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Natural Transmission of Helicobacter saguini Causes Multigenerational Inflammatory Bowel Disease in C57/129 IL-10-/- Mice.

Mannion A, Shen Z, Feng Y, Puglisi D, Muthupalani S, Whary MT, Fox JG.

mSphere. 2020 Mar 25;5(2). pii: e00011-20. doi: 10.1128/mSphere.00011-20.


Helicobacter pylori antibiotic eradication coupled with a chemically defined diet in INS-GAS mice triggers dysbiosis and vitamin K deficiency resulting in gastric hemorrhage.

Quinn L, Sheh A, Ellis JL, Smith DE, Booth SL, Fu X, Muthupalani S, Ge Z, Puglisi DA, Wang TC, Gonda TA, Holcombe H, Fox JG.

Gut Microbes. 2020 Jan 19:1-22. doi: 10.1080/19490976.2019.1710092. [Epub ahead of print]


Muc5ac null mice are predisposed to spontaneous gastric antro-pyloric hyperplasia and adenomas coupled with attenuated H. pylori-induced corpus mucous metaplasia.

Muthupalani S, Ge Z, Joy J, Feng Y, Dobey C, Cho HY, Langenbach R, Wang TC, Hagen SJ, Fox JG.

Lab Invest. 2019 Dec;99(12):1887-1905. doi: 10.1038/s41374-019-0293-y. Epub 2019 Aug 9.


High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett's Esophagus via Interleukin 8 and Alterations to the Gut Microbiome.

Münch NS, Fang HY, Ingermann J, Maurer HC, Anand A, Kellner V, Sahm V, Wiethaler M, Baumeister T, Wein F, Einwächter H, Bolze F, Klingenspor M, Haller D, Kavanagh M, Lysaght J, Friedman R, Dannenberg AJ, Pollak M, Holt PR, Muthupalani S, Fox JG, Whary MT, Lee Y, Ren TY, Elliot R, Fitzgerald R, Steiger K, Schmid RM, Wang TC, Quante M.

Gastroenterology. 2019 Aug;157(2):492-506.e2. doi: 10.1053/j.gastro.2019.04.013. Epub 2019 Apr 15.


Mutagenicity of Helicobacter hepaticus infection in the lower bowel mucosa of 129/SvEv Rag2-/- Il10-/- gpt delta mice is influenced by sex.

Ge Z, Feng Y, Sheh A, Muthupalani S, Gong G, Chawanthayatham S, Essigmann JM, Fox JG.

Int J Cancer. 2019 Aug 15;145(4):1042-1054. doi: 10.1002/ijc.32332. Epub 2019 May 7.


Loss of Tight Junction Protein Claudin 18 Promotes Progressive Neoplasia Development in Mouse Stomach.

Hagen SJ, Ang LH, Zheng Y, Karahan SN, Wu J, Wang YE, Caron TJ, Gad AP, Muthupalani S, Fox JG.

Gastroenterology. 2018 Dec;155(6):1852-1867. doi: 10.1053/j.gastro.2018.08.041. Epub 2018 Sep 7.


Lung Lobe Torsion in an Adult Male Common Marmoset (Callithrix jacchus).

Winn CB, Artim SC, Jamiel MS, Burns MA, Haupt JL, Fox JG, Muthupalani S.

Comp Med. 2018 Aug 1;68(4):314-318. doi: 10.30802/AALAS-CM-17-000128. Epub 2018 Jul 16.


Evaluation of Lineage Changes in the Gastric Mucosa Following Infection With Helicobacter pylori and Specified Intestinal Flora in INS-GAS Mice.

Pinzon-Guzman C, Meyer AR, Wise R, Choi E, Muthupalani S, Wang TC, Fox JG, Goldenring JR.

J Histochem Cytochem. 2018 Jul 1:22155418785621. doi: 10.1369/0022155418785621. [Epub ahead of print]


Helicobacter pylori-infected C57BL/6 mice with different gastrointestinal microbiota have contrasting gastric pathology, microbial and host immune responses.

Ge Z, Sheh A, Feng Y, Muthupalani S, Ge L, Wang C, Kurnick S, Mannion A, Whary MT, Fox JG.

Sci Rep. 2018 May 22;8(1):8014. doi: 10.1038/s41598-018-25927-2.


Adult-onset, chronic, cyclic thrombocytopenia in a Rhesus macaque (Macaca mulatta) after dengue virus vaccination and viral challenge.

Frydman GH, Metcalf Pate KA, Marini RP, de Laforcade AM, Bosch I, Bakthavatchalu V, Muthupalani S, Swennes AG, Lyons CE, Tompkins RG, Fox JG.

Vet Clin Pathol. 2017 Jun;46(2):238-247. doi: 10.1111/vcp.12497. Epub 2017 May 18.


Local and Systemic Changes Associated with Long-term, Percutaneous, Static Implantation of Titanium Alloys in Rhesus Macaques (Macaca mulatta).

Frydman GH, Marini RP, Bakthavatchalu V, Biddle KE, Muthupalani S, Vanderburg CR, Lai B, Bendapudi PK, Tompkins RG, Fox JG.

Comp Med. 2017 Mar 1;67(2):165-175.


Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer.

Wang C, Gong G, Sheh A, Muthupalani S, Bryant EM, Puglisi DA, Holcombe H, Conaway EA, Parry NAP, Bakthavatchalu V, Short SP, Williams CS, Wogan GN, Tannenbaum SR, Fox JG, Horwitz BH.

Mucosal Immunol. 2017 Nov;10(6):1504-1517. doi: 10.1038/mi.2017.9. Epub 2017 Feb 15.


Helicobacter hepaticus cytolethal distending toxin promotes intestinal carcinogenesis in 129Rag2-deficient mice.

Ge Z, Feng Y, Ge L, Parry N, Muthupalani S, Fox JG.

Cell Microbiol. 2017 Jul;19(7). doi: 10.1111/cmi.12728. Epub 2017 Feb 20.


Novel Helicobacter species H.japonicum isolated from laboratory mice from Japan induces typhlocolitis and lower bowel carcinoma in C57BL/129 IL10-/- mice.

Shen Z, Feng Y, Muthupalani S, Sheh A, Cheaney LE, Kaufman CA, Gong G, Paster BJ, Fox JG.

Carcinogenesis. 2016 Dec;37(12):1190-1198. Epub 2016 Sep 21.


Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner.

Calvo JA, Allocca M, Fake KR, Muthupalani S, Corrigan JJ, Bronson RT, Samson LD.

Oncotarget. 2016 Jul 19;7(29):44950-44965. doi: 10.18632/oncotarget.10440.


Helicobacter saguini, a Novel Helicobacter Isolated from Cotton-Top Tamarins with Ulcerative Colitis, Has Proinflammatory Properties and Induces Typhlocolitis and Dysplasia in Gnotobiotic IL-10-/- Mice.

Shen Z, Mannion A, Whary MT, Muthupalani S, Sheh A, Feng Y, Gong G, Vandamme P, Holcombe HR, Paster BJ, Fox JG.

Infect Immun. 2016 Jul 21;84(8):2307-2316. doi: 10.1128/IAI.00235-16. Print 2016 Aug.


The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury.

Yu AM, Calvo JA, Muthupalani S, Samson LD.

Oncotarget. 2016 May 10;7(19):28624-36. doi: 10.18632/oncotarget.8721.


Lamellipodin-Deficient Mice: A Model of Rectal Carcinoma.

Miller CL, Muthupalani S, Shen Z, Drees F, Ge Z, Feng Y, Chen X, Gong G, Nagar KK, Wang TC, Gertler FB, Fox JG.

PLoS One. 2016 Apr 5;11(4):e0152940. doi: 10.1371/journal.pone.0152940. eCollection 2016.


Endocrinopathy and Aging in Ferrets.

Bakthavatchalu V, Muthupalani S, Marini RP, Fox JG.

Vet Pathol. 2016 Mar;53(2):349-65. doi: 10.1177/0300985815623621. Review.


Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer.

Dubeykovskaya Z, Si Y, Chen X, Worthley DL, Renz BW, Urbanska AM, Hayakawa Y, Xu T, Westphalen CB, Dubeykovskiy A, Chen D, Friedman RA, Asfaha S, Nagar K, Tailor Y, Muthupalani S, Fox JG, Kitajewski J, Wang TC.

Nat Commun. 2016 Feb 4;7:10517. doi: 10.1038/ncomms10517.


Systemic Coronaviral Disease in 5 Ferrets.

Autieri CR, Miller CL, Scott KE, Kilgore A, Papscoe VA, Garner MM, Haupt JL, Bakthavatchalu V, Muthupalani S, Fox JG.

Comp Med. 2015 Dec;65(6):508-16.


Helicobacter pylori Infection Induces Anemia, Depletes Serum Iron Storage, and Alters Local Iron-Related and Adult Brain Gene Expression in Male INS-GAS Mice.

Burns M, Muthupalani S, Ge Z, Wang TC, Bakthavatchalu V, Cunningham C, Ennis K, Georgieff M, Fox JG.

PLoS One. 2015 Nov 17;10(11):e0142630. doi: 10.1371/journal.pone.0142630. eCollection 2015.


Male Syrian Hamsters Experimentally Infected with Helicobacter spp. of the H. bilis Cluster Develop MALT-Associated Gastrointestinal Lymphomas.

Woods SE, Ek C, Shen Z, Feng Y, Ge Z, Muthupalani S, Whary MT, Fox JG.

Helicobacter. 2016 Jun;21(3):201-17. doi: 10.1111/hel.12265. Epub 2015 Sep 8.


Inflammation-induced cell proliferation potentiates DNA damage-induced mutations in vivo.

Kiraly O, Gong G, Olipitz W, Muthupalani S, Engelward BP.

PLoS Genet. 2015 Feb 3;11(2):e1004901. doi: 10.1371/journal.pgen.1004901. eCollection 2015 Feb.


Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.

Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar K, Wang H, Kheirbek MA, Kolhe A, Carpenter J, Glaire M, Nair A, Renders S, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY, Karsenty G, Mukherjee S, Wang TC.

Cell. 2015 Jan 15;160(1-2):269-84. doi: 10.1016/j.cell.2014.11.042.


Impaired cholecystokinin-induced gallbladder emptying incriminated in spontaneous "black" pigment gallstone formation in germfree Swiss Webster mice.

Woods SE, Leonard MR, Hayden JA, Brophy MB, Bernert KR, Lavoie B, Muthupalani S, Whary MT, Mawe GM, Nolan EM, Carey MC, Fox JG.

Am J Physiol Gastrointest Liver Physiol. 2015 Feb 15;308(4):G335-49. doi: 10.1152/ajpgi.00314.2014. Epub 2014 Dec 4.


Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney.

Ebrahimkhani MR, Daneshmand A, Mazumder A, Allocca M, Calvo JA, Abolhassani N, Jhun I, Muthupalani S, Ayata C, Samson LD.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4878-86. doi: 10.1073/pnas.1413582111. Epub 2014 Oct 27.


Helicobacter hepaticus infection promotes hepatitis and preneoplastic foci in farnesoid X receptor (FXR) deficient mice.

Swennes AG, Sheh A, Parry NM, Muthupalani S, Lertpiriyapong K, García A, Fox JG.

PLoS One. 2014 Sep 3;9(9):e106764. doi: 10.1371/journal.pone.0106764. eCollection 2014.


Denervation suppresses gastric tumorigenesis.

Zhao CM, Hayakawa Y, Kodama Y, Muthupalani S, Westphalen CB, Andersen GT, Flatberg A, Johannessen H, Friedman RA, Renz BW, Sandvik AK, Beisvag V, Tomita H, Hara A, Quante M, Li Z, Gershon MD, Kaneko K, Fox JG, Wang TC, Chen D.

Sci Transl Med. 2014 Aug 20;6(250):250ra115. doi: 10.1126/scitranslmed.3009569.


Isolation of Helicobacter spp. from mice with rectal prolapses.

Miller CL, Muthupalani S, Shen Z, Fox JG.

Comp Med. 2014 Jun;64(3):171-8.


CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis.

Hayakawa Y, Jin G, Wang H, Chen X, Westphalen CB, Asfaha S, Renz BW, Ariyama H, Dubeykovskaya ZA, Takemoto Y, Lee Y, Muley A, Tailor Y, Chen D, Muthupalani S, Fox JG, Shulkes A, Worthley DL, Takaishi S, Wang TC.

Gut. 2015 Apr;64(4):544-53. doi: 10.1136/gutjnl-2014-307190. Epub 2014 Jun 20.


Helicobacter hepaticus cholesterol-α-glucosyltransferase is essential for establishing colonization in male A/JCr mice.

Ge Z, Feng Y, Muthupalani S, Whary MT, Versalovic J, Fox JG.

Helicobacter. 2014 Aug;19(4):280-8. doi: 10.1111/hel.12135. Epub 2014 May 23.


Pathogenic properties of enterohepatic Helicobacter spp. isolated from rhesus macaques with intestinal adenocarcinoma.

Lertpiriyapong K, Handt L, Feng Y, Mitchell TW, Lodge KE, Shen Z, Dewhirst FE, Muthupalani S, Fox JG.

J Med Microbiol. 2014 Jul;63(Pt 7):1004-1016. doi: 10.1099/jmm.0.072462-0. Epub 2014 Apr 2.


GM1-gangliosidosis in American black bears: clinical, pathological, biochemical and molecular genetic characterization.

Muthupalani S, Torres PA, Wang BC, Zeng BJ, Eaton S, Erdelyi I, Ducore R, Maganti R, Keating J, Perry BJ, Tseng FS, Waliszewski N, Pokras M, Causey R, Seger R, March P, Tidwell A, Pfannl R, Seyfried T, Kolodny EH, Alroy J.

Mol Genet Metab. 2014 Apr;111(4):513-21. doi: 10.1016/j.ymgme.2014.02.002. Epub 2014 Feb 13.


Helminth co-infection in Helicobacter pylori infected INS-GAS mice attenuates gastric premalignant lesions of epithelial dysplasia and glandular atrophy and preserves colonization resistance of the stomach to lower bowel microbiota.

Whary MT, Muthupalani S, Ge Z, Feng Y, Lofgren J, Shi HN, Taylor NS, Correa P, Versalovic J, Wang TC, Fox JG.

Microbes Infect. 2014 Apr;16(4):345-55. doi: 10.1016/j.micinf.2014.01.005. Epub 2014 Feb 8.


Megaesophagus in a line of transgenic rats: a model of achalasia.

Pang J, Borjeson TM, Muthupalani S, Ducore RM, Carr CA, Feng Y, Sullivan MP, Cristofaro V, Luo J, Lindstrom JM, Fox JG.

Vet Pathol. 2014 Nov;51(6):1187-200. doi: 10.1177/0300985813519136. Epub 2014 Jan 23.


Mouse models of gastric cancer.

Hayakawa Y, Fox JG, Gonda T, Worthley DL, Muthupalani S, Wang TC.

Cancers (Basel). 2013 Jan 24;5(1):92-130. doi: 10.3390/cancers5010092.


Intestinal microbiota composition of interleukin-10 deficient C57BL/6J mice and susceptibility to Helicobacter hepaticus-induced colitis.

Yang I, Eibach D, Kops F, Brenneke B, Woltemate S, Schulze J, Bleich A, Gruber AD, Muthupalani S, Fox JG, Josenhans C, Suerbaum S.

PLoS One. 2013 Aug 9;8(8):e70783. doi: 10.1371/journal.pone.0070783. eCollection 2013.


An analysis of the role of the indigenous microbiota in cholesterol gallstone pathogenesis.

Fremont-Rahl JJ, Ge Z, Umana C, Whary MT, Taylor NS, Muthupalani S, Carey MC, Fox JG, Maurer KJ.

PLoS One. 2013 Jul 29;8(7):e70657. doi: 10.1371/journal.pone.0070657. Print 2013.


Colitis and colon cancer in WASP-deficient mice require helicobacter species.

Nguyen DD, Muthupalani S, Goettel JA, Eston MA, Mobley M, Taylor NS, McCabe A, Marin R, Snapper SB, Fox JG.

Inflamm Bowel Dis. 2013 Sep;19(10):2041-50. doi: 10.1097/MIB.0b013e318295fd8f.


Gastric colonisation with a restricted commensal microbiota replicates the promotion of neoplastic lesions by diverse intestinal microbiota in the Helicobacter pylori INS-GAS mouse model of gastric carcinogenesis.

Lertpiriyapong K, Whary MT, Muthupalani S, Lofgren JL, Gamazon ER, Feng Y, Ge Z, Wang TC, Fox JG.

Gut. 2014 Jan;63(1):54-63. doi: 10.1136/gutjnl-2013-305178. Epub 2013 Jun 28.


Obesity accelerates Helicobacter felis-induced gastric carcinogenesis by enhancing immature myeloid cell trafficking and TH17 response.

Ericksen RE, Rose S, Westphalen CB, Shibata W, Muthupalani S, Tailor Y, Friedman RA, Han W, Fox JG, Ferrante AW Jr, Wang TC.

Gut. 2014 Mar;63(3):385-94. doi: 10.1136/gutjnl-2013-305092. Epub 2013 May 31.


Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis.

Asfaha S, Dubeykovskiy AN, Tomita H, Yang X, Stokes S, Shibata W, Friedman RA, Ariyama H, Dubeykovskaya ZA, Muthupalani S, Ericksen R, Frucht H, Fox JG, Wang TC.

Gastroenterology. 2013 Jan;144(1):155-66. doi: 10.1053/j.gastro.2012.09.057. Epub 2012 Oct 3.


Systemic macrophage depletion inhibits Helicobacter bilis-induced proinflammatory cytokine-mediated typhlocolitis and impairs bacterial colonization dynamics in a BALB/c Rag2-/- mouse model of inflammatory bowel disease.

Muthupalani S, Ge Z, Feng Y, Rickman B, Mobley M, McCabe A, Van Rooijen N, Fox JG.

Infect Immun. 2012 Dec;80(12):4388-97. doi: 10.1128/IAI.00530-12. Epub 2012 Oct 1.


Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer.

Mangerich A, Knutson CG, Parry NM, Muthupalani S, Ye W, Prestwich E, Cui L, McFaline JL, Mobley M, Ge Z, Taghizadeh K, Wishnok JS, Wogan GN, Fox JG, Tannenbaum SR, Dedon PC.

Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):E1820-9. doi: 10.1073/pnas.1207829109. Epub 2012 Jun 11.


DNA repair is indispensable for survival after acute inflammation.

Calvo JA, Meira LB, Lee CY, Moroski-Erkul CA, Abolhassani N, Taghizadeh K, Eichinger LW, Muthupalani S, Nordstrand LM, Klungland A, Samson LD.

J Clin Invest. 2012 Jul;122(7):2680-9. doi: 10.1172/JCI63338. Epub 2012 Jun 11.


Enteric infection with Citrobacter rodentium induces coagulative liver necrosis and hepatic inflammation prior to peak infection and colonic disease.

Raczynski AR, Muthupalani S, Schlieper K, Fox JG, Tannenbaum SR, Schauer DB.

PLoS One. 2012;7(3):e33099. doi: 10.1371/journal.pone.0033099. Epub 2012 Mar 9.


Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors.

Shibata W, Ariyama H, Westphalen CB, Worthley DL, Muthupalani S, Asfaha S, Dubeykovskaya Z, Quante M, Fox JG, Wang TC.

Gut. 2013 Feb;62(2):192-200. doi: 10.1136/gutjnl-2011-301824. Epub 2012 Feb 23.


Folic acid increases global DNA methylation and reduces inflammation to prevent Helicobacter-associated gastric cancer in mice.

Gonda TA, Kim YI, Salas MC, Gamble MV, Shibata W, Muthupalani S, Sohn KJ, Abrams JA, Fox JG, Wang TC, Tycko B.

Gastroenterology. 2012 Apr;142(4):824-833.e7. doi: 10.1053/j.gastro.2011.12.058. Epub 2012 Jan 13.


Alkyl hydroperoxide reductase is required for Helicobacter cinaedi intestinal colonization and survival under oxidative stress in BALB/c and BALB/c interleukin-10-/- mice.

Charoenlap N, Shen Z, McBee ME, Muthupalani S, Wogan GN, Fox JG, Schauer DB.

Infect Immun. 2012 Mar;80(3):921-8. doi: 10.1128/IAI.05477-11. Epub 2011 Dec 19.

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