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Items: 9

1.

Is oxidative stress MYC's Achilles heel?

Muthalagu N, Murphy DJ.

Cell Death Differ. 2018 Jul;25(7):1189-1190. doi: 10.1038/s41418-018-0117-4. No abstract available.

2.

Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress.

Port J, Muthalagu N, Raja M, Ceteci F, Monteverde T, Kruspig B, Hedley A, Kalna G, Lilla S, Neilson L, Brucoli M, Gyuraszova K, Tait-Mulder J, Mezna M, Svambaryte S, Bryson A, Sumpton D, McVie A, Nixon C, Drysdale M, Esumi H, Murray GI, Sansom OJ, Zanivan SR, Murphy DJ.

Cancer Discov. 2018 May;8(5):632-647. doi: 10.1158/2159-8290.CD-17-0533. Epub 2018 Mar 2.

3.

MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance.

Farrell AS, Joly MM, Allen-Petersen BL, Worth PJ, Lanciault C, Sauer D, Link J, Pelz C, Heiser LM, Morton JP, Muthalagu N, Hoffman MT, Manning SL, Pratt ED, Kendsersky ND, Egbukichi N, Amery TS, Thoma MC, Jenny ZP, Rhim AD, Murphy DJ, Sansom OJ, Crawford HC, Sheppard BC, Sears RC.

Nat Commun. 2017 Nov 23;8(1):1728. doi: 10.1038/s41467-017-01967-6.

4.

Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics.

Sarosiek KA, Fraser C, Muthalagu N, Bhola PD, Chang W, McBrayer SK, Cantlon A, Fisch S, Golomb-Mello G, Ryan JA, Deng J, Jian B, Corbett C, Goldenberg M, Madsen JR, Liao R, Walsh D, Sedivy J, Murphy DJ, Carrasco DR, Robinson S, Moslehi J, Letai A.

Cancer Cell. 2017 Jan 9;31(1):142-156. doi: 10.1016/j.ccell.2016.11.011. Epub 2016 Dec 22.

5.

Evidence of cancer-promoting roles for AMPK and related kinases.

Monteverde T, Muthalagu N, Port J, Murphy DJ.

FEBS J. 2015 Dec;282(24):4658-71. doi: 10.1111/febs.13534. Epub 2015 Oct 19. Review.

6.

BIM's up first.

Murphy DJ, Muthalagu N.

Mol Cell Oncol. 2014 Dec 1;2(2):e975083. doi: 10.4161/23723556.2014.975083. eCollection 2015 Apr-Jun.

7.

Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death.

Ichim G, Lopez J, Ahmed SU, Muthalagu N, Giampazolias E, Delgado ME, Haller M, Riley JS, Mason SM, Athineos D, Parsons MJ, van de Kooij B, Bouchier-Hayes L, Chalmers AJ, Rooswinkel RW, Oberst A, Blyth K, Rehm M, Murphy DJ, Tait SWG.

Mol Cell. 2015 Mar 5;57(5):860-872. doi: 10.1016/j.molcel.2015.01.018. Epub 2015 Feb 19. Erratum in: Mol Cell. 2015 Jun 4;58(5):900.

8.

BIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues.

Muthalagu N, Junttila MR, Wiese KE, Wolf E, Morton J, Bauer B, Evan GI, Eilers M, Murphy DJ.

Cell Rep. 2014 Sep 11;8(5):1347-53. doi: 10.1016/j.celrep.2014.07.057. Epub 2014 Aug 28.

9.

Deregulated MYC expression induces dependence upon AMPK-related kinase 5.

Liu L, Ulbrich J, Müller J, Wüstefeld T, Aeberhard L, Kress TR, Muthalagu N, Rycak L, Rudalska R, Moll R, Kempa S, Zender L, Eilers M, Murphy DJ.

Nature. 2012 Mar 28;483(7391):608-12. doi: 10.1038/nature10927.

PMID:
22460906

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