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LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer.

Saito Y, Li L, Coyaud E, Luna A, Sander C, Raught B, Asara JM, Brown M, Muthuswamy SK.

Nature. 2019 May;569(7755):275-279. doi: 10.1038/s41586-019-1126-2. Epub 2019 Apr 17.


Golgi Stabilization, Not Its Front-Rear Bias, Is Associated with EMT-Enhanced Fibrillar Migration.

Natividad RJ, Lalli ML, Muthuswamy SK, Asthagiri AR.

Biophys J. 2018 Nov 20;115(10):2067-2077. doi: 10.1016/j.bpj.2018.10.006. Epub 2018 Oct 11.


Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo.

Sonzogni O, Haynes J, Seifried LA, Kamel YM, Huang K, BeGora MD, Yeung FA, Robert-Tissot C, Heng YJ, Yuan X, Wulf GM, Kron KJ, Wagenblast E, Lupien M, Kislinger T, Hannon GJ, Muthuswamy SK.

PLoS Biol. 2018 Jun 20;16(6):e2004049. doi: 10.1371/journal.pbio.2004049. eCollection 2018 Jun.


Organoid Models of Cancer Explode with Possibilities.

Muthuswamy SK.

Cell Stem Cell. 2018 Mar 1;22(3):290-291. doi: 10.1016/j.stem.2018.02.010.


Editorial overview: Cell differentiation and development: New kids in the block-new tools and concepts opening new doors in development.

Götz M, Muthuswamy SK.

Curr Opin Cell Biol. 2017 Dec;49:iv-v. doi: 10.1016/ No abstract available.


Reinterpreting polarity and cancer: The changing landscape from tumor suppression to tumor promotion.

Saito Y, Desai RR, Muthuswamy SK.

Biochim Biophys Acta Rev Cancer. 2018 Apr;1869(2):103-116. doi: 10.1016/j.bbcan.2017.12.001. Epub 2018 Jan 31. Review.


Personalized RNA Medicine for Pancreatic Cancer.

Gilles ME, Hao L, Huang L, Rupaimoole R, Lopez-Casas PP, Pulver E, Jeong JC, Muthuswamy SK, Hidalgo M, Bhatia SN, Slack FJ.

Clin Cancer Res. 2018 Apr 1;24(7):1734-1747. doi: 10.1158/1078-0432.CCR-17-2733. Epub 2018 Jan 12.


Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.

Dai X, Gan W, Li X, Wang S, Zhang W, Huang L, Liu S, Zhong Q, Guo J, Zhang J, Chen T, Shimizu K, Beca F, Blattner M, Vasudevan D, Buckley DL, Qi J, Buser L, Liu P, Inuzuka H, Beck AH, Wang L, Wild PJ, Garraway LA, Rubin MA, Barbieri CE, Wong KK, Muthuswamy SK, Huang J, Chen Y, Bradner JE, Wei W.

Nat Med. 2017 Sep;23(9):1063-1071. doi: 10.1038/nm.4378. Epub 2017 Aug 14.


Bringing together the organoid field: from early beginnings to the road ahead.

Muthuswamy SK.

Development. 2017 Mar 15;144(6):963-967. doi: 10.1242/dev.144444. Review.


An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function.

Zheng W, Umitsu M, Jagan I, Tran CW, Ishiyama N, BeGora M, Araki K, Ohashi PS, Ikura M, Muthuswamy SK.

Nat Cell Biol. 2016 Nov;18(11):1244-1252. doi: 10.1038/ncb3413. Epub 2016 Oct 3.


Positive Quantitative Relationship between EMT and Contact-Initiated Sliding on Fiber-like Tracks.

Milano DF, Natividad RJ, Saito Y, Luo CY, Muthuswamy SK, Asthagiri AR.

Biophys J. 2016 Oct 4;111(7):1569-1574. doi: 10.1016/j.bpj.2016.08.037.


Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland.

Baker L, BeGora M, Au Yeung F, Feigin ME, Rosenberg AZ, Lowe SW, Kislinger T, Muthuswamy SK.

J Cell Sci. 2016 Jun 15;129(12):2307-15. doi: 10.1242/jcs.185413. Epub 2016 May 13.


Regulators of Metastasis Modulate the Migratory Response to Cell Contact under Spatial Confinement.

Milano DF, Ngai NA, Muthuswamy SK, Asthagiri AR.

Biophys J. 2016 Apr 26;110(8):1886-1895. doi: 10.1016/j.bpj.2016.02.040.


Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids.

Huang L, Holtzinger A, Jagan I, BeGora M, Lohse I, Ngai N, Nostro C, Wang R, Muthuswamy LB, Crawford HC, Arrowsmith C, Kalloger SE, Renouf DJ, Connor AA, Cleary S, Schaeffer DF, Roehrl M, Tsao MS, Gallinger S, Keller G, Muthuswamy SK.

Nat Med. 2015 Nov;21(11):1364-71. doi: 10.1038/nm.3973. Epub 2015 Oct 26.


A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells.

Ramesh M, Krishnan N, Muthuswamy SK, Tonks NK.

J Biol Chem. 2015 Apr 10;290(15):9646-59. doi: 10.1074/jbc.M114.627968. Epub 2015 Feb 13.


Targeting the disordered C terminus of PTP1B with an allosteric inhibitor.

Krishnan N, Koveal D, Miller DH, Xue B, Akshinthala SD, Kragelj J, Jensen MR, Gauss CM, Page R, Blackledge M, Muthuswamy SK, Peti W, Tonks NK.

Nat Chem Biol. 2014 Jul;10(7):558-66. doi: 10.1038/nchembio.1528. Epub 2014 May 20.


Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancer.

Feigin ME, Akshinthala SD, Araki K, Rosenberg AZ, Muthuswamy LB, Martin B, Lehmann BD, Berman HK, Pietenpol JA, Cardiff RD, Muthuswamy SK.

Cancer Res. 2014 Jun 1;74(11):3180-94. doi: 10.1158/0008-5472.CAN-13-3415. Epub 2014 Mar 24.


G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion.

Feigin ME, Xue B, Hammell MC, Muthuswamy SK.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4191-6. doi: 10.1073/pnas.1320239111. Epub 2014 Mar 5.


Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion.

Xue B, Krishnamurthy K, Allred DC, Muthuswamy SK.

Nat Cell Biol. 2013 Feb;15(2):189-200. doi: 10.1038/ncb2663. Epub 2012 Dec 23.


Rotational motion during three-dimensional morphogenesis of mammary epithelial acini relates to laminin matrix assembly.

Wang H, Lacoche S, Huang L, Xue B, Muthuswamy SK.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):163-8. doi: 10.1073/pnas.1201141110. Epub 2012 Dec 17.


Autocrine prolactin: an emerging market for homegrown (prolactin) despite the imports.

Muthuswamy SK.

Genes Dev. 2012 Oct 15;26(20):2253-8. doi: 10.1101/gad.204636.112.


The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold.

Yang Z, Xue B, Umitsu M, Ikura M, Muthuswamy SK, Neel BG.

Mol Cell. 2012 Aug 10;47(3):469-83. doi: 10.1016/j.molcel.2012.06.037.


Cell polarity as a regulator of cancer cell behavior plasticity.

Muthuswamy SK, Xue B.

Annu Rev Cell Dev Biol. 2012;28:599-625. doi: 10.1146/annurev-cellbio-092910-154244. Epub 2012 Aug 6. Review.


Expression profiling during mammary epithelial cell three-dimensional morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2-mediated transformation.

Yu M, Lin G, Arshadi N, Kalatskaya I, Xue B, Haider S, Nguyen F, Boutros PC, Elson A, Muthuswamy LB, Tonks NK, Muthuswamy SK.

Mol Cell Biol. 2012 Oct;32(19):3913-24. doi: 10.1128/MCB.00068-12. Epub 2012 Jul 30.


Dysregulation of cell polarity proteins synergize with oncogenes or the microenvironment to induce invasive behavior in epithelial cells.

Chatterjee S, Seifried L, Feigin ME, Gibbons DL, Scuoppo C, Lin W, Rizvi ZH, Lind E, Dissanayake D, Kurie J, Ohashi P, Muthuswamy SK.

PLoS One. 2012;7(4):e34343. doi: 10.1371/journal.pone.0034343. Epub 2012 Apr 18.


The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation.

Anczuków O, Rosenberg AZ, Akerman M, Das S, Zhan L, Karni R, Muthuswamy SK, Krainer AR.

Nat Struct Mol Biol. 2012 Jan 15;19(2):220-8. doi: 10.1038/nsmb.2207.


Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'.

Lin G, Aranda V, Muthuswamy SK, Tonks NK.

Genes Dev. 2011 Jul 1;25(13):1412-25. doi: 10.1101/gad.2018911.


Epithelial cell organization suppresses Myc function by attenuating Myc expression.

Simpson DR, Yu M, Zheng S, Zhao Z, Muthuswamy SK, Tansey WP.

Cancer Res. 2011 Jun 1;71(11):3822-30. doi: 10.1158/0008-5472.CAN-10-3782. Epub 2011 May 24.


Trastuzumab resistance: all roads lead to SRC.

Muthuswamy SK.

Nat Med. 2011 Apr;17(4):416-8. doi: 10.1038/nm0411-416. No abstract available.


3D culture reveals a signaling network.

Muthuswamy SK.

Breast Cancer Res. 2011 Jan 27;13(1):103. doi: 10.1186/bcr2800.


ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis.

Keyes WM, Pecoraro M, Aranda V, Vernersson-Lindahl E, Li W, Vogel H, Guo X, Garcia EL, Michurina TV, Enikolopov G, Muthuswamy SK, Mills AA.

Cell Stem Cell. 2011 Feb 4;8(2):164-76. doi: 10.1016/j.stem.2010.12.009.


A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells.

Arias-Romero LE, Villamar-Cruz O, Pacheco A, Kosoff R, Huang M, Muthuswamy SK, Chernoff J.

Oncogene. 2010 Oct 28;29(43):5839-49. doi: 10.1038/onc.2010.318. Epub 2010 Aug 16.


p130Cas is an essential transducer element in ErbB2 transformation.

Cabodi S, Tinnirello A, Bisaro B, Tornillo G, del Pilar Camacho-Leal M, Forni G, Cojoca R, Iezzi M, Amici A, Montani M, Eva A, Di Stefano P, Muthuswamy SK, Tarone G, Turco E, Defilippi P.

FASEB J. 2010 Oct;24(10):3796-808. doi: 10.1096/fj.10-157347. Epub 2010 May 26.


Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators.

Huang L, Muthuswamy SK.

Curr Opin Genet Dev. 2010 Feb;20(1):41-50. doi: 10.1016/j.gde.2009.12.001. Epub 2010 Jan 21. Review.


Shc is required for ErbB2-induced inhibition of apoptosis but is dispensable for cell proliferation and disruption of cell polarity.

Lucs AV, Muller WJ, Muthuswamy SK.

Oncogene. 2010 Jan 14;29(2):174-87. doi: 10.1038/onc.2009.312. Epub 2009 Oct 12.


Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis.

Feigin ME, Muthuswamy SK.

Curr Opin Cell Biol. 2009 Oct;21(5):694-700. doi: 10.1016/ Epub 2009 Sep 2. Review.


A new tumor suppressor that regulates tissue architecture.

Muthuswamy SK.

PLoS Med. 2009 May 26;6(5):e1000073. doi: 10.1371/journal.pmed.1000073. Epub 2009 May 5. No abstract available.


Cyfip1 is a putative invasion suppressor in epithelial cancers.

Silva JM, Ezhkova E, Silva J, Heart S, Castillo M, Campos Y, Castro V, Bonilla F, Cordon-Cardo C, Muthuswamy SK, Powers S, Fuchs E, Hannon GJ.

Cell. 2009 Jun 12;137(6):1047-61. doi: 10.1016/j.cell.2009.04.013.


Epithelial-mesenchymal transition.

Zavadil J, Haley J, Kalluri R, Muthuswamy SK, Thompson E.

Cancer Res. 2008 Dec 1;68(23):9574-7. doi: 10.1158/0008-5472.CAN-08-2316. No abstract available.


Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma.

Zhan L, Rosenberg A, Bergami KC, Yu M, Xuan Z, Jaffe AB, Allred C, Muthuswamy SK.

Cell. 2008 Nov 28;135(5):865-78. doi: 10.1016/j.cell.2008.09.045.


Par complex in cancer: a regulator of normal cell polarity joins the dark side.

Aranda V, Nolan ME, Muthuswamy SK.

Oncogene. 2008 Nov 24;27(55):6878-87. doi: 10.1038/onc.2008.340. Review.


ErbB receptors and cell polarity: new pathways and paradigms for understanding cell migration and invasion.

Feigin ME, Muthuswamy SK.

Exp Cell Res. 2009 Feb 15;315(4):707-16. doi: 10.1016/j.yexcr.2008.10.034. Epub 2008 Nov 5. Review.


The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer.

Nolan ME, Aranda V, Lee S, Lakshmi B, Basu S, Allred DC, Muthuswamy SK.

Cancer Res. 2008 Oct 15;68(20):8201-9. doi: 10.1158/0008-5472.CAN-07-6567.


Brk is coamplified with ErbB2 to promote proliferation in breast cancer.

Xiang B, Chatti K, Qiu H, Lakshmi B, Krasnitz A, Hicks J, Yu M, Miller WT, Muthuswamy SK.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12463-8. doi: 10.1073/pnas.0805009105. Epub 2008 Aug 21.


A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells.

Ibarra I, Erlich Y, Muthuswamy SK, Sachidanandam R, Hannon GJ.

Genes Dev. 2007 Dec 15;21(24):3238-43.


A brake becomes an accelerator: PTP1B--a new therapeutic target for breast cancer.

Tonks NK, Muthuswamy SK.

Cancer Cell. 2007 Mar;11(3):214-6.


Illuminating the center: mechanisms regulating lumen formation and maintenance in mammary morphogenesis.

Reginato MJ, Muthuswamy SK.

J Mammary Gland Biol Neoplasia. 2006 Oct;11(3-4):205-11. Review.


Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control.

Aranda V, Haire T, Nolan ME, Calarco JP, Rosenberg AZ, Fawcett JP, Pawson T, Muthuswamy SK.

Nat Cell Biol. 2006 Nov;8(11):1235-45. Epub 2006 Oct 22.


ErbB2 makes beta 4 integrin an accomplice in tumorigenesis.

Muthuswamy SK.

Cell. 2006 Aug 11;126(3):443-5. Review.


HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors.

Wang SE, Narasanna A, Perez-Torres M, Xiang B, Wu FY, Yang S, Carpenter G, Gazdar AF, Muthuswamy SK, Arteaga CL.

Cancer Cell. 2006 Jul;10(1):25-38.

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