEF3-Rac1 Signaling.

Huang RT, Wu D, Meliton A, Oh MJ, Krause M, Lloyd JA, Nigdelioglu R, Hamanaka RB, Jain MK, Birukova A, Kress JP, Birukov KG, Mutlu GM, Fang Y.

Am J Respir Crit Care Med. 2017 Mar 1;195(5):639-651. doi: 10.1164/rccm.201604-0668OC.

27.

Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.

Nigdelioglu R, Hamanaka RB, Meliton AY, O'Leary E, Witt LJ, Cho T, Sun K, Bonham C, Wu D, Woods PS, Husain AN, Wolfgeher D, Dulin NO, Chandel NS, Mutlu GM.

J Biol Chem. 2016 Dec 30;291(53):27239-27251. doi: 10.1074/jbc.M116.756247. Epub 2016 Nov 11.

28.

SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage.

Bindu S, Pillai VB, Kanwal A, Samant S, Mutlu GM, Verdin E, Dulin N, Gupta MP.

Am J Physiol Lung Cell Mol Physiol. 2017 Jan 1;312(1):L68-L78. doi: 10.1152/ajplung.00188.2016. Epub 2016 Nov 4.

29.

Wandering Pleural Mesothelial Fatty Cyst.

Nicholson TT, Raparia K, Mutlu GM, Sporn PH, Bharat A.

Am J Respir Crit Care Med. 2016 Nov 1;194(9):1164-1165. No abstract available.

30.

Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection.

Peteranderl C, Morales-Nebreda L, Selvakumar B, Lecuona E, Vadász I, Morty RE, Schmoldt C, Bespalowa J, Wolff T, Pleschka S, Mayer K, Gattenloehner S, Fink L, Lohmeyer J, Seeger W, Sznajder JI, Mutlu GM, Budinger GR, Herold S.

J Clin Invest. 2016 Apr 1;126(4):1566-80. doi: 10.1172/JCI83931. Epub 2016 Mar 21.

31.

Regulation of myofibroblast differentiation by cardiac glycosides.

La J, Reed EB, Koltsova S, Akimova O, Hamanaka RB, Mutlu GM, Orlov SN, Dulin NO.

Am J Physiol Lung Cell Mol Physiol. 2016 May 1;310(9):L815-23. doi: 10.1152/ajplung.00322.2015. Epub 2016 Feb 5.

32.

Prolonged Exposures to Intermittent Hypoxia Promote Visceral White Adipose Tissue Inflammation in a Murine Model of Severe Sleep Apnea: Effect of Normoxic Recovery.

Gileles-Hillel A, Almendros I, Khalyfa A, Nigdelioglu R, Qiao Z, Hamanaka RB, Mutlu GM, Akbarpour M, Gozal D.

Sleep. 2017 Mar 1;40(3). doi: 10.1093/sleep/zsw074.

PMID:
28329220
33.

Pneumothorax following bronchoalveolar lavage for the diagnosis of non-tuberculous mycobacterial infection. An «atypical» complication of bronchoscopy?

Nicholson TT, Mutlu GM.

Arch Bronconeumol. 2016 May;52(5):278-9. doi: 10.1016/j.arbres.2015.07.009. Epub 2015 Nov 10. English, Spanish. No abstract available.

34.

Wood Smoke Particle Sequesters Cell Iron to Impact a Biological Effect.

Ghio AJ, Soukup JM, Dailey LA, Tong H, Kesic MJ, Budinger GR, Mutlu GM.

Chem Res Toxicol. 2015 Nov 16;28(11):2104-11. doi: 10.1021/acs.chemrestox.5b00270. Epub 2015 Oct 22.

35.

Regulation of allergic lung inflammation by endothelial cell transglutaminase 2.

Soveg F, Abdala-Valencia H, Campbell J, Morales-Nebreda L, Mutlu GM, Cook-Mills JM.

Am J Physiol Lung Cell Mol Physiol. 2015 Sep 15;309(6):L573-83. doi: 10.1152/ajplung.00199.2015. Epub 2015 Jul 24.

36.

Nitric oxide prevents alveolar senescence and emphysema in a mouse model.

Boe AE, Eren M, Morales-Nebreda L, Murphy SB, Budinger GR, Mutlu GM, Miyata T, Vaughan DE.

PLoS One. 2015 Mar 10;10(3):e0116504. doi: 10.1371/journal.pone.0116504. eCollection 2015.

37.

Oxidized phospholipids protect against lung injury and endothelial barrier dysfunction caused by heat-inactivated Staphylococcus aureus.

Meliton AY, Meng F, Tian Y, Sarich N, Mutlu GM, Birukova AA, Birukov KG.

Am J Physiol Lung Cell Mol Physiol. 2015 Mar 15;308(6):L550-62. doi: 10.1152/ajplung.00248.2014. Epub 2015 Jan 9.

38.

β₂-Agonist therapy may contribute to the air pollution and IL-6-associated risk of developing severe asthma with dual-positive TH2/TH17 cells.

Chiarella SE, Budinger GR, Mutlu GM.

J Allergy Clin Immunol. 2015 Jan;135(1):290-1. doi: 10.1016/j.jaci.2014.09.037. Epub 2014 Nov 11. No abstract available.

39.

Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice.

Misharin AV, Cuda CM, Saber R, Turner JD, Gierut AK, Haines GK 3rd, Berdnikovs S, Filer A, Clark AR, Buckley CD, Mutlu GM, Budinger GR, Perlman H.

Cell Rep. 2014 Oct 23;9(2):591-604. doi: 10.1016/j.celrep.2014.09.032. Epub 2014 Oct 16.

40.

Intratracheal administration of influenza virus is superior to intranasal administration as a model of acute lung injury.

Morales-Nebreda L, Chi M, Lecuona E, Chandel NS, Dada LA, Ridge K, Soberanes S, Nigdelioglu R, Sznajder JI, Mutlu GM, Budinger GR, Radigan KA.

J Virol Methods. 2014 Dec;209:116-20. doi: 10.1016/j.jviromet.2014.09.004. Epub 2014 Sep 17.

41.

Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages.

Radigan KA, Morales-Nebreda L, Soberanes S, Nicholson T, Nigdelioglu R, Cho T, Chi M, Hamanaka RB, Misharin AV, Perlman H, Budinger GR, Mutlu GM.

PLoS One. 2014 Sep 18;9(9):e108138. doi: 10.1371/journal.pone.0108138. eCollection 2014.

42.

Lung-specific loss of α3 laminin worsens bleomycin-induced pulmonary fibrosis.

Morales-Nebreda LI, Rogel MR, Eisenberg JL, Hamill KJ, Soberanes S, Nigdelioglu R, Chi M, Cho T, Radigan KA, Ridge KM, Misharin AV, Woychek A, Hopkinson S, Perlman H, Mutlu GM, Pardo A, Selman M, Jones JC, Budinger GR.

Am J Respir Cell Mol Biol. 2015 Apr;52(4):503-12. doi: 10.1165/rcmb.2014-0057OC.

43.

Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis.

Lam AP, Herazo-Maya JD, Sennello JA, Flozak AS, Russell S, Mutlu GM, Budinger GR, DasGupta R, Varga J, Kaminski N, Gottardi CJ.

Am J Respir Crit Care Med. 2014 Jul 15;190(2):185-95. doi: 10.1164/rccm.201401-0079OC.

44.

Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice.

Cheresh P, Morales-Nebreda L, Kim SJ, Yeldandi A, Williams DB, Cheng Y, Mutlu GM, Budinger GR, Ridge K, Schumacker PT, Bohr VA, Kamp DW.

Am J Respir Cell Mol Biol. 2015 Jan;52(1):25-36. doi: 10.1165/rcmb.2014-0038OC.

45.

Reply: β2-agonists and acute respiratory distress syndrome.

Budinger GR, Mutlu GM.

Am J Respir Crit Care Med. 2014 Jun 1;189(11):1448. doi: 10.1164/rccm.201404-0644LE. No abstract available.

46.

β₂-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis.

Chiarella SE, Soberanes S, Urich D, Morales-Nebreda L, Nigdelioglu R, Green D, Young JB, Gonzalez A, Rosario C, Misharin AV, Ghio AJ, Wunderink RG, Donnelly HK, Radigan KA, Perlman H, Chandel NS, Budinger GR, Mutlu GM.

J Clin Invest. 2014 Jul;124(7):2935-46. doi: 10.1172/JCI75157. Epub 2014 May 27.

47.

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis.

Wheaton WW, Weinberg SE, Hamanaka RB, Soberanes S, Sullivan LB, Anso E, Glasauer A, Dufour E, Mutlu GM, Budigner GS, Chandel NS.

Elife. 2014 May 13;3:e02242. doi: 10.7554/eLife.02242.

48.

Loss of TLR4 does not prevent influenza A-induced mortality.

Morales-Nebreda L, Mutlu GM, Scott Budinger GR, Radigan KA.

Am J Respir Crit Care Med. 2014 May 15;189(10):1280-1. doi: 10.1164/rccm.201401-0193LE. No abstract available.

49.

Markers of prognosis specific to influenza infection: are we there yet?

Radigan KA, Mutlu GM.

Am J Respir Crit Care Med. 2014 May 15;189(10):1159-60. doi: 10.1164/rccm.201403-0587ED. No abstract available.

PMID:
24832741
50.

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.

Eren M, Boe AE, Murphy SB, Place AT, Nagpal V, Morales-Nebreda L, Urich D, Quaggin SE, Budinger GR, Mutlu GM, Miyata T, Vaughan DE.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):7090-5. doi: 10.1073/pnas.1321942111. Epub 2014 Apr 28.

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